IL68366A - Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture - Google Patents

Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture

Info

Publication number
IL68366A
IL68366A IL68366A IL6836683A IL68366A IL 68366 A IL68366 A IL 68366A IL 68366 A IL68366 A IL 68366A IL 6836683 A IL6836683 A IL 6836683A IL 68366 A IL68366 A IL 68366A
Authority
IL
Israel
Prior art keywords
microorganism
expressing
protein
cell culture
gene encoding
Prior art date
Application number
IL68366A
Other languages
English (en)
Other versions
IL68366A0 (en
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Priority to IL8323683A priority Critical patent/IL83236A/xx
Publication of IL68366A0 publication Critical patent/IL68366A0/xx
Priority to IL83236A priority patent/IL83236A0/xx
Publication of IL68366A publication Critical patent/IL68366A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
IL68366A 1982-04-15 1983-04-12 Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture IL68366A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL8323683A IL83236A (en) 1982-04-15 1983-04-12 Preparation of bioactive human urokinase protein
IL83236A IL83236A0 (en) 1982-04-15 1987-07-17 Preparation of functional human urokinase proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36877382A 1982-04-15 1982-04-15
US47493083A 1983-03-14 1983-03-14

Publications (2)

Publication Number Publication Date
IL68366A0 IL68366A0 (en) 1983-07-31
IL68366A true IL68366A (en) 1990-08-31

Family

ID=27004326

Family Applications (2)

Application Number Title Priority Date Filing Date
IL68366A IL68366A (en) 1982-04-15 1983-04-12 Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture
IL83236A IL83236A0 (en) 1982-04-15 1987-07-17 Preparation of functional human urokinase proteins

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL83236A IL83236A0 (en) 1982-04-15 1987-07-17 Preparation of functional human urokinase proteins

Country Status (20)

Country Link
EP (2) EP0092182B1 (fr)
JP (3) JPH0655145B2 (fr)
AT (2) ATE112802T1 (fr)
AU (1) AU573523B2 (fr)
BR (1) BR8301918A (fr)
CA (1) CA1341301C (fr)
DE (2) DE3382837T2 (fr)
DK (1) DK173910B1 (fr)
ES (3) ES521418A0 (fr)
FI (1) FI88932C (fr)
GR (1) GR78180B (fr)
HK (1) HK38297A (fr)
IE (1) IE64536B1 (fr)
IL (2) IL68366A (fr)
MY (1) MY102472A (fr)
NO (1) NO831317L (fr)
NZ (1) NZ203869A (fr)
PH (4) PH24783A (fr)
PT (1) PT76546B (fr)
YU (1) YU45128B (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
IE81141B1 (en) * 1983-06-24 2000-04-05 Genencor Int Procaryotic carbonyl hydrolases
AU587960B2 (en) * 1983-06-24 1989-09-07 Genentech Inc. Procaryotic carbonyl hydrolases
DE3486023T2 (de) * 1983-09-13 1993-06-24 Green Cross Corp Verfahren zur herstellung von urokinase zymogen.
JPS60180591A (ja) * 1984-02-27 1985-09-14 Green Cross Corp:The ヒトウロキナ−ゼのｄνａ配列，プラスミド，宿主
EP0154272B1 (fr) * 1984-02-27 1992-01-08 Green Cross Corporation Production d'urokinase humaine
JPS61177987A (ja) * 1985-01-31 1986-08-09 Green Cross Corp:The ヒトウロキナ−ゼの製造方法
JPS61181377A (ja) * 1985-01-25 1986-08-14 Sagami Chem Res Center ヒトウロキナ−ゼ遺伝子
AU5390286A (en) * 1985-01-25 1986-08-13 Sagami Chemical Research Center Stabilized human prourokinase
US5219569A (en) * 1985-04-22 1993-06-15 Genentech, Inc. Protease resistant urokinase
US4916071A (en) 1985-08-14 1990-04-10 American Home Products Corporation Poly-kringle plasminogen activator
US4997766A (en) * 1986-07-11 1991-03-05 American Home Products Corporation Poly-kringle plasminogen activator
JPS62149625A (ja) * 1985-12-25 1987-07-03 Green Cross Corp:The 生理活性物質の製造方法
DE3613401A1 (de) * 1986-04-21 1987-12-17 Boehringer Mannheim Gmbh Verfahren zur herstellung von plasminogen-aktivatoren in prokaryonten
NL8601240A (nl) * 1986-05-15 1987-12-01 Leuven Res & Dev Vzw Plasminogeenactivator en trombolytisch geneesmiddel.
GB8623823D0 (en) * 1986-10-03 1986-11-05 Sandoz Ltd Therapeutic lysis of fibrin blood clots
JPS63105675A (ja) * 1986-10-23 1988-05-10 Green Cross Corp:The ヒトウロキナ−ゼの製造方法
ZA879286B (en) 1986-12-16 1988-10-26 Smith Kline Rit New plasminogen activators
US5376547A (en) * 1987-01-30 1994-12-27 American Home Products Corporation Des-epidermal growth factor plasminogen activators
MY103358A (en) * 1987-04-15 1993-06-30 Novartis Ag Process for the production of protiens.
WO1989001513A1 (fr) * 1987-08-19 1989-02-23 Sagami Chemical Research Center Prourokinase a action rapide
AU2334088A (en) * 1987-10-02 1989-05-18 Zymogenetics Inc. Bar1 secretion signal
JPH02438A (ja) * 1987-10-09 1990-01-05 Collaborative Res Inc 修飾した低分子量プラスミノーゲン活性化因子およびその製造方法
US4999194A (en) * 1988-01-14 1991-03-12 Collaborative Research, Inc. Two-chain urokinase plasminogen activators for treatment of thrombotic disease
US4920051A (en) * 1988-02-03 1990-04-24 Damon Biotech, Inc. Recovery of urokinase compounds
IE901849A1 (en) * 1989-07-19 1991-06-19 Gruenenthal Gmbh Plasmids, their preparation and their use in the manufacture¹of a plasminogen activator
AU6470590A (en) 1989-10-23 1991-04-26 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
JP3203599B2 (ja) * 1989-10-24 2001-08-27 カイロン コーポレイション 感染性タンパク質デリバリーシステム
DE4101736A1 (de) 1991-01-22 1992-07-23 Gruenenthal Gmbh Neue als plasminogenaktivatoren einsetzbare polypeptide, dafuer codierende plasmide und verfahren zu deren herstellung und deren verwendung
US5888814A (en) * 1994-06-06 1999-03-30 Chiron Corporation Recombinant host cells encoding TNF proteins
DE69924110D1 (de) * 1998-06-26 2005-04-14 Croptech Dev Corp Herstellung von urokinase in pflanzlichen expressionssystemen
US6833357B2 (en) 2000-06-20 2004-12-21 The Trustees Of The University Of Pennsylvania Compositions and methods for modulating muscle cell and tissue contractility
ES2400306T3 (es) * 2005-10-21 2013-04-09 Catalyst Biosciences, Inc. Proteasas modificadas que inhiben la activación del complemento
SG10201503055TA (en) 2006-07-05 2015-06-29 Catalyst Biosciences Inc Protease screening methods and proteases identified thereby

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0040238B1 (fr) * 1979-11-13 1984-07-11 HUSAIN, Syed Shaukat Activateurs plasminogenes utilies comme agents therapeutiques et diagnostiques et leur isolation
US4321363A (en) * 1980-02-21 1982-03-23 Nippon Soda Company Limited Adsorbent for urokinase containing agarose
US4370417A (en) * 1980-04-03 1983-01-25 Abbott Laboratories Recombinant deoxyribonucleic acid which codes for plasminogen activator
US4506013A (en) * 1980-10-03 1985-03-19 Eli Lilly And Company Stabilizing and selecting recombinant DNA host cells
EP0143081B1 (fr) * 1983-11-21 1989-08-23 Ciba-Geigy Ag Synthèse d'activateur du plasminogene tissulaire(TPA) par levure

Also Published As

Publication number Publication date
YU45128B (en) 1992-03-10
ES8506087A1 (es) 1985-07-01
FI831228A0 (fi) 1983-04-12
CA1341301C (fr) 2001-10-09
EP0620279B1 (fr) 2003-02-05
IE830850L (en) 1983-10-15
EP0092182A2 (fr) 1983-10-26
FI88932C (fi) 1993-07-26
HK38297A (en) 1997-04-04
MY102472A (en) 1992-06-30
FI831228L (fi) 1983-10-16
NO831317L (no) 1983-10-17
DE3382837D1 (de) 2003-03-13
DK163683D0 (da) 1983-04-14
DK163683A (da) 1983-11-28
JPH0824579B2 (ja) 1996-03-13
JP2584192B2 (ja) 1997-02-19
PH25120A (en) 1991-02-19
PT76546B (en) 1986-03-20
ES533924A0 (es) 1985-07-01
FI88932B (fi) 1993-04-15
IE64536B1 (en) 1995-08-09
JPH0655145B2 (ja) 1994-07-27
ATE232237T1 (de) 2003-02-15
ES8602121A1 (es) 1985-12-01
DE3382837T2 (de) 2004-01-15
ATE112802T1 (de) 1994-10-15
JPS5951300A (ja) 1984-03-24
PT76546A (en) 1983-05-01
PH24783A (en) 1990-10-30
DE3382760D1 (de) 1994-11-17
DK173910B1 (da) 2002-02-11
IL83236A0 (en) 1987-12-31
PH22461A (en) 1988-09-12
ES8500325A1 (es) 1984-11-01
BR8301918A (pt) 1983-12-20
NZ203869A (en) 1987-04-30
EP0092182B1 (fr) 1994-10-12
PH25312A (en) 1991-04-30
DE3382760T2 (de) 1995-03-02
GR78180B (fr) 1984-09-26
AU1352483A (en) 1983-10-20
IE950235L (en) 1983-10-15
IL68366A0 (en) 1983-07-31
EP0620279A1 (fr) 1994-10-19
ES521418A0 (es) 1984-11-01
JPH07186A (ja) 1995-01-06
YU86883A (en) 1988-10-31
ES533925A0 (es) 1985-12-01
JPH0530970A (ja) 1993-02-09
EP0092182A3 (en) 1984-07-18
AU573523B2 (en) 1988-06-16

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