IL275617B2 - cationic lipids - Google Patents
cationic lipidsInfo
- Publication number
- IL275617B2 IL275617B2 IL275617A IL27561720A IL275617B2 IL 275617 B2 IL275617 B2 IL 275617B2 IL 275617 A IL275617 A IL 275617A IL 27561720 A IL27561720 A IL 27561720A IL 275617 B2 IL275617 B2 IL 275617B2
- Authority
- IL
- Israel
- Prior art keywords
- cationic lipids
- lipids
- cationic
- Prior art date
Links
- 125000002091 cationic group Chemical group 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/533—Monocarboxylic acid esters having only one carbon-to-carbon double bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017254667 | 2017-12-28 | ||
| PCT/JP2018/048054 WO2019131839A1 (ja) | 2017-12-28 | 2018-12-27 | カチオン性脂質 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL275617A IL275617A (en) | 2020-08-31 |
| IL275617B1 IL275617B1 (en) | 2023-07-01 |
| IL275617B2 true IL275617B2 (en) | 2023-11-01 |
Family
ID=67063849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL275617A IL275617B2 (en) | 2017-12-28 | 2018-12-27 | cationic lipids |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20200331841A1 (pl) |
| EP (1) | EP3733641B1 (pl) |
| JP (1) | JP7211973B2 (pl) |
| KR (1) | KR102589314B1 (pl) |
| CN (1) | CN111511713B (pl) |
| AU (1) | AU2018397957B2 (pl) |
| CA (1) | CA3086824A1 (pl) |
| DK (1) | DK3733641T3 (pl) |
| ES (1) | ES2978261T3 (pl) |
| FI (1) | FI3733641T3 (pl) |
| IL (1) | IL275617B2 (pl) |
| MX (1) | MX2020006800A (pl) |
| PL (1) | PL3733641T3 (pl) |
| PT (1) | PT3733641T (pl) |
| SG (1) | SG11202006154UA (pl) |
| TW (1) | TWI802627B (pl) |
| WO (1) | WO2019131839A1 (pl) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2020006800A (es) | 2017-12-28 | 2020-09-03 | Takeda Pharmaceuticals Co | Lipidos cationicos. |
| FI3835287T3 (fi) * | 2018-08-10 | 2024-12-03 | Takeda Pharmaceuticals Co | Kationinen lipidi |
| EP3842538A4 (en) | 2018-08-10 | 2022-06-08 | Kyoto University | METHOD OF TRANSFECTION INTO CARDIOMYOCYTES USING CATIONIC LIPID |
| CN119876276A (zh) | 2018-10-18 | 2025-04-25 | 武田药品工业株式会社 | T细胞的活化/增殖方法 |
| WO2022045334A1 (ja) | 2020-08-31 | 2022-03-03 | 武田薬品工業株式会社 | 推論装置、推論方法、推論プログラム、モデル生成方法、推論サービス提供システム、推論サービス提供方法及び推論サービス提供プログラム |
| KR20230118715A (ko) | 2020-10-14 | 2023-08-11 | 조지 메이슨 리서치 파운데이션 인코포레이티드 | 이온화 가능 지질 및 이의 제조 및 사용 방법 |
| AR127312A1 (es) | 2021-10-08 | 2024-01-10 | Suzhou Abogen Biosciences Co Ltd | Compuestos lipídicos ycomposiciones de nanopartículas lipídicas |
| MX2024005608A (es) | 2021-11-10 | 2024-05-22 | Takeda Pharmaceuticals Co | Lipido cationico. |
| US20250191703A1 (en) | 2022-02-28 | 2025-06-12 | Takeda Pharmaceutical Company Limited | Inference device, generation device, inference program, and generation program |
| WO2023250197A2 (en) * | 2022-06-23 | 2023-12-28 | Turn Biotechnologies, Inc. | Lipid structures and compositions comprising same |
| WO2024121814A1 (en) | 2022-12-09 | 2024-06-13 | Takeda Pharmaceutical Company Limited | Modified immunomodulators |
| EP4687990A1 (en) | 2023-03-30 | 2026-02-11 | Ose Immunotherapeutics | Method of synthesis of targeted lipid nanoparticle and uses thereof |
| JP2026512425A (ja) | 2023-03-30 | 2026-04-16 | オーエスイー・イミュノセラピューティクス | 免疫細胞増強分子の発現のための活性化免疫細胞に標的化された脂質ベースのナノ粒子及びその使用 |
| AR132276A1 (es) | 2023-04-07 | 2025-06-11 | Takeda Pharmaceuticals Co | Complejo de conjugación |
| WO2024236361A1 (en) | 2023-05-15 | 2024-11-21 | Takeda Pharmaceutical Company Limited | Compositions and methods for delivery of nucleic acids to cells |
| WO2024236504A1 (en) | 2023-05-15 | 2024-11-21 | Takeda Pharmaceutical Company Limited | Sequences and methods for delivery of dna and rna |
| AU2024279278A1 (en) | 2023-05-31 | 2025-12-18 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| CN121620589A (zh) | 2023-08-01 | 2026-03-06 | 法国居里学院 | 包含编码环gmp-amp合酶的核酸序列的纳米粒子 |
| WO2025133115A1 (en) | 2023-12-21 | 2025-06-26 | Ose Immunotherapeutics | Lipid-based nanoparticles comprising il-35 |
| JP7836475B1 (ja) | 2024-03-05 | 2026-03-26 | 武田薬品工業株式会社 | Ｕｎｃ１３ａのスプライシングモジュレーションのための組成物および方法 |
| WO2026068705A1 (en) | 2024-09-26 | 2026-04-02 | Ose Immunotherapeutics | Lipid-based nanoparticles comprising non-glycosylated fc domains and uses thereof |
| WO2026093414A1 (en) | 2024-10-30 | 2026-05-07 | Ose Immunotherapeutics | Lipid-based nanoparticles comprising membrane il-35 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003102150A2 (en) * | 2002-05-31 | 2003-12-11 | Genteric, Inc. | Multi-functional polyamines for delivery of biologically-active polynucleotides |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7223887B2 (en) | 2001-12-18 | 2007-05-29 | The University Of British Columbia | Multivalent cationic lipids and methods of using same in the production of lipid particles |
| US8969543B2 (en) | 2003-04-03 | 2015-03-03 | Bioneer Corporation | SiRNA-hydrophilic polymer conjugates for intracellular delivery of siRNA and method thereof |
| SG190613A1 (en) | 2003-07-16 | 2013-06-28 | Protiva Biotherapeutics Inc | Lipid encapsulated interfering rna |
| WO2005120152A2 (en) | 2004-06-07 | 2005-12-22 | Protiva Biotherapeutics, Inc. | Cationic lipids and methods of use |
| CN107028886A (zh) | 2009-11-04 | 2017-08-11 | 不列颠哥伦比亚大学 | 含有核酸的脂质粒子及相关的方法 |
| US9408914B2 (en) | 2010-04-28 | 2016-08-09 | Kyowa Hakko Kirin Co., Ltd. | Cationic lipid |
| JP2013544488A (ja) | 2010-08-30 | 2013-12-19 | エフ．ホフマン−ラ ロシュ アーゲー | テトラネクチン−アポリポタンパク質ａ−ｉ脂質粒子を産生するための方法、脂質粒子自体、及びその使用 |
| JP6108197B2 (ja) | 2012-07-02 | 2017-04-05 | 日油株式会社 | 三級アミノ基含有脂質の製造方法 |
| ES3029138T3 (en) | 2013-06-05 | 2025-06-23 | Univ Duke | Rna-guided gene editing and gene regulation |
| BR112016013213A2 (pt) | 2013-12-12 | 2017-12-05 | Massachusetts Inst Technology | administração, uso e aplicações terapêuticas dos sistemas crispr-cas e composições para visar distúrbios e doenças usando componentes de administração de partículas |
| CN105916839B (zh) | 2014-01-09 | 2018-09-18 | 卫材R&D管理有限公司 | 阳离子性脂质 |
| US20170015994A1 (en) | 2014-02-24 | 2017-01-19 | Massachusetts Institute Of Technology | Methods for in vivo genome editing |
| CN104116643B (zh) | 2014-07-10 | 2016-08-24 | 上海应用技术学院 | 一种包覆曲酸双棕榈酸酯的纳米固体脂质载体及制备方法 |
| KR101882634B1 (ko) | 2014-08-07 | 2018-07-26 | 다케다 야쿠힝 고교 가부시키가이샤 | 양이온성 지질 |
| CN106714845A (zh) | 2014-08-11 | 2017-05-24 | 得克萨斯州大学系统董事会 | 通过crispr/cas9介导的基因编辑预防肌营养不良 |
| US11298326B2 (en) | 2015-03-24 | 2022-04-12 | Kyowa Kirin Co., Ltd. | Nucleic acid-containing lipid nanoparticles |
| CN104873976B (zh) | 2015-05-08 | 2016-04-20 | 厦门成坤生物技术有限公司 | 一类阳离子类脂化合物的应用 |
| WO2016197133A1 (en) | 2015-06-04 | 2016-12-08 | Protiva Biotherapeutics, Inc. | Delivering crispr therapeutics with lipid nanoparticles |
| AU2016344609B2 (en) | 2015-10-28 | 2022-05-12 | Vertex Pharmaceuticals Incorporated | Materials and methods for treatment of duchenne muscular dystrophy |
| MX2020006843A (es) | 2017-12-27 | 2020-09-03 | Takeda Pharmaceuticals Co | Nanoparticula de lipido que contiene acido nucleico y uso de la misma. |
| TWI825057B (zh) | 2017-12-28 | 2023-12-11 | 國立大學法人京都大學 | 標的基因改變用組成物 |
| MX2020006800A (es) | 2017-12-28 | 2020-09-03 | Takeda Pharmaceuticals Co | Lipidos cationicos. |
-
2018
- 2018-12-27 MX MX2020006800A patent/MX2020006800A/es unknown
- 2018-12-27 EP EP18896553.7A patent/EP3733641B1/en active Active
- 2018-12-27 FI FIEP18896553.7T patent/FI3733641T3/fi active
- 2018-12-27 CA CA3086824A patent/CA3086824A1/en active Pending
- 2018-12-27 CN CN201880083465.4A patent/CN111511713B/zh active Active
- 2018-12-27 SG SG11202006154UA patent/SG11202006154UA/en unknown
- 2018-12-27 ES ES18896553T patent/ES2978261T3/es active Active
- 2018-12-27 TW TW107147438A patent/TWI802627B/zh active
- 2018-12-27 KR KR1020207018172A patent/KR102589314B1/ko active Active
- 2018-12-27 DK DK18896553.7T patent/DK3733641T3/da active
- 2018-12-27 IL IL275617A patent/IL275617B2/en unknown
- 2018-12-27 PT PT188965537T patent/PT3733641T/pt unknown
- 2018-12-27 AU AU2018397957A patent/AU2018397957B2/en active Active
- 2018-12-27 PL PL18896553.7T patent/PL3733641T3/pl unknown
- 2018-12-27 US US16/958,244 patent/US20200331841A1/en not_active Abandoned
- 2018-12-27 JP JP2019562145A patent/JP7211973B2/ja active Active
- 2018-12-27 WO PCT/JP2018/048054 patent/WO2019131839A1/ja not_active Ceased
-
2022
- 2022-08-31 US US17/900,412 patent/US11993570B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003102150A2 (en) * | 2002-05-31 | 2003-12-11 | Genteric, Inc. | Multi-functional polyamines for delivery of biologically-active polynucleotides |
Also Published As
| Publication number | Publication date |
|---|---|
| SG11202006154UA (en) | 2020-07-29 |
| KR102589314B1 (ko) | 2023-10-13 |
| MX2020006800A (es) | 2020-09-03 |
| EP3733641A4 (en) | 2021-11-03 |
| ES2978261T3 (es) | 2024-09-09 |
| US20200331841A1 (en) | 2020-10-22 |
| BR112020012424A2 (pt) | 2020-11-24 |
| AU2018397957A1 (en) | 2020-07-09 |
| JPWO2019131839A1 (ja) | 2021-01-21 |
| IL275617B1 (en) | 2023-07-01 |
| CA3086824A1 (en) | 2019-07-04 |
| CN111511713B (zh) | 2024-01-02 |
| PL3733641T3 (pl) | 2024-07-15 |
| AU2018397957B2 (en) | 2024-05-23 |
| JP7211973B2 (ja) | 2023-01-24 |
| TWI802627B (zh) | 2023-05-21 |
| US11993570B2 (en) | 2024-05-28 |
| EP3733641A1 (en) | 2020-11-04 |
| CN111511713A (zh) | 2020-08-07 |
| DK3733641T3 (da) | 2024-07-22 |
| PT3733641T (pt) | 2024-05-07 |
| EP3733641B1 (en) | 2024-04-10 |
| US20230257338A1 (en) | 2023-08-17 |
| RU2020124751A (ru) | 2022-01-28 |
| KR20200103679A (ko) | 2020-09-02 |
| RU2020124751A3 (pl) | 2022-02-22 |
| WO2019131839A1 (ja) | 2019-07-04 |
| FI3733641T3 (fi) | 2024-06-28 |
| TW201932446A (zh) | 2019-08-16 |
| IL275617A (en) | 2020-08-31 |
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