IL71621A0 - Use of alpha factor sequences in yeast expression systems - Google Patents
Use of alpha factor sequences in yeast expression systemsInfo
- Publication number
- IL71621A0 IL71621A0 IL71621A IL7162184A IL71621A0 IL 71621 A0 IL71621 A0 IL 71621A0 IL 71621 A IL71621 A IL 71621A IL 7162184 A IL7162184 A IL 7162184A IL 71621 A0 IL71621 A0 IL 71621A0
- Authority
- IL
- Israel
- Prior art keywords
- expression systems
- yeast expression
- alpha factor
- factor sequences
- sequences
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
- C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48832383A | 1983-04-25 | 1983-04-25 | |
US50135283A | 1983-06-06 | 1983-06-06 | |
US50609883A | 1983-06-20 | 1983-06-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
IL71621A0 true IL71621A0 (en) | 1984-07-31 |
Family
ID=27413799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL71621A IL71621A0 (en) | 1983-04-25 | 1984-04-24 | Use of alpha factor sequences in yeast expression systems |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0123544A3 (de) |
KR (1) | KR840008695A (de) |
DK (1) | DK204784A (de) |
ES (1) | ES8603957A1 (de) |
IL (1) | IL71621A0 (de) |
NZ (1) | NZ207926A (de) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK172738B1 (da) * | 1983-04-07 | 1999-06-21 | Chiron Corp | Fremgangsmåde til at udtrykke modent insulin og DNA-struktur til anvendelse ved fremgangsmåden |
ATE95236T1 (de) | 1983-04-25 | 1993-10-15 | Chiron Corp | Hybrid-dns-synthesis von reifen insulinaehnlichen wachstumsfaktoren. |
IL71991A (en) | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
US4870008A (en) * | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
AU573883B2 (en) * | 1984-07-20 | 1988-06-23 | Celltech Limited | Vectors |
GB2177095B (en) * | 1984-07-20 | 1988-05-25 | Celltech Ltd | Eucaryotic expression vectors |
EP0170266B1 (de) * | 1984-07-30 | 1993-03-24 | Wakunaga Seiyaku Kabushiki Kaisha | Verfahren zur Herstellung eines Proteins und dafür zu verwendender Vektor, rekombinante DNS und transformierte Zelle |
US5498600A (en) * | 1984-10-12 | 1996-03-12 | Zymogenetics, Inc. | Biologically active mosaic proteins |
US5187263A (en) * | 1984-10-12 | 1993-02-16 | Zymogenetics, Inc. | Expression of biologically active PDGE analogs in eucaryotic cells |
EP0487116B1 (de) * | 1984-10-12 | 1999-12-29 | ZymoGenetics, Inc. | Von Blutplättchen abstammende biologisch aktive Analoga eines Wachstumsfaktors in eukaryotischen Zellen |
US5045633A (en) * | 1985-02-25 | 1991-09-03 | Zymogenetics, Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
US5821079A (en) * | 1985-05-02 | 1998-10-13 | Transgene S.A. | Vectors for the expression and secretion of hirudin by transformed yeasts |
FR2593518B1 (fr) * | 1985-05-02 | 1989-09-08 | Transgene Sa | Vecteurs d'expression et de secretion de l'hirudine par les levures transformees |
GB8521496D0 (en) * | 1985-08-29 | 1985-10-02 | Ciba Geigy Ag | Repressible yeast promoters |
US4937189A (en) * | 1985-10-18 | 1990-06-26 | Pfizer Inc. | Expression and secretion of heterologous proteins by Yarrowia lipolytica transformants |
DE3540075A1 (de) * | 1985-11-12 | 1987-05-14 | Boehringer Ingelheim Int | Human-lysozym |
US5024941A (en) * | 1985-12-18 | 1991-06-18 | Biotechnica International, Inc. | Expression and secretion vector for yeast containing a glucoamylase signal sequence |
ZA872534B (en) * | 1986-05-08 | 1987-11-25 | Phillips Petroleum Co | Yeast production of streptokinase |
US5002876A (en) * | 1986-09-22 | 1991-03-26 | Phillips Petroleum Company | Yeast production of human tumor necrosis factor |
US5013652A (en) * | 1986-10-14 | 1991-05-07 | Genex Corporation | Composite yeast vectors |
US5420242A (en) * | 1986-10-22 | 1995-05-30 | Kaare M. Gautvik | Production of human parathyroid hormone from microorganisms |
US5010010A (en) * | 1986-10-22 | 1991-04-23 | Selmer-Sande, A.S. | Production of human parathyroid hormone from microorganisms |
EP0604706A1 (de) | 1986-10-22 | 1994-07-06 | GAUTVIK, Kaare M., Dr. | Herstellung von humanem Parathormon mittels Mikroorganismen |
MY103358A (en) * | 1987-04-15 | 1993-06-30 | Novartis Ag | Process for the production of protiens. |
US5266474A (en) * | 1987-06-24 | 1993-11-30 | Genentech, Inc. | Balanced inducible transcription system |
WO1988010308A1 (en) * | 1987-06-24 | 1988-12-29 | Whitehead Institute For Biomedical Research | Pheromone-inducible yeast promoter |
US5063154A (en) * | 1987-06-24 | 1991-11-05 | Whitehead Institute For Biomedical Research | Pheromone - inducible yeast promoter |
US5010182A (en) * | 1987-07-28 | 1991-04-23 | Chiron Corporation | DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides |
US5879907A (en) * | 1987-09-14 | 1999-03-09 | Skandigen Ab | Artificial gene coding for authentic human serum albumin, use thereof and method |
SE459586B (sv) * | 1987-09-14 | 1989-07-17 | Mta Szegedi Biolog Koezponti | Strukturgen som kodar foer autentiskt humant serum albumin och foerfarande foer dess framstaellning |
ZA889415B (en) * | 1987-12-18 | 1989-09-27 | Chiron Corp | Compositions and method for recombinant production of crotalidus venum fibrolase |
CA1340772C (en) * | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
JP3092811B2 (ja) * | 1988-07-23 | 2000-09-25 | デルタ バイオテクノロジー リミテッド | ペプチドおよびdna配列 |
JPH0671434B2 (ja) * | 1989-09-18 | 1994-09-14 | 株式会社ミドリ十字 | ヒト血清アルブミンの製造方法 |
IE20020110A1 (en) | 1990-09-13 | 2003-05-28 | Univ Duke | Expression of G Protein Coupled Receptors in Yeast |
US5378823A (en) * | 1990-11-29 | 1995-01-03 | Institut National De La Recherche Agronomique-I.N.R.A. | Nucleic acids encoding type I interferon variants |
FR2669931B1 (fr) * | 1990-11-29 | 1995-03-31 | Transgene | Nouveaux variants derives des interferons-alpha et leur procede de production. |
JPH0671432B2 (ja) * | 1991-03-20 | 1994-09-14 | 株式会社ミドリ十字 | ヒト血清アルブミンの製造方法 |
FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
US5538863A (en) * | 1993-07-01 | 1996-07-23 | Immunex Corporation | Expression system comprising mutant yeast strain and expression vector encoding synthetic signal peptide |
JPH07308199A (ja) | 1994-05-18 | 1995-11-28 | Green Cross Corp:The | ヒト血清アルブミンの製造方法 |
US6500645B1 (en) | 1994-06-17 | 2002-12-31 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
DE69635700T3 (de) | 1995-03-17 | 2015-05-21 | Novozymes A/S | Neue Endoglukanase |
GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
EP1231218B1 (de) | 1996-03-01 | 2008-05-14 | Novo Nordisk A/S | Peptid zur Appetitzügelung, dessen Zusammensetzungen und Verwendung |
AU733007B2 (en) * | 1996-09-24 | 2001-05-03 | Cadus Pharmaceutical Corporation | Methods and compositions for identifying receptor effectors |
US6265186B1 (en) | 1997-04-11 | 2001-07-24 | Dsm N.V. | Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces |
SE9702401D0 (sv) | 1997-06-19 | 1997-06-19 | Astra Ab | Pharmaceutical use |
US6946134B1 (en) | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP1278544A4 (de) | 2000-04-12 | 2004-08-18 | Human Genome Sciences Inc | Albumin fusionsproteine |
MXPA03008590A (es) | 2001-03-22 | 2003-12-08 | Novo Nordisk Healthcare Ag | Derivados del factor vii de coagulacion. |
US7507413B2 (en) | 2001-04-12 | 2009-03-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
CN1602354A (zh) | 2001-09-27 | 2005-03-30 | 诺和诺德医疗保健公司 | 人凝血因子ⅶ多肽 |
EP2277910A1 (de) | 2001-12-21 | 2011-01-26 | Human Genome Sciences, Inc. | Albumin Fusionsproteine |
GB0217033D0 (en) | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
ATE492631T1 (de) | 2002-09-13 | 2011-01-15 | Cornell Res Foundation Inc | Verwendung von mutationen zur verbesserung von aspergillus-phytasen |
ATE547519T1 (de) | 2003-09-09 | 2012-03-15 | Novo Nordisk Healthcare Ag | Gerinnungsfaktor-vii-polypeptide |
MX2007012887A (es) | 2005-04-18 | 2007-12-10 | Novo Nordisk As | Variantes il-21. |
US20090055942A1 (en) | 2005-09-14 | 2009-02-26 | Novo Nordisk Healthcare A/G | Human Coagulation Factor VII Polypeptides |
EP2069396B1 (de) | 2006-09-08 | 2015-10-21 | Ambrx, Inc. | Modifiziertes polypeptid oder fc-gerüste aus humanem plasma und ihre verwendung |
US20110065642A1 (en) | 2008-05-15 | 2011-03-17 | R-Tech Ueno, Ltd. | Pharmaceutical composition for the treatment of dry eye and/or corneal and conjunctival lesion |
WO2010103038A1 (en) | 2009-03-11 | 2010-09-16 | Novo Nordisk A/S | Interleukin-21 variants having antagonistic binding to the il-21 receptor |
CA2767755C (en) | 2009-07-17 | 2021-10-12 | Rigshospitalet | Inhibitors of complement activation |
CN102666570B (zh) | 2009-12-01 | 2015-12-02 | 诺沃—诺迪斯克有限公司 | 新的肽基α-羟基甘氨酸α-酰胺化裂合酶 |
WO2011107591A1 (en) | 2010-03-05 | 2011-09-09 | Rigshospitalet | Chimeric inhibitor molecules of complement activation |
JP6517018B2 (ja) | 2012-02-09 | 2019-05-22 | ヴァー2・ファーマシューティカルズ・アンパルトセルスカブVAR2 Pharmaceuticals ApS | コンドロイチン硫酸グリカンのターゲティング |
CN104704118A (zh) | 2012-10-15 | 2015-06-10 | 诺和诺德保健Ag(股份有限公司) | 凝血因子vii多肽 |
US10364421B2 (en) | 2015-02-06 | 2019-07-30 | Cargill, Incorporated | Modified glucoamylase enzymes and yeast strains having enhanced bioproduct production |
WO2016160584A1 (en) | 2015-03-27 | 2016-10-06 | Cargill, Incorporated | Glucoamylase-modified yeast strains and methods for bioproduct production |
EA037848B1 (ru) | 2016-07-14 | 2021-05-27 | Общество С Ограниченной Ответственностью "Биохимический Агент" | Гибридный белок, полинуклеотид, генетическая конструкция, продуцент, препарат для регенерации хряща (варианты) |
CA3032736A1 (en) | 2016-08-05 | 2018-02-08 | Cargill, Incorporated | Leader-modified glucoamylase polypeptides and engineered yeast strains having enhanced bioproduct production |
US20210278406A1 (en) | 2018-07-13 | 2021-09-09 | Varct Diagnostic Aps | Isolation of circulating cells of fetal origin using recombinant malaria protein var2csa |
WO2022049409A1 (en) | 2020-09-02 | 2022-03-10 | Sia Terragen | Express diagnosticum for sars-cov-2 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3382547D1 (de) * | 1983-01-12 | 1992-05-27 | Chiron Corp | Sekretorische expression in eukaryoten. |
DK172738B1 (da) * | 1983-04-07 | 1999-06-21 | Chiron Corp | Fremgangsmåde til at udtrykke modent insulin og DNA-struktur til anvendelse ved fremgangsmåden |
WO1984004330A1 (en) * | 1983-04-22 | 1984-11-08 | Amgen | Secretion of exogenous polypeptides from yeast |
ATE95236T1 (de) * | 1983-04-25 | 1993-10-15 | Chiron Corp | Hybrid-dns-synthesis von reifen insulinaehnlichen wachstumsfaktoren. |
US4588684A (en) * | 1983-04-26 | 1986-05-13 | Chiron Corporation | a-Factor and its processing signals |
JPS59227899A (ja) * | 1983-05-25 | 1984-12-21 | チロン・コ−ポレイシヨン | 成長ホルモン放出因子の製造方法 |
IL71991A (en) * | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
JPS61500586A (ja) * | 1983-11-14 | 1986-04-03 | チロン コ−ポレイシヨン | インタ−ロイキン−2産生のための方法及び組成物 |
EP0180615B1 (de) * | 1984-04-19 | 1995-04-05 | Scios Nova Inc. | Atrielle natriumuretische/gefässerweiterende polypeptide |
-
1984
- 1984-04-19 NZ NZ207926A patent/NZ207926A/en unknown
- 1984-04-24 KR KR1019840002188A patent/KR840008695A/ko not_active IP Right Cessation
- 1984-04-24 IL IL71621A patent/IL71621A0/xx unknown
- 1984-04-24 DK DK204784A patent/DK204784A/da not_active Application Discontinuation
- 1984-04-24 EP EP84302723A patent/EP0123544A3/de not_active Withdrawn
- 1984-04-25 ES ES531898A patent/ES8603957A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
KR840008695A (ko) | 1984-12-17 |
DK204784A (da) | 1984-10-26 |
DK204784D0 (da) | 1984-04-24 |
EP0123544A3 (de) | 1986-07-16 |
ES531898A0 (es) | 1986-01-16 |
NZ207926A (en) | 1988-04-29 |
ES8603957A1 (es) | 1986-01-16 |
EP0123544A2 (de) | 1984-10-31 |
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