IL276483B2 - A continuous process for the preparation of trazodone - Google Patents
A continuous process for the preparation of trazodoneInfo
- Publication number
- IL276483B2 IL276483B2 IL276483A IL27648320A IL276483B2 IL 276483 B2 IL276483 B2 IL 276483B2 IL 276483 A IL276483 A IL 276483A IL 27648320 A IL27648320 A IL 27648320A IL 276483 B2 IL276483 B2 IL 276483B2
- Authority
- IL
- Israel
- Prior art keywords
- process according
- chlorophenyl
- piperazine
- flow reactor
- continuously
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J14/00—Chemical processes in general for reacting liquids with liquids; Apparatus specially adapted therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2204/00—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices
- B01J2204/007—Aspects relating to the heat-exchange of the feed or outlet devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00002—Chemical plants
- B01J2219/00027—Process aspects
- B01J2219/00029—Batch processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00002—Chemical plants
- B01J2219/00027—Process aspects
- B01J2219/00033—Continuous processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00788—Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
- B01J2219/00792—One or more tube-shaped elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00801—Means to assemble
- B01J2219/0081—Plurality of modules
- B01J2219/00813—Fluidic connections
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00851—Additional features
- B01J2219/00867—Microreactors placed in series, on the same or on different supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00851—Additional features
- B01J2219/00869—Microreactors placed in parallel, on the same or on different supports
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00851—Additional features
- B01J2219/00871—Modular assembly
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00873—Heat exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
- B01J8/02—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with stationary particles, e.g. in fixed beds
- B01J8/0292—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with stationary particles, e.g. in fixed beds with stationary packing material in the bed, e.g. bricks, wire rings, baffles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
- B01J8/18—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with fluidised particles
- B01J8/24—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with fluidised particles according to "fluidised-bed" technique
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Combustion & Propulsion (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18155470 | 2018-02-07 | ||
| PCT/EP2019/052690 WO2019154770A1 (en) | 2018-02-07 | 2019-02-05 | Continuous process for the preparation of trazodone |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL276483A IL276483A (en) | 2020-09-30 |
| IL276483B1 IL276483B1 (en) | 2023-05-01 |
| IL276483B2 true IL276483B2 (en) | 2023-09-01 |
Family
ID=61187146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL276483A IL276483B2 (en) | 2018-02-07 | 2019-02-05 | A continuous process for the preparation of trazodone |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US12221438B2 (https=) |
| EP (1) | EP3749668B1 (https=) |
| JP (1) | JP7301858B2 (https=) |
| KR (1) | KR102646651B1 (https=) |
| CN (1) | CN111886235B (https=) |
| AU (1) | AU2019217490B2 (https=) |
| BR (1) | BR112020015885A2 (https=) |
| CA (1) | CA3089552A1 (https=) |
| CY (1) | CY1125298T1 (https=) |
| DK (1) | DK3749668T3 (https=) |
| EA (1) | EA202091834A1 (https=) |
| ES (1) | ES2916406T3 (https=) |
| GE (2) | GEAP202215429A (https=) |
| HR (1) | HRP20220733T1 (https=) |
| HU (1) | HUE058990T2 (https=) |
| IL (1) | IL276483B2 (https=) |
| LT (1) | LT3749668T (https=) |
| MD (1) | MD3749668T2 (https=) |
| MX (1) | MX394182B (https=) |
| PL (1) | PL3749668T3 (https=) |
| PT (1) | PT3749668T (https=) |
| RS (1) | RS63323B1 (https=) |
| SG (1) | SG11202006948XA (https=) |
| SI (1) | SI3749668T1 (https=) |
| SM (1) | SMT202200277T1 (https=) |
| UA (1) | UA126870C2 (https=) |
| WO (1) | WO2019154770A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116253696A (zh) * | 2021-12-10 | 2023-06-13 | 安徽省化工研究院 | 一种噁草酮的连续流制备方法 |
| CN114891019B (zh) * | 2022-02-25 | 2024-06-04 | 复旦大学 | 一种乙烯基硫醚化合物的连续流制备方法 |
| CN117358178A (zh) * | 2023-12-08 | 2024-01-09 | 天津凯莱英医药科技发展有限公司 | 丙硫菌唑的连续化合成系统及方法 |
| CN118162064B (zh) * | 2024-05-15 | 2024-08-30 | 济南大学 | 一种美罗培南母核中间体的连续化生产装置及方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1066857B (it) | 1965-12-15 | 1985-03-12 | Acraf | Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione |
| US4252806A (en) * | 1979-09-24 | 1981-02-24 | Mead Johnson & Company | Triazoloquinolones |
| US4254124A (en) | 1979-09-24 | 1981-03-03 | Mead Johnson & Company | Antidepressant agent |
| HU201324B (en) | 1988-07-29 | 1990-10-28 | Egyt Gyogyszervegyeszeti Gyar | New process for production of substituated 1,2,4-triasole (4,3-a)-piridin-2 (2h)-on |
| AU663057B2 (en) | 1990-09-28 | 1995-09-28 | Pharmacia & Upjohn Company | Anthelmintic and anticoccidal 3-carbamoyl-4-hydroxycoumarins |
| CA2182241C (en) | 1996-07-29 | 2002-09-17 | Bo Lei | Methods for the manufacture of nefazodone |
| IT1314283B1 (it) | 1999-12-16 | 2002-12-06 | Acraf | Trazodone cloridrato ed un procedimento per prepararlo. |
| ITMI20071603A1 (it) | 2007-08-03 | 2009-02-04 | Acraf | Trazodone e trazodone cloridrato in forma purificata |
| WO2017166050A1 (zh) * | 2016-03-29 | 2017-10-05 | 深圳市泛谷药业股份有限公司 | 一种盐酸曲唑酮的制备方法 |
| CN105777745A (zh) | 2016-03-29 | 2016-07-20 | 深圳市泛谷药业股份有限公司 | 一种盐酸曲唑酮的制备方法 |
-
2019
- 2019-02-05 DK DK19702619.8T patent/DK3749668T3/da active
- 2019-02-05 MX MX2020008241A patent/MX394182B/es unknown
- 2019-02-05 LT LTEPPCT/EP2019/052690T patent/LT3749668T/lt unknown
- 2019-02-05 JP JP2020542436A patent/JP7301858B2/ja active Active
- 2019-02-05 US US16/967,337 patent/US12221438B2/en active Active
- 2019-02-05 BR BR112020015885-2A patent/BR112020015885A2/pt unknown
- 2019-02-05 WO PCT/EP2019/052690 patent/WO2019154770A1/en not_active Ceased
- 2019-02-05 PT PT197026198T patent/PT3749668T/pt unknown
- 2019-02-05 RS RS20220563A patent/RS63323B1/sr unknown
- 2019-02-05 AU AU2019217490A patent/AU2019217490B2/en active Active
- 2019-02-05 EP EP19702619.8A patent/EP3749668B1/en active Active
- 2019-02-05 SM SM20220277T patent/SMT202200277T1/it unknown
- 2019-02-05 KR KR1020207023772A patent/KR102646651B1/ko active Active
- 2019-02-05 IL IL276483A patent/IL276483B2/en unknown
- 2019-02-05 SG SG11202006948XA patent/SG11202006948XA/en unknown
- 2019-02-05 GE GEAP202215429A patent/GEAP202215429A/en unknown
- 2019-02-05 UA UAA202004708A patent/UA126870C2/uk unknown
- 2019-02-05 CA CA3089552A patent/CA3089552A1/en active Pending
- 2019-02-05 ES ES19702619T patent/ES2916406T3/es active Active
- 2019-02-05 HR HRP20220733TT patent/HRP20220733T1/hr unknown
- 2019-02-05 SI SI201930263T patent/SI3749668T1/sl unknown
- 2019-02-05 EA EA202091834A patent/EA202091834A1/ru unknown
- 2019-02-05 CN CN201980011910.0A patent/CN111886235B/zh active Active
- 2019-02-05 GE GEAP201915429A patent/GEP20227417B/en unknown
- 2019-02-05 HU HUE19702619A patent/HUE058990T2/hu unknown
- 2019-02-05 MD MDE20201242T patent/MD3749668T2/ro unknown
- 2019-02-05 PL PL19702619.8T patent/PL3749668T3/pl unknown
-
2022
- 2022-06-23 CY CY20221100435T patent/CY1125298T1/el unknown
Also Published As
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