IL272449A - Adiponectin peptide deletions for the treatment of ocular disorders - Google Patents

Adiponectin peptide deletions for the treatment of ocular disorders

Info

Publication number
IL272449A
IL272449A IL272449A IL27244920A IL272449A IL 272449 A IL272449 A IL 272449A IL 272449 A IL272449 A IL 272449A IL 27244920 A IL27244920 A IL 27244920A IL 272449 A IL272449 A IL 272449A
Authority
IL
Israel
Prior art keywords
ocular disorders
treating ocular
adiponectin peptidomimetics
adiponectin
peptidomimetics
Prior art date
Application number
IL272449A
Other languages
English (en)
Hebrew (he)
Original Assignee
Allysta Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allysta Pharmaceuticals Inc filed Critical Allysta Pharmaceuticals Inc
Publication of IL272449A publication Critical patent/IL272449A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Dermatology (AREA)
IL272449A 2015-05-01 2020-02-04 Adiponectin peptide deletions for the treatment of ocular disorders IL272449A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562156127P 2015-05-01 2015-05-01
US15/676,968 US10537608B2 (en) 2015-05-01 2017-08-14 Adiponectin peptidomimetics for treating ocular disorders
PCT/US2018/045527 WO2019036223A1 (en) 2015-05-01 2018-08-07 PEPTIDOMIMETICS OF ADIPONECTIN FOR THE TREATMENT OF OCULAR DISORDERS

Publications (1)

Publication Number Publication Date
IL272449A true IL272449A (en) 2020-03-31

Family

ID=57218292

Family Applications (1)

Application Number Title Priority Date Filing Date
IL272449A IL272449A (en) 2015-05-01 2020-02-04 Adiponectin peptide deletions for the treatment of ocular disorders

Country Status (12)

Country Link
US (6) US10987401B2 (OSRAM)
EP (3) EP4014985A1 (OSRAM)
JP (1) JP7245649B2 (OSRAM)
KR (2) KR20170141692A (OSRAM)
CN (3) CN107530396B (OSRAM)
AU (3) AU2016257724B2 (OSRAM)
CA (3) CA3191203A1 (OSRAM)
DK (1) DK3288577T3 (OSRAM)
ES (1) ES2903448T3 (OSRAM)
IL (1) IL272449A (OSRAM)
SG (1) SG11202001140UA (OSRAM)
WO (2) WO2016179007A1 (OSRAM)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107530396B (zh) * 2015-05-01 2022-08-26 雅利斯塔制药公司 用于治疗眼科疾病的脂联素拟肽
KR20200004789A (ko) * 2017-03-09 2020-01-14 알리스타 파마슈티컬즈, 인크. 안구 건조증 질환을 위한 펩티드
CN107149676A (zh) * 2017-05-05 2017-09-12 杨硕 脂联素和脂联素/胰岛素混合液在改善及治疗眼表角膜上皮及神经损伤中的应用
WO2019061491A1 (en) * 2017-09-30 2019-04-04 Pro Sunfun Biotech Research And Development Co., Ltd. PEPTIDE FOR OCULAR CARE, COMPOSITION AND METHOD OF USE THEREOF
CN109912685B (zh) * 2017-12-13 2022-05-06 三凡生技研发股份有限公司 眼睛保护胜肽及其组合物及使用该胜肽的用途
CN112165954A (zh) * 2018-03-23 2021-01-01 阿奇生物外科有限公司 用于治疗眼病的sap和拟肽
CA3116065A1 (en) 2018-10-24 2020-04-30 Allysta Pharmaceuticals, Inc. Adiponectin peptidomimetics formulations
JP7699426B2 (ja) * 2018-11-30 2025-06-27 ロート製薬株式会社 光線による障害からの細胞保護用眼科組成物
KR20220034199A (ko) 2019-09-18 2022-03-17 알콘 인코포레이티드 습식-패킹 소프트 하이드로겔 안구 삽입물
US11229549B2 (en) * 2019-09-18 2022-01-25 Vance M. Thompson Tear transplantation and multi-part contact lens with absorbent portion
US11213551B1 (en) 2021-04-05 2022-01-04 Korb Research, Llc. Ocular treatment compositions and methods of use thereof
WO2023069255A1 (en) * 2021-10-20 2023-04-27 Stealth Biotherapeutics Inc. Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions
EP4419123A1 (en) * 2021-10-20 2024-08-28 Stealth BioTherapeutics Inc. Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions
WO2023107796A1 (en) * 2021-12-11 2023-06-15 The Regents Of The University Of California Ophthalmic formulations for macular degeneration
WO2024180472A1 (en) 2023-02-28 2024-09-06 Alcon Inc. Ocular inserts
KR102609115B1 (ko) * 2023-06-08 2023-12-05 주식회사 엔큐라젠 펩타이드를 포함하는 안구 질환의 치료용 조성물
WO2026032238A1 (en) * 2024-08-06 2026-02-12 The Chinese University Of Hong Kong Compositions and methods for treating tendon and ligament injuries utilizing biomaterials and adiponectin or its mimics

Family Cites Families (13)

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US5108921A (en) 1989-04-03 1992-04-28 Purdue Research Foundation Method for enhanced transmembrane transport of exogenous molecules
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
DE4437604A1 (de) 1994-10-21 1996-04-25 Basf Ag Konjugate aus einem Poly- oder Oligopeptid und einer niedermolekularen lipophilen Verbindung
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
TR200101751T2 (tr) 1998-04-28 2002-05-21 Applied Research Systems Ars Holding N.V. Poliol-IFN-beta konjugatları
GB9814527D0 (en) 1998-07-03 1998-09-02 Cyclacel Ltd Delivery system
EP1474445A4 (en) * 2002-01-18 2007-02-21 Protemix Corp Ltd ADIPONECTIN GLYCO-ISOFORMS, AND USES THEREOF
EP1890715A4 (en) * 2005-04-29 2009-10-28 Univ California PEPTIDES AND PEPTIDE MIMETICS FOR TREATMENT BY INFLAMMATORY REACTION OF CHARACTERIZED PATHOLOGIES
WO2012142142A2 (en) * 2011-04-12 2012-10-18 Temple University - Of The Commonwealth System Higher Education Adiponectin receptor agonists and methods of use
KR101438744B1 (ko) * 2012-08-02 2014-09-15 전남대학교산학협력단 아디포넥틴을 유효성분으로 포함하는 안구건조증 또는 염증성 안구표면 질환의 예방 또는 치료용 조성물
EP2911623B1 (en) * 2012-10-26 2019-08-14 Forsight Vision5, Inc. Ophthalmic system for sustained release of drug to eye
CN107530396B (zh) * 2015-05-01 2022-08-26 雅利斯塔制药公司 用于治疗眼科疾病的脂联素拟肽

Also Published As

Publication number Publication date
DK3288577T3 (da) 2022-01-10
JP2018514592A (ja) 2018-06-07
AU2016257724B2 (en) 2021-02-25
CN107530396B (zh) 2022-08-26
US11464825B2 (en) 2022-10-11
AU2021203254A1 (en) 2021-06-17
EP3668530A1 (en) 2020-06-24
US20200085907A1 (en) 2020-03-19
US20180161390A1 (en) 2018-06-14
ES2903448T3 (es) 2022-04-01
US20220331393A1 (en) 2022-10-20
WO2016179007A1 (en) 2016-11-10
CA2981822C (en) 2023-04-11
US10537608B2 (en) 2020-01-21
EP3288577B1 (en) 2021-10-27
US20210128671A1 (en) 2021-05-06
US10987401B2 (en) 2021-04-27
CN107530396A (zh) 2018-01-02
US20230074446A1 (en) 2023-03-09
US11273197B2 (en) 2022-03-15
US20180078616A1 (en) 2018-03-22
EP3668530A4 (en) 2021-07-21
EP3288577A1 (en) 2018-03-07
CA3191203A1 (en) 2016-11-10
CN111032070A (zh) 2020-04-17
EP3288577A4 (en) 2018-12-26
JP7245649B2 (ja) 2023-03-24
CA2981822A1 (en) 2016-11-10
CA3071670A1 (en) 2019-02-21
AU2018318008A1 (en) 2020-02-06
CN115919996A (zh) 2023-04-07
SG11202001140UA (en) 2020-03-30
EP4014985A1 (en) 2022-06-22
KR20200039749A (ko) 2020-04-16
KR20170141692A (ko) 2017-12-26
AU2016257724A1 (en) 2017-10-12
HK1246178A1 (zh) 2018-09-07
WO2019036223A1 (en) 2019-02-21

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