IL47299A - 3-thiomethyl-3-cephem-4-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them - Google Patents

3-thiomethyl-3-cephem-4-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them

Info

Publication number
IL47299A
IL47299A IL47299A IL4729975A IL47299A IL 47299 A IL47299 A IL 47299A IL 47299 A IL47299 A IL 47299A IL 4729975 A IL4729975 A IL 4729975A IL 47299 A IL47299 A IL 47299A
Authority
IL
Israel
Prior art keywords
cephem
thiomethyl
preparation
carboxylic acid
pharmaceutical compositions
Prior art date
Application number
IL47299A
Other languages
English (en)
Other versions
IL47299A0 (en
Original Assignee
Sparamedica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sparamedica Ag filed Critical Sparamedica Ag
Publication of IL47299A0 publication Critical patent/IL47299A0/xx
Publication of IL47299A publication Critical patent/IL47299A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL47299A 1974-06-21 1975-05-14 3-thiomethyl-3-cephem-4-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them IL47299A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH853774A CH609989A5 (en) 1974-06-21 1974-06-21 Process for the preparation of acyl derivatives

Publications (2)

Publication Number Publication Date
IL47299A0 IL47299A0 (en) 1976-10-31
IL47299A true IL47299A (en) 1979-01-31

Family

ID=4341690

Family Applications (1)

Application Number Title Priority Date Filing Date
IL47299A IL47299A (en) 1974-06-21 1975-05-14 3-thiomethyl-3-cephem-4-carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them

Country Status (25)

Country Link
JP (1) JPS625917B2 (fr)
AT (1) AT337897B (fr)
AU (1) AU498387B2 (fr)
BE (1) BE830455A (fr)
BR (1) BR7503782A (fr)
CA (1) CA1111021A (fr)
CH (1) CH609989A5 (fr)
CU (1) CU34293A (fr)
DD (1) DD121113A5 (fr)
DE (1) DE2527291A1 (fr)
DK (2) DK153155C (fr)
FI (1) FI751815A (fr)
FR (1) FR2275215A1 (fr)
GB (1) GB1471804A (fr)
HU (1) HU170576B (fr)
IE (1) IE41888B1 (fr)
IL (1) IL47299A (fr)
LU (1) LU72771A1 (fr)
NL (1) NL180665C (fr)
NO (1) NO752202L (fr)
NZ (1) NZ177508A (fr)
PH (1) PH13030A (fr)
SE (1) SE431755B (fr)
SU (2) SU635873A3 (fr)
ZA (1) ZA753086B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7805715A (nl) * 1977-06-03 1978-12-05 Hoffmann La Roche Werkwijze voor het bereiden van acylderivaten.
JPS5419990A (en) * 1977-07-14 1979-02-15 Shionogi & Co Ltd Dihydrotriazinylthioxacephalosporin
MC1259A1 (fr) * 1978-05-30 1980-01-14 Hoffmann La Roche Derives acyles
FR2474030A1 (fr) * 1980-01-17 1981-07-24 Rhone Poulenc Ind Nouvelles dioxotriazines et leur preparation
FR2494278A1 (fr) * 1980-11-20 1982-05-21 Rhone Poulenc Ind Nouveaux derives de la cephalosporine, leurs preparations et les medicaments qui les contiennent
WO2002086143A2 (fr) * 2001-04-19 2002-10-31 Bioferma Murcia, S.A. Procede relatif a l'elaboration de derives de cephalosporine
EP2250156B1 (fr) 2008-03-05 2015-05-06 Merck Patent GmbH Dérivés de pyrazinone comme stimulateurs de la sécrétion d'insuline, leurs procédés d'obtention et leur utilisation pour le traitement du diabète

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868369A (en) * 1972-11-14 1975-02-25 Smithkline Corp 3-heterocyclicthiomethylcephalosporins

Also Published As

Publication number Publication date
JPS5113793A (fr) 1976-02-03
GB1471804A (en) 1977-04-27
DK453687A (da) 1987-08-28
DK271975A (da) 1975-12-22
DE2527291A1 (de) 1976-01-08
CH609989A5 (en) 1979-03-30
IE41888B1 (en) 1980-04-23
HU170576B (fr) 1977-07-28
CA1111021A (fr) 1981-10-20
LU72771A1 (fr) 1977-03-04
DD121113A5 (fr) 1976-07-12
SE431755B (sv) 1984-02-27
IE41888L (en) 1975-12-21
DK453687D0 (da) 1987-08-28
DK155329B (da) 1989-03-28
ATA476975A (de) 1976-11-15
AU8191275A (en) 1976-12-09
NO752202L (fr) 1975-12-23
DK155329C (da) 1989-08-07
DK153155C (da) 1988-10-31
BE830455A (fr) 1975-12-22
JPS625917B2 (fr) 1987-02-07
SU589921A3 (ru) 1978-01-25
AU498387B2 (en) 1979-03-08
FR2275215A1 (fr) 1976-01-16
BR7503782A (pt) 1976-07-06
AT337897B (de) 1977-07-25
DE2527291C2 (fr) 1988-01-14
DK153155B (da) 1988-06-20
PH13030A (en) 1979-11-15
NL180665C (nl) 1987-04-01
FI751815A (fr) 1975-12-22
IL47299A0 (en) 1976-10-31
ZA753086B (en) 1976-04-28
NL7507390A (nl) 1975-12-23
SE7506908L (sv) 1975-12-22
CU34293A (es) 1979-01-16
NL180665B (nl) 1986-11-03
SU635873A3 (ru) 1978-11-30
FR2275215B1 (fr) 1980-05-16
NZ177508A (en) 1978-04-03

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