IL273405B2 - Rpe cell populations and methods of generating same - Google Patents

Rpe cell populations and methods of generating same

Info

Publication number
IL273405B2
IL273405B2 IL273405A IL27340520A IL273405B2 IL 273405 B2 IL273405 B2 IL 273405B2 IL 273405 A IL273405 A IL 273405A IL 27340520 A IL27340520 A IL 27340520A IL 273405 B2 IL273405 B2 IL 273405B2
Authority
IL
Israel
Prior art keywords
cells
rpe
cell
medium
human
Prior art date
Application number
IL273405A
Other languages
English (en)
Hebrew (he)
Other versions
IL273405B1 (en
IL273405A (en
Original Assignee
Cell Cure Neurosciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Cure Neurosciences Ltd filed Critical Cell Cure Neurosciences Ltd
Publication of IL273405A publication Critical patent/IL273405A/en
Publication of IL273405B1 publication Critical patent/IL273405B1/en
Publication of IL273405B2 publication Critical patent/IL273405B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/02—Atmosphere, e.g. low oxygen conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL273405A 2014-12-30 2015-12-30 Rpe cell populations and methods of generating same IL273405B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462097753P 2014-12-30 2014-12-30
US201562116972P 2015-02-17 2015-02-17
US201562195309P 2015-07-22 2015-07-22
PCT/IL2015/051269 WO2016108239A1 (en) 2014-12-30 2015-12-30 Rpe cell populations and methods of generating same

Publications (3)

Publication Number Publication Date
IL273405A IL273405A (en) 2020-05-31
IL273405B1 IL273405B1 (en) 2023-09-01
IL273405B2 true IL273405B2 (en) 2024-01-01

Family

ID=55315463

Family Applications (4)

Application Number Title Priority Date Filing Date
IL273405A IL273405B2 (en) 2014-12-30 2015-12-30 Rpe cell populations and methods of generating same
IL321407A IL321407A (en) 2014-12-30 2015-12-30 RPE cell populations and methods for their production
IL253238A IL253238B (en) 2014-12-30 2017-06-29 rpe cell populations and methods for their production
IL305070A IL305070B2 (en) 2014-12-30 2023-08-08 RPE cell populations and methods for their production

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL321407A IL321407A (en) 2014-12-30 2015-12-30 RPE cell populations and methods for their production
IL253238A IL253238B (en) 2014-12-30 2017-06-29 rpe cell populations and methods for their production
IL305070A IL305070B2 (en) 2014-12-30 2023-08-08 RPE cell populations and methods for their production

Country Status (17)

Country Link
US (6) US11891622B2 (enExample)
EP (2) EP3674397A1 (enExample)
JP (4) JP6882981B2 (enExample)
KR (1) KR20170115514A (enExample)
CN (1) CN107406830A (enExample)
AU (3) AU2015373050B2 (enExample)
BR (1) BR112017014345A2 (enExample)
CA (1) CA2972575A1 (enExample)
DK (1) DK3240892T5 (enExample)
EA (1) EA201791416A1 (enExample)
ES (1) ES2774456T3 (enExample)
HK (1) HK1246348A1 (enExample)
IL (4) IL273405B2 (enExample)
MX (1) MX2017008737A (enExample)
PH (1) PH12017501218A1 (enExample)
SG (1) SG11201705379VA (enExample)
WO (1) WO2016108239A1 (enExample)

Families Citing this family (13)

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EA201791518A1 (ru) 2014-12-30 2017-10-31 Селл Кьюр Нейросайансес Лтд. Способы лечения заболеваний сетчатки
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AU2016303631B2 (en) 2015-08-05 2022-07-28 Cell Cure Neurosciences Ltd. Preparation of photoreceptors for the treatment of retinal diseases
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CN109957545A (zh) 2017-12-26 2019-07-02 江苏艾尔康生物医药科技有限公司 一种消化rpe细胞的方法
SG11202005795TA (en) * 2017-12-29 2020-07-29 Cell Cure Neurosciences Ltd Retinal pigment epithelium cell compositions
WO2020229628A1 (en) * 2019-05-15 2020-11-19 Novo Nordisk A/S Methods for obtaining eye field progenitor cells from human pluripotent stem cells
CN111972399B (zh) * 2020-08-06 2021-11-30 温州医科大学 维持肝细胞活性的保存液
MX2024001213A (es) 2021-07-28 2024-03-14 Lineage Cell Therapeutics Inc Expansion de celulas del epitelio pigmentario retiniano.
CN115840045B (zh) * 2023-02-23 2023-04-28 中国农业大学 一种猪胚胎期毛囊基板前体细胞的鉴定方法及其应用

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CN110913874A (zh) 2017-03-16 2020-03-24 谱系细胞疗法公司 用于测量视网膜疾病疗法的疗效的方法
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Also Published As

Publication number Publication date
WO2016108239A9 (en) 2017-08-10
IL305070A (en) 2023-10-01
ES2774456T9 (es) 2020-11-05
US20220169982A1 (en) 2022-06-02
IL253238B (en) 2020-04-30
CN107406830A (zh) 2017-11-28
US20220154141A1 (en) 2022-05-19
JP7608192B2 (ja) 2025-01-06
JP2023052646A (ja) 2023-04-11
AU2015373050B2 (en) 2022-09-29
KR20170115514A (ko) 2017-10-17
US20210332325A1 (en) 2021-10-28
US20220169981A1 (en) 2022-06-02
AU2015373050A9 (en) 2017-09-07
EP3240892A1 (en) 2017-11-08
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