IL40088A - Tri-iodinated n-methyldicarboxylic acid anilides and process for their manufacture - Google Patents
Tri-iodinated n-methyldicarboxylic acid anilides and process for their manufactureInfo
- Publication number
- IL40088A IL40088A IL40088A IL4008872A IL40088A IL 40088 A IL40088 A IL 40088A IL 40088 A IL40088 A IL 40088A IL 4008872 A IL4008872 A IL 4008872A IL 40088 A IL40088 A IL 40088A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- alkoxy
- group
- compounds
- general formula
- Prior art date
Links
- 239000002253 acid Substances 0.000 title claims abstract 7
- 238000000034 method Methods 0.000 title claims 6
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 229940051881 anilide analgesics and antipyretics Drugs 0.000 title abstract 2
- 150000003931 anilides Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 23
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 12
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 9
- 239000003795 chemical substances by application Substances 0.000 claims abstract 6
- 150000003839 salts Chemical class 0.000 claims abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 4
- 239000001257 hydrogen Substances 0.000 claims abstract 4
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims abstract 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000002947 alkylene group Chemical group 0.000 claims abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 2
- 229910052801 chlorine Inorganic materials 0.000 claims abstract 2
- 239000000460 chlorine Substances 0.000 claims abstract 2
- 229930195734 saturated hydrocarbon Natural products 0.000 claims abstract 2
- 125000005843 halogen group Chemical group 0.000 claims 5
- 239000012442 inert solvent Substances 0.000 claims 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- -1 chloro, carboxy, acetylaminomethyl Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
- 125000004442 acylamino group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- WFLUHYUKINZPNZ-UHFFFAOYSA-N 3-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]propanoic acid Chemical compound OC(=O)CCOCCOCCOCCC(O)=O WFLUHYUKINZPNZ-UHFFFAOYSA-N 0.000 abstract 1
- UISVSZSWVZLSKG-UHFFFAOYSA-N 4-[2-[2-[2-(3-carboxypropoxy)ethoxy]ethoxy]ethoxy]butanoic acid Chemical compound C(CCOCCOCCOCCOCCCC(=O)O)C(=O)O UISVSZSWVZLSKG-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2141803A DE2141803A1 (de) | 1971-08-17 | 1971-08-17 | Trijodierte n-methyl-dicarbonsaeureani-lide und verfahren zu iher herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL40088A0 IL40088A0 (en) | 1972-10-29 |
| IL40088A true IL40088A (en) | 1976-05-31 |
Family
ID=5817319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL40088A IL40088A (en) | 1971-08-17 | 1972-08-09 | Tri-iodinated n-methyldicarboxylic acid anilides and process for their manufacture |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4001298A (fr) |
| JP (1) | JPS4829736A (fr) |
| AR (1) | AR204073A1 (fr) |
| AT (2) | AT317417B (fr) |
| AU (1) | AU476763B2 (fr) |
| BE (1) | BE787669A (fr) |
| CA (1) | CA977759A (fr) |
| DD (1) | DD100156A5 (fr) |
| DE (1) | DE2141803A1 (fr) |
| DK (1) | DK132375C (fr) |
| ES (2) | ES405769A1 (fr) |
| FR (1) | FR2150784B1 (fr) |
| GB (1) | GB1409733A (fr) |
| HU (1) | HU164151B (fr) |
| IL (1) | IL40088A (fr) |
| NL (1) | NL7209286A (fr) |
| SU (1) | SU474974A3 (fr) |
| ZA (1) | ZA725664B (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4225725A (en) * | 1975-10-20 | 1980-09-30 | Mallinckrodt, Inc. | Lower alkoxymethyl esters of 2,4,6-triiodobenzoic acid derivatives |
| GB1539791A (en) * | 1976-04-08 | 1979-02-07 | Guerbet Sa | X-ray contrast media |
| DE2628517C2 (de) * | 1976-06-23 | 1985-02-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel |
| DE2629228C2 (de) * | 1976-06-25 | 1984-10-18 | Schering AG, 1000 Berlin und 4709 Bergkamen | Jodierte Isophthalamsäure-Derivate Verfahren zu deren Herstellung sowie deren Verwendung |
| EP0079397A1 (fr) * | 1981-11-13 | 1983-05-25 | Schering Aktiengesellschaft | (2,4,6-triiodoanilides) asymétriquement substitués d'acides dicarboxyliques, leur préparation et agents de contraste pour rayons X les contenant |
| ATE79368T1 (de) * | 1987-05-22 | 1992-08-15 | Bracco Spa | Herstellung von 5-acylamino-2,4,6-trijodo- oder tribromo-benzoesaeure-derivate. |
| US5614638A (en) * | 1989-11-29 | 1997-03-25 | Bracco International B.V. | Nonionic radiographic contrast agents |
| US5869024A (en) * | 1989-11-29 | 1999-02-09 | Bracco International B.V. | Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures |
| US5527926A (en) * | 1990-11-26 | 1996-06-18 | Bracco International B.V. | Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures |
| US5278311A (en) * | 1992-06-05 | 1994-01-11 | E. R. Squibb & Sons, Inc. | Nonionic radiographic contrast agents |
| US5463080A (en) * | 1992-08-27 | 1995-10-31 | Bracco International B.V. | 2,4,6-triiodo-1,3-benzenedicarboxylic acid compounds used as radiolabelling reagents |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3542861A (en) * | 1967-05-08 | 1970-11-24 | Sterling Drug Inc | 3-amino-5-cycloalkylcarbonylamino-2,4,6-triiodobenzoic acids |
| US3732293A (en) * | 1968-03-15 | 1973-05-08 | Sterling Drug Inc | Iodinated bis(aminobenzoic acids) and esters thereof |
-
0
- BE BE787669D patent/BE787669A/fr unknown
-
1971
- 1971-08-17 DE DE2141803A patent/DE2141803A1/de active Pending
-
1972
- 1972-01-01 AR AR243597A patent/AR204073A1/es active
- 1972-06-30 NL NL7209286A patent/NL7209286A/xx unknown
- 1972-07-06 DD DD164237A patent/DD100156A5/xx unknown
- 1972-07-07 DK DK340372A patent/DK132375C/da active
- 1972-08-03 SU SU1817911A patent/SU474974A3/ru active
- 1972-08-07 GB GB3673472A patent/GB1409733A/en not_active Expired
- 1972-08-09 IL IL40088A patent/IL40088A/en unknown
- 1972-08-11 ES ES405769A patent/ES405769A1/es not_active Expired
- 1972-08-11 ES ES405770A patent/ES405770A1/es not_active Expired
- 1972-08-14 AT AT700972A patent/AT317417B/de not_active IP Right Cessation
- 1972-08-14 AT AT713473*7A patent/AT329543B/de not_active IP Right Cessation
- 1972-08-16 HU HU72SE405A patent/HU164151B/hu unknown
- 1972-08-16 FR FR7229332A patent/FR2150784B1/fr not_active Expired
- 1972-08-16 AU AU45650/72A patent/AU476763B2/en not_active Expired
- 1972-08-17 CA CA149,662A patent/CA977759A/en not_active Expired
- 1972-08-17 JP JP47082447A patent/JPS4829736A/ja active Pending
- 1972-08-17 US US05/281,379 patent/US4001298A/en not_active Expired - Lifetime
- 1972-08-17 ZA ZA725664A patent/ZA725664B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU4565072A (en) | 1974-02-21 |
| HU164151B (fr) | 1973-12-28 |
| BE787669A (fr) | 1973-02-19 |
| US4001298A (en) | 1977-01-04 |
| AU476763B2 (en) | 1976-10-07 |
| GB1409733A (en) | 1975-10-15 |
| ATA713473A (de) | 1975-08-15 |
| CA977759A (en) | 1975-11-11 |
| AT317417B (de) | 1974-08-26 |
| ZA725664B (en) | 1973-05-30 |
| DK132375B (da) | 1975-12-01 |
| DD100156A5 (fr) | 1973-09-12 |
| SU474974A3 (ru) | 1975-06-25 |
| JPS4829736A (fr) | 1973-04-19 |
| DE2141803A1 (de) | 1973-03-01 |
| FR2150784A1 (fr) | 1973-04-13 |
| AR204073A1 (es) | 1975-11-20 |
| DK132375C (da) | 1976-05-03 |
| ES405769A1 (es) | 1975-09-16 |
| FR2150784B1 (fr) | 1975-06-20 |
| IL40088A0 (en) | 1972-10-29 |
| NL7209286A (fr) | 1973-02-20 |
| AT329543B (de) | 1976-05-10 |
| ES405770A1 (es) | 1975-09-16 |
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