IL274893B2 - Pharmaceutical formulation of 3 alpha-ethynyl-3 beta-hydroxyandrostan-17-one oxime - Google Patents
Pharmaceutical formulation of 3 alpha-ethynyl-3 beta-hydroxyandrostan-17-one oximeInfo
- Publication number
- IL274893B2 IL274893B2 IL274893A IL27489320A IL274893B2 IL 274893 B2 IL274893 B2 IL 274893B2 IL 274893 A IL274893 A IL 274893A IL 27489320 A IL27489320 A IL 27489320A IL 274893 B2 IL274893 B2 IL 274893B2
- Authority
- IL
- Israel
- Prior art keywords
- pharmaceutical formulation
- propylene glycol
- glycerol
- hydroxyandrostan
- ethynyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762590757P | 2017-11-27 | 2017-11-27 | |
| PCT/EP2018/082727 WO2019102040A1 (en) | 2017-11-27 | 2018-11-27 | PHARMACEUTICAL FORMULATION OF 3α-ETHYNYL-3β-HYDROXYANDROSTAN-17-ONE OXIME |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL274893A IL274893A (en) | 2020-07-30 |
| IL274893B1 IL274893B1 (en) | 2024-04-01 |
| IL274893B2 true IL274893B2 (en) | 2024-08-01 |
Family
ID=64556898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL274893A IL274893B2 (en) | 2017-11-27 | 2018-11-27 | Pharmaceutical formulation of 3 alpha-ethynyl-3 beta-hydroxyandrostan-17-one oxime |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US10603326B2 (https=) |
| EP (1) | EP3716954A1 (https=) |
| JP (1) | JP7314459B2 (https=) |
| KR (1) | KR102771577B1 (https=) |
| CN (1) | CN111432805B (https=) |
| AU (1) | AU2018374029B2 (https=) |
| BR (1) | BR112020010519A2 (https=) |
| CA (1) | CA3083555A1 (https=) |
| IL (1) | IL274893B2 (https=) |
| MX (1) | MX391097B (https=) |
| UA (1) | UA128186C2 (https=) |
| WO (1) | WO2019102040A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3716954A1 (en) | 2017-11-27 | 2020-10-07 | Umecrine Cognition AB | Pharmaceutical formulation of 3 -ethynyl-3 -hydroxyandrostan-17-one oxime |
| EP4079307A1 (en) | 2021-04-20 | 2022-10-26 | Umecrine Cognition AB | New medical use |
| EP4389129A1 (en) | 2022-12-22 | 2024-06-26 | Umecrine Cognition AB | 3a-ethynyl-3beta hydroxyandrostan 17-one oxime for treating parkinson's disease and l-dopa-induced dyskinesia |
| WO2025252725A1 (en) | 2024-06-04 | 2025-12-11 | Umecrine Cognition Ab | Novel pharmaceutical formulation of golexanolone |
| WO2025252724A1 (en) | 2024-06-04 | 2025-12-11 | Umecrine Cognition Ab | Novel pharmaceutical formulation of golexanolone |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015114308A1 (en) * | 2014-01-29 | 2015-08-06 | Umecrine Cognition Ab | Steroid compound for use in the treatment of hepatic encephalopathy |
| WO2016033556A1 (en) * | 2014-08-28 | 2016-03-03 | Lipocine Inc. | BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9405304D0 (en) | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| GB9608719D0 (en) | 1996-04-26 | 1996-07-03 | Scherer Ltd R P | Pharmaceutical compositions |
| SE511313C2 (sv) | 1997-01-13 | 1999-09-06 | Gs Dev Ab | Komposition med reglerad frisättning innefattande fettsyraester av diacylglycerol |
| GB9907715D0 (en) | 1999-04-01 | 1999-05-26 | Scherer Corp R P | Pharmaceutical compositions |
| KR20010100194A (ko) * | 2000-03-13 | 2001-11-14 | 박호군 | 여러 가지 물질의 가용화용 조성물과 제형 및 그들의제조방법 |
| US20040191207A1 (en) | 2003-03-31 | 2004-09-30 | Lipari John M. | Alpha-hydroxy acid ester drug delivery compositions and methods of use |
| US20100209496A1 (en) | 2006-09-06 | 2010-08-19 | Eleni Dokou | Liquid and semi-solid pharmaceutical formulations for oral administration of a substituted amide |
| DK2792681T3 (en) | 2006-11-21 | 2017-01-23 | Umecrine Ab | Use of Pregnancy and Androstan Steroids in the Preparation of a Pharmaceutical Composition for the Treatment of CNS Disorders. |
| RU2012133627A (ru) | 2010-01-14 | 2014-04-20 | Умекрине Муд Аб | Фармацевтическая композиция, содержащая 3-бета-гидрокси-5-альфа-прегнан-20-он, с улучшенными свойствами хранения и растворимости |
| US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US8951996B2 (en) | 2011-07-28 | 2015-02-10 | Lipocine Inc. | 17-hydroxyprogesterone ester-containing oral compositions and related methods |
| US9801819B2 (en) | 2012-06-28 | 2017-10-31 | Johnson & Johnson Consumer Inc. | Racecadotril compositions |
| HK1223300A1 (zh) * | 2013-06-03 | 2017-07-28 | Tolmar, Inc. | 皮质类固醇组合物 |
| WO2015193224A1 (en) | 2014-06-17 | 2015-12-23 | Merck Sharp & Dohme B.V. | Stable formulations of testosterone undecanoate |
| KR101679992B1 (ko) | 2015-12-31 | 2016-11-28 | 주식회사 유유제약 | 프로필렌글리콜 모노라우레이트를 포함하는 두타스테리드의 약학적 조성물 및 이의 제조 방법 |
| KR101716878B1 (ko) | 2016-05-12 | 2017-03-15 | 주식회사 유유제약 | 글리세롤 지방산에스테르유도체 또는 프로필렌글리콜 지방산에스테르유도체를 함유한 두타스테리드와 타다라필의 복합 캡슐제제 조성물 및 이의 제조방법 |
| US10278977B2 (en) | 2016-06-06 | 2019-05-07 | Umecrine Cognition Ab | Methods for treating hypersomnolence |
| EP3716954A1 (en) | 2017-11-27 | 2020-10-07 | Umecrine Cognition AB | Pharmaceutical formulation of 3 -ethynyl-3 -hydroxyandrostan-17-one oxime |
-
2018
- 2018-11-27 EP EP18811225.4A patent/EP3716954A1/en active Pending
- 2018-11-27 KR KR1020207018543A patent/KR102771577B1/ko active Active
- 2018-11-27 UA UAA202003834A patent/UA128186C2/uk unknown
- 2018-11-27 CN CN201880076423.8A patent/CN111432805B/zh active Active
- 2018-11-27 BR BR112020010519-8A patent/BR112020010519A2/pt unknown
- 2018-11-27 MX MX2020005442A patent/MX391097B/es unknown
- 2018-11-27 WO PCT/EP2018/082727 patent/WO2019102040A1/en not_active Ceased
- 2018-11-27 AU AU2018374029A patent/AU2018374029B2/en active Active
- 2018-11-27 CA CA3083555A patent/CA3083555A1/en active Pending
- 2018-11-27 JP JP2020545883A patent/JP7314459B2/ja active Active
- 2018-11-27 IL IL274893A patent/IL274893B2/en unknown
-
2019
- 2019-06-24 US US16/450,620 patent/US10603326B2/en active Active
-
2020
- 2020-02-21 US US16/797,426 patent/US11123351B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015114308A1 (en) * | 2014-01-29 | 2015-08-06 | Umecrine Cognition Ab | Steroid compound for use in the treatment of hepatic encephalopathy |
| WO2016033556A1 (en) * | 2014-08-28 | 2016-03-03 | Lipocine Inc. | BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS |
Also Published As
| Publication number | Publication date |
|---|---|
| IL274893B1 (en) | 2024-04-01 |
| KR20200093008A (ko) | 2020-08-04 |
| EP3716954A1 (en) | 2020-10-07 |
| US20190358244A1 (en) | 2019-11-28 |
| CN111432805B (zh) | 2023-02-17 |
| MX2020005442A (es) | 2022-03-30 |
| US11123351B2 (en) | 2021-09-21 |
| RU2020121142A3 (https=) | 2022-03-28 |
| AU2018374029B2 (en) | 2024-01-11 |
| US20200297737A1 (en) | 2020-09-24 |
| IL274893A (en) | 2020-07-30 |
| CN111432805A (zh) | 2020-07-17 |
| UA128186C2 (uk) | 2024-05-01 |
| NZ764901A (en) | 2025-05-02 |
| US10603326B2 (en) | 2020-03-31 |
| CA3083555A1 (en) | 2019-05-31 |
| KR102771577B1 (ko) | 2025-02-20 |
| MX391097B (es) | 2025-03-21 |
| WO2019102040A1 (en) | 2019-05-31 |
| AU2018374029A1 (en) | 2020-06-18 |
| BR112020010519A2 (pt) | 2020-10-20 |
| JP7314459B2 (ja) | 2023-07-26 |
| RU2020121142A (ru) | 2021-12-29 |
| JP2021504468A (ja) | 2021-02-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11123351B2 (en) | Pharmaceutical formulation of 3-alpha-ethynyl-3-beta-hydroxyandrostan-17-one oxime | |
| ES2863500T3 (es) | Formulaciones lipídicas de acetato de abiraterona | |
| ES2983643T3 (es) | Terapia oral con tridecanoato de testosterona | |
| TW201521719A (zh) | 含有脂質化合物、三酸甘油酯及界面活性劑之組成物與使用該組成物之方法 | |
| AU2015270187A1 (en) | Oral pharmaceutical composition of isotretinoin | |
| US20220071983A1 (en) | Pharmaceutical Composition | |
| CN113473974A (zh) | 药物组合物 | |
| RU2639482C2 (ru) | Фармацевтические композиции | |
| KR20170020779A (ko) | 테스토스테론 운데카노에이트의 안정한 제제 | |
| AU2006222117A1 (en) | Microemulsions of cannabinoid receptor binding compounds | |
| RU2779262C2 (ru) | ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ 3α-ЭТИНИЛ-3β-ГИДРОКСИАНДРОСТАН-17-ОНА ОКСИМА | |
| JP2948111B2 (ja) | 経口投与用油性組成物 | |
| PT1715848E (pt) | Formulações em microemulsão compreendendo certos antagonistas da substância p | |
| JP6887520B2 (ja) | 経口医薬組成物 | |
| WO2025252725A1 (en) | Novel pharmaceutical formulation of golexanolone | |
| CN115804753A (zh) | 阿戈美拉汀自微乳组合物、胶囊剂及其应用 | |
| JP2017500355A (ja) | ラセカドトリル組成物 | |
| BRPI0720489A2 (pt) | Cápsulas de gelatina compreendendo um ácido | |
| HK1219061A1 (zh) | 乳液制剂 |