IL280850B2 - Multifunctional Immature Stem Cells of Dental Floss and Medical Uses - Google Patents

Multifunctional Immature Stem Cells of Dental Floss and Medical Uses

Info

Publication number
IL280850B2
IL280850B2 IL280850A IL28085021A IL280850B2 IL 280850 B2 IL280850 B2 IL 280850B2 IL 280850 A IL280850 A IL 280850A IL 28085021 A IL28085021 A IL 28085021A IL 280850 B2 IL280850 B2 IL 280850B2
Authority
IL
Israel
Prior art keywords
cells
idpscs
idpsc
composition
cell
Prior art date
Application number
IL280850A
Other languages
English (en)
Hebrew (he)
Other versions
IL280850B1 (en
IL280850A (en
Inventor
Irina Kerkis
Sabina Glozman
Original Assignee
Avita Int Ltd
Fund Butantan
Irina Kerkis
Sabina Glozman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51538238&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL280850(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Avita Int Ltd, Fund Butantan, Irina Kerkis, Sabina Glozman filed Critical Avita Int Ltd
Publication of IL280850A publication Critical patent/IL280850A/en
Publication of IL280850B1 publication Critical patent/IL280850B1/en
Publication of IL280850B2 publication Critical patent/IL280850B2/en

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0664—Dental pulp stem cells, Dental follicle stem cells
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    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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    • C12N2506/1361—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from dental pulp or dental follicle stem cells
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IL280850A 2013-03-15 2014-03-15 Multifunctional Immature Stem Cells of Dental Floss and Medical Uses IL280850B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361791594P 2013-03-15 2013-03-15
US201361800245P 2013-03-15 2013-03-15
PCT/IB2014/059850 WO2014141210A2 (en) 2013-03-15 2014-03-15 Multifunctional immature dental pulp stem cells and therapeutic applications

Publications (3)

Publication Number Publication Date
IL280850A IL280850A (en) 2021-04-29
IL280850B1 IL280850B1 (en) 2023-06-01
IL280850B2 true IL280850B2 (en) 2023-10-01

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Application Number Title Priority Date Filing Date
IL280850A IL280850B2 (en) 2013-03-15 2014-03-15 Multifunctional Immature Stem Cells of Dental Floss and Medical Uses
IL241470A IL241470B (en) 2013-03-15 2015-09-10 Multifunctional immature dental pulp stem cells and therapeutic applications

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Application Number Title Priority Date Filing Date
IL241470A IL241470B (en) 2013-03-15 2015-09-10 Multifunctional immature dental pulp stem cells and therapeutic applications

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Country Link
US (4) US9790468B2 (cg-RX-API-DMAC10.html)
EP (2) EP2970880B1 (cg-RX-API-DMAC10.html)
JP (2) JP6491606B2 (cg-RX-API-DMAC10.html)
BR (1) BR102014006335B8 (cg-RX-API-DMAC10.html)
CA (1) CA2904804A1 (cg-RX-API-DMAC10.html)
IL (2) IL280850B2 (cg-RX-API-DMAC10.html)
WO (1) WO2014141210A2 (cg-RX-API-DMAC10.html)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11278574B2 (en) 2013-03-15 2022-03-22 Avita International Ltd. Use of stem cells expressing mesenchymal and neuronal markers and compositions thereof to treat neurological disease
US11306290B2 (en) 2013-03-15 2022-04-19 Avita International Ltd. Stem cells expressing mesenchymal and neuronal markers, compositions thereof, and methods of preparation thereof
US11207352B2 (en) 2013-03-15 2021-12-28 Avita International Ltd. Compositions comprising stem cells expressing mesenchymal and neuronal markers and uses thereof to treat neurological disease
RU2714236C2 (ru) * 2014-08-14 2020-02-13 Авита Интернэшнл Лтд. Композиции стволовых клеток и способы получения стволовых клеток для применения в терапии
EP3426267B1 (en) * 2016-03-09 2023-01-11 Avita International Ltd. Uses of dental pulp stem cells expressing mesenchymal and neuronal markers and compositions thereof to treat neurological disease
GB201703058D0 (en) * 2017-02-24 2017-04-12 Ucl Business Plc Biomarkers
US20190167724A1 (en) * 2017-12-04 2019-06-06 Caire Medical-Biotechnology International Co. Neuroprotective composition, preparation process thereof and medical uses thereof
BR112020022168A2 (pt) * 2018-04-30 2021-01-26 Avita International Ltd. células-tronco imaturas de polpa dentária e métodos de uso para tratar falência da medula óssea
WO2019213256A1 (en) * 2018-05-02 2019-11-07 Morse Leslie Dental pulp stem cells and uses thereof
JP7650068B2 (ja) * 2019-05-14 2025-03-24 国立大学法人 筑波大学 神経系細胞集団、神経系細胞含有製剤およびそれらの製造方法
KR20210029569A (ko) * 2019-09-06 2021-03-16 경상국립대학교산학협력단 치아 주변조직 유래 다분화능 줄기세포를 포함하는 비만 또는 비알코올성 지방간의 예방 또는 치료용 약학적 조성물
EP4531562A1 (en) 2022-05-24 2025-04-09 Iceta - Instituto De Ciências, Tecnologias E Agroambiente Da Universidade Do Porto Process for preparation and cryopreservation of dental pulp from definitive teeth and products thereof based on isolated mesenchymal stem cells
CN115671137A (zh) * 2022-11-14 2023-02-03 北京大学口腔医学院 人脱落乳牙牙髓干细胞外泌体在制备肌腱损伤药物中的应用
IL322642A (en) * 2023-02-10 2025-10-01 Avita Int Ltd Method for producing and preparing exosomes derived from immature human stem cells from dental pulp, for medical uses
CN119868281B (zh) * 2025-03-28 2025-06-24 新北辰(湖北)生物科技集团有限公司 一种含有牙髓干细胞的修复注射制剂及其制备方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5082670A (en) 1988-12-15 1992-01-21 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system
US5650148A (en) 1988-12-15 1997-07-22 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system
US5612211A (en) 1990-06-08 1997-03-18 New York University Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
US5928947A (en) 1992-07-27 1999-07-27 California Institute Of Technology Mammalian multipotent neural stem cells
US7927587B2 (en) 1999-08-05 2011-04-19 Regents Of The University Of Minnesota MAPC administration for the treatment of lysosomal storage disorders
GB0003930D0 (en) 2000-02-18 2000-04-12 King S College London Cell
WO2001076507A2 (en) 2000-04-11 2001-10-18 The University Of Miami Use of oxygen carriers to improve grafted cell survival in neural transplantation
AU7707801A (en) 2000-07-21 2002-02-05 Us Health Adult human dental pulp stem cells in vitro and in vivo
US6899915B2 (en) 2000-11-29 2005-05-31 President And Fellows Of Harvard College Methods and compositions for culturing a biological tooth
AUPR540301A0 (en) * 2001-06-01 2001-06-28 Walter And Eliza Hall Institute Of Medical Research, The A method of purification of cells
WO2003060082A2 (en) 2002-01-14 2003-07-24 The Board Of Trustees Of The University Of Illinois Use of modified pyrimidine compounds to promote stem cell migration and proliferation
US20050106724A1 (en) 2002-02-06 2005-05-19 Joerg Schierholz Pluripotent embryonic-like stem cells derived from teeth and uses thereof
CA2500587A1 (en) * 2002-10-04 2004-04-22 The Regents Of The University Of California Screening and therapeutic methods relating to neurogenesis
US7597885B2 (en) 2004-03-26 2009-10-06 Aderans Research Institute, Inc. Tissue engineered biomimetic hair follicle graft
DE602005014537D1 (de) * 2005-03-23 2009-07-02 Stiftung Caesar Neurale Stammzellen
JP2009508650A (ja) 2005-09-21 2009-03-05 ダスク テクノロジーズ， エルエルシー 臓器および組織機能のための方法および組成
WO2007089627A2 (en) 2006-01-27 2007-08-09 Auxocell Laboratories, Inc. Methods and compositions relating to stem cell transplantation
WO2008080200A1 (en) 2006-12-29 2008-07-10 Irina Kerkis Process for obtaining stem cells
US20110002895A1 (en) 2007-12-05 2011-01-06 Minoru Ueda Composition for autotransplantation or allotransplantation using dental pulp stem cell, and use of the composition
US20120219531A1 (en) 2008-03-17 2012-08-30 Agency For Science, Technology And Research Microcarriers for Stem Cell Culture
ITRM20080342A1 (it) * 2008-06-26 2009-12-27 Univ Degli Studi Udine Cellule di polpa dentale midollo-simili, metodi per isolamento ed uso.
KR101685209B1 (ko) 2008-07-30 2016-12-09 고쿠리츠 다이가쿠 호진 교토 다이가쿠 유도된 다능성 줄기 세포의 효율적인 확립 방법
JP5709751B2 (ja) * 2008-09-04 2015-04-30 エイビーティー ホールディング カンパニー ニューロンの軸索退縮を予防するための幹細胞の使用
US7847353B2 (en) * 2008-12-05 2010-12-07 Bae Systems Information And Electronic Systems Integration Inc. Multi-thickness semiconductor with fully depleted devices and photonic integration
US20100297094A1 (en) 2009-01-30 2010-11-25 Harlan John M Therapy or prevention of diseases with cells or cell supernatant
ES2360434B1 (es) * 2009-07-21 2012-04-12 Universitat Internacional De Catalunya Celulas madre pluripotenciales obtenidas a partir de la pulpa dental.
EP2339611B1 (en) 2009-12-23 2015-11-11 ISMECA Semiconductor Holding SA Wafer handler comprising a vision system
US8481308B2 (en) 2010-07-01 2013-07-09 Regenerative Research Foundation Methods for culturing undifferentiated cells using sustained release compositions
US20120009601A1 (en) 2010-07-08 2012-01-12 The General Hospital Corporation Methods and compositions for reprogramming cells
JP5892661B2 (ja) 2010-08-13 2016-03-23 国立大学法人京都大学 多能性幹細胞から生殖細胞への分化誘導方法
BR102013021202B1 (pt) 2013-08-20 2022-09-06 Ccb - Centro De Criogenia Brasil Ltda Processo de produção de células tronco multipotentes e progenitores

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