IL285386A - Biotechnological optimization of microorganisms for 2,1-dehydrogenation of steroids - Google Patents

Biotechnological optimization of microorganisms for 2,1-dehydrogenation of steroids

Info

Publication number
IL285386A
IL285386A IL285386A IL28538621A IL285386A IL 285386 A IL285386 A IL 285386A IL 285386 A IL285386 A IL 285386A IL 28538621 A IL28538621 A IL 28538621A IL 285386 A IL285386 A IL 285386A
Authority
IL
Israel
Prior art keywords
biotechnological
dehydrogenation
steroids
microorganisms
optimization
Prior art date
Application number
IL285386A
Other languages
English (en)
Hebrew (he)
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of IL285386A publication Critical patent/IL285386A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/02—Dehydrogenating; Dehydroxylating
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01053—3-Alpha (or 20-beta)-hydroxysteroid dehydrogenase (1.1.1.53)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/99—Oxidoreductases acting on the CH-CH group of donors (1.3) with other acceptors (1.3.99)
    • C12Y103/99004—3-Oxosteroid 1-dehydrogenase (1.3.99.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/365—Nocardia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
IL285386A 2019-02-08 2021-08-04 Biotechnological optimization of microorganisms for 2,1-dehydrogenation of steroids IL285386A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19305153 2019-02-08
PCT/EP2020/053167 WO2020161317A1 (en) 2019-02-08 2020-02-07 Biotechnological optimization of microorganisms for the 1,2-dehydrogenation of steroids

Publications (1)

Publication Number Publication Date
IL285386A true IL285386A (en) 2021-09-30

Family

ID=66554300

Family Applications (1)

Application Number Title Priority Date Filing Date
IL285386A IL285386A (en) 2019-02-08 2021-08-04 Biotechnological optimization of microorganisms for 2,1-dehydrogenation of steroids

Country Status (14)

Country Link
US (1) US20220136029A1 (https=)
EP (1) EP3921414A1 (https=)
JP (2) JP7661229B2 (https=)
KR (1) KR20210125490A (https=)
CN (1) CN113423827A (https=)
AU (1) AU2020219424A1 (https=)
BR (1) BR112021015481A2 (https=)
CA (1) CA3128954A1 (https=)
IL (1) IL285386A (https=)
MX (1) MX2021009515A (https=)
SG (1) SG11202108529WA (https=)
TW (1) TWI852986B (https=)
WO (1) WO2020161317A1 (https=)
ZA (1) ZA202105566B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202108529WA (en) * 2019-02-08 2021-09-29 Sanofi Sa Biotechnological optimization of microorganisms for the 1,2-dehydrogenation of steroids
CN118325997B (zh) * 2024-04-10 2025-07-22 湖南玉新药业有限公司 采用诺卡氏菌一步发酵生产泼尼松龙的方法
CN119464157B (zh) * 2025-01-13 2025-06-27 山东绿邦生物科技有限公司 居瘤胃棒状杆菌、微生物菌剂及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1232278A1 (en) * 1999-10-22 2002-08-21 Akzo Nobel N.V. MICROBIAL 9$g(a)-HYDROXYLATION OF STEROIDS
JP2007515490A (ja) * 2003-12-22 2007-06-14 アムジェン インコーポレーティッド アリールスルホンアミド化合物およびそれに関連する使用法
US20050239853A1 (en) * 2004-02-04 2005-10-27 Tjeerd Barf New compounds
WO2006124141A2 (en) * 2005-04-05 2006-11-23 Taro Pharmaceuticals North America, Inc. A process of preparing prednisolone devoid of steroid-derived impurities using recombinant e. coli transformed with a δ1-dehydrogenase gene
AU2013200516B2 (en) * 2006-07-12 2015-09-03 University Of Tennessee Research Foundation Substituted Acylanilides and Methods of Use Thereof
DK2084519T3 (da) * 2006-10-10 2012-08-20 Los Alamos Nat Security Llc Røntgenfluorescens-analysefremgangsmåde
CN106754775B (zh) * 2016-12-23 2019-08-20 华东理工大学 一种羰基还原酶突变体及其基因与应用
WO2018204764A1 (en) * 2017-05-05 2018-11-08 Camp4 Therapeutics Corporation Identification and targeted modulation of gene signaling networks
AU2019384074B2 (en) * 2018-11-20 2025-04-10 Sparrow Pharmaceuticals, Inc. Methods for administering corticosteroids
SG11202108529WA (en) * 2019-02-08 2021-09-29 Sanofi Sa Biotechnological optimization of microorganisms for the 1,2-dehydrogenation of steroids

Also Published As

Publication number Publication date
JP2025038080A (ja) 2025-03-18
US20220136029A1 (en) 2022-05-05
TW202045720A (zh) 2020-12-16
KR20210125490A (ko) 2021-10-18
ZA202105566B (en) 2024-05-30
JP2022519711A (ja) 2022-03-24
AU2020219424A1 (en) 2021-08-26
TWI852986B (zh) 2024-08-21
SG11202108529WA (en) 2021-09-29
MX2021009515A (es) 2021-10-26
CA3128954A1 (en) 2020-08-13
CN113423827A (zh) 2021-09-21
BR112021015481A2 (pt) 2021-12-07
EP3921414A1 (en) 2021-12-15
WO2020161317A1 (en) 2020-08-13
JP7661229B2 (ja) 2025-04-14

Similar Documents

Publication Publication Date Title
EP3705321B8 (en) Suspension system
EP3914463B8 (de) Feder-dämpfer-system
IL285386A (en) Biotechnological optimization of microorganisms for 2,1-dehydrogenation of steroids
EP3955069A4 (en) CONTROL DEVICE SYSTEM
GB201913196D0 (en) Culture method
EP3986462A4 (en) ANTI-TIM-3 ANTIBODIES
PT3458467T (pt) Processo para a epoxidação 6,7-alfa de esteroide-4,6-dienos
EP3943775A4 (en) SUSPENSION DEVICE
NO20190133A1 (en) Fremgangsmåte for inspeksjon av rør
GB201912021D0 (en) Methods, products & Uses relating thereto
EP3670642A4 (en) MICRO-ORGANISM CULTURE SYSTEM
EP3681365A4 (en) LARGE-SCALE BIOREACTOR
EP4064834A4 (en) INCUBATOR
HK40058979A (en) Biotechnological optimization of microorganisms for the 1,2-dehydrogenation of steroids
EP4065148A4 (en) PHAGEN-RESISTANT MICROORGANISMS
GB201910302D0 (en) Microscopy system
HK40078446A (en) Dynamic monosaccharide control processes
GB201913707D0 (en) The Nanobrewery Distributed Fermentation System
GB201902262D0 (en) Micro-organism
GB201902258D0 (en) Micro-organism
AU2019902795A0 (en) Suspension
HK40080571A (en) Anti-cd73 antibodies
HK40077792A (en) Anti-fucosyl-gm1 antibodies
HK40062931A (en) Fermentation process
HK40062445A (en) Yoghurt suitable for cooking