IL272314A - Use of inhaled nitric oxide for the treatment of pulmonary hypertension associated with lung disease - Google Patents

Use of inhaled nitric oxide for the treatment of pulmonary hypertension associated with lung disease

Info

Publication number
IL272314A
IL272314A IL272314A IL27231420A IL272314A IL 272314 A IL272314 A IL 272314A IL 272314 A IL272314 A IL 272314A IL 27231420 A IL27231420 A IL 27231420A IL 272314 A IL272314 A IL 272314A
Authority
IL
Israel
Prior art keywords
nitrous oxide
lung disease
pulmonary hypertension
hypertension associated
treat pulmonary
Prior art date
Application number
IL272314A
Other languages
English (en)
Hebrew (he)
Original Assignee
Bellerophon Pulse Tech Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bellerophon Pulse Tech Llc filed Critical Bellerophon Pulse Tech Llc
Publication of IL272314A publication Critical patent/IL272314A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/021—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes operated by electrical means
    • A61M16/022—Control means therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0027—Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
    • A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0208—Oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0266—Nitrogen (N)
    • A61M2202/0275—Nitric oxide [NO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1025—Respiratory system
    • A61M2210/1039—Lungs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/12—Blood circulatory system
    • A61M2210/125—Heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/30—Blood pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/40—Respiratory characteristics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
IL272314A 2017-08-30 2020-01-28 Use of inhaled nitric oxide for the treatment of pulmonary hypertension associated with lung disease IL272314A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762552022P 2017-08-30 2017-08-30
US201762611325P 2017-12-28 2017-12-28
PCT/US2018/048526 WO2019046415A1 (en) 2017-08-30 2018-08-29 USE OF INHALED NITRIC OXIDE FOR THE TREATMENT OF PULMONARY HYPERTENSION ASSOCIATED WITH PULMONARY DISEASE

Publications (1)

Publication Number Publication Date
IL272314A true IL272314A (en) 2020-03-31

Family

ID=65526008

Family Applications (2)

Application Number Title Priority Date Filing Date
IL272314A IL272314A (en) 2017-08-30 2020-01-28 Use of inhaled nitric oxide for the treatment of pulmonary hypertension associated with lung disease
IL272308A IL272308A (en) 2017-08-30 2020-01-28 Use of inhaled nitric oxide for the improvement of right and/or left ventricular function

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL272308A IL272308A (en) 2017-08-30 2020-01-28 Use of inhaled nitric oxide for the improvement of right and/or left ventricular function

Country Status (14)

Country Link
US (2) US20200360647A1 (https=)
EP (2) EP3675840A4 (https=)
JP (4) JP2020532521A (https=)
KR (1) KR20200083443A (https=)
CN (3) CN120131593A (https=)
AU (2) AU2018324004A1 (https=)
BR (1) BR112020004205A2 (https=)
CA (4) CA3073948A1 (https=)
IL (2) IL272314A (https=)
MX (2) MX2020002194A (https=)
PH (1) PH12020500197A1 (https=)
SG (1) SG11202000893QA (https=)
TW (3) TWI887195B (https=)
WO (2) WO2019046415A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2717525C1 (ru) 2017-02-27 2020-03-23 Сёрд Поул, Инк. Системы и способы получения оксида азота
US10328228B2 (en) 2017-02-27 2019-06-25 Third Pole, Inc. Systems and methods for ambulatory generation of nitric oxide
MX2020010523A (es) 2017-02-27 2021-02-09 Third Pole Inc Sistemas y metodos para generar oxido nitrico.
MX2021008418A (es) * 2019-01-14 2021-08-19 Bellerophon Therapeutics Terapias de farmaco de combinacion de inhibidores de fosfodiesterasa tipo 5 (pde-5) y oxido nitrico inhalado.
EP3969416A4 (en) 2019-05-15 2023-11-01 Third Pole, Inc. SYSTEMS AND DEVICES FOR GENERATING NITROGEN OXIDE
EP3969016A4 (en) 2019-05-15 2023-08-16 Third Pole, Inc. ARCHITECTURES FOR THE PRODUCTION OF NITROUS OXIDE
JP2022533628A (ja) 2019-05-15 2022-07-25 サード ポール，インコーポレイテッド 一酸化窒素生成用電極
US11691879B2 (en) 2020-01-11 2023-07-04 Third Pole, Inc. Systems and methods for nitric oxide generation with humidity control
US12239460B2 (en) * 2020-05-06 2025-03-04 Janssen Pharmaceuticals, Inc. Controlling operation of drug administration devices using surgical hubs
CA3180709A1 (en) * 2020-05-29 2021-12-02 Martin DEKKER Method for pulsatile delivery of a gaseous drug
US20210395905A1 (en) 2020-06-18 2021-12-23 Third Pole, Inc. Systems and methods for preventing and treating infections with nitric oxide
WO2022082072A1 (en) 2020-10-16 2022-04-21 Third Pole, Inc. Nitric oxide generation process controls
US11975139B2 (en) 2021-09-23 2024-05-07 Third Pole, Inc. Systems and methods for delivering nitric oxide
US12569628B2 (en) 2022-04-14 2026-03-10 Third Pole, Inc. Delivery of medicinal gas in a liquid medium

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2101777B1 (en) * 2006-12-12 2015-05-20 Gilead Sciences, Inc. Composition for treating a pulmonary hypertension
US7943667B2 (en) * 2007-10-11 2011-05-17 Duke University Potentiating the effect of compound comprising nitric oxide
CN101969974A (zh) * 2008-01-31 2011-02-09 范德比尔特大学 对于肺部病症的治疗
CA2671029A1 (en) * 2009-06-30 2010-12-30 James S. Baldassarre Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension
US20120093948A1 (en) * 2009-11-20 2012-04-19 Fine David H Nitric Oxide Treatments
AU2011336358B2 (en) * 2010-12-03 2016-09-29 VERO Biotech LLC. Nitric oxide treatments
JP6215314B2 (ja) * 2012-05-31 2017-10-18 イノ セラピューティクス エルエルシー 一酸化窒素を動脈血または動脈血化血（ａｒｔｅｒｉａｌｉｚｅｄｂｌｏｏｄ）に投与する方法
KR102357044B1 (ko) * 2012-12-04 2022-02-08 말린크로트 파마슈티칼스 아일랜드 리미티드 일산화질소 전달 동안 투약량의 희석을 최소화하기 위한 캐뉼라
US9795756B2 (en) * 2012-12-04 2017-10-24 Mallinckrodt Hospital Products IP Limited Cannula for minimizing dilution of dosing during nitric oxide delivery
CA2936490C (en) * 2014-01-10 2022-10-04 Ino Therapeutics Llc Methods of using inhaled nitric oxide gas for treatment of acute respiratory distress syndrome in children
CN106572813B (zh) * 2014-03-28 2020-07-17 沙普医疗系统公司 用于量化慢性疾病的多种可能形式对被报告呼吸困难的患者的贡献的可能性的模式识别系统
EP3386574A4 (en) * 2015-12-11 2019-07-17 Vero Biotech LLC METHOD AND APPARATUS FOR GAS ADMINISTRATION COMPRISING NITRIC OXIDE FOR TREATING FIBROSIS
CA3009986A1 (en) * 2015-12-28 2017-07-06 Vero Biotech LLC Method and apparatus for administering nitric oxide with supplemental drugs
EP3413899A4 (en) * 2016-02-12 2019-10-02 Mallinckrodt Hospital Products IP Limited USE AND MONITORING OF INHALED STAIN OXIDE WITH LEFT-VENTRICULAR SUPPORT DEVICES

Also Published As

Publication number Publication date
CA3266267A1 (en) 2025-04-28
WO2019046413A1 (en) 2019-03-07
US20200360647A1 (en) 2020-11-19
SG11202000893QA (en) 2020-02-27
MX2020002194A (es) 2020-11-24
AU2018324004A1 (en) 2020-02-13
KR20200083443A (ko) 2020-07-08
EP3675840A1 (en) 2020-07-08
CA3073948A1 (en) 2019-03-07
EP3675719A4 (en) 2021-07-14
EP3675719A1 (en) 2020-07-08
JP2025029093A (ja) 2025-03-05
EP3675840A4 (en) 2021-05-12
BR112020004205A2 (pt) 2020-09-01
CN120131593A (zh) 2025-06-13
JP2020532531A (ja) 2020-11-12
PH12020500197A1 (en) 2020-10-19
TW201919590A (zh) 2019-06-01
CA3073949A1 (en) 2019-03-07
US20200188319A1 (en) 2020-06-18
CN111372577A (zh) 2020-07-03
JP2023100985A (ja) 2023-07-19
TW201912151A (zh) 2019-04-01
IL272308A (en) 2020-03-31
CN111315283A (zh) 2020-06-19
CA3266320A1 (en) 2025-05-31
WO2019046415A1 (en) 2019-03-07
JP2020532521A (ja) 2020-11-12
AU2018323547A1 (en) 2020-02-13
TW202416939A (zh) 2024-05-01
TWI887195B (zh) 2025-06-21
MX2025004666A (es) 2025-05-02

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