IL43745A - Process for the manufacture of 3,20-dioxo-pregn-4-en-21-oic acids - Google Patents
Process for the manufacture of 3,20-dioxo-pregn-4-en-21-oic acidsInfo
- Publication number
- IL43745A IL43745A IL43745A IL4374573A IL43745A IL 43745 A IL43745 A IL 43745A IL 43745 A IL43745 A IL 43745A IL 4374573 A IL4374573 A IL 4374573A IL 43745 A IL43745 A IL 43745A
- Authority
- IL
- Israel
- Prior art keywords
- general formula
- halogen atom
- steroid
- oxide
- cuprlc
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 19
- 238000004519 manufacturing process Methods 0.000 title claims 2
- LWKCHEXQYCMNME-GQDVPIKJSA-N 2-[(8s,9s,10r,13s,14s,17s)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoacetic acid Chemical class O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)C(=O)C(O)=O)[C@@H]4[C@@H]3CCC2=C1 LWKCHEXQYCMNME-GQDVPIKJSA-N 0.000 title 1
- 125000005843 halogen group Chemical group 0.000 claims abstract 10
- 229910003439 heavy metal oxide Inorganic materials 0.000 claims abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 4
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 2
- -1 steroid aldehyde Chemical class 0.000 claims 11
- 239000007795 chemical reaction product Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 4
- 229910052783 alkali metal Inorganic materials 0.000 claims 3
- GNTDGMZSJNCJKK-UHFFFAOYSA-N divanadium pentaoxide Chemical compound O=[V](=O)O[V](=O)=O GNTDGMZSJNCJKK-UHFFFAOYSA-N 0.000 claims 3
- 150000002430 hydrocarbons Chemical group 0.000 claims 3
- WGLPBDUCMAPZCE-UHFFFAOYSA-N Trioxochromium Chemical group O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- YADSGOSSYOOKMP-UHFFFAOYSA-N dioxolead Chemical compound O=[Pb]=O YADSGOSSYOOKMP-UHFFFAOYSA-N 0.000 claims 2
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 claims 2
- 230000003647 oxidation Effects 0.000 claims 2
- 238000007254 oxidation reaction Methods 0.000 claims 2
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical group [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 claims 2
- JWMFYGXQPXQEEM-NUNROCCHSA-N 5β-pregnane Chemical compound C([C@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](CC)[C@@]2(C)CC1 JWMFYGXQPXQEEM-NUNROCCHSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- PUHAKHQMSBQAKT-UHFFFAOYSA-L copper;butanoate Chemical compound [Cu+2].CCCC([O-])=O.CCCC([O-])=O PUHAKHQMSBQAKT-UHFFFAOYSA-L 0.000 claims 1
- 239000011133 lead Substances 0.000 claims 1
- 239000007800 oxidant agent Substances 0.000 claims 1
- 229910001923 silver oxide Inorganic materials 0.000 claims 1
- GWZUYOSMTQIJMY-DIKHCDEOSA-N 2-[(8s,9s,10s,13r,14s,17r)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]acetic acid Chemical class C1CCC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)CC(O)=O)[C@@H]4[C@@H]3CCC21 GWZUYOSMTQIJMY-DIKHCDEOSA-N 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical class [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 150000002373 hemiacetals Chemical class 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0023—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16
- C07J5/003—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes
- C07J5/0038—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes by an alkyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2260303A DE2260303C2 (de) | 1972-12-06 | 1972-12-06 | Verfahren zur Herstellung von Pregnansäurederivaten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL43745A0 IL43745A0 (en) | 1974-03-14 |
| IL43745A true IL43745A (en) | 1976-11-30 |
Family
ID=5863960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL43745A IL43745A (en) | 1972-12-06 | 1973-12-03 | Process for the manufacture of 3,20-dioxo-pregn-4-en-21-oic acids |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US3875194A (de) |
| JP (1) | JPS5710880B2 (de) |
| AR (1) | AR203738A1 (de) |
| AT (1) | AT336810B (de) |
| AU (1) | AU6311373A (de) |
| BE (1) | BE808301A (de) |
| CA (1) | CA1007633A (de) |
| CH (1) | CH606099A5 (de) |
| CS (1) | CS165967B2 (de) |
| DD (1) | DD108529A5 (de) |
| DE (1) | DE2260303C2 (de) |
| DK (1) | DK131864C (de) |
| ES (1) | ES421238A1 (de) |
| FI (1) | FI52347C (de) |
| FR (1) | FR2209754B1 (de) |
| GB (1) | GB1456675A (de) |
| HU (1) | HU167384B (de) |
| IE (1) | IE38608B1 (de) |
| IL (1) | IL43745A (de) |
| NL (1) | NL184897C (de) |
| NO (1) | NO142307C (de) |
| PL (1) | PL89573B1 (de) |
| RO (1) | RO71431A (de) |
| SE (1) | SE399712B (de) |
| SU (1) | SU524523A3 (de) |
| YU (1) | YU35451B (de) |
| ZA (1) | ZA739298B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3919421A (en) * | 1972-12-22 | 1975-11-11 | Schering Ag | Pregnanoic acid derivatives and process for the preparation thereof |
| DE2336438C2 (de) * | 1973-07-14 | 1983-07-07 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 17 β- Oxalylsteroiden |
| DD119586A5 (de) * | 1973-12-21 | 1976-05-05 | ||
| CH614960A5 (de) * | 1976-04-15 | 1979-12-28 | Ciba Geigy Ag | |
| CH633562A5 (de) * | 1976-12-10 | 1982-12-15 | Schering Ag | Verfahren zur herstellung neuer kortikoide. |
| JPS614680U (ja) * | 1984-06-13 | 1986-01-11 | 株式会社 ソフイア | パチンコ機の入賞装置 |
| US5215979A (en) * | 1985-12-19 | 1993-06-01 | Aktiebolaget Draco | 16,17-acetalsubstituted pregnane 21-oic acid derivatives |
-
1972
- 1972-12-06 DE DE2260303A patent/DE2260303C2/de not_active Expired
-
1973
- 1973-11-22 DK DK631373A patent/DK131864C/da not_active IP Right Cessation
- 1973-11-23 FI FI733621A patent/FI52347C/fi active
- 1973-11-25 YU YU3068/73A patent/YU35451B/xx unknown
- 1973-11-26 SE SE7315979A patent/SE399712B/xx unknown
- 1973-11-29 DD DD174979A patent/DD108529A5/xx unknown
- 1973-11-30 AU AU63113/73A patent/AU6311373A/en not_active Expired
- 1973-12-03 IL IL43745A patent/IL43745A/en unknown
- 1973-12-04 SU SU1976253A patent/SU524523A3/ru active
- 1973-12-04 IE IE2192/73A patent/IE38608B1/xx unknown
- 1973-12-04 RO RO7376884A patent/RO71431A/ro unknown
- 1973-12-04 PL PL1973167042A patent/PL89573B1/pl unknown
- 1973-12-05 AR AR251376A patent/AR203738A1/es active
- 1973-12-05 CS CS8382A patent/CS165967B2/cs unknown
- 1973-12-05 US US421820A patent/US3875194A/en not_active Expired - Lifetime
- 1973-12-05 NO NO4634/73A patent/NO142307C/no unknown
- 1973-12-05 FR FR7343369A patent/FR2209754B1/fr not_active Expired
- 1973-12-05 HU HUSCHE454*1A patent/HU167384B/hu not_active IP Right Cessation
- 1973-12-06 CA CA187,541A patent/CA1007633A/en not_active Expired
- 1973-12-06 ES ES421238A patent/ES421238A1/es not_active Expired
- 1973-12-06 CH CH1713073A patent/CH606099A5/xx not_active IP Right Cessation
- 1973-12-06 ZA ZA739298A patent/ZA739298B/xx unknown
- 1973-12-06 NL NLAANVRAGE7316695,A patent/NL184897C/xx not_active IP Right Cessation
- 1973-12-06 GB GB5663673A patent/GB1456675A/en not_active Expired
- 1973-12-06 BE BE138584A patent/BE808301A/xx not_active IP Right Cessation
- 1973-12-06 AT AT1021173A patent/AT336810B/de not_active IP Right Cessation
- 1973-12-06 JP JP13671473A patent/JPS5710880B2/ja not_active Expired
Also Published As
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