IL51694A - 1-azacarbocyclic-2-ylidene derivatives of guanidine,their preparation and pharmaceutical compositions containing them - Google Patents
1-azacarbocyclic-2-ylidene derivatives of guanidine,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL51694A IL51694A IL51694A IL5169477A IL51694A IL 51694 A IL51694 A IL 51694A IL 51694 A IL51694 A IL 51694A IL 5169477 A IL5169477 A IL 5169477A IL 51694 A IL51694 A IL 51694A
- Authority
- IL
- Israel
- Prior art keywords
- azacarbocyclic
- guanidine
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66838676A | 1976-03-19 | 1976-03-19 | |
| US75258876A | 1976-12-20 | 1976-12-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL51694A0 IL51694A0 (en) | 1977-05-31 |
| IL51694A true IL51694A (en) | 1982-01-31 |
Family
ID=27099888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL51694A IL51694A (en) | 1976-03-19 | 1977-03-18 | 1-azacarbocyclic-2-ylidene derivatives of guanidine,their preparation and pharmaceutical compositions containing them |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS52136168A (ru) |
| AT (1) | AT356669B (ru) |
| AU (1) | AU517804B2 (ru) |
| CA (1) | CA1100494A (ru) |
| CH (4) | CH635073A5 (ru) |
| DD (1) | DD130242A5 (ru) |
| DE (1) | DE2711757A1 (ru) |
| DK (1) | DK119477A (ru) |
| ES (1) | ES457010A1 (ru) |
| FI (1) | FI65243C (ru) |
| FR (1) | FR2361366A1 (ru) |
| GB (1) | GB1573532A (ru) |
| GR (1) | GR60780B (ru) |
| IE (1) | IE44792B1 (ru) |
| IL (1) | IL51694A (ru) |
| NL (1) | NL7703011A (ru) |
| NO (1) | NO148524C (ru) |
| NZ (1) | NZ183570A (ru) |
| PH (1) | PH16561A (ru) |
| RO (1) | RO71209A (ru) |
| SE (1) | SE423628B (ru) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4101659A (en) * | 1977-08-29 | 1978-07-18 | Mcneil Laboratories, Incorporated | Benzhydryl guanidines |
| ZA793186B (en) * | 1978-07-06 | 1981-02-25 | Duphar Int Res | New urea and thiourea compounds, method of preparing the new compounds, as well as insecticidal compositions on the basis of these compounds |
| ATE2075T1 (de) * | 1979-04-20 | 1983-01-15 | Beecham Group Plc | Oxazolin- und thiazolin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen. |
| JPS55160764A (en) * | 1979-05-29 | 1980-12-13 | Ciba Geigy Ag | Guanidine* its manufacture and pharmaceutic medicine containing same |
| EP0028883A3 (en) * | 1979-11-10 | 1981-06-03 | Beecham Group Plc | Benzimidazoline derivatives, processes for their preparation and pharmaceutical compositions containing them |
| JPH06198992A (ja) * | 1992-11-30 | 1994-07-19 | Shinko Seisakusho Co Ltd | 紙葉類搬送装置 |
| AU6286294A (en) * | 1993-03-23 | 1994-10-11 | Astra Aktiebolag | Guanidine derivatives useful in therapy |
| US6090846A (en) * | 1994-06-01 | 2000-07-18 | Glaxo Wellcome Inc. | Substituted urea and isothiourea derivatives as no synthase inhibitors |
| US6297276B1 (en) | 1993-10-04 | 2001-10-02 | Glaxosmithkline | Substituted urea and isothiourea derivatives as no synthase inhibitors |
| US6225305B1 (en) | 1993-10-04 | 2001-05-01 | Glaxo Wellcome Inc. | Substituted urea and isothiorea derivatives as no synthase inhibitors |
| AU7705694A (en) * | 1993-10-04 | 1995-05-01 | Glaxo Wellcome House | Substituted urea and isothiourea derivatives as no synthase inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2205744A1 (de) * | 1972-02-08 | 1973-08-09 | Thomae Gmbh Dr K | Neue durch einen guanidinylidenrest substituierte heterocyclen und verfahren zu ihrer herstellung |
| GB1414048A (en) * | 1972-03-17 | 1975-11-12 | Mcneilab Inc | Pyrrolidylidene piperidylidene and hexahydroazepinylidene ureas |
| US3803170A (en) * | 1972-08-11 | 1974-04-09 | Richardson Merrell Inc | 2-((1-benzylcyclopentyl)imino)pyrrolidine |
-
1977
- 1977-03-10 NZ NZ183570A patent/NZ183570A/xx unknown
- 1977-03-14 GR GR52986A patent/GR60780B/el unknown
- 1977-03-15 GB GB10988/77A patent/GB1573532A/en not_active Expired
- 1977-03-17 DE DE19772711757 patent/DE2711757A1/de not_active Ceased
- 1977-03-17 AU AU23351/77A patent/AU517804B2/en not_active Expired
- 1977-03-17 NO NO770959A patent/NO148524C/no unknown
- 1977-03-18 IL IL51694A patent/IL51694A/xx unknown
- 1977-03-18 FI FI770864A patent/FI65243C/fi not_active IP Right Cessation
- 1977-03-18 CH CH344877A patent/CH635073A5/de not_active IP Right Cessation
- 1977-03-18 FR FR7708229A patent/FR2361366A1/fr active Granted
- 1977-03-18 AT AT190677A patent/AT356669B/de not_active IP Right Cessation
- 1977-03-18 RO RO7789709A patent/RO71209A/ro unknown
- 1977-03-18 DK DK119477A patent/DK119477A/da not_active Application Discontinuation
- 1977-03-18 ES ES457010A patent/ES457010A1/es not_active Expired
- 1977-03-18 CA CA274,239A patent/CA1100494A/en not_active Expired
- 1977-03-18 PH PH19565A patent/PH16561A/en unknown
- 1977-03-18 SE SE7703114A patent/SE423628B/xx not_active IP Right Cessation
- 1977-03-18 NL NL7703011A patent/NL7703011A/xx not_active Application Discontinuation
- 1977-03-18 JP JP2941177A patent/JPS52136168A/ja active Granted
- 1977-03-18 IE IE584/77A patent/IE44792B1/en unknown
- 1977-03-21 DD DD7700197955A patent/DD130242A5/xx unknown
-
1981
- 1981-03-13 CH CH175081A patent/CH632994A5/de not_active IP Right Cessation
-
1982
- 1982-04-02 CH CH206282A patent/CH636084A5/de not_active IP Right Cessation
- 1982-04-02 CH CH206182A patent/CH634557A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IE44792L (en) | 1977-09-19 |
| NO770959L (no) | 1977-09-20 |
| IE44792B1 (en) | 1982-04-07 |
| IL51694A0 (en) | 1977-05-31 |
| ATA190677A (de) | 1979-10-15 |
| GB1573532A (en) | 1980-08-28 |
| CH635073A5 (en) | 1983-03-15 |
| NO148524C (no) | 1983-10-26 |
| NO148524B (no) | 1983-07-18 |
| CH632994A5 (en) | 1982-11-15 |
| NL7703011A (nl) | 1977-09-21 |
| AU2335177A (en) | 1978-09-21 |
| JPS6327342B2 (ru) | 1988-06-02 |
| ES457010A1 (es) | 1978-07-16 |
| FR2361366A1 (fr) | 1978-03-10 |
| CH636084A5 (en) | 1983-05-13 |
| GR60780B (en) | 1978-08-28 |
| PH16561A (en) | 1983-11-18 |
| FR2361366B1 (ru) | 1984-03-02 |
| FI65243C (fi) | 1984-04-10 |
| FI770864A (ru) | 1977-09-20 |
| AT356669B (de) | 1980-05-12 |
| DE2711757A1 (de) | 1977-09-22 |
| DK119477A (da) | 1977-09-20 |
| AU517804B2 (en) | 1981-08-27 |
| CH634557A5 (en) | 1983-02-15 |
| JPS52136168A (en) | 1977-11-14 |
| FI65243B (fi) | 1983-12-30 |
| CA1100494A (en) | 1981-05-05 |
| SE423628B (sv) | 1982-05-17 |
| RO71209A (ro) | 1981-11-04 |
| DD130242A5 (de) | 1978-03-15 |
| NZ183570A (en) | 1979-06-08 |
| SE7703114L (sv) | 1977-09-20 |
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