IL299732A - Macrocycles and their use - Google Patents

Macrocycles and their use

Info

Publication number
IL299732A
IL299732A IL299732A IL29973223A IL299732A IL 299732 A IL299732 A IL 299732A IL 299732 A IL299732 A IL 299732A IL 29973223 A IL29973223 A IL 29973223A IL 299732 A IL299732 A IL 299732A
Authority
IL
Israel
Prior art keywords
macrocycles
Prior art date
Application number
IL299732A
Other languages
English (en)
Hebrew (he)
Original Assignee
Blossomhill Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blossomhill Therapeutics Inc filed Critical Blossomhill Therapeutics Inc
Publication of IL299732A publication Critical patent/IL299732A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D515/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL299732A 2020-07-10 2021-07-08 Macrocycles and their use IL299732A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063050559P 2020-07-10 2020-07-10
US202163143569P 2021-01-29 2021-01-29
US202163217950P 2021-07-02 2021-07-02
PCT/US2021/040859 WO2022011123A1 (en) 2020-07-10 2021-07-08 Macrocycles and their use

Publications (1)

Publication Number Publication Date
IL299732A true IL299732A (en) 2023-03-01

Family

ID=79552077

Family Applications (1)

Application Number Title Priority Date Filing Date
IL299732A IL299732A (en) 2020-07-10 2021-07-08 Macrocycles and their use

Country Status (12)

Country Link
US (1) US20230257396A1 (zh)
EP (1) EP4178958A1 (zh)
JP (1) JP2023532946A (zh)
KR (1) KR20230037564A (zh)
CN (1) CN116171279A (zh)
BR (1) BR112023000463A2 (zh)
CA (1) CA3187834A1 (zh)
CL (1) CL2023000061A1 (zh)
IL (1) IL299732A (zh)
MX (1) MX2023000503A (zh)
TW (1) TW202216730A (zh)
WO (1) WO2022011123A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2023204770A1 (en) * 2022-01-05 2024-07-18 Blossomhill Therapeutics, Inc. Macrocyclic compounds and use as kinase inhibitors
WO2023240140A1 (en) * 2022-06-08 2023-12-14 Blossomhill Therapeutics, Inc. Indazole macrocycles and their use
WO2024016986A1 (zh) * 2022-07-21 2024-01-25 贝达药业股份有限公司 大环化合物及其药物组合物和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5823066B2 (ja) * 2012-03-06 2015-11-25 ファイザー・インク 増殖性疾患の治療のための大環状誘導体
SG10201806965XA (en) * 2013-03-13 2018-09-27 Boston Biomedical Inc 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer
RS65417B1 (sr) * 2014-01-24 2024-05-31 Turning Point Therapeutics Inc Diaril makrocikli kao modulatori protein kinaza
JOP20190213A1 (ar) * 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1

Also Published As

Publication number Publication date
WO2022011123A1 (en) 2022-01-13
CL2023000061A1 (es) 2023-11-17
KR20230037564A (ko) 2023-03-16
US20230257396A1 (en) 2023-08-17
EP4178958A1 (en) 2023-05-17
CA3187834A1 (en) 2022-01-13
MX2023000503A (es) 2023-02-09
JP2023532946A (ja) 2023-08-01
TW202216730A (zh) 2022-05-01
CN116171279A (zh) 2023-05-26
BR112023000463A2 (pt) 2023-03-28

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