IL294611B1 - Treatment of fibrodysplasia ossificans progressive - Google Patents

Treatment of fibrodysplasia ossificans progressive

Info

Publication number
IL294611B1
IL294611B1 IL294611A IL29461122A IL294611B1 IL 294611 B1 IL294611 B1 IL 294611B1 IL 294611 A IL294611 A IL 294611A IL 29461122 A IL29461122 A IL 29461122A IL 294611 B1 IL294611 B1 IL 294611B1
Authority
IL
Israel
Prior art keywords
activin
antibody
antigen
binding fragment
lesions
Prior art date
Application number
IL294611A
Other languages
English (en)
Hebrew (he)
Other versions
IL294611A (en
Inventor
Aristides Economides
Neto Eduardo Forleo
Trotter Dinko Gonzalez
Gary Herman
Andrew Rankin
Scott Mellis
Original Assignee
Regeneron Pharma
Aristides Economides
Neto Eduardo Forleo
Trotter Dinko Gonzalez
Gary Herman
Andrew Rankin
Scott Mellis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma, Aristides Economides, Neto Eduardo Forleo, Trotter Dinko Gonzalez, Gary Herman, Andrew Rankin, Scott Mellis filed Critical Regeneron Pharma
Publication of IL294611A publication Critical patent/IL294611A/en
Publication of IL294611B1 publication Critical patent/IL294611B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
IL294611A 2020-01-08 2021-01-07 Treatment of fibrodysplasia ossificans progressive IL294611B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202062958448P 2020-01-08 2020-01-08
US202063076691P 2020-09-10 2020-09-10
US202063081428P 2020-09-22 2020-09-22
PCT/US2021/012598 WO2021142191A1 (en) 2020-01-08 2021-01-08 Treatment of fibrodysplasia ossificans progressiva

Publications (2)

Publication Number Publication Date
IL294611A IL294611A (en) 2022-09-01
IL294611B1 true IL294611B1 (en) 2026-05-01

Family

ID=74550734

Family Applications (1)

Application Number Title Priority Date Filing Date
IL294611A IL294611B1 (en) 2020-01-08 2021-01-07 Treatment of fibrodysplasia ossificans progressive

Country Status (12)

Country Link
US (2) US12344665B2 (enExample)
EP (1) EP4087652A1 (enExample)
JP (2) JP7802672B2 (enExample)
KR (1) KR20220139886A (enExample)
CN (1) CN115243763A (enExample)
AU (1) AU2021205929A1 (enExample)
BR (1) BR112022013589A2 (enExample)
CA (1) CA3164168A1 (enExample)
CL (1) CL2022001861A1 (enExample)
IL (1) IL294611B1 (enExample)
MX (1) MX2022008494A (enExample)
WO (1) WO2021142191A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3235627A1 (en) * 2021-10-18 2023-04-27 Byomass Inc. Anti-activin a antibodies, compositions and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016039796A2 (en) * 2014-09-12 2016-03-17 Regeneron Pharmaceuticals, Inc. Treatment of fibrodysplasia ossificans progressiva
US20170211070A1 (en) * 2014-03-31 2017-07-27 Sumitomo Dainippon Pharma Co., Ltd. Prophylactic Agent and Therapeutic Agent for Fibrodysplasia Ossificans Progressiva

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WO2016039796A2 (en) * 2014-09-12 2016-03-17 Regeneron Pharmaceuticals, Inc. Treatment of fibrodysplasia ossificans progressiva

Also Published As

Publication number Publication date
WO2021142191A1 (en) 2021-07-15
US12344665B2 (en) 2025-07-01
US20260103508A1 (en) 2026-04-16
US20210253685A1 (en) 2021-08-19
IL294611A (en) 2022-09-01
CL2022001861A1 (es) 2023-02-24
BR112022013589A2 (pt) 2022-09-13
CA3164168A1 (en) 2021-07-15
JP2023510270A (ja) 2023-03-13
EP4087652A1 (en) 2022-11-16
AU2021205929A1 (en) 2022-09-01
KR20220139886A (ko) 2022-10-17
CN115243763A (zh) 2022-10-25
MX2022008494A (es) 2022-10-10
JP7802672B2 (ja) 2026-01-20
JP2026031632A (ja) 2026-02-24

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