IL64035A - 2-guanidino-4-(4-thiazolyl or-5-1,2,4-triazolyl)thiazoles,certain intermediates for their preparation and pharmaceutical compositions containing them - Google Patents

2-guanidino-4-(4-thiazolyl or-5-1,2,4-triazolyl)thiazoles,certain intermediates for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL64035A
IL64035A IL64035A IL6403581A IL64035A IL 64035 A IL64035 A IL 64035A IL 64035 A IL64035 A IL 64035A IL 6403581 A IL6403581 A IL 6403581A IL 64035 A IL64035 A IL 64035A
Authority
IL
Israel
Prior art keywords
thiazoles
guanidino
triazolyl
thiazolyl
preparation
Prior art date
Application number
IL64035A
Other languages
English (en)
Other versions
IL64035A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to IL7304081A priority Critical patent/IL73040A/xx
Publication of IL64035A0 publication Critical patent/IL64035A0/xx
Priority to IL73040A priority patent/IL73040A0/xx
Publication of IL64035A publication Critical patent/IL64035A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL64035A 1980-10-14 1981-10-12 2-guanidino-4-(4-thiazolyl or-5-1,2,4-triazolyl)thiazoles,certain intermediates for their preparation and pharmaceutical compositions containing them IL64035A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL7304081A IL73040A (en) 1980-10-14 1981-10-12 4-haloacetyl-imidazole derivatives
IL73040A IL73040A0 (en) 1980-10-14 1984-09-24 4-haloacetyl-imidazole derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19623180A 1980-10-14 1980-10-14
US06/293,574 US4374843A (en) 1980-10-14 1981-08-20 2-Guanidino-4-heteroarylthiazoles

Publications (2)

Publication Number Publication Date
IL64035A0 IL64035A0 (en) 1982-01-31
IL64035A true IL64035A (en) 1986-01-31

Family

ID=26891753

Family Applications (1)

Application Number Title Priority Date Filing Date
IL64035A IL64035A (en) 1980-10-14 1981-10-12 2-guanidino-4-(4-thiazolyl or-5-1,2,4-triazolyl)thiazoles,certain intermediates for their preparation and pharmaceutical compositions containing them

Country Status (28)

Country Link
US (1) US4374843A (pl)
EP (1) EP0050458B1 (pl)
KR (1) KR850001858B1 (pl)
AR (3) AR228675A1 (pl)
AT (1) ATE11048T1 (pl)
AU (2) AU530589B2 (pl)
CA (1) CA1156239A (pl)
CS (1) CS231182B2 (pl)
DD (4) DD202293A5 (pl)
DE (1) DE3168067D1 (pl)
DK (1) DK453181A (pl)
ES (4) ES8301978A1 (pl)
FI (1) FI75821C (pl)
GR (1) GR75098B (pl)
HK (1) HK52387A (pl)
HU (2) HU191895B (pl)
IE (1) IE51642B1 (pl)
IL (1) IL64035A (pl)
KE (1) KE3707A (pl)
MY (1) MY8700512A (pl)
NO (1) NO159654C (pl)
NZ (1) NZ198629A (pl)
PH (3) PH17562A (pl)
PL (3) PL135331B1 (pl)
PT (1) PT73817B (pl)
SG (1) SG23487G (pl)
SU (1) SU1153829A3 (pl)
YU (4) YU42434B (pl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482723A (en) * 1983-04-11 1984-11-13 Pfizer Inc. Process for preparation of 4-acetyl-2-substituted-imidazoles
US4435396A (en) * 1982-05-10 1984-03-06 Pfizer Inc. Antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles and process therefor
AU542287B2 (en) * 1982-06-17 1985-02-14 Toyama Chemical Co. Ltd. Process for producing 2-(2-aminothiazol-4-yl) glyoxylic acid derivative, it:s salt and intermediates therefor
EP0156644A1 (en) * 1984-04-02 1985-10-02 Pfizer Inc. Process and intermediates for 4-acetylimidazoles
US4560690A (en) * 1984-04-30 1985-12-24 Pfizer Inc. 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents
US4567179A (en) * 1984-10-11 1986-01-28 Pfizer, Inc. Antiinflammatory salts of piroxicam
US4632993A (en) * 1984-10-11 1986-12-30 Pfizer Inc. Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide
US4591595A (en) * 1984-10-11 1986-05-27 Pfizer Inc. 2-guanidino-4-(2-methyl-4-imidazolyl)thiazoles in the treatment of rheumatoid arthritis
WO1986003203A1 (fr) * 1984-11-22 1986-06-05 Yoshitomi Pharmaceutical Industries, Ltd. Derives de thienylthiazole
US4814341A (en) * 1986-08-26 1989-03-21 Reiter Lawrence A 2-guanidino-4-(2-furyl) thiazoles as antiulcer agents
EP0259085B1 (en) * 1986-08-29 1991-08-21 Pfizer Inc. 2-guanidino-4-arylthiazoles for treatment of peptic ulcers
ATE106884T1 (de) * 1986-10-29 1994-06-15 Pfizer Verfahren zur herstellung von 2-(1-pentyl-3- guanidino)-4-(2-methyl-4-imidazolyl)thiazol und dessen kristallinisches dihydrochlorid-trihydrat.
IL95548A0 (en) * 1989-09-15 1991-06-30 Fujisawa Pharmaceutical Co Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same
WO1992016526A1 (en) * 1991-03-13 1992-10-01 Fujisawa Pharmaceutical Co., Ltd. Thiazole derivatives
SI0928793T1 (en) * 1998-01-02 2002-10-31 F. Hoffmann-La Roche Ag Thiazole derivatives
CN101287711A (zh) * 2005-08-23 2008-10-15 宇部兴产株式会社 1-取代-5-酰基咪唑化合物的制备方法
US9499533B2 (en) 2012-03-27 2016-11-22 Shionogi & Co., Ltd. Aromatic 5-membered heterocyclic derivative having TRPV4-Inhibiting activity
KR20220119653A (ko) 2019-12-20 2022-08-30 테나야 테라퓨틱스, 인코포레이티드 플루오로알킬-옥사디아졸 및 이의 용도
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1516777A (fr) * 1966-08-02 1968-02-05 Innothera Lab Sa Dérivés du thiazole ainsi que de la thiazolo [4,5-d] pyridazine et leur préparation
US3519637A (en) * 1966-12-06 1970-07-07 Hoffmann La Roche 1-(4-thiazolylmethyl)nitroimidazole derivatives
BE758146A (fr) * 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
US3950353A (en) * 1971-03-09 1976-04-13 Smith Kline & French Laboratories Limited Pharmacologically active thiourea and urea compounds
HU168776B (pl) * 1973-11-09 1976-07-28
DE2614189A1 (de) * 1976-04-02 1977-10-20 Hoechst Ag Therapeutisch wirksame ureido- und semicarbazido-derivate des tiazols und verfahren zu ihrer herstellung
NZ186965A (en) * 1977-04-20 1980-02-21 Ici Ltd Guanidino derivatives and pharmaceutical compositions
JPS54132566A (en) * 1978-01-18 1979-10-15 Ici Ltd Guanidine derivative*its manufacture and secretion controlling pharmaceutical composition containing it
EP0014057B1 (en) * 1979-01-18 1985-01-02 Imperial Chemical Industries Plc Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them
US4220654A (en) * 1979-06-04 1980-09-02 Merck & Co., Inc. Cyclic imidazole cyanoguanidines
AU518569B2 (en) * 1979-08-07 1981-10-08 Farmos-Yhtyma Oy 4-benzyl- and 4-benzoyl imidazole derivatives

Also Published As

Publication number Publication date
DD207718A5 (de) 1984-03-14
ES506216A0 (es) 1982-12-16
DK453181A (da) 1982-04-15
ES8306750A1 (es) 1983-06-01
US4374843A (en) 1983-02-22
YU42434B (en) 1988-08-31
PH17856A (en) 1985-01-09
ES8306751A1 (es) 1983-06-01
YU105383A (en) 1983-10-31
IE812384L (en) 1982-04-14
YU105183A (en) 1983-10-31
AR228675A1 (es) 1983-03-30
CS750081A2 (en) 1984-02-13
FI813177L (fi) 1982-04-15
KR850001858B1 (ko) 1985-12-28
DE3168067D1 (en) 1985-02-14
PL133712B1 (en) 1985-06-29
DD207719A5 (de) 1984-03-14
PL241643A1 (en) 1983-11-21
NO813442L (no) 1982-04-15
HK52387A (en) 1987-07-17
SU1153829A3 (ru) 1985-04-30
PH17562A (en) 1984-10-01
AU530589B2 (en) 1983-07-21
CA1156239A (en) 1983-11-01
AR228674A1 (es) 1983-03-30
AR229703A1 (es) 1983-10-31
ES8301978A1 (es) 1982-12-16
PL233430A1 (en) 1983-11-21
ES8306749A1 (es) 1983-06-01
CS231182B2 (en) 1984-10-15
GR75098B (pl) 1984-07-13
DD202293A5 (de) 1983-09-07
SG23487G (en) 1987-07-10
AU7628781A (en) 1982-04-22
YU42078B (en) 1988-04-30
ATE11048T1 (de) 1985-01-15
NZ198629A (en) 1985-02-28
NO159654C (no) 1989-01-25
PT73817B (en) 1983-11-07
PL241644A1 (en) 1983-11-21
FI75821B (fi) 1988-04-29
YU105283A (en) 1983-10-31
MY8700512A (en) 1987-12-31
YU246481A (en) 1983-10-31
AU548992B2 (en) 1986-01-09
HU186788B (en) 1985-09-30
ES515157A0 (es) 1983-06-01
IE51642B1 (en) 1987-01-21
DD207913A5 (de) 1984-03-21
PL134491B1 (en) 1985-08-31
NO159654B (no) 1988-10-17
IL64035A0 (en) 1982-01-31
EP0050458B1 (en) 1985-01-02
ES515158A0 (es) 1983-06-01
FI75821C (fi) 1988-08-08
KR830007638A (ko) 1983-11-04
ES515159A0 (es) 1983-06-01
YU42076B (en) 1988-04-30
YU42077B (en) 1988-04-30
EP0050458A2 (en) 1982-04-28
EP0050458A3 (en) 1982-09-01
PT73817A (en) 1981-11-01
PH18467A (en) 1985-07-18
KE3707A (en) 1987-04-03
AU3206284A (en) 1984-11-29
PL135331B1 (en) 1985-10-31
HU191895B (en) 1987-04-28

Similar Documents

Publication Publication Date Title
PH18015A (en) Antifungal bis-triazole derivatives and pharmaceutical compositions containing them
IL66501A (en) Benzazepine-2-one derivatives,their manufacture and pharmaceutical compositions containing them
DE3163938D1 (en) Heterocyclic compounds, their preparation and pharmaceutical compositions containing them
IL57178A0 (en) 1,3,4-triazole derivatives their preparation and pharmaceutical compositions containing them
IL65076A (en) 3,4-dihydro-5h-2,3-benzo-diazepine derivatives,their preparation and pharmaceutical compositions containing them
IL64847A0 (en) Hexapyranose compounds,their manufacture and pharmaceutical compositions containing them
DE3270202D1 (en) 3,5-di-tert-butylstyrene derivatives, processes for their preparations, and pharmaceutical compositions containing them
DE3275296D1 (en) Azabicyclo-(3,3,1)-nonylbenzamide derivatives, processes for their preparation, and pharmaceutical compositions containing them
IL65285A0 (en) Thiazole derivatives,their manufacture and pharmaceutical compositions containing them
IL64563A (en) 1,2,5-oxadiazole 3,4-dicarboxamide-2-oxide derivatives,their preparation and pharmaceutical compositions containing them
IL62229A (en) 3-substituted-5-amino-1,2,4-triazole derivatives,their preparation and pharmaceutical compositions containing them
DE3173130D1 (en) Amino-1,2,4-triazole derivatives, processes for their preparation and pharmaceutical compositions containing them
IL64416A (en) N-cyclopropyloxyphenyl-n'-benzoylurea derivatives,process for the preparation thereof and insecticidal compositions containing them
PH16945A (en) Substituted triphenyl thiazole compounds,their pharmaceutical compositions and their use
DE3273781D1 (en) Novel thiazole compounds, process for their preparation, and medicinal composition containing same
DE3163490D1 (en) 1,2,4-triazinylthiomethyl-3-cephem sulfoxides, process for their preparation and pharmaceutical compositions containing them
IL66954A0 (en) Oxazolidinedione derivatives and pharmaceutical compositions containing them
IL75823A0 (en) 2-benzyl-4-(4-pyridyl)thiazoles and derivatives thereof,their preparation and pharmaceutical compositions containing them
IL62400A0 (en) Thiazole derivatives,their preparation and pharmaceutical compositions containing them
KE3749A (en) Heterocyclic compounds,their preparation and pharmaceutical compositions containing them
IL65876A0 (en) Heterocyclic amidoxime derivatives,their preparation and pharmaceutical compositions containing them
DE3160290D1 (en) Hypoglycemic guanylamidines, processes for their preparation, and pharmaceutical compositions containing them
DE3261857D1 (en) Substituted 1,5-diaminopentanes, their preparation and pharmaceutical compositions containing them
GB2096990B (en) Imidazole derivatives a process for the preparation thereof and pharmaceutical compositions containing them
HK90387A (en) Heterocyclic compounds,their preparation and pharmaceutical compositions containing them