IL277243A - Inverted pyrazoles are FFA4/GPR120 receptor agonists - Google Patents
Inverted pyrazoles are FFA4/GPR120 receptor agonistsInfo
- Publication number
- IL277243A IL277243A IL277243A IL27724320A IL277243A IL 277243 A IL277243 A IL 277243A IL 277243 A IL277243 A IL 277243A IL 27724320 A IL27724320 A IL 27724320A IL 277243 A IL277243 A IL 277243A
- Authority
- IL
- Israel
- Prior art keywords
- ffa4
- receptor agonists
- substituted pyrazoles
- gpr120 receptor
- gpr120
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18162003 | 2018-03-15 | ||
| PCT/EP2019/056131 WO2019175152A1 (fr) | 2018-03-15 | 2019-03-12 | Pyrazoles substitués agonistes du récepteur ffa4/gpr120 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL277243A true IL277243A (en) | 2020-10-29 |
Family
ID=61683660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL277243A IL277243A (en) | 2018-03-15 | 2020-09-09 | Inverted pyrazoles are FFA4/GPR120 receptor agonists |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11597702B2 (fr) |
| EP (1) | EP3765446A1 (fr) |
| JP (1) | JP2021517142A (fr) |
| CN (1) | CN111868035A (fr) |
| CA (1) | CA3090445A1 (fr) |
| IL (1) | IL277243A (fr) |
| RU (1) | RU2020132179A (fr) |
| WO (1) | WO2019175152A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112079782B (zh) * | 2020-09-25 | 2022-06-28 | 西南大学 | 辛弗林唑类衍生物及其制备方法和应用 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI443090B (zh) * | 2007-05-25 | 2014-07-01 | Abbvie Deutschland | 作為代謝性麩胺酸受體２（ｍｇｌｕ２ 受體）之正向調節劑之雜環化合物 |
| JP2010083763A (ja) * | 2008-09-29 | 2010-04-15 | Mitsui Chemicals Inc | ピラゾール誘導体およびその製造方法、ならびに殺菌剤 |
| BRPI0920237A2 (pt) * | 2008-10-21 | 2015-12-29 | Metabolex Inc | agonistas do receptor aril gpr120 e suas respectivas utilizações |
| US20130137865A1 (en) * | 2010-08-11 | 2013-05-30 | Taisho Pharmaceutical Co., Ltd. | Heteroaryl-pyrazole derivative |
| JP2015078127A (ja) * | 2012-01-25 | 2015-04-23 | 大正製薬株式会社 | Ｎ−置換ピラゾール誘導体 |
| WO2013139341A1 (fr) | 2012-03-20 | 2013-09-26 | Syddansk Universitet | Modulateurs de récepteurs gpr120 |
| WO2013185766A1 (fr) | 2012-06-15 | 2013-12-19 | Syddansk Universitet | Modulateurs du récepteur gpr120 |
| EP2906542B1 (fr) | 2012-10-11 | 2019-08-07 | Merck Sharp & Dohme Corp. | Composés spiropipéridinyliques substitués utiles comme agonistes de gpr120 |
| KR101942752B1 (ko) | 2012-11-05 | 2019-01-28 | 주식회사 엘지화학 | Ｇｐｒ120 효능제로서의 티오아릴 유도체 |
| US8962660B2 (en) | 2013-03-14 | 2015-02-24 | Bristol-Myers Squibb Company | Oxabicyclo [2.2.2] acid GPR120 modulators |
| UA117241C2 (uk) | 2013-03-14 | 2018-07-10 | Янссен Фармацевтика Нв | Бензоконденсовані гетероциклічні похідні, що використовуються як агоністи gpr120 |
| CA2905726C (fr) | 2013-03-14 | 2022-05-31 | Janssen Pharmaceutica Nv | Agonistes de gpr120 pour le traitement du diabete de type 2 |
| AU2014244474B2 (en) | 2013-03-14 | 2018-04-26 | Bristol-Myers Squibb Company | Bicyclo [2.2.1] acid GPR120 modulators |
| JP2016516708A (ja) | 2013-03-14 | 2016-06-09 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | ビシクロ［２．２．２］酸のｇｐｒ１２０モジュレーター |
| WO2014149987A1 (fr) | 2013-03-14 | 2014-09-25 | Janssen Pharmaceutica Nv | Dérivés pyrroles bicycliques utiles en tant qu'agonistes de gpr120 |
| JP6052673B2 (ja) * | 2013-04-25 | 2016-12-27 | 富士フイルム株式会社 | ピラゾール誘導体またはその塩ならびにそれらを含有する医薬組成物 |
| EP3628661A1 (fr) | 2013-06-27 | 2020-04-01 | Lg Chem, Ltd. | Dérivés de biaryle en tant qu'agonistes de gpr120 |
| EP3107901B1 (fr) | 2014-02-19 | 2020-04-01 | Piramal Enterprises Limited | Composés pouvant être utilisés à titre d'agonistes de gpr120 |
| ES2673578T3 (es) | 2014-03-07 | 2018-06-22 | Janssen Pharmaceutica Nv | Derivados de isotiazol como agonistas GPR120 para el tratamiento de diabetes de tipo II |
| MX368076B (es) | 2014-03-07 | 2019-09-17 | Janssen Pharmaceutica Nv | Derivados de pirrol biciclicos utiles como agonistas de gpr120. |
| US8912227B1 (en) | 2014-03-07 | 2014-12-16 | Janssen Pharmaceutica Nv | Bicyclic pyrrole derivatives useful as agonists of GPR120 |
| AU2015293541B2 (en) | 2014-07-25 | 2019-11-21 | Piramal Enterprises Limited | Substituted phenyl alkanoic acid compounds as GPR120 agonists and uses thereof |
| JP6667507B2 (ja) * | 2014-09-02 | 2020-03-18 | 石薬集団中奇制薬技術（石家庄）有限公司 | ピラゾロ［３，４−ｃ］ピリジン誘導体 |
| EP3191445B1 (fr) | 2014-09-09 | 2019-06-12 | Bristol-Myers Squibb Company | Acide carboxylique contenant du cyclobutane servant de modulateurs de gpr120 |
| WO2016040222A1 (fr) | 2014-09-09 | 2016-03-17 | Bristol-Myers Squibb Company | Modulateurs des récepteurs gpr120 à base d'acide cyclopropanecarboxylique |
| WO2016040225A1 (fr) | 2014-09-09 | 2016-03-17 | Bristol-Myers Squibb Company | Modulateurs des récepteurs gpr120 à base d'acide phényl-(aza)cycloalkylcarboxylique |
| US10214521B2 (en) | 2014-09-11 | 2019-02-26 | Piramal Enterprises Limited | Fused heterocyclic compounds as GPR120 agonists |
| US10941133B2 (en) | 2015-02-05 | 2021-03-09 | Piramal Enterprises Limited | Compounds containing carbon-carbon linker as GPR120 agonists |
| US10278973B2 (en) * | 2015-05-20 | 2019-05-07 | Guangdong Raynovent Biotech Co., Ltd. | Hydroxyl purine compounds and use thereof |
| WO2017139487A1 (fr) * | 2016-02-09 | 2017-08-17 | Northwind Medical, Inc. | Méthodes, agents et dispositifs pour la neuromodulation locale de nerfs autonomes |
| WO2017201683A1 (fr) | 2016-05-25 | 2017-11-30 | Merck Sharp & Dohme Corp. | Composés de tétrahydroisoquinoline substitués utiles à titre d'agonistes de gpr120 |
-
2019
- 2019-03-12 EP EP19715396.8A patent/EP3765446A1/fr active Pending
- 2019-03-12 CA CA3090445A patent/CA3090445A1/fr active Pending
- 2019-03-12 US US16/977,401 patent/US11597702B2/en active Active
- 2019-03-12 RU RU2020132179A patent/RU2020132179A/ru unknown
- 2019-03-12 JP JP2020547202A patent/JP2021517142A/ja active Pending
- 2019-03-12 CN CN201980016345.7A patent/CN111868035A/zh active Pending
- 2019-03-12 WO PCT/EP2019/056131 patent/WO2019175152A1/fr active Application Filing
-
2020
- 2020-09-09 IL IL277243A patent/IL277243A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN111868035A (zh) | 2020-10-30 |
| EP3765446A1 (fr) | 2021-01-20 |
| US11597702B2 (en) | 2023-03-07 |
| US20210087148A1 (en) | 2021-03-25 |
| RU2020132179A (ru) | 2022-04-15 |
| CA3090445A1 (fr) | 2019-09-19 |
| WO2019175152A1 (fr) | 2019-09-19 |
| JP2021517142A (ja) | 2021-07-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL280290A (en) | IL2 agonists | |
| IL288921A (en) | Melanocortin-4 receptor agonists | |
| DK3762380T3 (da) | Phenylpyrrolidinon-formylpeptid-2-receptoragonister | |
| HK1253366A1 (zh) | Apj受體的三唑激動劑 | |
| ZA202101537B (en) | Anti-trem-2 agonist antibodies | |
| HK1257166A1 (zh) | 作為大麻素受體2激動劑的苯基衍生物 | |
| EP3440051A4 (fr) | Agonistes du récepteur du neuropeptide s (npsr) | |
| GB201619637D0 (en) | C3a receptor agonists | |
| IL280199A (en) | Receptor for VISTA | |
| GB201801831D0 (en) | Chimeric receptor | |
| IL277243A (en) | Inverted pyrazoles are FFA4/GPR120 receptor agonists | |
| MA50509A (fr) | Agonistes de triazole fusionnés du récepteur apj | |
| IL290024A (en) | Bicyclic cx3cr1 receptor agonists | |
| GB201903900D0 (en) | Adenosine receptor agonists | |
| GB201816637D0 (en) | Selective somatostatin receptor agonists | |
| GB201817943D0 (en) | Galanin-2 receptor agonists | |
| GB201816747D0 (en) | Linear apelin receptor agonists | |
| GB201903985D0 (en) | GLP receptor agonists | |
| ZA202100513B (en) | Isoxazole as fxr receptor agonists |