IL64083A - Meta-substituted 4-phenylalanyl-enkephalin analogs,their preparation and pharmaceutical compositions comprising them - Google Patents

Meta-substituted 4-phenylalanyl-enkephalin analogs,their preparation and pharmaceutical compositions comprising them

Info

Publication number
IL64083A
IL64083A IL64083A IL6408381A IL64083A IL 64083 A IL64083 A IL 64083A IL 64083 A IL64083 A IL 64083A IL 6408381 A IL6408381 A IL 6408381A IL 64083 A IL64083 A IL 64083A
Authority
IL
Israel
Prior art keywords
phenylalanyl
meta
substituted
preparation
pharmaceutical compositions
Prior art date
Application number
IL64083A
Other languages
English (en)
Other versions
IL64083A0 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL64083A0 publication Critical patent/IL64083A0/xx
Publication of IL64083A publication Critical patent/IL64083A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IL64083A 1980-10-20 1981-10-19 Meta-substituted 4-phenylalanyl-enkephalin analogs,their preparation and pharmaceutical compositions comprising them IL64083A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/198,900 US4322340A (en) 1980-10-20 1980-10-20 Pharmacologically active peptides

Publications (2)

Publication Number Publication Date
IL64083A0 IL64083A0 (en) 1982-01-31
IL64083A true IL64083A (en) 1985-03-31

Family

ID=22735344

Family Applications (1)

Application Number Title Priority Date Filing Date
IL64083A IL64083A (en) 1980-10-20 1981-10-19 Meta-substituted 4-phenylalanyl-enkephalin analogs,their preparation and pharmaceutical compositions comprising them

Country Status (27)

Country Link
US (1) US4322340A (ja)
EP (1) EP0050502B1 (ja)
JP (1) JPS57108052A (ja)
KR (1) KR830007518A (ja)
AR (1) AR230046A1 (ja)
AT (1) ATE6777T1 (ja)
AU (1) AU547221B2 (ja)
BG (1) BG36928A3 (ja)
CA (1) CA1187871A (ja)
DD (1) DD200798A5 (ja)
DE (1) DE3162823D1 (ja)
DK (1) DK461481A (ja)
ES (1) ES8306713A1 (ja)
FI (1) FI813198L (ja)
GB (1) GB2085893B (ja)
GR (1) GR75342B (ja)
HU (1) HU185320B (ja)
IE (1) IE52186B1 (ja)
IL (1) IL64083A (ja)
NZ (1) NZ198628A (ja)
PH (1) PH17006A (ja)
PL (1) PL131155B1 (ja)
PT (1) PT73839B (ja)
RO (1) RO83301B (ja)
SU (1) SU1082319A3 (ja)
YU (1) YU249081A (ja)
ZA (1) ZA817063B (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE16495T1 (de) * 1981-06-22 1985-11-15 Ici Plc Peptide und pseudopeptide, die zwei substituenten am n-terminus aufweisen.
US4448717A (en) * 1982-11-12 1984-05-15 Eli Lilly And Company Pharmacologically active peptides
US4510082A (en) * 1983-03-07 1985-04-09 Eli Lilly And Company Pharmacologically active peptides
US4473497A (en) * 1983-03-07 1984-09-25 Eli Lilly And Company Pharmacologically active peptides
DK134784A (da) * 1983-03-07 1984-09-08 Lilly Co Eli Farmakologisk virksomme tripeptid-derivater og fremgangsmaade til fremstilling deraf
US4495178A (en) * 1983-10-06 1985-01-22 G. D. Searle & Co. Enkephalin analogs
JPH0449298A (ja) * 1990-06-19 1992-02-18 Univ New York State 新規なエンケファリン誘導体および鎮痛剤
US5209930A (en) * 1990-12-10 1993-05-11 Rohm And Haas Company Preparation and use of n-iodopropargyl oxycarbonyl amino acid esters and derivatives as antimicrobial agents
WO1994025482A1 (en) * 1993-04-23 1994-11-10 Evans Herbert J Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5952465A (en) * 1993-04-23 1999-09-14 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5928896A (en) * 1993-04-23 1999-07-27 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US6258550B1 (en) 1993-04-23 2001-07-10 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5965698A (en) * 1993-04-23 1999-10-12 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US6084066A (en) * 1993-10-29 2000-07-04 Virginia Commonwealth University Polypetides that include conformation-constraining groups which flank a protein-protein interaction site

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1577115A (en) * 1976-07-27 1980-10-22 Reckitt & Colmann Prod Ltd Container closure units
CH619686A5 (en) * 1976-02-02 1980-10-15 Sandoz Ag Process for the preparation of novel peptides or peptide derivatives
DE2702711A1 (de) * 1976-02-02 1977-08-04 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
US4264491A (en) * 1977-10-03 1981-04-28 Eli Lilly And Company Analgesic compounds
US4265808A (en) * 1979-12-17 1981-05-05 Eli Lilly And Company Pharmacologically active peptides

Also Published As

Publication number Publication date
ATE6777T1 (de) 1984-04-15
IL64083A0 (en) 1982-01-31
DK461481A (da) 1982-04-21
YU249081A (en) 1983-12-31
KR830007518A (ko) 1983-10-21
AR230046A1 (es) 1984-02-29
ES506316A0 (es) 1983-06-01
PL233498A1 (ja) 1982-05-24
PL131155B1 (en) 1984-10-31
SU1082319A3 (ru) 1984-03-23
DD200798A5 (de) 1983-06-15
IE812442L (en) 1982-04-20
FI813198L (fi) 1982-04-21
DE3162823D1 (en) 1984-04-26
US4322340A (en) 1982-03-30
AU547221B2 (en) 1985-10-10
ZA817063B (en) 1983-05-25
PT73839B (en) 1983-01-17
HU185320B (en) 1985-01-28
IE52186B1 (en) 1987-08-05
ES8306713A1 (es) 1983-06-01
NZ198628A (en) 1985-01-31
GB2085893B (en) 1984-03-21
GR75342B (ja) 1984-07-13
RO83301B (ro) 1984-02-28
PT73839A (en) 1981-11-01
EP0050502B1 (en) 1984-03-21
PH17006A (en) 1984-05-11
AU7657481A (en) 1982-04-29
CA1187871A (en) 1985-05-28
BG36928A3 (en) 1985-02-15
EP0050502A1 (en) 1982-04-28
GB2085893A (en) 1982-05-06
RO83301A (ro) 1984-02-21
JPS57108052A (en) 1982-07-05

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