JP6215314B2 - 一酸化窒素を動脈血または動脈血化血(arterializedblood)に投与する方法 - Google Patents
一酸化窒素を動脈血または動脈血化血(arterializedblood)に投与する方法 Download PDFInfo
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- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0266—Nitrogen (N)
- A61M2202/0275—Nitric oxide [NO]
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Description
本明細書および添付の特許請求の範囲で用いられる場合、特に断りがなければ、以下の用語は、示された意味を有する。
Claims (9)
- 一酸化窒素含有気体を動脈血または動脈血化血(arterialized blood)に直接投与することにより一酸化窒素に応答性のある疾患、障害または状態を処置するための一酸化窒素を使用する装置であって、前記装置は、
第一の反応エリアと第二の反応エリアとを有する体外式膜型人工肺システムの酸素化コンパートメント内の気体輸送ユニットであって、前記第一の反応エリアは、ガス交換膜を介して患者から引き出された血液を酸素化して動脈血化血を生成し、前記第二の反応エリアは、前記第一の反応エリアの下流にあり、前記ガス交換膜を介して治療有効量の一酸化窒素含有気体を前記患者の動脈血化血へ直接送達する、気体輸送ユニットと、
一酸化窒素を含有する前記動脈血化血を前記患者へ投与するための動脈カニューレと、を備え、
前記第二の反応エリアの下流にある前記気体輸送ユニットの出口を介して、残留する酸素及び一酸化窒素が前記気体輸送ユニットから取り除かれることを特徴とする、
装置。 - 前記一酸化窒素含有気体のボーラス投与のための、請求項1に記載の装置。
- 0.1〜500ppmの送達濃度の連続投与のための、請求項1に記載の装置。
- 虚血または低酸素症の処置のための、請求項1〜3のいずれかに記載の装置。
- 前記一酸化窒素含有気体を直接、前記患者の動脈に投与するための、請求項1〜4のいずれかに記載の装置。
- 注射または連続輸注により投与される、請求項5に記載の装置。
- 体外式人工肺システムを含む、一酸化窒素含有気体を動脈血化血液に投与する装置であって、前記体外式人工肺システムが、一酸化窒素含有気体を保持または発生するためのレセプタクルと、酸素化された血液を患者の体に輸注する前に前記一酸化窒素含有気体を前記酸素化された血液に送達するためのデバイスと、を含む、装置であって、
前記体外式人工肺システムは、酸素化コンパートメントと換気デバイスとを備え、
前記酸素化コンパートメントは、
チャンバ―であって、血液が前記チャンバ―を介して酸素化コンパートメントへ進入する、チャンバ―と、
気体輸送ユニットであって、第一の反応エリアと、前記第一の反応エリアの下流にある第二の反応エリアと及び前記第二の反応エリアの下流にある出口とを有する、気体輸送ユニットと、を備え、
前記気体輸送ユニットは、ガス交換膜によって前記チャンバーから分離されており、前記ガス交換膜は、前記血液中の二酸化炭素を酸素と交換して前記気体輸送ユニットの前記第一の反応エリア内で動脈血化血を生成し、且つ前記気体輸送ユニットの前記第二の反応エリア内で動脈血化血中の酸素と一酸化窒素を交換することを特徴とし、
前記換気デバイスは、残留する酸素及び一酸化窒素を操作可能に受け取るために前記気体輸送ユニットの前記出口を介して前記気体輸送ユニットと流体連通をする、装置。 - 前記気体輸送ユニット内の第一の入口を介して前記気体輸送ユニットと流体連通する酸素供給源を更に備える、請求項7に記載の装置。
- 前記一酸化窒素を含有する気体の送達装置が、前記第一の入口の下流にある前記気体輸送ユニット内の第二の入口を介して前記気体輸送ユニットと流体連通している、請求項8に記載の装置。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US201261653499P | 2012-05-31 | 2012-05-31 | |
US61/653,499 | 2012-05-31 | ||
US201361787865P | 2013-03-15 | 2013-03-15 | |
US61/787,865 | 2013-03-15 | ||
PCT/US2013/043232 WO2013181322A1 (en) | 2012-05-31 | 2013-05-30 | Methods of administering nitric oxide to arterial or arterialized blood |
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JP2017180236A Division JP2018011979A (ja) | 2012-05-31 | 2017-09-20 | 一酸化窒素を動脈血または動脈血化血(arterialized blood)に投与する方法 |
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JP2015519143A JP2015519143A (ja) | 2015-07-09 |
JP6215314B2 true JP6215314B2 (ja) | 2017-10-18 |
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JP2017180236A Pending JP2018011979A (ja) | 2012-05-31 | 2017-09-20 | 一酸化窒素を動脈血または動脈血化血(arterialized blood)に投与する方法 |
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US (2) | US10052426B2 (ja) |
EP (1) | EP2854894A1 (ja) |
JP (2) | JP6215314B2 (ja) |
AU (2) | AU2013267418B2 (ja) |
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JP2018011979A (ja) * | 2012-05-31 | 2018-01-25 | イノ セラピューティクス エルエルシー | 一酸化窒素を動脈血または動脈血化血(arterialized blood)に投与する方法 |
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US9629358B2 (en) * | 2013-03-15 | 2017-04-25 | Mallinckrodt Hospital Products IP Limited | Administration and monitoring of nitric oxide in ex vivo fluids |
BR112019004635A2 (pt) * | 2016-09-10 | 2019-06-18 | Vero Biotech LLC | sistema e método para liberação de óxido nítrico portátil |
CN111201048A (zh) * | 2017-06-08 | 2020-05-26 | 凯斯西储大学 | 对血液进行亚硝化的设备和方法 |
WO2019046413A1 (en) * | 2017-08-30 | 2019-03-07 | Bellerophon Pulse Technologies Llc | USE OF INHALED NITRIC OXIDE FOR ENHANCED RIGHT AND / OR LEFT VENTRICULAR FUNCTION |
CN113797404B (zh) * | 2021-01-06 | 2023-05-09 | 郝云玲 | 一种向血液中补充一氧化氮(no)的装置 |
WO2023086409A1 (en) * | 2021-11-12 | 2023-05-19 | The Feinstein Institutes For Medical Research | Methods and medical compositions administered to protect mammals treated using an extracorporeal membrane oxygenation device |
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US5725492A (en) * | 1996-03-04 | 1998-03-10 | Cormedics Corp | Extracorporeal circulation apparatus and method |
JP4258908B2 (ja) * | 1999-09-14 | 2009-04-30 | 株式会社ジェイ・エム・エス | 人工肺装置 |
US20080160107A1 (en) * | 2002-09-10 | 2008-07-03 | Nitric Biotherapeutics, Inc. | Use of nitric oxide gas to treat blood and blood products |
US7485324B2 (en) * | 2003-09-29 | 2009-02-03 | Pulmonox Technologies Corporation | Use of exogenous gaseous nitric oxide in the treatment and disinfection of biofilms |
JP4562490B2 (ja) * | 2004-10-26 | 2010-10-13 | 泉工医科工業株式会社 | 人工肺ガス交換モニタ |
US8790715B2 (en) * | 2006-02-16 | 2014-07-29 | Ino Therapeutics Llc | Method and apparatus for generating nitric oxide for medical use |
MX363507B (es) * | 2012-05-31 | 2019-03-26 | Mallinckrodt Hospital Products Ip Ltd | Metodos para administrar óxido nítrico a la sangre arterial o arterializada. |
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JP2018011979A (ja) * | 2012-05-31 | 2018-01-25 | イノ セラピューティクス エルエルシー | 一酸化窒素を動脈血または動脈血化血(arterialized blood)に投与する方法 |
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Publication number | Publication date |
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AU2018203332A1 (en) | 2018-05-31 |
AU2018203332B2 (en) | 2019-09-19 |
CA2874842A1 (en) | 2013-12-05 |
EP2854894A1 (en) | 2015-04-08 |
JP2018011979A (ja) | 2018-01-25 |
AU2013267418A1 (en) | 2014-12-04 |
US10052426B2 (en) | 2018-08-21 |
CA2874842C (en) | 2021-01-26 |
MX363507B (es) | 2019-03-26 |
WO2013181322A1 (en) | 2013-12-05 |
US20150151034A1 (en) | 2015-06-04 |
AU2013267418B2 (en) | 2018-06-07 |
JP2015519143A (ja) | 2015-07-09 |
US20180339095A1 (en) | 2018-11-29 |
MX2014014502A (es) | 2015-05-11 |
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