KR830009775A - 조제가능한 조성물 - Google Patents
조제가능한 조성물 Download PDFInfo
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- KR830009775A KR830009775A KR1019820002107A KR820002107A KR830009775A KR 830009775 A KR830009775 A KR 830009775A KR 1019820002107 A KR1019820002107 A KR 1019820002107A KR 820002107 A KR820002107 A KR 820002107A KR 830009775 A KR830009775 A KR 830009775A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- benzene ring
- trifluoromethyl
- chloro
- Prior art date
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- 239000013022 formulation composition Substances 0.000 title 1
- -1 1′-substituted-spiro [pyrrolidine-3,3′-indolin] -2,2 ′, 5-trione Chemical class 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 5
- 125000001153 fluoro group Chemical group F* 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 239000002585 base Substances 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 150000001768 cations Chemical class 0.000 claims 3
- 231100000252 nontoxic Toxicity 0.000 claims 3
- 230000003000 nontoxic effect Effects 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- 125000001246 bromo group Chemical group Br* 0.000 claims 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 239000000499 gel Substances 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 230000000699 topical effect Effects 0.000 claims 2
- AVHWPRATBLQYNQ-UHFFFAOYSA-N 1-[(4-chlorophenyl)methyl]spiro[indole-3,3'-pyrrolidine]-2,2',5'-trione Chemical compound C1=CC(Cl)=CC=C1CN1C2=CC=CC=C2C2(C(NC(=O)C2)=O)C1=O AVHWPRATBLQYNQ-UHFFFAOYSA-N 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- 125000004975 3-butenyl group Chemical group C(CC=C)* 0.000 claims 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- SBUKLPSBNFWJCU-UHFFFAOYSA-N ClIBr Chemical compound ClIBr SBUKLPSBNFWJCU-UHFFFAOYSA-N 0.000 claims 1
- QZRGKCOWNLSUDK-UHFFFAOYSA-N Iodochlorine Chemical compound ICl QZRGKCOWNLSUDK-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000005194 alkoxycarbonyloxy group Chemical group 0.000 claims 1
- 150000004996 alkyl benzenes Chemical class 0.000 claims 1
- 239000002168 alkylating agent Substances 0.000 claims 1
- 229940100198 alkylating agent Drugs 0.000 claims 1
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 claims 1
- 230000031709 bromination Effects 0.000 claims 1
- 238000005893 bromination reaction Methods 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000005660 chlorination reaction Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000002270 dispersing agent Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 150000004820 halides Chemical class 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000005394 methallyl group Chemical group 0.000 claims 1
- 230000000802 nitrating effect Effects 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 150000007530 organic bases Chemical class 0.000 claims 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 210000001938 protoplast Anatomy 0.000 claims 1
- GDKIJXFCWCUTFR-UHFFFAOYSA-N spiro[1h-indole-3,3'-pyrrolidine]-2,2',5'-trione Chemical compound O=C1NC(=O)CC21C1=CC=CC=C1NC2=O GDKIJXFCWCUTFR-UHFFFAOYSA-N 0.000 claims 1
- 239000008174 sterile solution Substances 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 125000006493 trifluoromethyl benzyl group Chemical group 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 활성성분으로 구조식(Ⅰ)의 1′-치환된-스피로 [피롤리딘-3,3′-인돌린]-2,2′,5-트리온, 혹은 약리적으로 수용가능한 양이온을 제공하는 염기를 가진 그것의 염, 혹은 비독성이며 생물학적 변성가능한 그것의 전구물질과 약리적으로 수용가능한 희석제 또는 담체를 포함하는, 조제가능한 조성물.상기 구조식에서는 Ra는 (2-C)인 알킬 혹은 (3-7C)인 알케닐, 나프틸메틸, 또는 1-2가지의 할로겐 핵치환체를 선택적으로 갖는 신나밀이며,또는 Ra는 2,3,4,5 위치에서 위치하며 할로겐, (1-4C)인 알킬, (1-4C)인 알콕시, 시안, 니트로와 트리플루오로메틸에서 독립적으로 선택된 1-2개의 할로겐 치환제를 선택적으로 갖는 벤질이다. 벤젠환 A는 할로겐, (1-4C)인 알킬, 트리플루오로메틸과 니트로에서 선택된 1-2개의 치환체를 선택적으로 갖는다.
- Ra가 에틸 프로필, 부틸, 펜틸, 헥실, 알릴, 2-메틸알릴, 3-부테닐, 나프틸메틸 또는 1-2개의 플루오로, 클로로, 브로모 또는 요오드 핵치환체를 선택적으로 갖는 신나밀이며 또는 Ra가 2,3,4,5 위치에 위치하며, 플루오로, 클로로, 요오드, 메틸, 에틸, 메톡시, 에톡시, 시안, 니트로와 트리플루오로메틸에서 독립적으로 선택된 1-2개의 치환체를 갖는 벤질이며, 벤젠환는 플루오로, 클로로, 브로모, 요오드, 메틸, 에틸, 트리플루오로메틸과 니트로치환체에서 독립적으로 선택된 1-2개의 치환체를 선택적으로 갖는, 제1항에 따르는 조성물.
- Ra가 프로필, 부틸, 헥틸, 헵틸 1-나프틸메틸, 2-나프틸메틸, 신나밀, 할로게노신나밀, 디할로겐노-신나밀, 벤질, (1-4C)인 알킬벤젠, 할로겐노벤질, 트리플루오로메틸벤질 또는 디할로겐노벤질이며, 벤젠환 A는 비치환되거나, 5′,6′,7위치에 위치한 플루오로, 클로로, 브로모, 메틸 또는 트리플루오로메틸 치환체를 갖는, 제1항에 따르는 조성물.
- 활성성분이 1′-(4-클로로벤질)-스피로 [피롤리딘-3,3′-인돌린]-2,2′,5-트리온, 1′-(3,4-디메톡시벤질)-스피로 [피롤리딘-3,3′-인돌린]-2,2′,5-트리온과 약리적으로 수용가능한 양이온을 제공하는 염기를 갖는 그것의 염중에서 선택하며, 제1항에 따르는 조성물.
- 경구, 비경구적 직장 혹은 국소안과적 투여에 적당한 형태로의 제1항 내지 4항에 따르는 조성물.
- 정제, 캅설제, 과립제, 분산제, 시럽, 엑릭실제, 유제, 현탁액 혹은 겔의 형태로의, 제5항에 따르는 경구투여용 조성물.
- 연고제, 겔, 혹은 멸균용액의 형태로의 제5항에 따르는 국소 안과 투여용 조성물.
- (a) 열 영향하에서, 구조식(Ⅱ)의 산을 탈카르복실화하며,(b) 구조식(Ⅷ) 화합물을 보호해제하며,(c) Q가 적당한 잔기인 Ra,Q(알킬화제)와 반응시켜서 다음의 구조식(Ⅹ)이 염을 알킬화하며,(d) 벤젠환 A가 니트로 치환체를 가지며 Ra가 니트로 치환체를 갖는 구조식 Ⅰ 화합물을 위해서 벤젠환 A가 비치환되었거나, 단독 치환되었으며, Ra가 비치환된 벤질 혹은 단독치환된 벤질인 대응하는 구조식(Ⅰ) 화합물을 니트로화하며,(e) 벤젠환 A가 클로로치환체 또는 브롬치환체를 갖는 구조식(Ⅰ) 화합물을 위해서,벤젠환 A가 비치환되었거나 단독 치환된 상응하는 구조식 Ⅰ 화합물을 염소화하거나 브롬화시키는 것을 특징으로 하며,제1항에 따르는,구조식(Ⅰ) 화합물 혹은 그것의 염 또는 비독성 생물학적 변성가능한 전구문지의 제조방법.(Ⅰ)(Ⅱ)(Ⅶ)(Ⅹ)상기 구조식에서,Ra, 벤젠환 A는 제1항의 정의대로이며,Rc는 보호기이다.M은 알칼리 금속양이온이다.비독성이며, 생물학적 변성가능한 전구물질이 필요하면 구조식(Ⅰ) 화합물과 알콕시카르보닐, 1-(알콕시카르보닐옥시)-알킬, 아랄콕시카르보닐 또는 알콕시옥살릴할라이드를 반응시킨다. 염은 유리염기상태의 구조식(Ⅰ) 화합물을 약리적으로 수용가능한 양이온을 제공하는 염기와 반응시켜 생성한다. 광학적으로 활성형은 구조식(Ⅰ) 화합물의 라세미체를 적당한 유기염기의 광학활성형과 반응시키고 얻게 된 염 또는 복합물의 부분 입체 이성체 혼합물을 분리하고 적당한 부분 입체 이성질체의 산성화에 의해 구조식(Ⅰ) 화합물의 광학활성체를 유리해낸다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8114397 | 1981-05-12 | ||
| GB8114397 | 1981-05-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR830009775A true KR830009775A (ko) | 1983-12-23 |
Family
ID=10521723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019820002107A KR830009775A (ko) | 1981-05-12 | 1982-05-12 | 조제가능한 조성물 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US4478847A (ko) |
| EP (1) | EP0065407B1 (ko) |
| JP (1) | JPS57192314A (ko) |
| KR (1) | KR830009775A (ko) |
| AT (1) | ATE12113T1 (ko) |
| AU (1) | AU561390B2 (ko) |
| CA (1) | CA1182823A (ko) |
| DD (1) | DD202576A5 (ko) |
| DE (1) | DE3262529D1 (ko) |
| DK (1) | DK203882A (ko) |
| ES (2) | ES8306485A1 (ko) |
| FI (1) | FI821579L (ko) |
| GR (1) | GR75871B (ko) |
| HU (1) | HU186016B (ko) |
| IE (1) | IE53102B1 (ko) |
| IL (1) | IL65604A (ko) |
| MW (1) | MW1982A1 (ko) |
| NO (1) | NO821557L (ko) |
| NZ (1) | NZ200576A (ko) |
| PH (1) | PH18101A (ko) |
| PL (1) | PL236283A1 (ko) |
| PT (1) | PT74876B (ko) |
| ZA (1) | ZA822797B (ko) |
| ZM (1) | ZM3282A1 (ko) |
| ZW (1) | ZW7882A1 (ko) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU566869B2 (en) * | 1982-05-11 | 1987-11-05 | Imperial Chemical Industries Plc | Spiro (imidazolidine-4,3'-indoline) 2,2',5-triones |
| GB8331194D0 (en) * | 1982-12-20 | 1983-12-29 | Ici Plc | Chemical process |
| JPS60142984A (ja) | 1983-12-28 | 1985-07-29 | Kyorin Pharmaceut Co Ltd | 新規なスピロピロリジン−２，５−ジオン誘導体およびその製造法 |
| US4567278A (en) * | 1984-03-26 | 1986-01-28 | Imperial Chemical Industries Plc | Process for racemizing certain spiro compounds |
| GB8415635D0 (en) * | 1984-06-19 | 1984-07-25 | Ici Plc | Cyclic amides |
| SK590689A3 (en) * | 1988-10-18 | 1996-03-06 | Pfizer | 3-aryl-2-oxindole-1-carboxamides and method of their preparation |
| US4946858A (en) * | 1988-10-20 | 1990-08-07 | American Home Products Corporation | Novel spirosuccinimides as aldose reductase inhibitors and antihyperglycemic agents |
| US4900739A (en) * | 1988-10-20 | 1990-02-13 | American Home Products Corp. | Novel spirosuccinimides as aldose reductase inhibitors and antihyperglycemic agents |
| FR2708606B1 (fr) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
| US6837696B2 (en) * | 2001-09-28 | 2005-01-04 | Mcneil-Ppc, Inc. | Apparatus for manufacturing dosage forms |
| US20040062804A1 (en) * | 2001-09-28 | 2004-04-01 | Der-Yang Lee | Modified release dosage forms |
| WO2006125784A1 (en) * | 2005-05-24 | 2006-11-30 | Laboratoires Serono S.A. | Tricyclic spiro derivatives as crth2 modulators |
| US20080057023A1 (en) * | 2006-08-29 | 2008-03-06 | Chynn Emil W | Oxygenated ophthalmic composition |
| US8512581B2 (en) * | 2006-10-09 | 2013-08-20 | Solexel, Inc. | Methods for liquid transfer coating of three-dimensional substrates |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4117230A (en) * | 1976-10-18 | 1978-09-26 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
| US4177230A (en) * | 1978-06-02 | 1979-12-04 | The United States Of America As Represented By The Secretary Of The Air Force | Process for producing reaction sintered silicon nitride of increased density |
| US4307108A (en) * | 1979-12-26 | 1981-12-22 | Pfizer Inc. | Method for lowering sorbitol levels using spiro-imides |
-
1982
- 1982-04-20 IE IE928/82A patent/IE53102B1/en not_active IP Right Cessation
- 1982-04-21 ZW ZW78/82A patent/ZW7882A1/xx unknown
- 1982-04-23 MW MW19/82A patent/MW1982A1/xx unknown
- 1982-04-23 AU AU82994/82A patent/AU561390B2/en not_active Ceased
- 1982-04-23 ZA ZA822797A patent/ZA822797B/xx unknown
- 1982-04-26 IL IL65604A patent/IL65604A/xx unknown
- 1982-04-29 GR GR68025A patent/GR75871B/el unknown
- 1982-04-30 ZM ZM32/82A patent/ZM3282A1/xx unknown
- 1982-05-04 PL PL23628382A patent/PL236283A1/xx unknown
- 1982-05-05 FI FI821579A patent/FI821579L/fi not_active Application Discontinuation
- 1982-05-06 DK DK203882A patent/DK203882A/da not_active Application Discontinuation
- 1982-05-10 HU HU821453A patent/HU186016B/hu unknown
- 1982-05-10 PH PH27252A patent/PH18101A/en unknown
- 1982-05-11 PT PT74876A patent/PT74876B/pt unknown
- 1982-05-11 US US06/377,135 patent/US4478847A/en not_active Expired - Fee Related
- 1982-05-11 ES ES512093A patent/ES8306485A1/es not_active Expired
- 1982-05-11 DE DE8282302395T patent/DE3262529D1/de not_active Expired
- 1982-05-11 NO NO821557A patent/NO821557L/no unknown
- 1982-05-11 EP EP82302395A patent/EP0065407B1/en not_active Expired
- 1982-05-11 AT AT82302395T patent/ATE12113T1/de not_active IP Right Cessation
- 1982-05-11 NZ NZ200576A patent/NZ200576A/en unknown
- 1982-05-11 CA CA000402665A patent/CA1182823A/en not_active Expired
- 1982-05-12 KR KR1019820002107A patent/KR830009775A/ko unknown
- 1982-05-12 DD DD82239804A patent/DD202576A5/de unknown
- 1982-05-12 JP JP57078475A patent/JPS57192314A/ja active Pending
-
1983
- 1983-02-14 ES ES519780A patent/ES519780A0/es active Granted
-
1984
- 1984-08-07 US US06/638,500 patent/US4523021A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT74876B (en) | 1983-12-07 |
| ES512093A0 (es) | 1983-06-01 |
| AU8299482A (en) | 1982-11-18 |
| FI821579L (fi) | 1982-11-13 |
| ATE12113T1 (de) | 1985-03-15 |
| IE820928L (en) | 1982-11-12 |
| FI821579A0 (fi) | 1982-05-05 |
| EP0065407A3 (en) | 1983-03-16 |
| ZA822797B (en) | 1983-07-27 |
| PH18101A (en) | 1985-03-20 |
| NZ200576A (en) | 1984-11-09 |
| PL236283A1 (en) | 1983-09-12 |
| ZM3282A1 (en) | 1982-12-21 |
| EP0065407B1 (en) | 1985-03-13 |
| ZW7882A1 (en) | 1983-11-30 |
| CA1182823A (en) | 1985-02-19 |
| JPS57192314A (en) | 1982-11-26 |
| ES8402840A1 (es) | 1984-03-01 |
| NO821557L (no) | 1982-11-15 |
| US4478847A (en) | 1984-10-23 |
| AU561390B2 (en) | 1987-05-07 |
| ES519780A0 (es) | 1984-03-01 |
| DD202576A5 (de) | 1983-09-21 |
| GR75871B (ko) | 1984-08-02 |
| PT74876A (en) | 1982-06-01 |
| IL65604A (en) | 1986-12-31 |
| ES8306485A1 (es) | 1983-06-01 |
| MW1982A1 (en) | 1984-02-08 |
| US4523021A (en) | 1985-06-11 |
| DK203882A (da) | 1982-11-13 |
| IE53102B1 (en) | 1988-06-22 |
| EP0065407A2 (en) | 1982-11-24 |
| DE3262529D1 (en) | 1985-04-18 |
| HU186016B (en) | 1985-05-28 |
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