IL272924A - שיטות להכנה ולשימוש באנדוקסיפן - Google Patents
שיטות להכנה ולשימוש באנדוקסיפןInfo
- Publication number
- IL272924A IL272924A IL272924A IL27292420A IL272924A IL 272924 A IL272924 A IL 272924A IL 272924 A IL272924 A IL 272924A IL 27292420 A IL27292420 A IL 27292420A IL 272924 A IL272924 A IL 272924A
- Authority
- IL
- Israel
- Prior art keywords
- endoxifen
- making
- methods
- Prior art date
Links
- MHJBZVSGOZTKRH-IZHYLOQSSA-N 4-Hydroxy-N-desmethyltamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCNC)=CC=1)/C1=CC=C(O)C=C1 MHJBZVSGOZTKRH-IZHYLOQSSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Dental Preparations (AREA)
- Primary Cells (AREA)
- Paper (AREA)
- Catalysts (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762556884P | 2017-09-11 | 2017-09-11 | |
US201762556799P | 2017-09-11 | 2017-09-11 | |
US201862624787P | 2018-01-31 | 2018-01-31 | |
US201862693885P | 2018-07-03 | 2018-07-03 | |
PCT/US2018/050272 WO2019051416A1 (en) | 2017-09-11 | 2018-09-10 | METHODS FOR THE MANUFACTURE AND USE OF ENDOXIFEN |
Publications (3)
Publication Number | Publication Date |
---|---|
IL272924A true IL272924A (he) | 2020-04-30 |
IL272924B1 IL272924B1 (he) | 2023-09-01 |
IL272924B2 IL272924B2 (he) | 2024-01-01 |
Family
ID=65635248
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL304863A IL304863A (he) | 2017-09-11 | 2018-09-10 | שיטות להכנה ולשימוש באנדוקסיפן |
IL272924A IL272924B2 (he) | 2017-09-11 | 2018-09-10 | שיטות להכנה ולשימוש באנדוקסיפן |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL304863A IL304863A (he) | 2017-09-11 | 2018-09-10 | שיטות להכנה ולשימוש באנדוקסיפן |
Country Status (12)
Country | Link |
---|---|
US (4) | US11261151B2 (he) |
EP (1) | EP3681491A4 (he) |
JP (2) | JP2020533283A (he) |
KR (1) | KR20200052349A (he) |
CN (2) | CN111328280A (he) |
AU (2) | AU2018329202B2 (he) |
CA (1) | CA3073836A1 (he) |
IL (2) | IL304863A (he) |
MX (1) | MX2020002649A (he) |
SG (1) | SG11202002105WA (he) |
TW (1) | TWI793165B (he) |
WO (1) | WO2019051416A1 (he) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2018329202B2 (en) | 2017-09-11 | 2022-10-27 | Atossa Therapeutics, Inc. | Methods for making and using endoxifen |
WO2021003433A1 (en) * | 2019-07-03 | 2021-01-07 | Atossa Therapeutics, Inc. | Sustained release compositions of endoxifen |
CN110564962B (zh) * | 2019-10-14 | 2020-12-22 | 中南大学 | 一种黑白钨混合矿的冶炼方法 |
CN113975279A (zh) * | 2021-10-13 | 2022-01-28 | 复旦大学附属肿瘤医院 | 维拉佐酮及其衍生物在制备抗肿瘤药物中的应用 |
IL314075A (he) * | 2022-01-12 | 2024-09-01 | Atossa Therapeutics Inc | הרכבים של (z)-אנדוקסיפן ושיטות להעשרתם |
WO2023211939A1 (en) * | 2022-04-26 | 2023-11-02 | Atossa Therapeutics, Inc. | High dose endoxifen formulations and methods of use |
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JP7376105B2 (ja) | 2017-09-11 | 2023-11-08 | アトッサ・セラピューティクス・インコーポレイテッド | 局所用組成物及び処置方法 |
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2018
- 2018-09-10 AU AU2018329202A patent/AU2018329202B2/en active Active
- 2018-09-10 MX MX2020002649A patent/MX2020002649A/es unknown
- 2018-09-10 CN CN201880072905.6A patent/CN111328280A/zh active Pending
- 2018-09-10 CN CN202310795504.6A patent/CN116832020A/zh active Pending
- 2018-09-10 US US16/641,985 patent/US11261151B2/en active Active
- 2018-09-10 IL IL304863A patent/IL304863A/he unknown
- 2018-09-10 SG SG11202002105WA patent/SG11202002105WA/en unknown
- 2018-09-10 KR KR1020207010196A patent/KR20200052349A/ko not_active Application Discontinuation
- 2018-09-10 TW TW107131790A patent/TWI793165B/zh active
- 2018-09-10 JP JP2020511956A patent/JP2020533283A/ja active Pending
- 2018-09-10 IL IL272924A patent/IL272924B2/he unknown
- 2018-09-10 WO PCT/US2018/050272 patent/WO2019051416A1/en unknown
- 2018-09-10 EP EP18853361.6A patent/EP3681491A4/en active Pending
- 2018-09-10 CA CA3073836A patent/CA3073836A1/en active Pending
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2022
- 2022-01-20 US US17/580,428 patent/US11572334B2/en active Active
- 2022-12-29 US US18/090,757 patent/US11680036B1/en active Active
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2023
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TW201919596A (zh) | 2019-06-01 |
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EP3681491A4 (en) | 2021-06-30 |
US20220242816A1 (en) | 2022-08-04 |
IL272924B1 (he) | 2023-09-01 |
AU2023200013A1 (en) | 2023-02-09 |
IL304863A (he) | 2023-10-01 |
CN111328280A (zh) | 2020-06-23 |
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