IL42685A - Antibiotic a-2315 and process for preparation thereof - Google Patents
Antibiotic a-2315 and process for preparation thereofInfo
- Publication number
- IL42685A IL42685A IL42685A IL4268573A IL42685A IL 42685 A IL42685 A IL 42685A IL 42685 A IL42685 A IL 42685A IL 4268573 A IL4268573 A IL 4268573A IL 42685 A IL42685 A IL 42685A
- Authority
- IL
- Israel
- Prior art keywords
- antibiotic
- culture medium
- producing
- methanol
- nitrogen
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title claims abstract 11
- 238000000034 method Methods 0.000 title claims abstract 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims abstract 4
- 241001495438 Actinoplanes philippinensis Species 0.000 claims abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000001963 growth medium Substances 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 238000000862 absorption spectrum Methods 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000032050 esterification Effects 0.000 claims 1
- 238000005886 esterification reaction Methods 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000001819 mass spectrum Methods 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 101000993347 Gallus gallus Ciliary neurotrophic factor Proteins 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 239000000645 desinfectant Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 208000028169 periodontal disease Diseases 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000000741 silica gel Substances 0.000 abstract 1
- 229910002027 silica gel Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
1433417 Antibiotic A-2315 ELI LILLY & CO 30 July 1973 [31 July 1972] 36111/73 Headings C2A and C2C The new antibiotic "A-2315" having the possible structural formula is prepared by aerobic cultivation of the organism Actinoplanes philippinensis NRRL 5462 (nov. spec.). It may be separated from the fermentation medium by conventional procedures, e.g. extraction with chloroform and purification by chromatography on silica gel. The antibiotic is stated to have antibacterial activity, in particular against gram-positive streptococci, especially those responsible for periodontal disease. It also has animal growth promoting activity and may be used to combat plant fungal infections as well as a general disinfectant.
[GB1433417A]
Claims (5)
1. The antibiotic Λ-2315, said antibiotic being 27 a white amorphous solid having a specific rotation [a] D of -132 (c = 0.375 in methanol); having an approximate elemental composition of 61.51% carbon, 7.51% hydrogen, 8.69% nitrogen, and 21.53% oxygen; having an approximate molecular weight of 503 as determined by mass spectrum; having an empirical formula of C2gH37N;j0.7 ; having in chloroform the following distinguishable bands in its infrared absorption spectrum: 2.81, 2.99, 3.38, 5.82, 6.02, 6.20, 6.30, 6.40, 6.66, 6.82, 6.94, 7.05, 7.30, 7.71, 8.88, 9.11, 10.41, 10.89, and 11.14 microns; having in 95% ethanol solution an ultraviolet absorption maximum at 214u with an absorptivity value of approximately 799; being soluble in methanol and ethanol, but being only slightly soluble in water; releasing alanine upon amino-acid analysis; and containing hydroxyl groups which are capable of esterification.
2. A process for producing the antibiotic of Claim 1 which comprises cultivating Actinoplanes philippinensis NRRL 5462 in a culture medium containing assimilable sources of carbon, nitrogen, and inorganic salts under submerged aerobic conditions until a substantial amount of antibiotic A-2315 is produced by said organism in said culture medium.
3. A process for producing the compound of Claim 1 which comprises recovering antibiotic A-2315 from the culture medium.
4. A process for producing the antibiotic A-2315 as defined in Claim 1 substantially as hereinbefore described with particular reference to Examples 1 and 2.
5. The antibiotic A-2315 as defined in Claim 1 substantially as hereinbefore described. S. HOROWITZ & CO. AGENTS FOR APPLICANTS X-3683 27
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27654672A | 1972-07-31 | 1972-07-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL42685A0 IL42685A0 (en) | 1973-10-25 |
| IL42685A true IL42685A (en) | 1976-01-30 |
Family
ID=23057068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL42685A IL42685A (en) | 1972-07-31 | 1973-07-09 | Antibiotic a-2315 and process for preparation thereof |
Country Status (28)
| Country | Link |
|---|---|
| JP (3) | JPS5551556B2 (en) |
| AR (1) | AR195360A1 (en) |
| AT (1) | AT324563B (en) |
| AU (1) | AU470296B2 (en) |
| BE (1) | BE802937A (en) |
| BG (1) | BG24957A3 (en) |
| CA (1) | CA989338A (en) |
| CH (1) | CH584286A5 (en) |
| CS (1) | CS190393B2 (en) |
| DD (1) | DD109027A5 (en) |
| DE (1) | DE2336811C2 (en) |
| DK (1) | DK132233C (en) |
| ES (1) | ES417327A1 (en) |
| FR (1) | FR2194414B1 (en) |
| GB (1) | GB1433417A (en) |
| HK (1) | HK48279A (en) |
| HU (1) | HU165340B (en) |
| IE (1) | IE37892B1 (en) |
| IL (1) | IL42685A (en) |
| KE (1) | KE2964A (en) |
| MY (1) | MY8000015A (en) |
| NL (1) | NL175321C (en) |
| PL (1) | PL87754B1 (en) |
| RO (1) | RO64170A (en) |
| SE (1) | SE390542B (en) |
| SU (1) | SU517265A3 (en) |
| YU (1) | YU36192B (en) |
| ZA (1) | ZA734701B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR207359A1 (en) * | 1974-04-16 | 1976-09-30 | Pfizer | PROCEDURE TO PREPARE AN ANTIBIOTIC BROTH |
| JPS5618869B2 (en) * | 1974-05-17 | 1981-05-01 | ||
| JPS5893790U (en) * | 1981-12-18 | 1983-06-25 | 日本酸素株式会社 | High purity nitrogen production equipment |
| JPS59202380A (en) * | 1983-04-30 | 1984-11-16 | 大同酸素株式会社 | Method of recovering argon |
| JPS59202381A (en) * | 1983-04-30 | 1984-11-16 | 大同酸素株式会社 | Method of recovering argon |
| JPS61225568A (en) * | 1985-03-29 | 1986-10-07 | 株式会社日立製作所 | air separation equipment |
| JPS6223968U (en) * | 1985-07-29 | 1987-02-13 |
-
1973
- 1973-07-09 IE IE1153/73A patent/IE37892B1/en unknown
- 1973-07-09 IL IL42685A patent/IL42685A/en unknown
- 1973-07-11 ZA ZA00734701A patent/ZA734701B/en unknown
- 1973-07-16 AU AU58136/73A patent/AU470296B2/en not_active Expired
- 1973-07-17 CA CA176,622A patent/CA989338A/en not_active Expired
- 1973-07-19 DE DE2336811A patent/DE2336811C2/en not_active Expired
- 1973-07-20 CH CH1066773A patent/CH584286A5/xx not_active IP Right Cessation
- 1973-07-24 YU YU2009/73A patent/YU36192B/en unknown
- 1973-07-25 CS CS735334A patent/CS190393B2/en unknown
- 1973-07-27 AT AT663073A patent/AT324563B/en not_active IP Right Cessation
- 1973-07-27 ES ES417327A patent/ES417327A1/en not_active Expired
- 1973-07-30 SU SU1954501A patent/SU517265A3/en active
- 1973-07-30 DD DD172602A patent/DD109027A5/xx unknown
- 1973-07-30 BE BE1005265A patent/BE802937A/en not_active IP Right Cessation
- 1973-07-30 GB GB3611173A patent/GB1433417A/en not_active Expired
- 1973-07-30 SE SE7310503A patent/SE390542B/en unknown
- 1973-07-30 DK DK418273*A patent/DK132233C/en not_active IP Right Cessation
- 1973-07-30 HU HUEI488A patent/HU165340B/hu unknown
- 1973-07-31 BG BG024231A patent/BG24957A3/en unknown
- 1973-07-31 NL NLAANVRAGE7310613,A patent/NL175321C/en not_active IP Right Cessation
- 1973-07-31 FR FR7327952A patent/FR2194414B1/fr not_active Expired
- 1973-07-31 AR AR249380A patent/AR195360A1/en active
- 1973-07-31 JP JP8626573A patent/JPS5551556B2/ja not_active Expired
- 1973-07-31 PL PL1973164423A patent/PL87754B1/pl unknown
- 1973-07-31 RO RO7375674A patent/RO64170A/en unknown
-
1979
- 1979-06-04 KE KE2964A patent/KE2964A/en unknown
- 1979-07-12 HK HK482/79A patent/HK48279A/en unknown
-
1980
- 1980-05-26 JP JP7070780A patent/JPS55162985A/en active Granted
- 1980-05-26 JP JP55070706A patent/JPS5831327B2/en not_active Expired
- 1980-12-30 MY MY15/80A patent/MY8000015A/en unknown
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