IL53353A - Spirolactones,process for their preparation and pharmaceutical compositions containing them - Google Patents
Spirolactones,process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL53353A IL53353A IL53353A IL5335377A IL53353A IL 53353 A IL53353 A IL 53353A IL 53353 A IL53353 A IL 53353A IL 5335377 A IL5335377 A IL 5335377A IL 53353 A IL53353 A IL 53353A
- Authority
- IL
- Israel
- Prior art keywords
- spirolactones
- preparation
- pharmaceutical compositions
- compositions containing
- pharmaceutical
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/007—3 membered carbocyclic rings in position 6-7
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/001—Lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2652761A DE2652761C2 (de) | 1976-11-16 | 1976-11-16 | 15,16-Methylen-Spirolactone, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL53353A0 IL53353A0 (en) | 1978-01-31 |
| IL53353A true IL53353A (en) | 1982-04-30 |
Family
ID=5993550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL53353A IL53353A (en) | 1976-11-16 | 1977-11-10 | Spirolactones,process for their preparation and pharmaceutical compositions containing them |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4129564A (enEXAMPLES) |
| JP (2) | JPS5363373A (enEXAMPLES) |
| AT (1) | AT356827B (enEXAMPLES) |
| AU (1) | AU512611B2 (enEXAMPLES) |
| BE (1) | BE860877A (enEXAMPLES) |
| CA (1) | CA1092094A (enEXAMPLES) |
| CH (2) | CH631463A5 (enEXAMPLES) |
| CS (1) | CS194823B2 (enEXAMPLES) |
| DD (1) | DD132968B3 (enEXAMPLES) |
| DE (1) | DE2652761C2 (enEXAMPLES) |
| DK (1) | DK141967C (enEXAMPLES) |
| ES (1) | ES464193A1 (enEXAMPLES) |
| FR (1) | FR2370755A1 (enEXAMPLES) |
| GB (1) | GB1550568A (enEXAMPLES) |
| GR (1) | GR65227B (enEXAMPLES) |
| HU (1) | HU174983B (enEXAMPLES) |
| IE (1) | IE46076B1 (enEXAMPLES) |
| IL (1) | IL53353A (enEXAMPLES) |
| IT (1) | IT1092262B (enEXAMPLES) |
| LU (1) | LU78514A1 (enEXAMPLES) |
| NL (1) | NL7711946A (enEXAMPLES) |
| SE (1) | SE436425B (enEXAMPLES) |
| SU (2) | SU695560A3 (enEXAMPLES) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2922500A1 (de) * | 1979-05-31 | 1980-12-04 | Schering Ag | 6 beta .7 beta |
| DE3022337A1 (de) * | 1980-06-11 | 1982-01-07 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | Praeparate zur kontrazeption und zur behandlung gynaekologischer stoerungen |
| DE3051166C2 (en) * | 1980-06-11 | 1990-10-18 | Schering Ag, 1000 Berlin Und 4709 Bergkamen, De | Compsns. for contraception or treatment of gynaecological disorders |
| DE3111951A1 (de) * | 1981-03-23 | 1982-09-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel |
| EP0075189B1 (en) * | 1981-09-21 | 1985-08-28 | Schering Aktiengesellschaft | 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation |
| DE3213962A1 (de) * | 1982-04-13 | 1983-10-13 | Schering AG, 1000 Berlin und 4709 Bergkamen | 1(alpha).2(alpha);6(beta).7(beta).15(beta).16(beta)-trimethylen-3-oxo-17(alpha)-pregn-4-en-21.17-carbolacton, dessen herstellung und verwendung als arzneimittel |
| DE3227598A1 (de) * | 1982-07-22 | 1984-01-26 | Schering AG, 1000 Berlin und 4709 Bergkamen | 7(alpha)-acylthio-15.16-methylen-3-oxo-17(alpha)-pregna-1.4-dien-21,17-carbolactone, verfahren zu ihrer herstellung und verwendung als arzneimittel |
| DE3234972A1 (de) * | 1982-09-17 | 1984-03-22 | Schering AG, 1000 Berlin und 4709 Bergkamen | 7(alpha)-alkyl-17(alpha)-pregn-4-en-21.17-carbolactone und -21-carbonsaeuresalze sowie verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE3240510A1 (de) * | 1982-10-29 | 1984-05-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue 7(alpha)-acylthio-1(alpha),2(alpha)-methylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, deren herstellung und diese enthaltende arzneimittel |
| JPS59139400A (ja) * | 1983-01-31 | 1984-08-10 | Shionogi & Co Ltd | 抗アルドステロン活性ステロイド誘導体 |
| DE3306554A1 (de) * | 1983-02-22 | 1984-08-23 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verfahren zur herstellung von 3-((delta)(pfeil hoch)4(pfeil hoch)-3-ketosteroid-17(alpha)-yl)-propionsaeurelactonen |
| FI77669C (fi) * | 1983-04-13 | 1989-04-10 | Ciba Geigy Ag | 20-spiroxaner och analoger, som innehaoller en oeppen ring e, foerfarande foer deras framstaellning samt dessa innehaollande farmaceutiska preparat. |
| EP0134529B1 (de) * | 1983-08-17 | 1990-03-21 | Schering Aktiengesellschaft | 7-alpha-Substituierte 3-Oxo-17alpha-pregn-4-en-21.17-carbolactone, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
| DE3347510A1 (de) * | 1983-12-27 | 1985-08-01 | Schering AG, 1000 Berlin und 4709 Bergkamen | Verfahren zur herstellung von 3-oxo-17(alpha)-pregna-4,6-dien-21,17-carbolactonen |
| DE3402329A1 (de) * | 1984-01-20 | 1985-08-01 | Schering AG, 1000 Berlin und 4709 Bergkamen | 6,6-ethylen-15,16-methylen-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| US4670551A (en) * | 1984-06-21 | 1987-06-02 | Ciba-Geigy Corporation | Epoxy steroids |
| JPS6248694A (ja) * | 1985-08-28 | 1987-03-03 | Shionogi & Co Ltd | 抗アルドステロン活性ステロイド誘導体 |
| DE3544661A1 (de) * | 1985-12-13 | 1987-06-19 | Schering Ag | Verfahren zur herstellung von 7(alpha)-acetylthiosteroiden |
| JPS62132932U (enEXAMPLES) * | 1986-02-14 | 1987-08-21 | ||
| US4837211A (en) * | 1987-04-06 | 1989-06-06 | Carolina Medical Products, Inc. | Spironolactone composition |
| JPS6453026U (enEXAMPLES) * | 1987-09-29 | 1989-03-31 | ||
| DE3916112A1 (de) * | 1989-05-16 | 1990-11-22 | Schering Ag | Dihydrospirorenon als antiandrogen |
| DE4344462C2 (de) | 1993-12-22 | 1996-02-01 | Schering Ag | Zusammensetzung für die Empfängnisverhütung |
| EP0831911B1 (en) * | 1995-06-07 | 2002-04-17 | G.D. Searle & Co. | Spironolactone and angiotensin ii antagonist combination therapy for treatment of congestive heart failure |
| DE19633685C1 (de) * | 1996-08-12 | 1997-10-09 | Schering Ag | Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens |
| DE19651000A1 (de) * | 1996-12-01 | 1998-06-04 | Schering Ag | Oxyiminopregnancarbolactone |
| HUP0104249A3 (en) * | 1998-11-06 | 2002-06-28 | G D Searle & Co Chicago | Pharmaceutical composition for combination therapy of angiotensin converting enzyme inhibitor and aldosterone antagonist for reducing morbidity and mortality from cardiovascular disease |
| EP2305267A3 (en) | 1999-08-31 | 2011-08-17 | Bayer Schering Pharma Aktiengesellschaft | Pharmaceutical combination of ethinylestradiol and drospirenone for use as a contraceptive |
| WO2001015701A1 (en) | 1999-08-31 | 2001-03-08 | Schering Aktiengesellschaft | Pharmaceutical combination of ethinylestradiol and drospirenone for use as a contraceptive |
| US6787531B1 (en) * | 1999-08-31 | 2004-09-07 | Schering Ag | Pharmaceutical composition for use as a contraceptive |
| HRP20020258B1 (hr) * | 1999-08-31 | 2007-05-31 | Schering Aktiengesellschaft | Farmaceutska kombinacija etinilestradiola i drospirenona za upotrebu kao kontracepcijskog sredstva |
| RU2275198C2 (ru) * | 2000-01-18 | 2006-04-27 | Шеринг Акциенгезелльшафт | Дроспиренон для гормональной заместительной терапии |
| US20020132801A1 (en) * | 2001-01-11 | 2002-09-19 | Schering Aktiengesellschaft | Drospirenone for hormone replacement therapy |
| US6716829B2 (en) | 2000-07-27 | 2004-04-06 | Pharmacia Corporation | Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders |
| JP2004518611A (ja) * | 2000-07-27 | 2004-06-24 | ファルマシア・コーポレーション | 炎症関連障害を予防するか又は治療するためのアルドステロン遮断薬療法 |
| EP1216713A1 (en) * | 2000-12-20 | 2002-06-26 | Schering Aktiengesellschaft | Compositions of estrogen-cyclodextrin complexes |
| EP1216712A1 (en) | 2000-12-20 | 2002-06-26 | Schering Aktiengesellschaft | Cyclodextrin-drospirenone inclusion complexes |
| EP1406634A1 (en) * | 2001-07-13 | 2004-04-14 | Schering Aktiengesellschaft | Combination of drospirenone and an estrogen sulphamate for hrt |
| MXPA04009033A (es) * | 2002-03-18 | 2005-01-25 | Pharmacia Corp | Combinacion de un antagonista de receptor de aldosterona y acido nicotinico o un derivado de acido nicotinico. |
| BR0308517A (pt) * | 2002-03-18 | 2005-02-01 | Pharmacia Corp | Combinação de um antagonista do receptor de aldosterona e de um agente sequestrante de ácido biliar |
| ITMI20040367A1 (it) * | 2004-03-01 | 2004-06-01 | Ind Chimica Srl | Processo per la preparazione di drospirenone |
| US20050220825A1 (en) * | 2004-03-10 | 2005-10-06 | Adrian Funke | Molecular dispersions of drospirenone |
| HUP0402466A2 (en) * | 2004-11-30 | 2006-07-28 | Richter Gedeon Vegyeszet | Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process |
| HUP0402465A2 (en) * | 2004-11-30 | 2006-07-28 | Richter Gedeon Vegyeszet | Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main intermediates of the process |
| US8617597B2 (en) | 2006-07-06 | 2013-12-31 | Bayer Intellectual Property Gmbh | Pharmaceutical composition containing a tetrahydrofolic acid |
| EP2057182A2 (en) * | 2007-05-01 | 2009-05-13 | Sicor, Inc. | A process for preparing drospirenone and intermediate thereof |
| FR2917975B1 (fr) | 2007-06-26 | 2009-10-16 | Ceva Sante Animale Sa | Compositions et traitement de l'insuffisance cardiaque chez les animaux mammiferes non humains |
| US20090035374A1 (en) * | 2007-07-31 | 2009-02-05 | Katrin Mittmann | Method of making a single-stage pharmaceutical preparation for oral therapy to regulate blood pressure and kit containing same |
| US20090035373A1 (en) * | 2007-07-31 | 2009-02-05 | Katrin Mittmann | Pharmaceutical composition for contraception and blood pressure regulation, kit for contraception containing same and method of production of same |
| HUP0700826A3 (en) | 2007-12-20 | 2010-03-29 | Richter Gedeon Nyrt | Coated tablet containing drospirenone and process for producing the same |
| EP2265629B1 (en) * | 2008-03-05 | 2015-06-24 | Evestra, Inc. | Bismethylene-17 carbolactones and related uses |
| WO2010068500A2 (en) * | 2008-11-25 | 2010-06-17 | Evestra, Inc. | PROGESTATIONAL 3-(6,6-ETHYLENE-17b-HYDROXY-3-OXO-17a-PREGNA-4-ENE-17a -YL) PROPIONIC ACID g-LACTONES |
| WO2010094623A1 (en) | 2009-02-18 | 2010-08-26 | Bayer Schering Pharma Aktiengesellschaft | Formulation comprising drospirenone for subcutaneous or intramuscular administration |
| CA2759667A1 (en) | 2009-02-18 | 2010-08-26 | Bayer Pharma Aktiengesellschaft | Particles comprising drospirenone encapsulated in a polymer |
| US8334375B2 (en) * | 2009-04-10 | 2012-12-18 | Evestra, Inc. | Methods for the preparation of drospirenone |
| EP2266998B1 (en) | 2009-06-16 | 2013-07-24 | Crystal Pharma, S.A.U. | Process for obtaining 17-spirolactones in steroids |
| EP2568986B1 (en) | 2010-05-10 | 2016-01-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for the treatment of fluid accumulation in and/ or under the retina |
| EP2582365B1 (en) | 2010-06-16 | 2019-03-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions for stimulating reepithelialisation during wound healing |
| AR081670A1 (es) | 2010-06-29 | 2012-10-10 | Leon Farma Sa Lab | Composicion farmaceutica que comprende drospirenona y kit anticonceptivo |
| US11351122B1 (en) | 2010-07-28 | 2022-06-07 | Laboratorios Leon Farma Sa | Synthetic progestogens and pharmaceutical compositions comprising the same |
| US10849857B2 (en) | 2010-07-28 | 2020-12-01 | Laboratorios Leon Farma Sa | Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same |
| US9603860B2 (en) | 2010-07-28 | 2017-03-28 | Laboratorios Leon Farma Sa | Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same |
| CN102887934B (zh) * | 2012-09-20 | 2015-05-27 | 杭州福斯特药业有限公司 | 一种屈螺酮的制备方法 |
| WO2016063269A1 (en) | 2014-10-20 | 2016-04-28 | Prendergast Patrick T | Use of antagonists to the nuclear steroid receptor alone or in combination as direct antiviral agents to inhibit alphavirus, togaviridae, arenaviridae, filoviridae, bunyaviridae, flaviviridae and rhabdoviridae |
| EP3108889A1 (en) | 2015-06-23 | 2016-12-28 | Philippe Perrin | Drospirenone-based contraceptive for a female patient affected with excess weight |
| KR102217942B1 (ko) | 2015-06-23 | 2021-02-19 | 라보라토리오스 레온 파르마 에스에이 | 과한 체중으로 영향 받은 여성 환자를 위한 드로스피레논-기반의 피임제 |
| WO2017055248A1 (en) | 2015-09-28 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of heart failure |
| ES2846835T3 (es) | 2015-10-13 | 2021-07-29 | Inst Nat Sante Rech Med | Métodos y composiciones farmacéuticas para el tratamiento de la neovascularización coroidea |
| EP3490606B8 (en) | 2016-07-26 | 2024-04-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antagonist of mineralocorticoid receptor for the treatment of osteoarthritis |
| EP4134082A1 (en) | 2021-08-12 | 2023-02-15 | Chemo Research, S.L. | Method for treating endometriosis and providing effective contraception |
| EP4395785A1 (en) | 2021-08-31 | 2024-07-10 | Inserm (Institut National de la Santé et de la Recherche Scientifique) | Methods for the treatment of ocular rosacea |
| WO2023152658A1 (en) | 2022-02-10 | 2023-08-17 | Lupin Limited | Slow release drospirenone tablet composition |
| WO2023165988A1 (en) | 2022-03-01 | 2023-09-07 | Chemo Research, S.L. | Chewable oral contraceptive |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3257390A (en) * | 1963-06-12 | 1966-06-21 | Merck & Co Inc | Ring a unsaturated 21-hydroxy-3-oxo-17alpha-pregnane-17-carboxylic acid lactone diuretic agents |
| NL166267C (nl) * | 1968-03-22 | 1981-07-15 | Merck & Co Inc | Werkwijze ter bereiding van farmaceutische preparaten, de onder toepassing daarvan verkregen gevormde voort- brengselen, alsmede werkwijze ter bereiding van 6,7-methyleen-20-spirox-4-en-3-onderivaten met aldoste- ron remmende werking. |
| DE2237143A1 (de) * | 1972-07-28 | 1974-02-14 | Hoechst Ag | Verfahren zur herstellung von beta(3-keto-7alpha-acetylthio-17beta-hydroxy4-androsten-17alpha-yl)-propionsaeuregamma-lacton und dessen 1-dehydro-derivat |
| CH601352A5 (enEXAMPLES) * | 1973-09-26 | 1978-07-14 | Hoffmann La Roche |
-
1976
- 1976-11-16 DE DE2652761A patent/DE2652761C2/de not_active Expired
-
1977
- 1977-10-31 NL NL7711946A patent/NL7711946A/xx not_active Application Discontinuation
- 1977-11-03 SU SU772537651A patent/SU695560A3/ru active
- 1977-11-04 IE IE2247/77A patent/IE46076B1/en not_active IP Right Cessation
- 1977-11-08 CH CH1361677A patent/CH631463A5/de not_active IP Right Cessation
- 1977-11-09 AU AU30509/77A patent/AU512611B2/en not_active Expired
- 1977-11-10 IL IL53353A patent/IL53353A/xx unknown
- 1977-11-11 US US05/850,524 patent/US4129564A/en not_active Expired - Lifetime
- 1977-11-14 GR GR54787A patent/GR65227B/el unknown
- 1977-11-14 DD DD77202077A patent/DD132968B3/de unknown
- 1977-11-14 LU LU78514A patent/LU78514A1/xx unknown
- 1977-11-15 HU HU77SCHE630A patent/HU174983B/hu unknown
- 1977-11-15 GB GB47440/77A patent/GB1550568A/en not_active Expired
- 1977-11-15 AT AT815577A patent/AT356827B/de not_active IP Right Cessation
- 1977-11-15 SE SE7712891A patent/SE436425B/xx not_active IP Right Cessation
- 1977-11-15 IT IT29658/77A patent/IT1092262B/it active
- 1977-11-16 JP JP13775877A patent/JPS5363373A/ja active Granted
- 1977-11-16 FR FR7734434A patent/FR2370755A1/fr active Granted
- 1977-11-16 BE BE182661A patent/BE860877A/xx not_active IP Right Cessation
- 1977-11-16 CS CS777551A patent/CS194823B2/cs unknown
- 1977-11-16 ES ES464193A patent/ES464193A1/es not_active Expired
- 1977-11-16 CA CA291,065A patent/CA1092094A/en not_active Expired
- 1977-11-16 DK DK508077A patent/DK141967C/da not_active IP Right Cessation
-
1979
- 1979-01-11 SU SU792706061A patent/SU743582A3/ru active
-
1982
- 1982-02-09 CH CH79382A patent/CH632774A5/de not_active IP Right Cessation
-
1985
- 1985-09-27 JP JP60212779A patent/JPS61218595A/ja active Granted
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| IL52148A (en) | Substituted 1-phenoxy-2-hydroxy-3-aminopropanes,process for preparing same and pharmaceutical compositions containing them | |
| ZA793682B (en) | New piperidylbenzimidazolinone derivatives,processes for their preparation and pharmaceutical compositions containing them | |
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| IL54111A (en) | 3,6-disubstituted-1,2,4-triazine-5-one-derivatives,process for their preparation and pharmaceutical compositions containing them | |
| IL52207A (en) | Substituted 2-vinyl-chromones, process for their preparation and pharmaceutical compositions containing them | |
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| ZA782432B (en) | 2-benzyl-perhydroazepines,process for their preparation and pharmaceutical compositions containing them | |
| IL55139A (en) | Substituted 2-cyclopropyl-chromones,process for their preparation and pharmaceutical compositions containing them | |
| ZA772026B (en) | Naphthyl derivatives,processes for their preparation and pharmaceutical compositions containing them | |
| IL54718A (en) | 17beta-hydroxy delta4-androsten-3-ones,process for their manufacture and pharmaceutical compositions containing them | |
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