IL265599A - RNA-directed amino acid-modifying enzymes and methods of using them - Google Patents
RNA-directed amino acid-modifying enzymes and methods of using themInfo
- Publication number
- IL265599A IL265599A IL265599A IL26559919A IL265599A IL 265599 A IL265599 A IL 265599A IL 265599 A IL265599 A IL 265599A IL 26559919 A IL26559919 A IL 26559919A IL 265599 A IL265599 A IL 265599A
- Authority
- IL
- Israel
- Prior art keywords
- rna
- methods
- nucleic acid
- modifying enzymes
- acid modifying
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Materials For Medical Uses (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662402849P | 2016-09-30 | 2016-09-30 | |
PCT/US2017/054047 WO2018064352A1 (en) | 2016-09-30 | 2017-09-28 | Rna-guided nucleic acid modifying enzymes and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
IL265599A true IL265599A (en) | 2019-05-30 |
Family
ID=61760117
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL265599A IL265599A (en) | 2016-09-30 | 2019-03-25 | RNA-directed amino acid-modifying enzymes and methods of using them |
Country Status (13)
Country | Link |
---|---|
US (2) | US11371062B2 (de) |
EP (1) | EP3532089A4 (de) |
JP (2) | JP7306696B2 (de) |
KR (2) | KR20190072548A (de) |
CN (1) | CN110418647A (de) |
AU (1) | AU2017335883B2 (de) |
BR (1) | BR112019006388A2 (de) |
CA (1) | CA3038982A1 (de) |
EA (1) | EA201990860A1 (de) |
GB (1) | GB2569734B (de) |
IL (1) | IL265599A (de) |
MX (1) | MX2019003678A (de) |
WO (1) | WO2018064352A1 (de) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2853829C (en) | 2011-07-22 | 2023-09-26 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
US9340800B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | Extended DNA-sensing GRNAS |
US20150166982A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting pi3k point mutations |
US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
WO2016073990A2 (en) | 2014-11-07 | 2016-05-12 | Editas Medicine, Inc. | Methods for improving crispr/cas-mediated genome-editing |
CA2986310A1 (en) | 2015-05-11 | 2016-11-17 | Editas Medicine, Inc. | Optimized crispr/cas9 systems and methods for gene editing in stem cells |
JP7396783B2 (ja) | 2015-06-09 | 2023-12-12 | エディタス・メディシン、インコーポレイテッド | 移植を改善するためのcrispr/cas関連方法および組成物 |
CA2999500A1 (en) | 2015-09-24 | 2017-03-30 | Editas Medicine, Inc. | Use of exonucleases to improve crispr/cas-mediated genome editing |
EP4269577A3 (de) | 2015-10-23 | 2024-01-17 | President and Fellows of Harvard College | Nukleobaseeditoren und deren verwendungen |
WO2017165826A1 (en) | 2016-03-25 | 2017-09-28 | Editas Medicine, Inc. | Genome editing systems comprising repair-modulating enzyme molecules and methods of their use |
EP4047092A1 (de) | 2016-04-13 | 2022-08-24 | Editas Medicine, Inc. | Cas9-fusionsmoleküle, geneditierungssysteme und verfahren zur verwendung davon |
US10337051B2 (en) | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
SG11201900907YA (en) | 2016-08-03 | 2019-02-27 | Harvard College | Adenosine nucleobase editors and uses thereof |
WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
EA201990861A1 (ru) | 2016-09-30 | 2019-09-30 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Рнк-направляемые модифицирующие нуклеиновые кислоты ферменты и способы их применения |
CA3038982A1 (en) | 2016-09-30 | 2018-04-05 | The Regents Of The University Of California | Rna-guided nucleic acid modifying enzymes and methods of use thereof |
CN110214180A (zh) | 2016-10-14 | 2019-09-06 | 哈佛大学的校长及成员们 | 核碱基编辑器的aav递送 |
US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
US20180201921A1 (en) * | 2017-01-18 | 2018-07-19 | Excision Biotherapeutics, Inc. | CRISPRs |
US10995333B2 (en) * | 2017-02-06 | 2021-05-04 | 10X Genomics, Inc. | Systems and methods for nucleic acid preparation |
EP3592853A1 (de) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Unterdrückung von schmerzen durch geneditierung |
EP3592777A1 (de) | 2017-03-10 | 2020-01-15 | President and Fellows of Harvard College | Cytosin-zu-guanin-baseneditor |
CN110914426A (zh) | 2017-03-23 | 2020-03-24 | 哈佛大学的校长及成员们 | 包含核酸可编程dna结合蛋白的核碱基编辑器 |
WO2018201086A1 (en) | 2017-04-28 | 2018-11-01 | Editas Medicine, Inc. | Methods and systems for analyzing guide rna molecules |
WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
CN110997908A (zh) | 2017-06-09 | 2020-04-10 | 爱迪塔斯医药公司 | 工程化的cas9核酸酶 |
EP3652312A1 (de) | 2017-07-14 | 2020-05-20 | Editas Medicine, Inc. | Systeme und verfahren zur gezielten integration und genomeditierung und deren detektion unter verwendung von integrierten bindungsstellen |
WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
JP2021500036A (ja) | 2017-10-16 | 2021-01-07 | ザ ブロード インスティテュート, インコーポレーテッドThe Broad Institute, Inc. | アデノシン塩基編集因子の使用 |
CN117487776A (zh) | 2017-11-01 | 2024-02-02 | 加利福尼亚大学董事会 | Casz组合物和使用方法 |
WO2019089808A1 (en) * | 2017-11-01 | 2019-05-09 | The Regents Of The University Of California | Class 2 crispr/cas compositions and methods of use |
US11807877B1 (en) | 2018-03-22 | 2023-11-07 | National Technology & Engineering Solutions Of Sandia, Llc | CRISPR/Cas activity assays and compositions thereof |
JP2021521825A (ja) * | 2018-04-24 | 2021-08-30 | リガンダル・インコーポレイテッド | ゲノム編集方法及び組成物 |
WO2019214604A1 (zh) * | 2018-05-07 | 2019-11-14 | 中国农业大学 | CRISPR/Cas效应蛋白及系统 |
AU2019282812A1 (en) | 2018-06-07 | 2020-12-17 | Arc Bio, Llc | Compositions and methods for making guide nucleic acids |
WO2020023529A1 (en) * | 2018-07-24 | 2020-01-30 | The Regents Of The University Of California | Rna-guided nucleic acid modifying enzymes and methods of use thereof |
EP3830301B1 (de) | 2018-08-01 | 2024-05-22 | Mammoth Biosciences, Inc. | Programmierbare nuklease-zusammensetzungen und verwendungsverfahren dafür |
EP3931313A2 (de) | 2019-01-04 | 2022-01-05 | Mammoth Biosciences, Inc. | Verbesserungen an programmierbarer nuklease und zusammensetzungen und verfahren zur nukleinsäureamplifikation und -detektion |
MX2021008487A (es) * | 2019-01-14 | 2021-11-12 | Univ Rochester | Escisión y poliadenilación del arn nuclear dirigido con crispr-cas. |
MX2021010559A (es) | 2019-03-07 | 2021-12-15 | Univ California | Polipéptidos efectores de crispr-cas y métodos de uso de estos. |
BR112021018607A2 (pt) | 2019-03-19 | 2021-11-23 | Massachusetts Inst Technology | Métodos e composições para editar sequências de nucleotídeos |
CA3158403A1 (en) * | 2019-12-23 | 2021-07-01 | Jennifer A. Doudna | Crispr-cas effector polypeptides and methods of use thereof |
KR102651824B1 (ko) * | 2020-01-31 | 2024-03-27 | 현대모비스 주식회사 | 루프 에어백 장치 |
WO2021216772A1 (en) * | 2020-04-21 | 2021-10-28 | Mammoth Biosciences, Inc. | Casy programmable nucleases and rna component systems |
CN116096873A (zh) | 2020-05-08 | 2023-05-09 | 布罗德研究所股份有限公司 | 同时编辑靶标双链核苷酸序列的两条链的方法和组合物 |
EP4267743A2 (de) | 2020-12-22 | 2023-11-01 | Chroma Medicine, Inc. | Zusammensetzungen und verfahren zur epigenetischen bearbeitung |
CN113151387B (zh) * | 2021-04-16 | 2022-08-16 | 安徽国肽生物科技有限公司 | 一种具有抗氧化和增强免疫功能的鳕鱼皮胶原蛋白肽及其制备方法 |
US20230023791A1 (en) | 2021-06-01 | 2023-01-26 | Arbor Biotechnologies, Inc. | Gene editing systems comprising a crispr nuclease and uses thereof |
US11814689B2 (en) | 2021-07-21 | 2023-11-14 | Montana State University | Nucleic acid detection using type III CRISPR complex |
CN114921439B (zh) * | 2022-06-16 | 2024-04-26 | 尧唐(上海)生物科技有限公司 | CRISPR-Cas效应子蛋白、其基因编辑系统及应用 |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004521606A (ja) | 2000-05-24 | 2004-07-22 | サード・ウェーブ・テクノロジーズ・インク | Rnaの検出法 |
US6773885B1 (en) | 2000-09-29 | 2004-08-10 | Integrated Dna Technologies, Inc. | Compositions and methods for visual ribonuclease detection assays |
US9689031B2 (en) | 2007-07-14 | 2017-06-27 | Ionian Technologies, Inc. | Nicking and extension amplification reaction for the exponential amplification of nucleic acids |
WO2011100749A2 (en) | 2010-02-15 | 2011-08-18 | Cascade Biosystems, Inc. | Methods and materials for detecting viral or microbial infections |
US20130261196A1 (en) | 2010-06-11 | 2013-10-03 | Lisa Diamond | Nucleic Acids For Multiplex Organism Detection and Methods Of Use And Making The Same |
US9730967B2 (en) | 2011-02-04 | 2017-08-15 | Katherine Rose Kovarik | Method and system for treating cancer cachexia |
US8815782B2 (en) | 2011-11-11 | 2014-08-26 | Agilent Technologies, Inc. | Use of DNAzymes for analysis of an RNA sample |
MX362866B (es) * | 2012-05-25 | 2019-02-20 | Univ California | Metodos y composiciones para la modificacion de adn objetivo dirigida por arn y para la modulacion de la transcripcion dirigida por arn. |
JP2016519652A (ja) | 2013-03-14 | 2016-07-07 | カリブー・バイオサイエンシーズ・インコーポレイテッド | 核酸ターゲティング核酸の組成物および方法 |
US9234213B2 (en) | 2013-03-15 | 2016-01-12 | System Biosciences, Llc | Compositions and methods directed to CRISPR/Cas genomic engineering systems |
JP2016537028A (ja) | 2013-11-18 | 2016-12-01 | クリスパー セラピューティクス アーゲー | Crispr−casシステムの材料及び方法 |
EP3080266B1 (de) * | 2013-12-12 | 2021-02-03 | The Regents of The University of California | Verfahren und zusammensetzungen zur modifizierung einer einzelsträngigen zielnukleinsäure |
WO2015116686A1 (en) | 2014-01-29 | 2015-08-06 | Agilent Technologies, Inc. | Cas9-based isothermal method of detection of specific dna sequence |
WO2015139139A1 (en) | 2014-03-20 | 2015-09-24 | UNIVERSITé LAVAL | Crispr-based methods and products for increasing frataxin levels and uses thereof |
US10253311B2 (en) | 2014-04-10 | 2019-04-09 | The Regents Of The University Of California | Methods and compositions for using argonaute to modify a single stranded target nucleic acid |
CA2951707A1 (en) | 2014-06-10 | 2015-12-17 | Massachusetts Institute Of Technology | Method for gene editing |
CN107075546B (zh) | 2014-08-19 | 2021-08-31 | 哈佛学院董事及会员团体 | 用于对核酸探测并作图的rna-引导的系统 |
WO2016094872A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Dead guides for crispr transcription factors |
EP3985115A1 (de) | 2014-12-12 | 2022-04-20 | The Broad Institute, Inc. | Geschützte guide-rnas (pgrnas) |
WO2016106236A1 (en) | 2014-12-23 | 2016-06-30 | The Broad Institute Inc. | Rna-targeting system |
WO2016123243A1 (en) | 2015-01-28 | 2016-08-04 | The Regents Of The University Of California | Methods and compositions for labeling a single-stranded target nucleic acid |
TWI813532B (zh) | 2015-06-18 | 2023-09-01 | 美商博得學院股份有限公司 | 降低脱靶效應的crispr酶突變 |
CA3012607A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Crispr enzymes and systems |
US9790490B2 (en) * | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
EP4159856A1 (de) | 2015-06-18 | 2023-04-05 | The Broad Institute, Inc. | Neuartige crispr-enzyme und systeme |
US9580727B1 (en) | 2015-08-07 | 2017-02-28 | Caribou Biosciences, Inc. | Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides |
US20170211142A1 (en) | 2015-10-22 | 2017-07-27 | The Broad Institute, Inc. | Novel crispr enzymes and systems |
EP3400299B1 (de) | 2016-01-08 | 2020-11-11 | University of Georgia Research Foundation, Inc. | Verfahren zur spaltung von dns- und rns-molekülen |
US11441146B2 (en) | 2016-01-11 | 2022-09-13 | Christiana Care Health Services, Inc. | Compositions and methods for improving homogeneity of DNA generated using a CRISPR/Cas9 cleavage system |
US9896696B2 (en) | 2016-02-15 | 2018-02-20 | Benson Hill Biosystems, Inc. | Compositions and methods for modifying genomes |
US20190024075A1 (en) | 2016-02-23 | 2019-01-24 | Arc Bio, Llc | Methods and compositions for target detection |
US20190093091A1 (en) | 2016-04-06 | 2019-03-28 | Temple University - Of The Commonwealth System Of Higher Education | Compositions for eradicating flavivirus infections in subjects |
WO2017205668A1 (en) | 2016-05-25 | 2017-11-30 | Arizona Board Of Regents On Behalf Of Arizona State University | Portable, low-cost pathogen detection and strain identification platform |
US10337051B2 (en) | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
KR20230156150A (ko) | 2016-06-17 | 2023-11-13 | 더 브로드 인스티튜트, 인코퍼레이티드 | 제vi형 crispr 오솔로그 및 시스템 |
US10017760B2 (en) | 2016-06-24 | 2018-07-10 | Inscripta, Inc. | Methods for generating barcoded combinatorial libraries |
US20210166783A1 (en) | 2016-08-17 | 2021-06-03 | The Broad Institute, Inc. | Methods for identifying class 2 crispr-cas systems |
EA201990861A1 (ru) | 2016-09-30 | 2019-09-30 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Рнк-направляемые модифицирующие нуклеиновые кислоты ферменты и способы их применения |
CA3038982A1 (en) | 2016-09-30 | 2018-04-05 | The Regents Of The University Of California | Rna-guided nucleic acid modifying enzymes and methods of use thereof |
CN106701830B (zh) | 2016-12-07 | 2020-01-03 | 湖南人文科技学院 | 一种敲除猪胚胎p66shc基因的方法 |
BR112018015871B1 (pt) | 2016-12-09 | 2021-12-07 | The Broad Institute, Inc. | Sistema, método e dispositivo para detectar a presença de uma sequência alvo de ácido nucleico em uma amostra |
CA3059956A1 (en) | 2017-04-21 | 2018-10-25 | The General Hospital Corporation | Variants of cpf1 (cas12a) with altered pam specificity |
KR102631985B1 (ko) | 2017-08-09 | 2024-02-01 | 라이스텍, 인크. | 게놈을 변형시키기 위한 조성물 및 방법 |
WO2019089796A1 (en) | 2017-11-01 | 2019-05-09 | The Regents Of The University Of California | Cas12c compositions and methods of use |
US20200255858A1 (en) | 2017-11-01 | 2020-08-13 | Jillian F. Banfield | Casy compositions and methods of use |
WO2019089808A1 (en) | 2017-11-01 | 2019-05-09 | The Regents Of The University Of California | Class 2 crispr/cas compositions and methods of use |
CN117487776A (zh) | 2017-11-01 | 2024-02-02 | 加利福尼亚大学董事会 | Casz组合物和使用方法 |
US10253365B1 (en) | 2017-11-22 | 2019-04-09 | The Regents Of The University Of California | Type V CRISPR/Cas effector proteins for cleaving ssDNAs and detecting target DNAs |
US20210108267A1 (en) | 2017-12-22 | 2021-04-15 | The Broad Institute, Inc. | Crispr effector system based multiplex diagnostics |
-
2017
- 2017-09-28 CA CA3038982A patent/CA3038982A1/en active Pending
- 2017-09-28 GB GB1905581.3A patent/GB2569734B/en active Active
- 2017-09-28 CN CN201780074122.7A patent/CN110418647A/zh active Pending
- 2017-09-28 JP JP2019517246A patent/JP7306696B2/ja active Active
- 2017-09-28 AU AU2017335883A patent/AU2017335883B2/en active Active
- 2017-09-28 WO PCT/US2017/054047 patent/WO2018064352A1/en active Application Filing
- 2017-09-28 KR KR1020197012246A patent/KR20190072548A/ko not_active IP Right Cessation
- 2017-09-28 KR KR1020237041560A patent/KR20230169449A/ko not_active Application Discontinuation
- 2017-09-28 US US16/335,630 patent/US11371062B2/en active Active
- 2017-09-28 MX MX2019003678A patent/MX2019003678A/es unknown
- 2017-09-28 EA EA201990860A patent/EA201990860A1/ru unknown
- 2017-09-28 BR BR112019006388A patent/BR112019006388A2/pt unknown
- 2017-09-28 EP EP17857432.3A patent/EP3532089A4/de active Pending
-
2019
- 2019-03-25 IL IL265599A patent/IL265599A/en unknown
-
2022
- 2022-05-19 US US17/749,017 patent/US20220396812A1/en active Pending
- 2022-12-19 JP JP2022202406A patent/JP2023030067A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP7306696B2 (ja) | 2023-07-11 |
GB2569734A (en) | 2019-06-26 |
MX2019003678A (es) | 2020-08-13 |
GB201905581D0 (en) | 2019-06-05 |
GB2569734B (en) | 2022-09-07 |
JP2019534695A (ja) | 2019-12-05 |
EP3532089A1 (de) | 2019-09-04 |
WO2018064352A1 (en) | 2018-04-05 |
EA201990860A1 (ru) | 2019-10-31 |
BR112019006388A2 (pt) | 2019-06-25 |
AU2017335883B2 (en) | 2024-06-13 |
JP2023030067A (ja) | 2023-03-07 |
KR20230169449A (ko) | 2023-12-15 |
CN110418647A (zh) | 2019-11-05 |
AU2017335883A1 (en) | 2019-04-11 |
US20190300908A1 (en) | 2019-10-03 |
KR20190072548A (ko) | 2019-06-25 |
US11371062B2 (en) | 2022-06-28 |
US20220396812A1 (en) | 2022-12-15 |
CA3038982A1 (en) | 2018-04-05 |
EP3532089A4 (de) | 2020-05-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL265598A (en) | Enzymes that modify RNA-directed nucleic acids and methods for using them | |
IL265599A (en) | RNA-directed amino acid-modifying enzymes and methods of using them | |
PT3568475T (pt) | Solução de preservação de ácido nucleico e métodos de utilização | |
IL264439A (en) | Nucleic acid products and methods of administering them | |
IL288263A (en) | CRISPR DNA/RNA hybrid polynucleotides and methods for using them | |
ZA201807001B (en) | Acrylic acid, and methods of producing thereof | |
EP3500355A4 (de) | Bioreaktor und verfahren zur verwendung davon | |
EP3416671A4 (de) | Nukleinsäureträger und therapeutische verfahren zur verwendung | |
IL282233A (en) | Nucleic acid structures and methods of use | |
EP3374494A4 (de) | Crispr-zusammensetzungen und verfahren zur verwendung davon zur gentherapie | |
EP3303634A4 (de) | Cas9-varianten und verfahren zur verwendung davon | |
EP3307762A4 (de) | Reporter-cas9-varianten und verfahren zur verwendung davon | |
EP3328399A4 (de) | Modifizierte zellen und therapieverfahren | |
LT3447137T (lt) | Skystas fermento preparatas ir jo gamybos būdas | |
EP3256585A4 (de) | Nukleinsäureprodukte und verabreichungsverfahren dafür | |
EP3416691A4 (de) | Nukleinsäureträger und therapeutische verfahren zur verwendung | |
IL268750A (en) | Nucleic acid structures containing many sites for gene editing and their uses | |
IL279272A (en) | Nucleic acid constructs and methods of using them | |
EP3390676A4 (de) | Auslaugungshilfen und verfahren zur verwendung von auslaugungshilfen | |
PL3510159T3 (pl) | Geny pestycydowe i sposoby stosowania | |
EP3212792A4 (de) | Nukleinsäuremodifikatoren und verwendungen davon | |
HK1245337A1 (zh) | 活化的甲酰甘氨酸生成酶及其生成和使用方法 | |
EP3494217A4 (de) | Lmp1-exprimierende zellen und verfahren zur verwendung davon | |
EP3256608A4 (de) | Rna-haltige zusammensetzungen und verfahren zu deren verwendung | |
EP3538667A4 (de) | Verfahren zur stabilisierung und trennung von nukleinsäuren |