IL267010B2 - Well-plate incubator - Google Patents
Well-plate incubatorInfo
- Publication number
- IL267010B2 IL267010B2 IL267010A IL26701019A IL267010B2 IL 267010 B2 IL267010 B2 IL 267010B2 IL 267010 A IL267010 A IL 267010A IL 26701019 A IL26701019 A IL 26701019A IL 267010 B2 IL267010 B2 IL 267010B2
- Authority
- IL
- Israel
- Prior art keywords
- openings
- sealing element
- incubator
- enclosure
- access structure
- Prior art date
Links
- 238000007789 sealing Methods 0.000 claims description 496
- 238000004113 cell culture Methods 0.000 claims description 242
- 239000000463 material Substances 0.000 claims description 125
- 238000000034 method Methods 0.000 claims description 121
- 238000010438 heat treatment Methods 0.000 claims description 102
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 86
- 238000001816 cooling Methods 0.000 claims description 76
- 239000007789 gas Substances 0.000 claims description 76
- 230000008676 import Effects 0.000 claims description 66
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 43
- 239000001569 carbon dioxide Substances 0.000 claims description 38
- 238000000151 deposition Methods 0.000 claims description 26
- 238000010276 construction Methods 0.000 claims description 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 239000001301 oxygen Substances 0.000 claims description 8
- 229910000831 Steel Inorganic materials 0.000 claims description 5
- 239000010959 steel Substances 0.000 claims description 5
- OKBJVIVEFXPEOU-UHFFFAOYSA-N 1,2,3-trichloro-4-(2,3,6-trichlorophenyl)benzene Chemical compound ClC1=C(Cl)C(Cl)=CC=C1C1=C(Cl)C=CC(Cl)=C1Cl OKBJVIVEFXPEOU-UHFFFAOYSA-N 0.000 description 80
- 210000004027 cell Anatomy 0.000 description 73
- 239000012530 fluid Substances 0.000 description 49
- 125000006850 spacer group Chemical group 0.000 description 41
- 229960004424 carbon dioxide Drugs 0.000 description 37
- 239000010410 layer Substances 0.000 description 37
- 239000010408 film Substances 0.000 description 34
- 238000009833 condensation Methods 0.000 description 24
- 230000005494 condensation Effects 0.000 description 24
- 238000005070 sampling Methods 0.000 description 23
- 239000003570 air Substances 0.000 description 19
- 238000010926 purge Methods 0.000 description 18
- 238000002156 mixing Methods 0.000 description 15
- 239000004033 plastic Substances 0.000 description 15
- 229920003023 plastic Polymers 0.000 description 15
- 239000000523 sample Substances 0.000 description 14
- 239000001963 growth medium Substances 0.000 description 13
- 239000003153 chemical reaction reagent Substances 0.000 description 12
- 230000033001 locomotion Effects 0.000 description 12
- 230000000670 limiting effect Effects 0.000 description 11
- 238000012546 transfer Methods 0.000 description 11
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 9
- 229910052802 copper Inorganic materials 0.000 description 9
- 239000010949 copper Substances 0.000 description 9
- 238000009413 insulation Methods 0.000 description 9
- 229910052751 metal Inorganic materials 0.000 description 9
- 239000002184 metal Substances 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 229910001369 Brass Inorganic materials 0.000 description 8
- 238000003556 assay Methods 0.000 description 8
- 239000011324 bead Substances 0.000 description 8
- 239000010951 brass Substances 0.000 description 8
- 230000000295 complement effect Effects 0.000 description 8
- 238000011109 contamination Methods 0.000 description 8
- 230000012010 growth Effects 0.000 description 8
- 230000035899 viability Effects 0.000 description 8
- 238000011534 incubation Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 229920000642 polymer Polymers 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 229910045601 alloy Inorganic materials 0.000 description 6
- 239000000956 alloy Substances 0.000 description 6
- 229910052782 aluminium Inorganic materials 0.000 description 6
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 6
- 230000003833 cell viability Effects 0.000 description 6
- 230000001143 conditioned effect Effects 0.000 description 6
- 239000011810 insulating material Substances 0.000 description 6
- 239000002609 medium Substances 0.000 description 6
- 238000010899 nucleation Methods 0.000 description 6
- 239000012790 adhesive layer Substances 0.000 description 5
- 230000032823 cell division Effects 0.000 description 5
- 230000007613 environmental effect Effects 0.000 description 5
- 239000012774 insulation material Substances 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 239000004696 Poly ether ether ketone Substances 0.000 description 4
- 238000013019 agitation Methods 0.000 description 4
- 239000012080 ambient air Substances 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 239000000919 ceramic Substances 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 238000007906 compression Methods 0.000 description 4
- 230000006835 compression Effects 0.000 description 4
- 230000001788 irregular Effects 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 102000039446 nucleic acids Human genes 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 230000010412 perfusion Effects 0.000 description 4
- 229920002530 polyetherether ketone Polymers 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 230000000284 resting effect Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000012054 celltiter-glo Methods 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 238000012258 culturing Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 239000002502 liposome Substances 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
- 238000004020 luminiscence type Methods 0.000 description 3
- 210000004962 mammalian cell Anatomy 0.000 description 3
- 239000011325 microbead Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000003566 sealing material Substances 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- UZOVYGYOLBIAJR-UHFFFAOYSA-N 4-isocyanato-4'-methyldiphenylmethane Chemical compound C1=CC(C)=CC=C1CC1=CC=C(N=C=O)C=C1 UZOVYGYOLBIAJR-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- 239000004697 Polyetherimide Substances 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 210000004102 animal cell Anatomy 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 239000007844 bleaching agent Substances 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 230000009089 cytolysis Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000007667 floating Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000002538 fungal effect Effects 0.000 description 2
- 210000004408 hybridoma Anatomy 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 230000009972 noncorrosive effect Effects 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 230000008823 permeabilization Effects 0.000 description 2
- 229920001601 polyetherimide Polymers 0.000 description 2
- 238000004382 potting Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000037452 priming Effects 0.000 description 2
- 231100000747 viability assay Toxicity 0.000 description 2
- 238000003026 viability measurement method Methods 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000007760 Iscove's Modified Dulbecco's Medium Substances 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 229920004738 ULTEM® Polymers 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 239000012809 cooling fluid Substances 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000004720 dielectrophoresis Methods 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 235000019441 ethanol Nutrition 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- LIYGYAHYXQDGEP-UHFFFAOYSA-N firefly oxyluciferin Natural products Oc1csc(n1)-c1nc2ccc(O)cc2s1 LIYGYAHYXQDGEP-UHFFFAOYSA-N 0.000 description 1
- 210000000497 foam cell Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 239000007792 gaseous phase Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000003670 luciferase enzyme activity assay Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- POFWRMVFWIJXHP-UHFFFAOYSA-N n-benzyl-9-(oxan-2-yl)purin-6-amine Chemical compound C=1C=CC=CC=1CNC(C=1N=C2)=NC=NC=1N2C1CCCCO1 POFWRMVFWIJXHP-UHFFFAOYSA-N 0.000 description 1
- 239000002107 nanodisc Substances 0.000 description 1
- 229910052756 noble gas Inorganic materials 0.000 description 1
- 150000002835 noble gases Chemical class 0.000 description 1
- 210000000287 oocyte Anatomy 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- JJVOROULKOMTKG-UHFFFAOYSA-N oxidized Photinus luciferin Chemical compound S1C2=CC(O)=CC=C2N=C1C1=NC(=O)CS1 JJVOROULKOMTKG-UHFFFAOYSA-N 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 229920001992 poloxamer 407 Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- -1 polytetrafluoroethylene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 239000002096 quantum dot Substances 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Natural products CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 238000004506 ultrasonic cleaning Methods 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/26—Inoculator or sampler
- C12M1/32—Inoculator or sampler multiple field or continuous type
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/12—Well or multiwell plates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/20—Material Coatings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/38—Caps; Covers; Plugs; Pouring means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
- C12M37/04—Seals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/14—Incubators; Climatic chambers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662428980P | 2016-12-01 | 2016-12-01 | |
| US201762480216P | 2017-03-31 | 2017-03-31 | |
| PCT/US2017/064357 WO2018102781A1 (en) | 2016-12-01 | 2017-12-01 | Well-plate incubator |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| IL267010A IL267010A (en) | 2019-07-31 |
| IL267010B1 IL267010B1 (en) | 2024-07-01 |
| IL267010B2 true IL267010B2 (en) | 2024-11-01 |
Family
ID=62242171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL267010A IL267010B2 (en) | 2016-12-01 | 2017-12-01 | Well-plate incubator |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11434462B2 (enExample) |
| EP (1) | EP3548602B1 (enExample) |
| JP (1) | JP6968169B2 (enExample) |
| KR (1) | KR102546384B1 (enExample) |
| CN (1) | CN110366591A (enExample) |
| AU (1) | AU2017366733B2 (enExample) |
| CA (1) | CA3045898A1 (enExample) |
| IL (1) | IL267010B2 (enExample) |
| WO (1) | WO2018102781A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI737631B (zh) | 2015-10-01 | 2021-09-01 | 美商柏克萊燈光有限公司 | 多槽盤培養器 |
| JP7356351B2 (ja) | 2016-12-12 | 2023-10-04 | エクセラ・バイオサイエンシーズ・インコーポレイテッド | マイクロキャピラリーアレイを使用したスクリーニングのための方法およびシステム |
| JP7208902B2 (ja) | 2016-12-30 | 2023-01-19 | エクセラ・バイオサイエンシーズ・インコーポレイテッド | マルチステージサンプル回収システム |
| EP3635112A2 (en) | 2017-06-06 | 2020-04-15 | Zymergen, Inc. | A htp genomic engineering platform for improving fungal strains |
| US12025276B2 (en) * | 2018-01-09 | 2024-07-02 | Cryoport, Inc. | Cryosphere |
| US11268655B2 (en) | 2018-01-09 | 2022-03-08 | Cryoport, Inc. | Cryosphere |
| KR20210018219A (ko) | 2018-06-06 | 2021-02-17 | 지머젠 인코포레이티드 | 발효 및 생산 중 곰팡이 형태를 제어하기 위한 신호 전달에 포함된 유전자의 조작 |
| KR102275961B1 (ko) * | 2018-08-30 | 2021-07-12 | 이옥재 | 서로 다른 배양 환경이 조성되는 배양공간을 구비한 배양조 |
| EP4371930B1 (en) | 2018-12-06 | 2025-08-20 | Xcella Biosciences, Inc. | Lateral loading of microcapillary arrays |
| US11591562B2 (en) * | 2018-12-18 | 2023-02-28 | Billups-Rothenberg, Inc. | Modular oxygen monitor |
| WO2021050796A1 (en) * | 2019-09-12 | 2021-03-18 | Corning Incorporated | Kits and methods for temperature maintenance and shipment integrity of cell cultures during transportation |
| US11479779B2 (en) | 2020-07-31 | 2022-10-25 | Zymergen Inc. | Systems and methods for high-throughput automated strain generation for non-sporulating fungi |
| LU102014B1 (en) * | 2020-08-25 | 2022-02-25 | Toby Overmaat | Micro-Thermocycler |
| CN113512494B (zh) * | 2021-05-06 | 2024-03-22 | 中国科学院上海高等研究院 | 一种细胞微流控培养芯片 |
| US12099012B2 (en) * | 2021-05-06 | 2024-09-24 | The Regents Of The University Of California | Remote microscopy for biological sciences |
| CN113564046B (zh) * | 2021-07-22 | 2023-08-22 | 深圳先进技术研究院 | 细胞表型控制装置的辅助拆装机构及拆装系统 |
| KR102582690B1 (ko) * | 2021-08-10 | 2023-09-25 | 인제대학교 산학협력단 | 3d 형태의 오가노이드 배양 장치 및 이를 이용한 오가노이드 배양 방법 |
| CN114574317B (zh) * | 2022-01-25 | 2024-04-09 | 长春中医药大学 | 多层细胞培养板的压装装置 |
| CN116200257B (zh) * | 2023-03-10 | 2023-08-11 | 赛赋(北京)检测技术服务有限公司 | 一种细胞增殖智能化检测试剂盒及其使用方法 |
| CN220166197U (zh) * | 2023-04-17 | 2023-12-12 | 小鳄生物技术(苏州)有限公司 | 一种微孔板的防挥发组件 |
| EP4520814A1 (en) * | 2023-09-05 | 2025-03-12 | GSI Helmholtzzentrum für Schwerionenforschung GmbH | Chamber for culturing cells in a controlled gas environment |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6114674A (en) * | 1996-10-04 | 2000-09-05 | Mcdonnell Douglas Corporation | Multilayer circuit board with electrically resistive heating element |
| US20010050276A1 (en) * | 2000-06-13 | 2001-12-13 | Shimadzu Corporation | Automatic temperature control device |
| US20030044969A1 (en) * | 2000-02-02 | 2003-03-06 | Shin Hon Siu | Thermal cycling device with mechanism for ejecting sample well trays |
| US20060024209A1 (en) * | 2004-07-30 | 2006-02-02 | Agnew Brian J | Apparatus, methods, and kits for assaying a plurality of fluid samples for a common analyte |
| US20060191893A1 (en) * | 1998-10-29 | 2006-08-31 | Applera Corporation | Manually-operable multi-well microfiltration apparatus and method |
| US20080220481A1 (en) * | 2005-09-06 | 2008-09-11 | Finnzymes Instruments Oy | Sample Plate Assembly and Method of Processing Biological Samples |
| US20100008828A1 (en) * | 2008-07-11 | 2010-01-14 | Bambi Lyn Cahilly | Well plate seal structure |
| US20100173400A1 (en) * | 1997-03-28 | 2010-07-08 | Life Technologies Corporation | Thermal Cycler for PCR |
| US20140273191A1 (en) * | 2013-03-15 | 2014-09-18 | New Renaissance Institute | Cell Incubator and Cellular Culture Laboratory Test bed |
| US9081001B2 (en) * | 2012-05-15 | 2015-07-14 | Wellstat Diagnostics, Llc | Diagnostic systems and instruments |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57100900A (en) | 1980-12-17 | 1982-06-23 | Aida Eng Ltd | Automatic setter for balance pressure in press machine |
| US4701415A (en) | 1984-03-02 | 1987-10-20 | Mallinckrodt, Inc. | Controlled atmosphere enclosure |
| US5484731A (en) | 1993-05-26 | 1996-01-16 | Becton, Dickinson And Company | Multiwell in-vitro fertilization plate |
| US5882918A (en) | 1995-08-08 | 1999-03-16 | Genespan Corporation | Cell culture incubator |
| BE1010984A3 (nl) | 1995-02-17 | 1999-03-02 | Praet Peter Van | Incubator voor microtiter plaat. |
| US6054100A (en) | 1996-11-18 | 2000-04-25 | Robbins Scientific Corporation | Apparatus for multi-well microscale synthesis |
| CA2285377C (en) * | 1997-03-28 | 2004-08-17 | The Perkin-Elmer Corporation | Improvements in thermal cycler for pcr |
| US5961925A (en) * | 1997-09-22 | 1999-10-05 | Bristol-Myers Squibb Company | Apparatus for synthesis of multiple organic compounds with pinch valve block |
| US6037168A (en) | 1997-12-31 | 2000-03-14 | Cytonix Corporation | Microbiological assembly comprising resealable closure means |
| WO1999054031A1 (en) * | 1998-04-23 | 1999-10-28 | Otter Coast Automation, Inc. | Method and apparatus for synthesis of libraries of organic compounds |
| US5952219A (en) | 1998-08-17 | 1999-09-14 | Zamoyski; Mark | Apparatus for culturing and harvesting fungal spores |
| US7135146B2 (en) | 2000-10-11 | 2006-11-14 | Innovadyne Technologies, Inc. | Universal non-contact dispense peripheral apparatus and method for a primary liquid handling device |
| US6682703B2 (en) | 2001-09-05 | 2004-01-27 | Irm, Llc | Parallel reaction devices |
| JP4169693B2 (ja) | 2001-09-07 | 2008-10-22 | イノベイダイン・テクノロジーズ・インコーポレーテッド | 液体ハンドリングシステムのための２次液体ディスペンシングモジュール |
| EP1291074A1 (en) | 2001-09-07 | 2003-03-12 | F. Hoffmann-La Roche Ag | Reaction block for parallel synthetic chemistry and vessel therefor |
| US7312071B2 (en) | 2001-12-06 | 2007-12-25 | Arbor Vita Corporation | Effective monitoring system for anthrax smallpox, or other pathogens |
| CA2480728A1 (en) | 2002-04-01 | 2003-10-16 | Fluidigm Corporation | Microfluidic particle-analysis systems |
| US20040151621A1 (en) * | 2003-01-24 | 2004-08-05 | Fuji Photo Film Co., Ltd. | Incubator |
| JP2004313028A (ja) * | 2003-04-11 | 2004-11-11 | Hitachi Ltd | 生物発光測定装置及び細胞内ａｔｐ測定キット |
| TWM249914U (en) * | 2003-12-17 | 2004-11-11 | Exon Science Inc | Fast opening/closing gate for biochemical facility |
| EP1609850A1 (en) | 2004-06-24 | 2005-12-28 | Biovir v/Jacob Mollenbach | Culture dish for culturing biological cells |
| FI117899B (fi) | 2004-07-09 | 2007-04-13 | Chip Man Technologies Oy | Solujen kasvatusalusta ja sen käyttö |
| US9637715B2 (en) | 2005-07-07 | 2017-05-02 | Emd Millipore Corporation | Cell culture and invasion assay method and system |
| US20100009335A1 (en) * | 2006-02-07 | 2010-01-14 | Victor Joseph | Temperature-regulated culture plates |
| JP4809791B2 (ja) | 2007-02-28 | 2011-11-09 | 日立アロカメディカル株式会社 | サンプル処理装置、サンプル容器、および、流動制御機構 |
| JP5590599B2 (ja) * | 2007-03-13 | 2014-09-17 | ザ・プロウボウスト・フェロウズ・ファウンデーション・スカラーズ・アンド・ザ・アザー・メンバーズ・オブ・ボード・オブ・ザ・カレッジ・オブ・ザ・ホリー・アンド・アンデバイデッド・トリニティ・オブ・クイーン・エリザベス・ニア・ダブリン | マルチウエルプレート |
| JP3133920U (ja) * | 2007-05-17 | 2007-07-26 | マイクロニクス株式会社 | マイクロプレートシール装置、シール膜、及びシールされたマイクロプレート |
| CA2691793A1 (en) * | 2007-06-29 | 2009-01-08 | Cellular Dynamics International, Inc. | Automated method and apparatus for embryonic stem cell culture |
| JP2009201509A (ja) * | 2008-02-01 | 2009-09-10 | Kunio Isono | 透明導電膜加工からなる培養容器とその製造方法 |
| EP2257376A1 (en) | 2008-02-20 | 2010-12-08 | ETH Zurich | Multiwell culture plate for three-dimensional cultures |
| JP5242223B2 (ja) * | 2008-04-07 | 2013-07-24 | オリンパス株式会社 | 培養観察装置 |
| JP5097618B2 (ja) * | 2008-05-29 | 2012-12-12 | 三洋電機株式会社 | インキュベータ |
| SG174435A1 (en) | 2009-03-26 | 2011-10-28 | Agency Science Tech & Res | Apparatus for cell or tissue culture |
| DE102009022354B4 (de) * | 2009-05-15 | 2015-05-07 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Bioreaktorsystem |
| GB0910330D0 (en) * | 2009-06-16 | 2009-07-29 | Univ Leiden | A biological microfluidics chip and related methods |
| JP2011000079A (ja) | 2009-06-19 | 2011-01-06 | Univ Of Tokyo | 粒子を操作する方法及びマイクロ流体装置 |
| KR101103031B1 (ko) | 2010-07-13 | 2012-01-05 | 강연균 | 냉장 시약장 |
| WO2014081840A1 (en) | 2012-11-21 | 2014-05-30 | Vanderbilt University | Organ on chip integration and applications of the same |
| WO2012127523A1 (ja) | 2011-03-22 | 2012-09-27 | 株式会社東海ヒット | 顕微鏡観察用培養装置およびその使用方法 |
| JP5707253B2 (ja) | 2011-06-27 | 2015-04-22 | 株式会社日立ハイテクノロジーズ | 冷却試薬保管庫及び核酸分析装置 |
| CN102719352B (zh) | 2012-06-06 | 2014-01-29 | 西安交通大学 | 一种用于制备微阵列细胞芯片的细胞芯片片基及制备方法 |
| US20140178158A1 (en) * | 2012-12-06 | 2014-06-26 | Michael Mermelstein | Robotic instrument rack |
| EP2948776B8 (en) * | 2013-01-25 | 2020-02-26 | Xcell Biosciences, Inc. | Methods, compositions, kits, and systems for selective enrichment of target cells |
| US20160139109A1 (en) * | 2013-06-26 | 2016-05-19 | Valitacell Limited | A Method of Determining or Predicting a Characteristic of a Cell |
| US9279801B2 (en) * | 2013-07-26 | 2016-03-08 | Axion Biosystems, Inc. | Devices, systems and methods for high-throughput electrophysiology |
| CN111638115A (zh) | 2014-05-16 | 2020-09-08 | 比奥利弗解决方案公司 | 用于自动样品解冻的系统、装置和方法 |
| TWI737631B (zh) | 2015-10-01 | 2021-09-01 | 美商柏克萊燈光有限公司 | 多槽盤培養器 |
-
2017
- 2017-12-01 AU AU2017366733A patent/AU2017366733B2/en active Active
- 2017-12-01 JP JP2019529609A patent/JP6968169B2/ja active Active
- 2017-12-01 IL IL267010A patent/IL267010B2/en unknown
- 2017-12-01 CN CN201780085368.4A patent/CN110366591A/zh active Pending
- 2017-12-01 WO PCT/US2017/064357 patent/WO2018102781A1/en not_active Ceased
- 2017-12-01 KR KR1020197018720A patent/KR102546384B1/ko active Active
- 2017-12-01 EP EP17876916.2A patent/EP3548602B1/en active Active
- 2017-12-01 CA CA3045898A patent/CA3045898A1/en active Pending
-
2019
- 2019-05-31 US US16/427,952 patent/US11434462B2/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6114674A (en) * | 1996-10-04 | 2000-09-05 | Mcdonnell Douglas Corporation | Multilayer circuit board with electrically resistive heating element |
| US20100173400A1 (en) * | 1997-03-28 | 2010-07-08 | Life Technologies Corporation | Thermal Cycler for PCR |
| US20060191893A1 (en) * | 1998-10-29 | 2006-08-31 | Applera Corporation | Manually-operable multi-well microfiltration apparatus and method |
| US20030044969A1 (en) * | 2000-02-02 | 2003-03-06 | Shin Hon Siu | Thermal cycling device with mechanism for ejecting sample well trays |
| US20010050276A1 (en) * | 2000-06-13 | 2001-12-13 | Shimadzu Corporation | Automatic temperature control device |
| US20060024209A1 (en) * | 2004-07-30 | 2006-02-02 | Agnew Brian J | Apparatus, methods, and kits for assaying a plurality of fluid samples for a common analyte |
| US20080220481A1 (en) * | 2005-09-06 | 2008-09-11 | Finnzymes Instruments Oy | Sample Plate Assembly and Method of Processing Biological Samples |
| US20100008828A1 (en) * | 2008-07-11 | 2010-01-14 | Bambi Lyn Cahilly | Well plate seal structure |
| US9081001B2 (en) * | 2012-05-15 | 2015-07-14 | Wellstat Diagnostics, Llc | Diagnostic systems and instruments |
| US20140273191A1 (en) * | 2013-03-15 | 2014-09-18 | New Renaissance Institute | Cell Incubator and Cellular Culture Laboratory Test bed |
Non-Patent Citations (1)
| Title |
|---|
| RYAN, JOHN A., CORNING GUIDE FOR IDENTIFYING AND CORRECTING COMMON CELL GROWTH PROBLEMS., 31 December 2012 (2012-12-31) * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3548602A4 (en) | 2020-07-15 |
| AU2017366733B2 (en) | 2022-09-15 |
| WO2018102781A1 (en) | 2018-06-07 |
| JP6968169B2 (ja) | 2021-11-17 |
| IL267010A (en) | 2019-07-31 |
| EP3548602A1 (en) | 2019-10-09 |
| US11434462B2 (en) | 2022-09-06 |
| CA3045898A1 (en) | 2018-06-07 |
| CN110366591A (zh) | 2019-10-22 |
| KR102546384B1 (ko) | 2023-06-21 |
| IL267010B1 (en) | 2024-07-01 |
| JP2020500534A (ja) | 2020-01-16 |
| KR20190086549A (ko) | 2019-07-22 |
| US20200017817A1 (en) | 2020-01-16 |
| AU2017366733A1 (en) | 2019-06-20 |
| EP3548602B1 (en) | 2024-09-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12286614B2 (en) | Well plate incubator | |
| US11434462B2 (en) | Well-plate incubator | |
| HK40062693A (en) | Well-plate incubator | |
| HK40012476A (en) | Well-plate incubator | |
| HK1259275B (zh) | 井孔板培养器 |