IL68496A - 8-heteroarylalkyl-ergoline derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
8-heteroarylalkyl-ergoline derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL68496A IL68496A IL68496A IL6849683A IL68496A IL 68496 A IL68496 A IL 68496A IL 68496 A IL68496 A IL 68496A IL 6849683 A IL6849683 A IL 6849683A IL 68496 A IL68496 A IL 68496A
- Authority
- IL
- Israel
- Prior art keywords
- heteroarylalkyl
- preparation
- pharmaceutical compositions
- compositions containing
- ergoline derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8212653 | 1982-04-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL68496A0 IL68496A0 (en) | 1983-07-31 |
IL68496A true IL68496A (en) | 1985-06-30 |
Family
ID=10530108
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL68496A IL68496A (en) | 1982-04-30 | 1983-04-26 | 8-heteroarylalkyl-ergoline derivatives,their preparation and pharmaceutical compositions containing them |
Country Status (21)
Country | Link |
---|---|
US (1) | US4657914A (da) |
JP (1) | JPS58194884A (da) |
AT (1) | AT385035B (da) |
AU (1) | AU553851B2 (da) |
BE (1) | BE896609A (da) |
CA (1) | CA1210389A (da) |
CH (1) | CH654305A5 (da) |
CS (1) | CS236874B2 (da) |
DE (1) | DE3314878A1 (da) |
DK (1) | DK164058C (da) |
FI (1) | FI73996C (da) |
FR (1) | FR2526022B1 (da) |
GB (1) | GB2120242A (da) |
GR (1) | GR78842B (da) |
HU (1) | HU193527B (da) |
IE (1) | IE53950B1 (da) |
IL (1) | IL68496A (da) |
IT (1) | IT1215630B (da) |
NL (1) | NL191709C (da) |
SE (1) | SE460967B (da) |
ZA (1) | ZA833008B (da) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8714767D0 (en) * | 1987-06-24 | 1987-07-29 | Erba Farmitalia | Egoline derivatives |
HU190105B (en) * | 1983-06-03 | 1986-08-28 | Gyogyszerkutato Intezet | Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts |
GB2173189B (en) * | 1985-02-21 | 1988-04-27 | Maruko Pharmaceutical Co | Ergoline derivatives and salts thereof and pharmaceutical compositions thereof |
GB8702364D0 (en) * | 1987-02-03 | 1987-03-11 | Erba Farmitalia | Ergolinyl heterocycles |
US8877795B2 (en) | 2010-05-07 | 2014-11-04 | The Board Of Trustees Of The Leland Stanford Junior University | Identification of stabilizers of multimeric proteins |
WO2016025129A1 (en) | 2014-08-14 | 2016-02-18 | Alhamadsheh Mamoun M | Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life |
EA201991921A1 (ru) | 2017-02-17 | 2020-02-06 | Эйдос Терапьютикс, Инк. | Способы получения ag-10, его промежуточных соединений и их солей |
AU2019239291A1 (en) | 2018-03-23 | 2020-10-08 | Eidos Therapeutics, Inc. | Methods of treating TTR amyloidosis using AG10 |
CA3104695A1 (en) | 2018-08-17 | 2020-02-20 | Eidos Therapeutics, Inc. | Formulations of ag10 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3238211A (en) * | 1966-03-01 | Derhvatives of g-methyl and i,g-dimethyl ergolhne | ||
US3296071A (en) * | 1963-05-31 | 1967-01-03 | Upjohn Co | Reducing blood sugar with 3-alkyl-5-alkoxymethylisoxazole |
CH507248A (de) * | 1967-03-16 | 1971-05-15 | Spofa Vereinigte Pharma Werke | Verfahren zur Herstellung von D-6-Methylergolin(I)ylessigsäure |
US3957785A (en) * | 1971-12-02 | 1976-05-18 | Societa' Farmaceutici Italia S.P.A. | Bβ-Pyrimidino-aminomethyl-10α-ergoline and 10α-methoxyergoline derivatives |
CH563376A5 (da) * | 1972-06-29 | 1975-06-30 | Lonza Ag | |
US3996228A (en) * | 1973-12-21 | 1976-12-07 | Societa' Farmaceutici Italia S.P.A. | Pyrimidinoaminoethyl ergoline derivatives |
NL7416120A (nl) * | 1973-12-21 | 1975-06-24 | Farmaceutici Italia | Werkwijze voor het bereiden van pyrimidinoami- nomethylergolinederivaten. |
US4147789A (en) * | 1974-03-14 | 1979-04-03 | Sandoz Ltd. | 6-Methyl-8-thiomethyl-ergolene derivatives |
IE41533B1 (en) * | 1974-03-14 | 1980-01-30 | Sandoz Ltd | Thiomethyl ergolene derivatives |
CS171480B1 (da) * | 1974-03-19 | 1976-10-29 | ||
CS177530B1 (en) * | 1974-07-19 | 1977-07-29 | Miroslav Semonsky | New nbeta-substituted derivatives of b-beta-aminoethyl-ergoline-i their salts and methods for the production thereof |
CH617452A5 (da) * | 1974-10-25 | 1980-05-30 | Hoffmann La Roche | |
CH615929A5 (en) * | 1975-06-02 | 1980-02-29 | Sandoz Ag | Process for the preparation of novel ergoline compounds |
CH622518A5 (en) * | 1976-12-14 | 1981-04-15 | Sandoz Ag | Process for the preparation of novel ergoline compounds |
AU526764B2 (en) * | 1978-09-08 | 1983-01-27 | Farmitalia Carlo Erba S.P.A. | Ergoline derivatives |
GB2056437A (en) * | 1979-08-07 | 1981-03-18 | Erba Farmitalia | Secoergoline derivatives |
US4382940A (en) * | 1979-12-06 | 1983-05-10 | Farmitalia Carlo Erba S.P.A. | Ercoline derivatives and therapeutic compositions having CNS affecting activity |
-
1983
- 1983-04-21 GB GB08310843A patent/GB2120242A/en not_active Withdrawn
- 1983-04-25 GR GR71190A patent/GR78842B/el unknown
- 1983-04-25 DE DE19833314878 patent/DE3314878A1/de active Granted
- 1983-04-25 IE IE932/83A patent/IE53950B1/en not_active IP Right Cessation
- 1983-04-25 FI FI831406A patent/FI73996C/fi not_active IP Right Cessation
- 1983-04-25 CS CS832921A patent/CS236874B2/cs unknown
- 1983-04-25 US US06/488,168 patent/US4657914A/en not_active Expired - Fee Related
- 1983-04-26 JP JP58072295A patent/JPS58194884A/ja active Granted
- 1983-04-26 CH CH2256/83A patent/CH654305A5/it not_active IP Right Cessation
- 1983-04-26 IL IL68496A patent/IL68496A/xx not_active IP Right Cessation
- 1983-04-27 IT IT8320807A patent/IT1215630B/it active
- 1983-04-27 HU HU851631A patent/HU193527B/hu not_active IP Right Cessation
- 1983-04-27 FR FR8306926A patent/FR2526022B1/fr not_active Expired
- 1983-04-27 CA CA000426874A patent/CA1210389A/en not_active Expired
- 1983-04-27 SE SE8302379A patent/SE460967B/sv not_active IP Right Cessation
- 1983-04-28 DK DK189983A patent/DK164058C/da not_active IP Right Cessation
- 1983-04-28 AU AU14029/83A patent/AU553851B2/en not_active Ceased
- 1983-04-28 ZA ZA833008A patent/ZA833008B/xx unknown
- 1983-04-29 AT AT0156783A patent/AT385035B/de not_active IP Right Cessation
- 1983-04-29 NL NL8301529A patent/NL191709C/xx not_active IP Right Cessation
- 1983-04-29 BE BE0/210660A patent/BE896609A/fr not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |