IL280511B - מערכת קואדריסיסטרונית המכילה קולטן מתבית או ציטוקין וקולטן אנטיגן כימרי לשינוי גנטי של תרפיות אימוניות - Google Patents

מערכת קואדריסיסטרונית המכילה קולטן מתבית או ציטוקין וקולטן אנטיגן כימרי לשינוי גנטי של תרפיות אימוניות

Info

Publication number
IL280511B
IL280511B IL280511A IL28051121A IL280511B IL 280511 B IL280511 B IL 280511B IL 280511 A IL280511 A IL 280511A IL 28051121 A IL28051121 A IL 28051121A IL 280511 B IL280511 B IL 280511B
Authority
IL
Israel
Prior art keywords
receptor
quadricistronic
immunotherapies
cytokine
chimeric antigen
Prior art date
Application number
IL280511A
Other languages
English (en)
Other versions
IL280511A (he
IL280511B2 (he
Inventor
Hans G Klingemann
Laurent H Boissel
John H Lee
Nathan T Schumer
Original Assignee
Immunitybio Inc
Hans G Klingemann
Laurent H Boissel
John H Lee
Nathan T Schumer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunitybio Inc, Hans G Klingemann, Laurent H Boissel, John H Lee, Nathan T Schumer filed Critical Immunitybio Inc
Publication of IL280511A publication Critical patent/IL280511A/he
Publication of IL280511B publication Critical patent/IL280511B/he
Publication of IL280511B2 publication Critical patent/IL280511B2/he

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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IL280511A 2018-08-01 2019-08-01 מערכת קואדריסיסטרונית המכילה קולטן מתבית או ציטוקין וקולטן אנטיגן כימרי לשינוי גנטי של תרפיות אימוניות IL280511B2 (he)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862713310P 2018-08-01 2018-08-01
US201862713278P 2018-08-01 2018-08-01
US201862713264P 2018-08-01 2018-08-01
US201862713323P 2018-08-01 2018-08-01
PCT/US2019/044655 WO2020028656A1 (en) 2018-08-01 2019-08-01 A quadricistronic system comprising a homing receptor or a cytokine, and chimeric antigen receptor for genetic modification of immunotherapies

Publications (3)

Publication Number Publication Date
IL280511A IL280511A (he) 2021-03-01
IL280511B true IL280511B (he) 2022-10-01
IL280511B2 IL280511B2 (he) 2023-02-01

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Family Applications (3)

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IL296050A IL296050B2 (he) 2018-08-01 2019-08-01 מערכת קואדריסיסטרונית המכילה קולטן מתבית או ציטוקין וקולטן אנטיגן כימרי לשינוי גנטי של תרפיות אימוניות
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