IL300476B2 - Use of chloroquine and clemizole compounds for treatment of inflammatory and cancerous conditions - Google Patents

Use of chloroquine and clemizole compounds for treatment of inflammatory and cancerous conditions

Info

Publication number
IL300476B2
IL300476B2 IL300476A IL30047623A IL300476B2 IL 300476 B2 IL300476 B2 IL 300476B2 IL 300476 A IL300476 A IL 300476A IL 30047623 A IL30047623 A IL 30047623A IL 300476 B2 IL300476 B2 IL 300476B2
Authority
IL
Israel
Prior art keywords
effective amount
subject
chloroquine
clemizole
liver
Prior art date
Application number
IL300476A
Other languages
English (en)
Hebrew (he)
Other versions
IL300476B1 (en
IL300476A (en
Original Assignee
Eiger Group Int Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eiger Group Int Inc filed Critical Eiger Group Int Inc
Publication of IL300476A publication Critical patent/IL300476A/en
Publication of IL300476B1 publication Critical patent/IL300476B1/en
Publication of IL300476B2 publication Critical patent/IL300476B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL300476A 2015-06-30 2016-06-30 Use of chloroquine and clemizole compounds for treatment of inflammatory and cancerous conditions IL300476B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562187061P 2015-06-30 2015-06-30
PCT/US2016/040566 WO2017004454A1 (en) 2015-06-30 2016-06-30 Use of chloroquine and clemizole compounds for treatment of inflammatory and cancerous conditions

Publications (3)

Publication Number Publication Date
IL300476A IL300476A (en) 2023-04-01
IL300476B1 IL300476B1 (en) 2024-03-01
IL300476B2 true IL300476B2 (en) 2024-07-01

Family

ID=57609247

Family Applications (4)

Application Number Title Priority Date Filing Date
IL300476A IL300476B2 (en) 2015-06-30 2016-06-30 Use of chloroquine and clemizole compounds for treatment of inflammatory and cancerous conditions
IL310969A IL310969A (en) 2015-06-30 2016-06-30 Use of chloroquine and clemizole compounds for treatment of inflammatory and cancerous conditions
IL256233A IL256233A (en) 2015-06-30 2017-12-10 Use of chloroquine and calamizole compounds to treat inflammatory and cancerous conditions
IL279020A IL279020B2 (en) 2015-06-30 2020-11-26 Use of chloroquine and calamizole compounds to treat inflammatory and cancerous conditions

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL310969A IL310969A (en) 2015-06-30 2016-06-30 Use of chloroquine and clemizole compounds for treatment of inflammatory and cancerous conditions
IL256233A IL256233A (en) 2015-06-30 2017-12-10 Use of chloroquine and calamizole compounds to treat inflammatory and cancerous conditions
IL279020A IL279020B2 (en) 2015-06-30 2020-11-26 Use of chloroquine and calamizole compounds to treat inflammatory and cancerous conditions

Country Status (14)

Country Link
US (3) US10688083B2 (OSRAM)
EP (1) EP3317274A4 (OSRAM)
JP (3) JP7068827B2 (OSRAM)
KR (2) KR20180032578A (OSRAM)
CN (2) CN113274386A (OSRAM)
AU (4) AU2016288699B2 (OSRAM)
CA (2) CA2989634C (OSRAM)
HK (1) HK1249508A1 (OSRAM)
IL (4) IL300476B2 (OSRAM)
MX (3) MX394605B (OSRAM)
NZ (1) NZ776616A (OSRAM)
TW (3) TWI881480B (OSRAM)
WO (1) WO2017004454A1 (OSRAM)
ZA (2) ZA201708471B (OSRAM)

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CN113527201A (zh) * 2020-04-14 2021-10-22 瀚海新拓(杭州)生物医药有限公司 光学活性氯喹和羟氯喹及其类似物、其制备方法、组合物和用途
CN115515935B (zh) * 2020-04-30 2025-01-07 中美华世通生物医药科技(武汉)股份有限公司 冠状病毒感染的治疗或预防
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CN111793026A (zh) * 2020-07-23 2020-10-20 珠海润都制药股份有限公司 一种硫酸羟氯喹及其对映体的晶型和制备方法
CN114057640A (zh) * 2020-08-05 2022-02-18 凯特立斯（深圳）科技有限公司 一种光学纯(r)/(s)-羟氯喹侧链的不对称合成方法
CN112225697B (zh) * 2020-10-16 2023-01-03 宁波大学 一种对映体纯氯喹及磷酸氯喹的制备方法
CN114573464A (zh) * 2022-03-02 2022-06-03 重庆南松凯博生物制药有限公司 一种羟氯喹侧链精制方法
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Also Published As

Publication number Publication date
MX2017016681A (es) 2018-07-06
AU2021201234A1 (en) 2021-03-11
IL279020B2 (en) 2023-07-01
CN113274386A (zh) 2021-08-20
BR112017028601A2 (pt) 2018-08-28
US20240398761A1 (en) 2024-12-05
IL279020B1 (en) 2023-03-01
TWI881480B (zh) 2025-04-21
AU2016288699A1 (en) 2018-01-18
IL256233A (en) 2018-02-28
NZ738291A (en) 2021-06-25
CA2989634C (en) 2022-12-06
CA3178499A1 (en) 2017-01-05
AU2023201397B2 (en) 2024-10-03
WO2017004454A1 (en) 2017-01-05
TW201717941A (zh) 2017-06-01
IL279020A (OSRAM) 2020-12-31
JP2018519340A (ja) 2018-07-19
JP2024083475A (ja) 2024-06-21
AU2024266943A1 (en) 2024-12-19
HK1249508A1 (zh) 2018-11-02
US20210052553A1 (en) 2021-02-25
US12090141B2 (en) 2024-09-17
US10688083B2 (en) 2020-06-23
MX394605B (es) 2025-03-24
IL310969A (en) 2024-04-01
AU2023201397A1 (en) 2023-04-06
TW202317103A (zh) 2023-05-01
TWI771272B (zh) 2022-07-21
JP7068827B2 (ja) 2022-05-17
ZA202004136B (en) 2025-08-27
EP3317274A4 (en) 2019-05-08
MX2023003792A (es) 2023-04-26
TW202402283A (zh) 2024-01-16
AU2016288699B2 (en) 2020-11-26
WO2017004454A8 (en) 2018-01-25
KR20180032578A (ko) 2018-03-30
US20180200228A1 (en) 2018-07-19
ZA201708471B (en) 2022-05-25
MX2022008100A (es) 2022-07-11
CN107922404B (zh) 2021-06-29
CA2989634A1 (en) 2017-01-05
CN107922404A (zh) 2018-04-17
NZ776616A (en) 2024-11-29
IL300476B1 (en) 2024-03-01
EP3317274A1 (en) 2018-05-09
TWI830262B (zh) 2024-01-21
JP2022105149A (ja) 2022-07-12
JP7470151B2 (ja) 2024-04-17
KR20230129590A (ko) 2023-09-08
IL300476A (en) 2023-04-01

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