IL301248B2 - Multivalent vaccine compositions and uses thereof - Google Patents
Multivalent vaccine compositions and uses thereofInfo
- Publication number
- IL301248B2 IL301248B2 IL301248A IL30124823A IL301248B2 IL 301248 B2 IL301248 B2 IL 301248B2 IL 301248 A IL301248 A IL 301248A IL 30124823 A IL30124823 A IL 30124823A IL 301248 B2 IL301248 B2 IL 301248B2
- Authority
- IL
- Israel
- Prior art keywords
- antigen
- coli
- polysaccharide
- composition
- carrier protein
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/739—Lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063079734P | 2020-09-17 | 2020-09-17 | |
| EP21154782 | 2021-02-02 | ||
| US202163191471P | 2021-05-21 | 2021-05-21 | |
| PCT/IB2021/058485 WO2022058945A1 (en) | 2020-09-17 | 2021-09-17 | Multivalent vaccine compositions and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL301248A IL301248A (en) | 2023-05-01 |
| IL301248B1 IL301248B1 (en) | 2023-12-01 |
| IL301248B2 true IL301248B2 (en) | 2024-04-01 |
Family
ID=77801756
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL301248A IL301248B2 (en) | 2020-09-17 | 2021-09-17 | Multivalent vaccine compositions and uses thereof |
| IL308201A IL308201A (en) | 2020-09-17 | 2021-09-17 | Multivalent vaccine compositions and uses thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL308201A IL308201A (en) | 2020-09-17 | 2021-09-17 | Multivalent vaccine compositions and uses thereof |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US12233118B2 (enExample) |
| EP (1) | EP4213870A1 (enExample) |
| JP (2) | JP7481585B2 (enExample) |
| KR (1) | KR20230043157A (enExample) |
| CN (3) | CN115803087B (enExample) |
| AU (1) | AU2021342797B2 (enExample) |
| BR (1) | BR112023004819A2 (enExample) |
| CA (1) | CA3190820C (enExample) |
| CL (1) | CL2023000740A1 (enExample) |
| CO (1) | CO2023002114A2 (enExample) |
| EC (1) | ECSP23019295A (enExample) |
| IL (2) | IL301248B2 (enExample) |
| MX (1) | MX2023003169A (enExample) |
| PE (1) | PE20231385A1 (enExample) |
| PH (1) | PH12023550020A1 (enExample) |
| TW (1) | TW202227128A (enExample) |
| UY (1) | UY39428A (enExample) |
| WO (1) | WO2022058945A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL286467B1 (en) | 2019-03-18 | 2025-10-01 | Janssen Pharmaceuticals Inc | Methods for producing bioconjugates of E. COLI O-antigen polysaccharides, preparations thereof and methods for using them |
| PE20212265A1 (es) | 2019-03-18 | 2021-11-30 | Janssen Pharmaceuticals Inc | Bioconjugados de antigenos-polisacaridos de e. coli, metodos de produccion y metodos de utilizacion de los mismos |
| AR131046A1 (es) * | 2022-11-15 | 2025-02-12 | Janssen Pharmaceuticals Inc | Composiciones de vacunas multivalentes y sus usos |
| WO2024146325A1 (zh) * | 2023-01-06 | 2024-07-11 | 中国人民解放军军事科学院军事医学研究院 | 用于生产抗原多糖-载体蛋白生物偶联产物的工程菌及其应用 |
| GB202302579D0 (en) * | 2023-02-23 | 2023-04-12 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| WO2024186262A1 (en) * | 2023-03-03 | 2024-09-12 | Agency For Science, Technology And Research | Use of o-antigens for treating bacterial infections |
| EP4478050A1 (en) | 2023-06-12 | 2024-12-18 | Janssen Pharmaceuticals, Inc. | Method for quantifying bound acetate in glycoconjugates |
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| EP0671948B1 (en) | 1992-06-25 | 1997-08-13 | SMITHKLINE BEECHAM BIOLOGICALS s.a. | Vaccine composition containing adjuvants |
| ES2231770T3 (es) | 1993-03-05 | 2005-05-16 | Wyeth Holdings Corporation | Nuevos plasmidos para la produccion de proteina crm y toxina difterica. |
| NZ274376A (en) | 1993-09-22 | 1997-11-24 | Jackson H M Found Military Med | Activating soluble carbohydrate using cyanylating reagents for the production of immunogenic constructs |
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| ES2200059T3 (es) | 1995-03-22 | 2004-03-01 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Produccion de construcciones inmunogenicas usando carbohidratos solubles activados mediante reactivos cianilados organicos. |
| US6299881B1 (en) | 1997-03-24 | 2001-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts |
| ATE278419T1 (de) | 1997-04-01 | 2004-10-15 | Corixa Corp | Wässerige immunologische adjuvantzusammensetzungen aus monophosphoryllipid a |
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| CA2716187C (en) | 2008-02-20 | 2020-01-07 | Glycovaxyn Ag | Bioconjugates made from recombinant n-glycosylated proteins from procaryotic cells |
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| PL2501406T3 (pl) | 2009-11-19 | 2018-05-30 | Glaxosmithkline Biologicals S.A. | Biosyntetyczny układ wytwarzający immunogenne polisacharydy w komórkach prokariotycznych |
| EP3336225B1 (en) | 2010-07-16 | 2020-02-19 | Adimab, LLC | Antibody libraries |
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| US9932598B2 (en) | 2012-08-02 | 2018-04-03 | The Regents Of The University Of California | Metabolic engineering of microbial organisms |
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| PE20212265A1 (es) | 2019-03-18 | 2021-11-30 | Janssen Pharmaceuticals Inc | Bioconjugados de antigenos-polisacaridos de e. coli, metodos de produccion y metodos de utilizacion de los mismos |
| IL286467B1 (en) | 2019-03-18 | 2025-10-01 | Janssen Pharmaceuticals Inc | Methods for producing bioconjugates of E. COLI O-antigen polysaccharides, preparations thereof and methods for using them |
| FR3098334B1 (fr) | 2019-07-05 | 2021-07-23 | Airbus Operations Sas | Procédé et système de surveillance d’un état de conscience d’un opérateur dans un poste de pilotage d’un aéronef |
| JP2024514074A (ja) * | 2021-04-01 | 2024-03-28 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | Ｅ．ｃｏｌｉ ｏ１８バイオコンジュゲートの産生 |
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2021
- 2021-09-17 EP EP21772844.3A patent/EP4213870A1/en active Pending
- 2021-09-17 IL IL301248A patent/IL301248B2/en unknown
- 2021-09-17 CA CA3190820A patent/CA3190820C/en active Active
- 2021-09-17 KR KR1020237006127A patent/KR20230043157A/ko active Pending
- 2021-09-17 PE PE2023001175A patent/PE20231385A1/es unknown
- 2021-09-17 US US17/478,584 patent/US12233118B2/en active Active
- 2021-09-17 IL IL308201A patent/IL308201A/en unknown
- 2021-09-17 BR BR112023004819A patent/BR112023004819A2/pt unknown
- 2021-09-17 CN CN202180049038.6A patent/CN115803087B/zh active Active
- 2021-09-17 MX MX2023003169A patent/MX2023003169A/es unknown
- 2021-09-17 JP JP2023517329A patent/JP7481585B2/ja active Active
- 2021-09-17 CN CN202411689651.6A patent/CN119454928A/zh active Pending
- 2021-09-17 UY UY0001039428A patent/UY39428A/es unknown
- 2021-09-17 AU AU2021342797A patent/AU2021342797B2/en active Active
- 2021-09-17 TW TW110135002A patent/TW202227128A/zh unknown
- 2021-09-17 CN CN202411689646.5A patent/CN119454927A/zh active Pending
- 2021-09-17 PH PH1/2023/550020A patent/PH12023550020A1/en unknown
- 2021-09-17 WO PCT/IB2021/058485 patent/WO2022058945A1/en not_active Ceased
-
2023
- 2023-02-27 CO CONC2023/0002114A patent/CO2023002114A2/es unknown
- 2023-03-15 CL CL2023000740A patent/CL2023000740A1/es unknown
- 2023-03-17 EC ECSENADI202319295A patent/ECSP23019295A/es unknown
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2024
- 2024-04-25 JP JP2024071024A patent/JP2024099716A/ja active Pending
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2025
- 2025-01-16 US US19/025,061 patent/US20250222088A1/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| SAADE, ELIE, ET AL., CHARACTERIZATION OF ESCHERICHIA COLI ISOLATES POTENTIALLY COVERED BY EXPEC4V AND EXPEC10V, THAT WERE COLLECTED FROM POST-TRANSRECTAL ULTRASOUND-GUIDED PROSTATE NEEDLE BIOPSY INVASIVE URINARY TRACT AND BLOODSTREAM INFECTIONS., 31 December 2020 (2020-12-31) * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3190820C (en) | 2024-11-19 |
| WO2022058945A1 (en) | 2022-03-24 |
| UY39428A (es) | 2022-03-31 |
| IL301248B1 (en) | 2023-12-01 |
| CN119454927A (zh) | 2025-02-18 |
| PE20231385A1 (es) | 2023-09-12 |
| KR20230043157A (ko) | 2023-03-30 |
| PH12023550020A1 (en) | 2024-03-11 |
| AU2021342797A1 (en) | 2023-02-16 |
| JP2024099716A (ja) | 2024-07-25 |
| BR112023004819A2 (pt) | 2023-04-18 |
| EP4213870A1 (en) | 2023-07-26 |
| US20220088165A1 (en) | 2022-03-24 |
| ECSP23019295A (es) | 2023-04-28 |
| CN115803087B (zh) | 2024-12-06 |
| CO2023002114A2 (es) | 2023-03-07 |
| CN115803087A (zh) | 2023-03-14 |
| CN119454928A (zh) | 2025-02-18 |
| JP7481585B2 (ja) | 2024-05-10 |
| MX2023003169A (es) | 2023-03-27 |
| IL308201A (en) | 2024-01-01 |
| US20250222088A1 (en) | 2025-07-10 |
| JP2023539943A (ja) | 2023-09-20 |
| CL2023000740A1 (es) | 2023-09-29 |
| TW202227128A (zh) | 2022-07-16 |
| US12233118B2 (en) | 2025-02-25 |
| AU2021342797B2 (en) | 2024-02-08 |
| IL301248A (en) | 2023-05-01 |
| CA3190820A1 (en) | 2022-03-24 |
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