IL51205A - Derivatives of 5-acyl-indane-2-carboxylic acid,their production and pharmaceutical compositions containing them - Google Patents

Derivatives of 5-acyl-indane-2-carboxylic acid,their production and pharmaceutical compositions containing them

Info

Publication number
IL51205A
IL51205A IL51205A IL5120577A IL51205A IL 51205 A IL51205 A IL 51205A IL 51205 A IL51205 A IL 51205A IL 5120577 A IL5120577 A IL 5120577A IL 51205 A IL51205 A IL 51205A
Authority
IL
Israel
Prior art keywords
indane
acyl
derivatives
production
carboxylic acid
Prior art date
Application number
IL51205A
Other languages
English (en)
Other versions
IL51205A0 (en
Original Assignee
Lipha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipha filed Critical Lipha
Publication of IL51205A0 publication Critical patent/IL51205A0/xx
Priority to IL60598A priority Critical patent/IL60598A/xx
Priority to IL60599A priority patent/IL60599A/xx
Priority to IL53561A priority patent/IL53561A/xx
Publication of IL51205A publication Critical patent/IL51205A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/784—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic with all keto groups bound to a non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
IL51205A 1976-01-12 1977-01-03 Derivatives of 5-acyl-indane-2-carboxylic acid,their production and pharmaceutical compositions containing them IL51205A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IL60598A IL60598A (en) 1976-12-14 1977-12-07 2-diethylaminoethyl 5-(2'-thenoyl)indane-2-carboxylate and salts thereof and pharmaceutical compositions containing them
IL60599A IL60599A (en) 1976-12-14 1977-12-07 5-acyl-n-dialkylaminoalkylindane-2-carboxamides and salts thereof and pharmaceutical compositions containing them
IL53561A IL53561A (en) 1976-12-14 1977-12-07 Derivatives of 5-acylindane-2-carboxylic acid,their preparation and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7600552A FR2337551A1 (fr) 1976-01-12 1976-01-12 Nouveaux acides carboxyliques derives de l'indane

Publications (2)

Publication Number Publication Date
IL51205A0 IL51205A0 (en) 1977-03-31
IL51205A true IL51205A (en) 1981-01-30

Family

ID=9167788

Family Applications (1)

Application Number Title Priority Date Filing Date
IL51205A IL51205A (en) 1976-01-12 1977-01-03 Derivatives of 5-acyl-indane-2-carboxylic acid,their production and pharmaceutical compositions containing them

Country Status (23)

Country Link
US (1) US4269848A (ko)
JP (1) JPS52118454A (ko)
AT (1) AT350544B (ko)
AU (1) AU510933B2 (ko)
BE (1) BE849285A (ko)
CA (1) CA1088943A (ko)
CH (1) CH617173A5 (ko)
DD (1) DD129549A5 (ko)
DE (1) DE2656750C2 (ko)
DK (1) DK144882C (ko)
ES (1) ES454901A1 (ko)
FR (1) FR2337551A1 (ko)
GB (1) GB1520089A (ko)
HU (1) HU172980B (ko)
IE (1) IE44758B1 (ko)
IL (1) IL51205A (ko)
MX (1) MX4227E (ko)
NL (1) NL7700287A (ko)
NO (1) NO770084L (ko)
NZ (1) NZ182995A (ko)
SE (1) SE7700200L (ko)
SU (1) SU688121A3 (ko)
ZA (1) ZA7741B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4224341A (en) 1976-01-12 1980-09-23 Lipha, Lyonnaise Industrielle Pharmaceutique 5-Substituted indan-2 carboxylic acid and functional derivatives
FR2407924A2 (fr) * 1977-11-08 1979-06-01 Lipha Lyonnaise Indle Pharmace Acides carboxyliques derives de l'indane utilisables notamment comme medicaments
US5149705A (en) * 1987-03-13 1992-09-22 Allergan, Inc. Acetylenes disubstituted with a heteroaromatic group and a tetralin group and having retinoid like activity

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3953500A (en) * 1973-08-11 1976-04-27 Takeda Chemical Industries, Ltd. Benzalicyclic carboxylic acid derivative
DE2438380C2 (de) 1973-08-11 1986-06-05 Takeda Chemical Industries, Ltd., Osaka 4-Benzoylindan-1-carbonsäuren, 4-Benzylindan-1-carbonsäuren, 4-Benzoylindan-1-carbonitrile, 4-Benzoylindan-1-one, 1-Carbamoylindan-4-carbonsäure, 1-Cyano-indan-4-carbonsäure und funktionelle Derivate der Carbonsäuren
CH601166A5 (ko) 1974-02-14 1978-06-30 Ciba Geigy Ag

Also Published As

Publication number Publication date
DK9477A (da) 1977-07-13
NO770084L (no) 1977-07-13
IL51205A0 (en) 1977-03-31
SE7700200L (sv) 1977-07-13
MX4227E (es) 1982-02-18
SU688121A3 (ru) 1979-09-25
CA1088943A (en) 1980-11-04
FR2337551B1 (ko) 1978-11-03
NZ182995A (en) 1979-10-25
NL7700287A (nl) 1977-07-14
DD129549A5 (de) 1978-01-25
DE2656750A1 (de) 1977-07-14
FR2337551A1 (fr) 1977-08-05
DK144882C (da) 1983-01-17
CH617173A5 (ko) 1980-05-14
AT350544B (de) 1979-06-11
ATA12377A (de) 1978-11-15
DE2656750C2 (de) 1982-11-04
AU510933B2 (en) 1980-07-24
ZA7741B (en) 1977-11-30
IE44758B1 (en) 1982-03-24
ES454901A1 (es) 1977-12-01
IE44758L (en) 1977-07-12
GB1520089A (en) 1978-08-02
DK144882B (da) 1982-06-28
BE849285A (fr) 1977-06-10
AU2115277A (en) 1978-07-13
US4269848A (en) 1981-05-26
HU172980B (hu) 1979-01-28
JPS52118454A (en) 1977-10-04

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