MX368076B - Derivados de pirrol biciclicos utiles como agonistas de gpr120. - Google Patents

Derivados de pirrol biciclicos utiles como agonistas de gpr120.

Info

Publication number
MX368076B
MX368076B MX2016011629A MX2016011629A MX368076B MX 368076 B MX368076 B MX 368076B MX 2016011629 A MX2016011629 A MX 2016011629A MX 2016011629 A MX2016011629 A MX 2016011629A MX 368076 B MX368076 B MX 368076B
Authority
MX
Mexico
Prior art keywords
gpr120
agonists
pyrrole derivatives
derivatives useful
bicyclic pyrrole
Prior art date
Application number
MX2016011629A
Other languages
English (en)
Other versions
MX2016011629A (es
Inventor
Zhihua Sui
Michael P Winters
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MX2016011629A publication Critical patent/MX2016011629A/es
Publication of MX368076B publication Critical patent/MX368076B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

La presente invención se dirige a derivados de pirrol bicíclicos de Fórmula (I), composiciones farmacéuticas que los contienen y su uso en el tratamiento de trastornos y afecciones moduladas por GPR120; más particularmente, los compuestos de la presente invención son agonistas de GPR120, útiles en el tratamiento de, por ejemplo, la diabetes mellitus Tipo II.
MX2016011629A 2014-03-07 2014-03-07 Derivados de pirrol biciclicos utiles como agonistas de gpr120. MX368076B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2014/021762 WO2015134038A1 (en) 2014-03-07 2014-03-07 Bicyclic pyrrole derivatives useful as agonists of gpr120

Publications (2)

Publication Number Publication Date
MX2016011629A MX2016011629A (es) 2016-11-29
MX368076B true MX368076B (es) 2019-09-17

Family

ID=50483489

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016011629A MX368076B (es) 2014-03-07 2014-03-07 Derivados de pirrol biciclicos utiles como agonistas de gpr120.

Country Status (8)

Country Link
EP (1) EP3114111B1 (es)
JP (1) JP6360569B2 (es)
CN (1) CN106061943B (es)
AU (1) AU2014385275B2 (es)
CA (1) CA2941442C (es)
ES (1) ES2715377T3 (es)
MX (1) MX368076B (es)
WO (1) WO2015134038A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111868035A (zh) 2018-03-15 2020-10-30 阿克萨姆股份公司 取代的吡唑ffa4/gpr120受体激动剂
CN110407740A (zh) * 2019-09-04 2019-11-05 上海毕得医药科技有限公司 一种3-溴-2-乙基吡啶的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004041266A1 (ja) * 2002-11-08 2004-05-21 Takeda Pharmaceutical Company Limited 受容体機能調節剤
CN1735408A (zh) * 2002-11-08 2006-02-15 武田药品工业株式会社 受体机能调节剂
CN1922165A (zh) * 2003-12-25 2007-02-28 武田药品工业株式会社 3－(4－苄氧基苯基)丙酸衍生物
BRPI0418148A (pt) * 2003-12-25 2007-04-17 Takeda Pharmaceutical composto, prodroga de um composto, modulador da função do receptor gpr40, agente farmacêutico, uso de um composto e métodos de modificação de uma função do receptor gpr40 em um mamìfero, de profilaxia ou tratamento de diabetes em um mamìfero e de produção de um composto
JP4859665B2 (ja) * 2004-03-30 2012-01-25 武田薬品工業株式会社 アルコキシフェニルプロパン酸誘導体
EP2064193A1 (en) * 2006-09-07 2009-06-03 Amgen, Inc Heterocyclic gpr40 modulators
EP2061760A1 (en) * 2006-09-07 2009-05-27 Amgen, Inc Benzo-fused compounds for use in treating metabolic disorders
WO2009117421A2 (en) * 2008-03-17 2009-09-24 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
NZ592603A (en) * 2008-10-21 2013-02-22 Metabolex Inc Aryl gpr120 receptor agonists and uses thereof
WO2011094890A1 (en) * 2010-02-02 2011-08-11 Argusina Inc. Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators
EP2970182B1 (en) * 2013-03-14 2017-05-03 Janssen Pharmaceutica NV Bicyclic pyrrole derivatives useful as agonists of gpr120

Also Published As

Publication number Publication date
JP6360569B2 (ja) 2018-07-18
JP2017507188A (ja) 2017-03-16
CA2941442C (en) 2022-01-11
AU2014385275A1 (en) 2016-09-01
CA2941442A1 (en) 2015-09-11
AU2014385275B2 (en) 2019-05-16
CN106061943B (zh) 2019-11-05
WO2015134038A1 (en) 2015-09-11
EP3114111B1 (en) 2019-01-09
ES2715377T3 (es) 2019-06-04
EP3114111A1 (en) 2017-01-11
CN106061943A (zh) 2016-10-26
MX2016011629A (es) 2016-11-29

Similar Documents

Publication Publication Date Title
TR201819138T4 (tr) FGFR Kinaz Modülatörleri Olarak Faydalı Kinoksalin Türevleri
PH12016501192B1 (en) Tetrahydropyridopyrazines modulators of gpr6
EA201891336A1 (ru) Гетероарилгидроксипиримидиноны в качестве агонистов рецептора apj
PH12019500467A1 (en) Benzo-fused heterocyclic derivatives useful agonists of gpr120
PH12017500653A1 (en) Substituted benzothiophenyl derivatives as gpr40 agonists for the treatment of type ii diabetes
MX2017003254A (es) 2-azabiciclos sustituidos y su uso como moduladores de receptores de orexina.
EA201790570A1 (ru) Модуляторы р2х7
MX2017007377A (es) Compuestos organicos.
MX2019013979A (es) Metodos para la preparacion de compuestos heterociclicos de 1,3-benzodioxol.
TW201613878A (en) Pyrazine GPR40 agonists for the treatment of type II diabetes
PH12016501613A1 (en) Pyrazines modulators of gpr6
PH12016501393A1 (en) Substituted bicyclic heteroaryl compounds as rxr agonists
MX2019011265A (es) Derivados del acido acetico azaindol y su uso como moduladores de receptor de prostaglandina d2.
MX2016011630A (es) Derivados de isotiazol como agonistas del gpr120 para el tratamiento de la diabetes tipo ii.
MX371158B (es) Compuestos inhibidores de pde2.
MX2016011629A (es) Derivados de pirrol biciclicos utiles como agonistas de gpr120.
MX2023001906A (es) Diarilureas como moduladores alostericos de cannabinoide cb1.
MX2016011900A (es) Derivados de acido azaindol-acetico y su uso como moduladores del receptor de prostaglandina d2.

Legal Events

Date Code Title Description
FG Grant or registration