IL65604A - 1'-substituted spiro(pyrrolidine-3,3'indoline)-2,2',5-trione derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
1'-substituted spiro(pyrrolidine-3,3'indoline)-2,2',5-trione derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL65604A IL65604A IL65604A IL6560482A IL65604A IL 65604 A IL65604 A IL 65604A IL 65604 A IL65604 A IL 65604A IL 6560482 A IL6560482 A IL 6560482A IL 65604 A IL65604 A IL 65604A
- Authority
- IL
- Israel
- Prior art keywords
- indoline
- pyrrolidine
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8114397 | 1981-05-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL65604A true IL65604A (en) | 1986-12-31 |
Family
ID=10521723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL65604A IL65604A (en) | 1981-05-12 | 1982-04-26 | 1'-substituted spiro(pyrrolidine-3,3'indoline)-2,2',5-trione derivatives,their preparation and pharmaceutical compositions containing them |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US4478847A (es) |
| EP (1) | EP0065407B1 (es) |
| JP (1) | JPS57192314A (es) |
| KR (1) | KR830009775A (es) |
| AT (1) | ATE12113T1 (es) |
| AU (1) | AU561390B2 (es) |
| CA (1) | CA1182823A (es) |
| DD (1) | DD202576A5 (es) |
| DE (1) | DE3262529D1 (es) |
| DK (1) | DK203882A (es) |
| ES (2) | ES8306485A1 (es) |
| FI (1) | FI821579L (es) |
| GR (1) | GR75871B (es) |
| HU (1) | HU186016B (es) |
| IE (1) | IE53102B1 (es) |
| IL (1) | IL65604A (es) |
| MW (1) | MW1982A1 (es) |
| NO (1) | NO821557L (es) |
| NZ (1) | NZ200576A (es) |
| PH (1) | PH18101A (es) |
| PL (1) | PL236283A1 (es) |
| PT (1) | PT74876B (es) |
| ZA (1) | ZA822797B (es) |
| ZM (1) | ZM3282A1 (es) |
| ZW (1) | ZW7882A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU566869B2 (en) * | 1982-05-11 | 1987-11-05 | Imperial Chemical Industries Plc | Spiro (imidazolidine-4,3'-indoline) 2,2',5-triones |
| GB8331194D0 (en) * | 1982-12-20 | 1983-12-29 | Ici Plc | Chemical process |
| JPS60142984A (ja) | 1983-12-28 | 1985-07-29 | Kyorin Pharmaceut Co Ltd | 新規なスピロピロリジン−２，５−ジオン誘導体およびその製造法 |
| US4567278A (en) * | 1984-03-26 | 1986-01-28 | Imperial Chemical Industries Plc | Process for racemizing certain spiro compounds |
| GB8415635D0 (en) * | 1984-06-19 | 1984-07-25 | Ici Plc | Cyclic amides |
| US5118703A (en) * | 1988-10-18 | 1992-06-02 | Pfizer Inc. | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
| US4900739A (en) * | 1988-10-20 | 1990-02-13 | American Home Products Corp. | Novel spirosuccinimides as aldose reductase inhibitors and antihyperglycemic agents |
| US4946858A (en) * | 1988-10-20 | 1990-08-07 | American Home Products Corporation | Novel spirosuccinimides as aldose reductase inhibitors and antihyperglycemic agents |
| FR2708606B1 (fr) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
| EP1429746B1 (en) * | 2001-09-28 | 2008-08-13 | McNEIL-PPC, INC. | Dosage forms having an inner core and outer shell |
| US6837696B2 (en) * | 2001-09-28 | 2005-01-04 | Mcneil-Ppc, Inc. | Apparatus for manufacturing dosage forms |
| RU2478639C2 (ru) * | 2005-05-24 | 2013-04-10 | Лаборатуар Сероно С.А. | Трициклические спиро-производные в качестве модуляторов crth2 |
| US20080057023A1 (en) * | 2006-08-29 | 2008-03-06 | Chynn Emil W | Oxygenated ophthalmic composition |
| WO2009026240A1 (en) * | 2007-08-17 | 2009-02-26 | Solexel, Inc. | Methods for liquid transfer coating of three-dimensional substrates |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4117230A (en) * | 1976-10-18 | 1978-09-26 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
| US4177230A (en) * | 1978-06-02 | 1979-12-04 | The United States Of America As Represented By The Secretary Of The Air Force | Process for producing reaction sintered silicon nitride of increased density |
| US4307108A (en) * | 1979-12-26 | 1981-12-22 | Pfizer Inc. | Method for lowering sorbitol levels using spiro-imides |
-
1982
- 1982-04-20 IE IE928/82A patent/IE53102B1/en not_active IP Right Cessation
- 1982-04-21 ZW ZW78/82A patent/ZW7882A1/xx unknown
- 1982-04-23 AU AU82994/82A patent/AU561390B2/en not_active Ceased
- 1982-04-23 ZA ZA822797A patent/ZA822797B/xx unknown
- 1982-04-23 MW MW19/82A patent/MW1982A1/xx unknown
- 1982-04-26 IL IL65604A patent/IL65604A/xx unknown
- 1982-04-29 GR GR68025A patent/GR75871B/el unknown
- 1982-04-30 ZM ZM32/82A patent/ZM3282A1/xx unknown
- 1982-05-04 PL PL23628382A patent/PL236283A1/xx unknown
- 1982-05-05 FI FI821579A patent/FI821579L/fi not_active Application Discontinuation
- 1982-05-06 DK DK203882A patent/DK203882A/da not_active Application Discontinuation
- 1982-05-10 PH PH27252A patent/PH18101A/en unknown
- 1982-05-10 HU HU821453A patent/HU186016B/hu unknown
- 1982-05-11 NO NO821557A patent/NO821557L/no unknown
- 1982-05-11 US US06/377,135 patent/US4478847A/en not_active Expired - Fee Related
- 1982-05-11 DE DE8282302395T patent/DE3262529D1/de not_active Expired
- 1982-05-11 CA CA000402665A patent/CA1182823A/en not_active Expired
- 1982-05-11 EP EP82302395A patent/EP0065407B1/en not_active Expired
- 1982-05-11 NZ NZ200576A patent/NZ200576A/en unknown
- 1982-05-11 PT PT74876A patent/PT74876B/pt unknown
- 1982-05-11 AT AT82302395T patent/ATE12113T1/de not_active IP Right Cessation
- 1982-05-11 ES ES512093A patent/ES8306485A1/es not_active Expired
- 1982-05-12 JP JP57078475A patent/JPS57192314A/ja active Pending
- 1982-05-12 DD DD82239804A patent/DD202576A5/de unknown
- 1982-05-12 KR KR1019820002107A patent/KR830009775A/ko unknown
-
1983
- 1983-02-14 ES ES519780A patent/ES8402840A1/es not_active Expired
-
1984
- 1984-08-07 US US06/638,500 patent/US4523021A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IE820928L (en) | 1982-11-12 |
| AU561390B2 (en) | 1987-05-07 |
| EP0065407B1 (en) | 1985-03-13 |
| ES512093A0 (es) | 1983-06-01 |
| US4523021A (en) | 1985-06-11 |
| DD202576A5 (de) | 1983-09-21 |
| GR75871B (es) | 1984-08-02 |
| FI821579A0 (fi) | 1982-05-05 |
| NO821557L (no) | 1982-11-15 |
| NZ200576A (en) | 1984-11-09 |
| CA1182823A (en) | 1985-02-19 |
| DK203882A (da) | 1982-11-13 |
| IE53102B1 (en) | 1988-06-22 |
| DE3262529D1 (en) | 1985-04-18 |
| EP0065407A2 (en) | 1982-11-24 |
| ZM3282A1 (en) | 1982-12-21 |
| US4478847A (en) | 1984-10-23 |
| FI821579L (fi) | 1982-11-13 |
| HU186016B (en) | 1985-05-28 |
| ES519780A0 (es) | 1984-03-01 |
| PT74876B (en) | 1983-12-07 |
| MW1982A1 (en) | 1984-02-08 |
| PL236283A1 (en) | 1983-09-12 |
| ZW7882A1 (en) | 1983-11-30 |
| ATE12113T1 (de) | 1985-03-15 |
| PT74876A (en) | 1982-06-01 |
| EP0065407A3 (en) | 1983-03-16 |
| ES8402840A1 (es) | 1984-03-01 |
| ZA822797B (en) | 1983-07-27 |
| JPS57192314A (en) | 1982-11-26 |
| KR830009775A (ko) | 1983-12-23 |
| AU8299482A (en) | 1982-11-18 |
| ES8306485A1 (es) | 1983-06-01 |
| PH18101A (en) | 1985-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL65604A (en) | 1'-substituted spiro(pyrrolidine-3,3'indoline)-2,2',5-trione derivatives,their preparation and pharmaceutical compositions containing them | |
| DE3069372D1 (en) | 1'-substituted-spiro(imidazolidine-4,3'-indoline)-2,2',5-triones, processes for their manufacture and pharmaceutical compositions thereof | |
| IL65603A0 (en) | Substituted spiro(imidazolidine-4,3'-indoline)trioamide derivatives ne derivatives,their preparation and pharmaceutical compositions containing them |