SG11202007583SA - 17β-HYDROXYSTEROID DEHYDROGENASE TYPE 13 (HSD17B13) iRNA COMPOSITIONS AND METHODS OF USE THEREOF - Google Patents

17β-HYDROXYSTEROID DEHYDROGENASE TYPE 13 (HSD17B13) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

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Publication number
SG11202007583SA
SG11202007583SA SG11202007583SA SG11202007583SA SG11202007583SA SG 11202007583S A SG11202007583S A SG 11202007583SA SG 11202007583S A SG11202007583S A SG 11202007583SA SG 11202007583S A SG11202007583S A SG 11202007583SA SG 11202007583S A SG11202007583S A SG 11202007583SA
Authority
SG
Singapore
Prior art keywords
hsd17b13
methods
hydroxysteroid dehydrogenase
dehydrogenase type
irna compositions
Prior art date
Application number
SG11202007583SA
Inventor
Gregory Hinkle
Frederic Tremblay
Noura Abul-Husn
Omri Gottesman
Alexander Li
Xiping Cheng
Yurong Xin
Jesper Gromada
Frederick Dewey
Aris Baras
Alan Shuldiner
Stuart Milstein
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of SG11202007583SA publication Critical patent/SG11202007583SA/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/35—Nature of the modification
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    • C12N2310/3521—Methyl
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity

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  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
SG11202007583SA 2018-03-21 2019-03-20 17β-HYDROXYSTEROID DEHYDROGENASE TYPE 13 (HSD17B13) iRNA COMPOSITIONS AND METHODS OF USE THEREOF SG11202007583SA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862645941P 2018-03-21 2018-03-21
US201862770298P 2018-11-21 2018-11-21
US201862775590P 2018-12-05 2018-12-05
PCT/US2019/023079 WO2019183164A1 (en) 2018-03-21 2019-03-20 17β-HYDROXYSTEROID DEHYDROGENASE TYPE 13 (HSD17B13) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

Publications (1)

Publication Number Publication Date
SG11202007583SA true SG11202007583SA (en) 2020-09-29

Family

ID=66001358

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202007583SA SG11202007583SA (en) 2018-03-21 2019-03-20 17β-HYDROXYSTEROID DEHYDROGENASE TYPE 13 (HSD17B13) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

Country Status (15)

Country Link
US (2) US20210380985A1 (en)
EP (1) EP3768838A1 (en)
KR (1) KR20200133373A (en)
CN (1) CN112020556A (en)
AU (1) AU2019239971A1 (en)
BR (1) BR112020018758A2 (en)
CA (1) CA3091146A1 (en)
CL (1) CL2020002401A1 (en)
CO (1) CO2020010342A2 (en)
IL (1) IL277329A (en)
MX (1) MX2020009812A (en)
PH (1) PH12020500622A1 (en)
SG (1) SG11202007583SA (en)
TW (1) TW202003848A (en)
WO (1) WO2019183164A1 (en)

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EP4328310A1 (en) * 2021-04-22 2024-02-28 Tuojie Biotech (Shanghai) Co., Ltd. Sirna targeting 17b-hydroxysteroid dehydrogenase type 13 and sirna conjugate
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TW202400791A (en) * 2022-05-06 2024-01-01 大陸商蘇州瑞博生物技術股份有限公司 Nucleic acid, composition and conjugate comprising same, preparation method therefor, and use thereof
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CL2020002401A1 (en) 2021-01-29
BR112020018758A2 (en) 2021-01-26
MX2020009812A (en) 2021-01-08
KR20200133373A (en) 2020-11-27
TW202003848A (en) 2020-01-16
EP3768838A1 (en) 2021-01-27
CA3091146A1 (en) 2019-09-26
PH12020500622A1 (en) 2021-03-15
US20210380985A1 (en) 2021-12-09
IL277329A (en) 2020-10-29
CN112020556A (en) 2020-12-01
CO2020010342A2 (en) 2020-08-31
WO2019183164A1 (en) 2019-09-26
US11180757B1 (en) 2021-11-23
AU2019239971A1 (en) 2020-09-03
JP2021518125A (en) 2021-08-02

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