KR830004585A - 치환 인돌린-2-은 유도체의 제범 - Google Patents

치환 인돌린-2-은 유도체의 제범 Download PDF

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Publication number
KR830004585A
KR830004585A KR1019800004336A KR800004336A KR830004585A KR 830004585 A KR830004585 A KR 830004585A KR 1019800004336 A KR1019800004336 A KR 1019800004336A KR 800004336 A KR800004336 A KR 800004336A KR 830004585 A KR830004585 A KR 830004585A
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South Korea
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compound
formula
nitro
group
general formula
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KR1019800004336A
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KR840002213B1 (ko
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로버트 브리톤 데이비드
우드 로빈
Original Assignee
퍼시 시드니 죠지 플린트
임페리알 케미칼 인더스트리스 리미티드
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Publication of KR830004585A publication Critical patent/KR830004585A/ko
Priority to KR1019840004392A priority Critical patent/KR850001228B1/ko
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Publication of KR840002213B1 publication Critical patent/KR840002213B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

치환 인돌린-2-은 유도체의 제범
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 본문에 상술한 바와같이, 다음 일반식(3)의 인돌린-2,3-디온을 알카리금속 사아나이드 및 알모늄 카보네이트 또는 카바메이트와 반응시키고, 다음 일반식(6)의 화합물을 일반식R2, X(R2는 R1이 페닐기 이의의 기일때와 같고, X는 할로게노 또는 아릴-또는 알킬-설포닐옥시기)인 화합물과 반응시키고, 일반식(7)의 화합물을 암모늄 카보네이트 또는 카바메이트와 반응시키고, 벤젠환 A가 비치환되거나 또는 단일 치환기를 함유하거나 또는 R1이 치환벤질기 또는 하나 또는 두개의 치환기를 함유하는 벤질기인 일반식(1)의 상용하는 화합물을 니트로화하여 벤젠환 A가 니트로치환기를 함유 하거나 또는 R1이 니트로 치환기를 함유하는 벤질기인 일반식(1)의 화합물을 제조하고, 벤젠환 A가 비치환된 상용하는 일반식(1)의 화합물을 클로로화 또는 브름확하여 벤젠환 A가 클로로 또는 의화합물을 클로로화 또는 브름화하여 벤젠환가클로로 또는 브로로치환기를 함유하는 일반식(1)의 화합물을 제조하는, 벤젠확 A및/또는 R1이 (1-4C)알콜시기를 함유하는 상응하는 일반식(1)의 화합물을 탈알킬화하여 벤젠환 A 및/또는 R1이 하이드록시기인 일반식(1)의 화합물을 제조함을 특징으로 하는바, 일반식(1) 화합물의 광학적으로 활성인 형태가 필요할때는 상기 화합물의 라세미형태를 광학적으로 활성형태인 적당한 유기염기와 반응시키고 이렇게 얻어진 염의 투공이성체 혼합물을 통상적으로 분리하여 통상적인 방법으로 산과 처리함으로서 광학적 활성형태의 상술한 화합물을 유리시키고, 제약학적으로 허용되는 염이 필요할때는 일반식(1)의 화합물을 제약학적으로 허용될 수 있는 양이온을 제공하는 적당한 염기와 통상적인 공정을 사용하여 반응시키는 것으로 구성된, 일반식(1)의 1'-치환된 스피로 [이미다졸리딘-4,3'-인돌린] 2,2',5-트리온의 제조방법.
    식중,
    R1은 1-2할로게노 치환기를 임의로 함유하는 (1-12C)칼킬, 페닐, 나프틸메틸 또는신나밀 또는 할로게노, 트릴플루오로메틸, (1-4C)알킬, (1-4C)알콕시, 니트로, 시아노 및 하이드록시로 부터 선택된 1-3-개의 치환기를 임의로 함유하는 벤질이고, 환 A는 할로게노, (1-4C)칼킬, (1-4C) 칼콕시, 니트로 및 하이드록시로 부터 선택된 하나의 치환기 또는 할로게노, (1-4C)칼킬 및 니트로로 부터 선택된 2개의 치환기를 임의로 함유하며,
    R3는 아실 또는 트리-[(1-4C)알킬]실리 기이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800004336A 1979-11-13 1980-11-12 치환 인돌린-2-온 유도체의 제조방법 KR840002213B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019840004392A KR850001228B1 (ko) 1979-11-13 1984-07-24 치환 인돌린-2-온 유도체의 제조방법

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB39235/79 1979-11-13
GB7939235 1979-11-13
GB26459/80 1980-08-13
GB8026459 1980-08-13
GB29760/80 1980-09-15
GB8029760 1980-09-15
GB32875/80 1980-10-10

Related Child Applications (1)

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KR1019840004392A Division KR850001228B1 (ko) 1979-11-13 1984-07-24 치환 인돌린-2-온 유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR830004585A true KR830004585A (ko) 1983-07-16
KR840002213B1 KR840002213B1 (ko) 1984-12-03

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KR1019800004336A KR840002213B1 (ko) 1979-11-13 1980-11-12 치환 인돌린-2-온 유도체의 제조방법
KR1019840004392A KR850001228B1 (ko) 1979-11-13 1984-07-24 치환 인돌린-2-온 유도체의 제조방법

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Country Status (21)

Country Link
US (1) US4490381A (ko)
EP (1) EP0028906B1 (ko)
KR (2) KR840002213B1 (ko)
AT (1) ATE9697T1 (ko)
AU (1) AU532110B2 (ko)
CA (1) CA1161848A (ko)
DD (1) DD158401A5 (ko)
DE (1) DE3069372D1 (ko)
DK (1) DK484880A (ko)
ES (3) ES8205803A1 (ko)
FI (1) FI70023C (ko)
GR (1) GR71855B (ko)
IE (1) IE50332B1 (ko)
IL (1) IL61426A (ko)
NO (1) NO154842C (ko)
NZ (1) NZ195446A (ko)
PH (1) PH16511A (ko)
PL (1) PL129212B1 (ko)
PT (1) PT72056B (ko)
YU (1) YU289080A (ko)
ZW (1) ZW27380A1 (ko)

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IE52879B1 (en) * 1981-05-12 1988-03-30 Ici Plc Pharmaceutical spiro-hydantoin derivatives
ZA832679B (en) * 1982-05-07 1983-12-28 Ici Plc Indoline derivatives
GB2119797B (en) * 1982-05-11 1985-09-04 Ici Plc Fluoroalkyl derivatives
AU566869B2 (en) * 1982-05-11 1987-11-05 Imperial Chemical Industries Plc Spiro (imidazolidine-4,3'-indoline) 2,2',5-triones
GB8331194D0 (en) * 1982-12-20 1983-12-29 Ici Plc Chemical process
GB8312379D0 (en) * 1983-05-05 1983-06-08 Ici Plc Heterocyclic compounds
US4533667A (en) * 1983-05-25 1985-08-06 Pfizer Inc. Imidazolidinedione derivatives
US4464380A (en) * 1983-05-25 1984-08-07 Pfizer Inc. Imidazolidinedione derivatives
US4567278A (en) * 1984-03-26 1986-01-28 Imperial Chemical Industries Plc Process for racemizing certain spiro compounds
US4762839A (en) * 1985-06-06 1988-08-09 Tanabe Seiyaku Co., Ltd. Quinazolinone copmpounds useful for the prophyloxis and treatment of diabetic complications
JPS63132889A (ja) * 1986-11-21 1988-06-04 Tanabe Seiyaku Co Ltd キナゾリノン誘導体
WO1992007830A2 (en) * 1990-10-29 1992-05-14 Pfizer Inc. Oxindole peptide antagonists
FR2708606B1 (fr) * 1993-07-30 1995-10-27 Sanofi Sa Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
AR059265A1 (es) 2006-02-07 2008-03-19 Astrazeneca Ab Compuestos espiro condensados con actividad inhibitoria en el receptor vaniloide1 (vr1)
WO2007091948A2 (en) * 2006-02-07 2007-08-16 Astrazeneca Ab Novel spiro [imidazolidine-4, 3´-indole] 2, 2´,5´(1h) triones for treatment of conditions associated with vanilloid receptor 1

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US4147795A (en) * 1977-02-11 1979-04-03 Pfizer Inc. Hydantoin derivatives as therapeutic agents
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Also Published As

Publication number Publication date
ES8301992A1 (es) 1982-11-16
IL61426A (en) 1984-05-31
FI70023B (fi) 1986-01-31
FI803539L (fi) 1981-05-14
ES496811A0 (es) 1982-06-16
PT72056A (en) 1980-12-01
PL227789A1 (ko) 1982-01-04
NO154842C (no) 1987-01-07
KR850001228B1 (ko) 1985-08-23
ZW27380A1 (en) 1982-06-30
ES8205803A1 (es) 1982-06-16
ATE9697T1 (de) 1984-10-15
YU289080A (en) 1984-02-29
FI70023C (fi) 1986-09-12
IE50332B1 (en) 1986-04-02
ES8305765A1 (es) 1983-05-01
ES507616A0 (es) 1982-11-16
EP0028906A1 (en) 1981-05-20
PL129212B1 (en) 1984-04-30
AU532110B2 (en) 1983-09-15
NO154842B (no) 1986-09-22
KR840002213B1 (ko) 1984-12-03
US4490381A (en) 1984-12-25
PT72056B (en) 1981-09-24
NZ195446A (en) 1983-04-12
EP0028906B1 (en) 1984-10-03
IE802239L (en) 1981-05-13
DE3069372D1 (en) 1984-11-08
PH16511A (en) 1983-11-08
CA1161848A (en) 1984-02-07
KR850001464A (ko) 1985-03-18
ES507617A0 (es) 1983-05-01
GR71855B (ko) 1983-07-05
DD158401A5 (de) 1983-01-12
DK484880A (da) 1981-05-14
NO803411L (no) 1981-05-14
IL61426A0 (en) 1980-12-31
AU6381380A (en) 1981-05-21

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