IL273398B2 - History of 4'-fluoro-2'-methyl-modified nucleosides as inhibitors of HCV RNA replication - Google Patents

History of 4'-fluoro-2'-methyl-modified nucleosides as inhibitors of HCV RNA replication

Info

Publication number
IL273398B2
IL273398B2 IL273398A IL27339820A IL273398B2 IL 273398 B2 IL273398 B2 IL 273398B2 IL 273398 A IL273398 A IL 273398A IL 27339820 A IL27339820 A IL 27339820A IL 273398 B2 IL273398 B2 IL 273398B2
Authority
IL
Israel
Prior art keywords
compound
combination
fluoro
inhibitors
hcv rna
Prior art date
Application number
IL273398A
Other languages
English (en)
Hebrew (he)
Other versions
IL273398B1 (en
IL273398A (en
Original Assignee
Riboscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riboscience Llc filed Critical Riboscience Llc
Publication of IL273398A publication Critical patent/IL273398A/en
Publication of IL273398B1 publication Critical patent/IL273398B1/en
Publication of IL273398B2 publication Critical patent/IL273398B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
IL273398A 2017-09-21 2018-09-21 History of 4'-fluoro-2'-methyl-modified nucleosides as inhibitors of HCV RNA replication IL273398B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762561237P 2017-09-21 2017-09-21
PCT/US2018/052239 WO2019060740A1 (en) 2017-09-21 2018-09-21 4'-FLUORO-2'-METHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION

Publications (3)

Publication Number Publication Date
IL273398A IL273398A (en) 2020-05-31
IL273398B1 IL273398B1 (en) 2024-10-01
IL273398B2 true IL273398B2 (en) 2025-02-01

Family

ID=65810030

Family Applications (1)

Application Number Title Priority Date Filing Date
IL273398A IL273398B2 (en) 2017-09-21 2018-09-21 History of 4'-fluoro-2'-methyl-modified nucleosides as inhibitors of HCV RNA replication

Country Status (12)

Country Link
US (2) US10682369B2 (https=)
EP (1) EP3684374B1 (https=)
JP (1) JP7299897B2 (https=)
KR (1) KR102735678B1 (https=)
CN (1) CN111194217B (https=)
AR (1) AR112702A1 (https=)
AU (1) AU2018335411B2 (https=)
CA (1) CA3075645A1 (https=)
IL (1) IL273398B2 (https=)
SG (1) SG11202002431SA (https=)
TW (1) TWI860279B (https=)
WO (1) WO2019060740A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180200280A1 (en) * 2013-05-16 2018-07-19 Riboscience Llc 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication
EP3684374B1 (en) * 2017-09-21 2025-07-30 Riboscience LLC 4'-fluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication
TW202144465A (zh) 2020-02-11 2021-12-01 瑞士商諾和席卓股份有限公司 合成聚葡萄胺糖衍生物之新方法及其用途
EP3865535A1 (en) 2020-02-11 2021-08-18 Bosti Trading Ltd. New method of synthesis of chitosan derivatives and uses thereof
WO2022174179A1 (en) * 2021-02-15 2022-08-18 Emory University 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto
AR126678A1 (es) 2021-08-06 2023-11-01 Novochizol Sa Composiciones para el cuidado de las plantas y usos de las mismas
US12403221B2 (en) 2021-08-06 2025-09-02 Novochizol Sa Preparation of composite gels, polymer scaffolds, aggregates and films comprising soluble cross-linked chitosan and uses thereof

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WO2014186637A1 (en) * 2013-05-16 2014-11-20 Riboscience Llc 4'-fluor0-2'-methyl substituted nucleoside derivatives

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Also Published As

Publication number Publication date
US20210046100A1 (en) 2021-02-18
SG11202002431SA (en) 2020-04-29
AU2018335411A1 (en) 2020-03-26
AR112702A1 (es) 2019-11-27
US10682369B2 (en) 2020-06-16
EP3684374A4 (en) 2021-06-16
WO2019060740A1 (en) 2019-03-28
EP3684374A1 (en) 2020-07-29
CN111194217B (zh) 2024-01-12
JP2020534374A (ja) 2020-11-26
EP3684374B1 (en) 2025-07-30
IL273398B1 (en) 2024-10-01
TW201919649A (zh) 2019-06-01
US11351186B2 (en) 2022-06-07
CA3075645A1 (en) 2019-03-28
JP7299897B2 (ja) 2023-06-28
US20190231804A1 (en) 2019-08-01
IL273398A (en) 2020-05-31
TWI860279B (zh) 2024-11-01
KR102735678B1 (ko) 2024-11-27
KR20200056420A (ko) 2020-05-22
CN111194217A (zh) 2020-05-22
AU2018335411B2 (en) 2024-06-27

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