IL280511B - מערכת קואדריסיסטרונית המכילה קולטן מתבית או ציטוקין וקולטן אנטיגן כימרי לשינוי גנטי של תרפיות אימוניות - Google Patents
מערכת קואדריסיסטרונית המכילה קולטן מתבית או ציטוקין וקולטן אנטיגן כימרי לשינוי גנטי של תרפיות אימוניותInfo
- Publication number
- IL280511B IL280511B IL280511A IL28051121A IL280511B IL 280511 B IL280511 B IL 280511B IL 280511 A IL280511 A IL 280511A IL 28051121 A IL28051121 A IL 28051121A IL 280511 B IL280511 B IL 280511B
- Authority
- IL
- Israel
- Prior art keywords
- receptor
- quadricistronic
- immunotherapies
- cytokine
- chimeric antigen
- Prior art date
Links
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 title 1
- 102000004127 Cytokines Human genes 0.000 title 1
- 108010057085 cytokine receptors Proteins 0.000 title 1
- 238000012239 gene modification Methods 0.000 title 1
- 230000005017 genetic modification Effects 0.000 title 1
- 235000013617 genetically modified food Nutrition 0.000 title 1
- 238000009169 immunotherapy Methods 0.000 title 1
- 108020003175 receptors Proteins 0.000 title 1
- 102000005962 receptors Human genes 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0646—Natural killers cells [NK], NKT cells
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- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4613—Natural-killer cells [NK or NK-T]
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- A61K39/4631—Chimeric Antigen Receptors [CAR]
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- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
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- C07K14/70546—Integrin superfamily
- C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
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- C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862713310P | 2018-08-01 | 2018-08-01 | |
US201862713323P | 2018-08-01 | 2018-08-01 | |
US201862713278P | 2018-08-01 | 2018-08-01 | |
US201862713264P | 2018-08-01 | 2018-08-01 | |
PCT/US2019/044655 WO2020028656A1 (en) | 2018-08-01 | 2019-08-01 | A quadricistronic system comprising a homing receptor or a cytokine, and chimeric antigen receptor for genetic modification of immunotherapies |
Publications (3)
Publication Number | Publication Date |
---|---|
IL280511A IL280511A (he) | 2021-03-01 |
IL280511B true IL280511B (he) | 2022-10-01 |
IL280511B2 IL280511B2 (he) | 2023-02-01 |
Family
ID=69227677
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL296050A IL296050A (he) | 2018-08-01 | 2019-08-01 | מערכת קואדריסיסטרונית המכילה קולטן מתבית או ציטוקין וקולטן אנטיגן כימרי לשינוי גנטי של תרפיות אימוניות |
IL280511A IL280511B2 (he) | 2018-08-01 | 2021-01-29 | מערכת קואדריסיסטרונית המכילה קולטן מתבית או ציטוקין וקולטן אנטיגן כימרי לשינוי גנטי של תרפיות אימוניות |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL296050A IL296050A (he) | 2018-08-01 | 2019-08-01 | מערכת קואדריסיסטרונית המכילה קולטן מתבית או ציטוקין וקולטן אנטיגן כימרי לשינוי גנטי של תרפיות אימוניות |
Country Status (9)
Country | Link |
---|---|
US (4) | US10960024B2 (he) |
EP (1) | EP3829605A4 (he) |
JP (2) | JP7241161B2 (he) |
KR (2) | KR102653878B1 (he) |
CN (2) | CN117925531A (he) |
AU (1) | AU2019314455B2 (he) |
CA (2) | CA3106324C (he) |
IL (2) | IL296050A (he) |
WO (1) | WO2020028656A1 (he) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201713078D0 (en) * | 2017-08-15 | 2017-09-27 | Adaptimmune Ltd | T Cell Modification |
US11649294B2 (en) | 2017-11-14 | 2023-05-16 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
US20210198342A1 (en) * | 2018-05-22 | 2021-07-01 | Nantkwest, Inc. | FC-EPSILON CAR (Very imp commercially - in clinical trial) |
CA3106324C (en) | 2018-08-01 | 2024-04-02 | Nantkwest, Inc. | A quadricistronic system comprising a homing receptor or a cytokine, and chimeric antigen receptor for stable genetic modification of cellular immunotherapies |
CN112292448A (zh) * | 2018-10-31 | 2021-01-29 | 南克维斯特公司 | 表达cd19-car的nk细胞消除cd19阳性淋巴系统恶性肿瘤 |
JP7092404B2 (ja) * | 2018-10-31 | 2022-06-28 | イミュニティーバイオ、インコーポレイテッド | Pd-l1キメラ抗原受容体を発現するnk細胞によるpd-l1陽性悪性腫瘍の排除 |
CN115190910A (zh) * | 2019-11-20 | 2022-10-14 | 免疫生物公司 | 细胞介导的免疫增强分子到肿瘤微环境中的瞬时递送 |
CN115315510A (zh) * | 2020-01-28 | 2022-11-08 | 免疫生物公司 | 靶向egfr超家族受体的嵌合抗原受体修饰的nk-92细胞 |
US11230699B2 (en) | 2020-01-28 | 2022-01-25 | Immunitybio, Inc. | Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors |
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AU2019314455B2 (en) | 2024-04-04 |
JP2021532771A (ja) | 2021-12-02 |
WO2020028656A4 (en) | 2020-03-26 |
IL280511B2 (he) | 2023-02-01 |
JP7241161B2 (ja) | 2023-03-16 |
US20200038441A1 (en) | 2020-02-06 |
KR102653878B1 (ko) | 2024-04-01 |
US20210386785A1 (en) | 2021-12-16 |
KR20240046632A (ko) | 2024-04-09 |
JP2023078209A (ja) | 2023-06-06 |
KR20210038637A (ko) | 2021-04-07 |
WO2020028656A1 (en) | 2020-02-06 |
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