IL277329A - Preparations of 17 beta-hydroxysteroid dehydrogenase type 13iRNA and methods of using them - Google Patents

Preparations of 17 beta-hydroxysteroid dehydrogenase type 13iRNA and methods of using them

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Publication number
IL277329A
IL277329A IL277329A IL27732920A IL277329A IL 277329 A IL277329 A IL 277329A IL 277329 A IL277329 A IL 277329A IL 27732920 A IL27732920 A IL 27732920A IL 277329 A IL277329 A IL 277329A
Authority
IL
Israel
Prior art keywords
hsd17b13
17beta
methods
hydroxysteroid dehydrogenase
dehydrogenase type
Prior art date
Application number
IL277329A
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English (en)
Hebrew (he)
Original Assignee
Regeneron Pharma
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=66001358&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL277329(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of IL277329A publication Critical patent/IL277329A/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/3125—Methylphosphonates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3521—Methyl
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
    • C12N2310/3533—Halogen
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    • C12N2320/00—Applications; Uses
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity

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  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL277329A 2018-03-21 2020-09-14 Preparations of 17 beta-hydroxysteroid dehydrogenase type 13iRNA and methods of using them IL277329A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862645941P 2018-03-21 2018-03-21
US201862770298P 2018-11-21 2018-11-21
US201862775590P 2018-12-05 2018-12-05
PCT/US2019/023079 WO2019183164A1 (en) 2018-03-21 2019-03-20 17β-HYDROXYSTEROID DEHYDROGENASE TYPE 13 (HSD17B13) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

Publications (1)

Publication Number Publication Date
IL277329A true IL277329A (en) 2020-10-29

Family

ID=66001358

Family Applications (1)

Application Number Title Priority Date Filing Date
IL277329A IL277329A (en) 2018-03-21 2020-09-14 Preparations of 17 beta-hydroxysteroid dehydrogenase type 13iRNA and methods of using them

Country Status (17)

Country Link
US (3) US12359201B2 (https=)
EP (1) EP3768838A1 (https=)
JP (3) JP7507093B2 (https=)
KR (2) KR20250154534A (https=)
CN (1) CN112020556A (https=)
AU (2) AU2019239971B2 (https=)
BR (1) BR112020018758A2 (https=)
CA (1) CA3091146A1 (https=)
CL (1) CL2020002401A1 (https=)
CO (1) CO2020010342A2 (https=)
IL (1) IL277329A (https=)
MX (2) MX2020009812A (https=)
MY (1) MY207352A (https=)
PH (1) PH12020500622A1 (https=)
SG (1) SG11202007583SA (https=)
TW (1) TWI877108B (https=)
WO (1) WO2019183164A1 (https=)

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