EA202091834A1 - Непрерывный способ получения тразодона - Google Patents

Непрерывный способ получения тразодона

Info

Publication number
EA202091834A1
EA202091834A1 EA202091834A EA202091834A EA202091834A1 EA 202091834 A1 EA202091834 A1 EA 202091834A1 EA 202091834 A EA202091834 A EA 202091834A EA 202091834 A EA202091834 A EA 202091834A EA 202091834 A1 EA202091834 A1 EA 202091834A1
Authority
EA
Eurasian Patent Office
Prior art keywords
trazodone
continuous method
preparation
relates
present
Prior art date
Application number
EA202091834A
Other languages
English (en)
Russian (ru)
Inventor
Томмазо Иакоанджели
Леонардо Марио Моро
Джулиано Караччоло Торкиароло
Клаудия Каварискиа
Гвидо Фурлотти
Original Assignee
Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А. filed Critical Ацьенде Кимике Рьюните Анджелини Франческо А.К.Р.А.Ф. С.П.А.
Publication of EA202091834A1 publication Critical patent/EA202091834A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J14/00—Chemical processes in general for reacting liquids with liquids; Apparatus specially adapted therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/18—Stationary reactors having moving elements inside
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2204/00—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices
    • B01J2204/007—Aspects relating to the heat-exchange of the feed or outlet devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00027—Process aspects
    • B01J2219/00029—Batch processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00002—Chemical plants
    • B01J2219/00027—Process aspects
    • B01J2219/00033—Continuous processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00788—Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • B01J2219/00792—One or more tube-shaped elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00801—Means to assemble
    • B01J2219/0081—Plurality of modules
    • B01J2219/00813—Fluidic connections
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00867—Microreactors placed in series, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00869—Microreactors placed in parallel, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00871—Modular assembly
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • B01J8/02—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with stationary particles, e.g. in fixed beds
    • B01J8/0292—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with stationary particles, e.g. in fixed beds with stationary packing material in the bed, e.g. bricks, wire rings, baffles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J8/00—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes
    • B01J8/18—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with fluidised particles
    • B01J8/24—Chemical or physical processes in general, conducted in the presence of fluids and solid particles; Apparatus for such processes with fluidised particles according to "fluidised-bed" technique

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Combustion & Propulsion (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EA202091834A 2018-02-07 2019-02-05 Непрерывный способ получения тразодона EA202091834A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18155470 2018-02-07
PCT/EP2019/052690 WO2019154770A1 (en) 2018-02-07 2019-02-05 Continuous process for the preparation of trazodone

Publications (1)

Publication Number Publication Date
EA202091834A1 true EA202091834A1 (ru) 2020-10-22

Family

ID=61187146

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202091834A EA202091834A1 (ru) 2018-02-07 2019-02-05 Непрерывный способ получения тразодона

Country Status (27)

Country Link
US (1) US12221438B2 (https=)
EP (1) EP3749668B1 (https=)
JP (1) JP7301858B2 (https=)
KR (1) KR102646651B1 (https=)
CN (1) CN111886235B (https=)
AU (1) AU2019217490B2 (https=)
BR (1) BR112020015885A2 (https=)
CA (1) CA3089552A1 (https=)
CY (1) CY1125298T1 (https=)
DK (1) DK3749668T3 (https=)
EA (1) EA202091834A1 (https=)
ES (1) ES2916406T3 (https=)
GE (2) GEAP202215429A (https=)
HR (1) HRP20220733T1 (https=)
HU (1) HUE058990T2 (https=)
IL (1) IL276483B2 (https=)
LT (1) LT3749668T (https=)
MD (1) MD3749668T2 (https=)
MX (1) MX394182B (https=)
PL (1) PL3749668T3 (https=)
PT (1) PT3749668T (https=)
RS (1) RS63323B1 (https=)
SG (1) SG11202006948XA (https=)
SI (1) SI3749668T1 (https=)
SM (1) SMT202200277T1 (https=)
UA (1) UA126870C2 (https=)
WO (1) WO2019154770A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116253696A (zh) * 2021-12-10 2023-06-13 安徽省化工研究院 一种噁草酮的连续流制备方法
CN114891019B (zh) * 2022-02-25 2024-06-04 复旦大学 一种乙烯基硫醚化合物的连续流制备方法
CN117358178A (zh) * 2023-12-08 2024-01-09 天津凯莱英医药科技发展有限公司 丙硫菌唑的连续化合成系统及方法
CN118162064B (zh) * 2024-05-15 2024-08-30 济南大学 一种美罗培南母核中间体的连续化生产装置及方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1066857B (it) 1965-12-15 1985-03-12 Acraf Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione
US4252806A (en) * 1979-09-24 1981-02-24 Mead Johnson & Company Triazoloquinolones
US4254124A (en) 1979-09-24 1981-03-03 Mead Johnson & Company Antidepressant agent
HU201324B (en) 1988-07-29 1990-10-28 Egyt Gyogyszervegyeszeti Gyar New process for production of substituated 1,2,4-triasole (4,3-a)-piridin-2 (2h)-on
AU663057B2 (en) 1990-09-28 1995-09-28 Pharmacia & Upjohn Company Anthelmintic and anticoccidal 3-carbamoyl-4-hydroxycoumarins
CA2182241C (en) 1996-07-29 2002-09-17 Bo Lei Methods for the manufacture of nefazodone
IT1314283B1 (it) 1999-12-16 2002-12-06 Acraf Trazodone cloridrato ed un procedimento per prepararlo.
ITMI20071603A1 (it) 2007-08-03 2009-02-04 Acraf Trazodone e trazodone cloridrato in forma purificata
WO2017166050A1 (zh) * 2016-03-29 2017-10-05 深圳市泛谷药业股份有限公司 一种盐酸曲唑酮的制备方法
CN105777745A (zh) 2016-03-29 2016-07-20 深圳市泛谷药业股份有限公司 一种盐酸曲唑酮的制备方法

Also Published As

Publication number Publication date
AU2019217490A1 (en) 2020-09-17
CN111886235A (zh) 2020-11-03
ES2916406T3 (es) 2022-06-30
JP2021512888A (ja) 2021-05-20
IL276483B2 (en) 2023-09-01
CA3089552A1 (en) 2019-08-15
PT3749668T (pt) 2022-06-02
SG11202006948XA (en) 2020-08-28
MD3749668T2 (ro) 2022-08-31
DK3749668T3 (da) 2022-06-20
SMT202200277T1 (it) 2022-09-14
AU2019217490B2 (en) 2023-06-29
EP3749668A1 (en) 2020-12-16
IL276483B1 (en) 2023-05-01
GEAP202215429A (en) 2022-05-10
MX2020008241A (es) 2022-07-25
IL276483A (en) 2020-09-30
KR20200130249A (ko) 2020-11-18
SI3749668T1 (sl) 2022-09-30
MX394182B (es) 2025-03-24
CY1125298T1 (el) 2025-03-28
UA126870C2 (uk) 2023-02-15
HUE058990T2 (hu) 2022-09-28
RS63323B1 (sr) 2022-07-29
EP3749668B1 (en) 2022-04-06
PL3749668T3 (pl) 2022-07-25
KR102646651B1 (ko) 2024-03-13
US20210032243A1 (en) 2021-02-04
BR112020015885A2 (pt) 2020-12-08
LT3749668T (lt) 2022-08-10
CN111886235B (zh) 2023-06-30
WO2019154770A1 (en) 2019-08-15
GEP20227417B (en) 2022-09-26
HRP20220733T1 (hr) 2022-09-02
AU2019217490A2 (en) 2020-09-24
US12221438B2 (en) 2025-02-11
JP7301858B2 (ja) 2023-07-03

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