EP3681365A4 - Large-scale bioreactor - Google Patents

Large-scale bioreactor Download PDF

Info

Publication number
EP3681365A4
EP3681365A4 EP18852871.5A EP18852871A EP3681365A4 EP 3681365 A4 EP3681365 A4 EP 3681365A4 EP 18852871 A EP18852871 A EP 18852871A EP 3681365 A4 EP3681365 A4 EP 3681365A4
Authority
EP
European Patent Office
Prior art keywords
scale bioreactor
bioreactor
scale
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP18852871.5A
Other languages
German (de)
French (fr)
Other versions
EP3681365A1 (en
Inventor
Zongsen Wang
Wing Lau
Faribourz Payvandi
Peter Materna
Jadali AZADEH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3D Biotek LLC
Original Assignee
3D Biotek LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3D Biotek LLC filed Critical 3D Biotek LLC
Publication of EP3681365A1 publication Critical patent/EP3681365A1/en
Publication of EP3681365A4 publication Critical patent/EP3681365A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/58—Reaction vessels connected in series or in parallel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/08—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by vibration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP18852871.5A 2017-09-11 2018-09-11 Large-scale bioreactor Withdrawn EP3681365A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762556646P 2017-09-11 2017-09-11
US201862636039P 2018-02-27 2018-02-27
PCT/US2018/050467 WO2019051486A1 (en) 2017-09-11 2018-09-11 Large-scale bioreactor

Publications (2)

Publication Number Publication Date
EP3681365A1 EP3681365A1 (en) 2020-07-22
EP3681365A4 true EP3681365A4 (en) 2021-06-16

Family

ID=65634631

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18852871.5A Withdrawn EP3681365A4 (en) 2017-09-11 2018-09-11 Large-scale bioreactor

Country Status (3)

Country Link
EP (1) EP3681365A4 (en)
CN (1) CN111132595A (en)
WO (1) WO2019051486A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4301841A1 (en) * 2021-03-26 2024-01-10 TERUMO Kabushiki Kaisha Cell culturing system
JP2024511915A (en) * 2021-03-26 2024-03-18 テルモ株式会社 cell culture system

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2314343A (en) * 1996-06-18 1997-12-24 Liau Ming Yi Apparatus for intermittently exposing cells during culture
CN1560225A (en) * 2004-03-01 2005-01-05 华东理工大学 Pouring type biologic reactor system in vitro constructure of dual active skin
US20060110822A1 (en) * 2004-09-16 2006-05-25 Robbins Neil F Perfusion bioreactors for culturing cells
WO2011142670A1 (en) * 2010-05-12 2011-11-17 Xpand Biotechnology B.V. Cell-culture-bag
WO2015132729A1 (en) * 2014-03-04 2015-09-11 Pluristem Ltd. Systems and methods for growing and harvesting cells
WO2017143640A1 (en) * 2016-02-26 2017-08-31 广州洁特生物过滤股份有限公司 Cell culture apparatus and method

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI233449B (en) * 1999-07-01 2005-06-01 Ind Tech Res Inst High efficient cell-cultivating device
US6875605B1 (en) * 2002-08-21 2005-04-05 Florida State University Research Foundation, Inc. Modular cell culture bioreactor and associated methods
EP2318505A1 (en) * 2008-08-01 2011-05-11 Smart Biosystems APS A chamber of a bioreactor platform
PT104155B (en) * 2008-08-06 2017-04-05 Ass For The Advancement Of Tissue Eng And Cell Based Tech & Therapies (A4Tec) MULTI-CAMERA BIOREACTOR WITH BIDIRECTIONAL PERFUSION INTEGRATED IN A CULTURE SYSTEM FOR APPLICATION IN STRATEGIES OF TISSUE ENGINEERING
CA2818514A1 (en) * 2009-11-17 2011-05-26 Harvard Bioscience, Inc. Bioreactors, systems, and methods for producing and/or analyzing organs
CN102296029B (en) * 2010-06-28 2013-01-30 裴国献 Perfusion bioreactor system
CN103298922B (en) * 2011-03-29 2014-11-19 南京新诺丹生物技术有限公司 Multifunctional bioreactor system and methods for cell sorting and culturing
IL254464B2 (en) * 2011-04-15 2023-12-01 Pluri Biotech Ltd Methods and systems for harvesting cells
BR102012033604A2 (en) * 2012-12-28 2014-08-19 Univ Minas Gerais THREE-DIMENSIONAL GROWING PERFUSION CHAMBER FOR TISSUE ENGINEERING
AU2014344726B2 (en) * 2013-10-30 2019-01-17 Milica Radisic Devices and methods for three-dimensional tissue culturing

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2314343A (en) * 1996-06-18 1997-12-24 Liau Ming Yi Apparatus for intermittently exposing cells during culture
CN1560225A (en) * 2004-03-01 2005-01-05 华东理工大学 Pouring type biologic reactor system in vitro constructure of dual active skin
US20060110822A1 (en) * 2004-09-16 2006-05-25 Robbins Neil F Perfusion bioreactors for culturing cells
WO2011142670A1 (en) * 2010-05-12 2011-11-17 Xpand Biotechnology B.V. Cell-culture-bag
WO2015132729A1 (en) * 2014-03-04 2015-09-11 Pluristem Ltd. Systems and methods for growing and harvesting cells
WO2017143640A1 (en) * 2016-02-26 2017-08-31 广州洁特生物过滤股份有限公司 Cell culture apparatus and method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2019051486A1 *

Also Published As

Publication number Publication date
CN111132595A (en) 2020-05-08
WO2019051486A1 (en) 2019-03-14
EP3681365A1 (en) 2020-07-22

Similar Documents

Publication Publication Date Title
EP3475410A4 (en) Variable diameter bioreactors
EP3626813A4 (en) Incubator
EP3174381A4 (en) Growing system
EP3127420A4 (en) Cultivation system
EP3196287A4 (en) Cell culture apparatus
EP3124591A4 (en) Culture vessel
EP3305885A4 (en) Culturing device
EP3504315A4 (en) Bioreactor
EP3294689A4 (en) Nutrient system
EP3255137A4 (en) Cell culture system
EP3199614A4 (en) Cell culture system
EP3168291A4 (en) Cell culture system
EP3674394A4 (en) Primary culture method
EP3365107B8 (en) Cell culture
EP3592837A4 (en) Integrated system to produce microalgae
EP3395189A4 (en) Continuous fermentation device
EP3597729A4 (en) Cell culturing using nanofibers
EP3532601A4 (en) Parallel bioreactor system
EP3235900A4 (en) Cell culture apparatus
EP3305886A4 (en) Culturing device
EP3592838A4 (en) Recirculating bioreactor
EP3448816A4 (en) Floating bioreactor
EP3304059A4 (en) Nerve culture system
EP3260529A4 (en) Incubator
EP3670642A4 (en) Microorganism culture system

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20200408

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20210514

RIC1 Information provided on ipc code assigned before grant

Ipc: A61B 1/00 20060101AFI20210508BHEP

Ipc: A61B 5/00 20060101ALI20210508BHEP

Ipc: A61L 27/00 20060101ALI20210508BHEP

Ipc: C12M 1/00 20060101ALI20210508BHEP

Ipc: C12M 1/12 20060101ALI20210508BHEP

Ipc: C12M 1/32 20060101ALI20210508BHEP

Ipc: C12M 1/34 20060101ALI20210508BHEP

Ipc: C12M 1/26 20060101ALI20210508BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20211114