IL265129A - - Google Patents

Info

Publication number
IL265129A
IL265129A IL26512919A IL26512919A IL265129A IL 265129 A IL265129 A IL 265129A IL 26512919 A IL26512919 A IL 26512919A IL 26512919 A IL26512919 A IL 26512919A IL 265129 A IL265129 A IL 265129A
Authority
IL
Israel
Application number
IL26512919A
Other languages
English (en)
Other versions
IL265129B1 (en
IL265129B2 (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2017/049689 external-priority patent/WO2018045208A1/en
Publication of IL265129A publication Critical patent/IL265129A/en
Publication of IL265129B1 publication Critical patent/IL265129B1/en
Publication of IL265129B2 publication Critical patent/IL265129B2/en

Links

Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045Devices for taking samples of body liquids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/02Devices for withdrawing samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/62Detectors specially adapted therefor
    • G01N30/72Mass spectrometers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/0027Methods for using particle spectrometers
    • H01J49/0031Step by step routines describing the use of the apparatus
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404Capillaries used for transferring samples or ions
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0605Metering of fluids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0655Valves, specific forms thereof with moving parts pinch valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02Burettes; Pipettes
    • B01L3/0289Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/02Devices for withdrawing samples
    • G01N2001/028Sampling from a surface, swabbing, vaporising
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40Concentrating samples
    • G01N1/4055Concentrating samples by solubility techniques
    • G01N2001/4061Solvent extraction
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00Chemical aspects of mass spectrometric analysis of biological material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Clinical Laboratory Science (AREA)
  • Electrochemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
IL265129A 2016-09-02 2017-08-31 Collection sensor and methods of using it IL265129B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662383234P 2016-09-02 2016-09-02
US201662411321P 2016-10-21 2016-10-21
US201762462524P 2017-02-23 2017-02-23
PCT/US2017/049689 WO2018045208A1 (en) 2016-09-02 2017-08-31 Collection probe and methods for the use thereof

Publications (3)

Publication Number Publication Date
IL265129A true IL265129A (https=) 2019-04-30
IL265129B1 IL265129B1 (en) 2023-10-01
IL265129B2 IL265129B2 (en) 2024-02-01

Family

ID=62243007

Family Applications (1)

Application Number Title Priority Date Filing Date
IL265129A IL265129B2 (en) 2016-09-02 2017-08-31 Collection sensor and methods of using it

Country Status (11)

Country Link
US (6) US10643832B2 (https=)
EP (2) EP4357784A3 (https=)
JP (3) JP7195002B2 (https=)
KR (1) KR102543773B1 (https=)
CN (2) CN113834869B (https=)
AU (1) AU2017318661B2 (https=)
CA (2) CA3035743A1 (https=)
ES (1) ES2971214T3 (https=)
IL (1) IL265129B2 (https=)
MX (1) MX2019002471A (https=)
SG (1) SG11201901866TA (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10643832B2 (en) 2016-09-02 2020-05-05 Board Of Regents, The University Of Texas System Collection probe and methods for the use thereof
US10998179B2 (en) * 2016-10-14 2021-05-04 Dh Technologies Development Pte. Ltd. Methods and systems for increasing sensitivity of direct sampling interfaces for mass spectrometric analysis
US20210343515A1 (en) * 2017-06-08 2021-11-04 Board Of Regents, The University Of Texas System Systems and methods for microarray droplet ionization analysis
US11348780B2 (en) * 2017-11-21 2022-05-31 Dh Technologies Development Pte. Ltd. Methods and systems utilizing ultrasound-assisted sampling interfaces for mass spectrometric analysis
MX2020005448A (es) * 2017-11-27 2020-08-27 Univ Texas Sonda de recoleccion minimamente invasiva y metodos para el uso de esta.
US10147052B1 (en) * 2018-01-29 2018-12-04 C-SATS, Inc. Automated assessment of operator performance
EP3522201B1 (en) * 2018-02-02 2020-10-07 Tofwerk AG Autosampler
US12089932B2 (en) 2018-06-05 2024-09-17 Trace Matters Scientific Llc Apparatus, system, and method for transferring ions
US11219393B2 (en) 2018-07-12 2022-01-11 Trace Matters Scientific Llc Mass spectrometry system and method for analyzing biological samples
US11450519B2 (en) 2018-06-07 2022-09-20 Dh Technologies Development Pte. Ltd. Sampling interface for a mass spectrometer
GB201812561D0 (en) 2018-08-01 2018-09-12 Univ Manchester Biomarkers and uses thereof
EP3647763B1 (en) * 2018-10-29 2021-07-14 FEI Company A method of preparing a biological sample for study in an analysis device
EP3914891B1 (en) * 2019-01-25 2026-04-01 Board of Regents, The University of Texas System Apparatus for cleaning and/or exchanging medical devices
US20220208538A1 (en) * 2019-05-31 2022-06-30 Purdue Research Foundation Integrated microfluidic probe (imfp) and methods of use thereof
KR20220018564A (ko) 2019-06-06 2022-02-15 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 자궁내막증 조직을 식별하기 위한 질량 분광법의 사용
CN114981919A (zh) * 2020-01-14 2022-08-30 Dh科技发展私人贸易有限公司 质量分析方法-控制opp操作溶剂的粘度
GB202001571D0 (en) * 2020-02-05 2020-03-18 Univ Manchester Identification of biomarkers and uses thereof
CN111351831A (zh) * 2020-02-26 2020-06-30 西安交通大学医学院第二附属医院 基于质谱分析组织术中检测、标记设备及其检测方法
AU2021265086A1 (en) * 2020-04-27 2022-12-08 Board Of Regents, The University Of Texas System Detecting chemical compounds for forensic analysis
EP4143872A4 (en) * 2020-04-27 2024-05-01 Board of Regents, The University of Texas System IDENTIFICATION AND CLASSIFICATION OF MICROORGANISMS
JP2023526434A (ja) 2020-05-22 2023-06-21 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 開放ポートサンプリングプローブのための高流率洗浄
JP2023526435A (ja) 2020-05-22 2023-06-21 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 開放ポートサンプリングプローブのための溢流センサ
WO2021252322A1 (en) * 2020-06-12 2021-12-16 Board Of Regents, The University Of Texas System Molecular markers and methods for sample analysis via mass spectrometry
EP4196767A4 (en) * 2020-08-12 2024-09-25 ODS Medical Inc. AUTOMATED RAMAN SIGNAL COLLECTION DEVICE
US20240011999A1 (en) * 2020-08-28 2024-01-11 Board Of Regents, The University Of Texas System Methods for fine needle sample analysis via mass spectrometry
CN112017942B (zh) * 2020-09-04 2021-03-02 中国地质科学院地质研究所 一种提高二次离子探针质谱仪质谱成像空间分辨率的方法
EP4288991A1 (en) * 2021-02-02 2023-12-13 DH Technologies Development Pte. Ltd. Methods and apparatus for washing sampling probe for use in mass spectrometry systems
CN113764257B (zh) * 2021-08-25 2024-01-12 清华大学深圳国际研究生院 一种基于3d打印的解吸电喷雾离子化装置
US11848094B2 (en) 2022-04-08 2023-12-19 Ohio State Innovation Foundation Multidimensional optical tissue classification and display
EP4507825A1 (en) * 2022-04-14 2025-02-19 Board of Regents, The University of Texas System Collection probe and methods of use thereof
CN116169005B (zh) * 2023-02-28 2023-07-28 厦门金诺花科学仪器有限公司 一次性疏水纳升点样针头及点样测试方法
KR102702105B1 (ko) * 2023-10-04 2024-09-06 대한민국 휴대용 dna 검체 채취장치
WO2025085615A1 (en) * 2023-10-17 2025-04-24 Baylor College Of Medicine Methods to rapidly detect methylthioadenosine and related metabolites directly from patient samples to identify 9p21 loss cancers and treatment strategies for patients
CL2024001366A1 (es) * 2024-05-04 2024-12-13 Ignacio Alberto Moscoso Gutierrez Dispositivo analizador de gases de combustión de tejidos humanos

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5152277A (en) 1987-07-23 1992-10-06 Terumo Kabushiki Kaisha Catheter tube
US5711816A (en) 1990-07-06 1998-01-27 Advanced Technolgy Materials, Inc. Source reagent liquid delivery apparatus, and chemical vapor deposition system comprising same
US5119827A (en) 1990-09-05 1992-06-09 Board Of Regents, The University Of Texas System Mechanisms of antiestrogen resistance in breast cancer
US5100402A (en) * 1990-10-05 1992-03-31 Megadyne Medical Products, Inc. Electrosurgical laparoscopic cauterization electrode
US5241990A (en) 1992-07-10 1993-09-07 Inlet Medical, Inc. Irrigation/aspiration valve and probe for laparoscopy
US5470308A (en) 1992-08-12 1995-11-28 Vidamed, Inc. Medical probe with biopsy stylet
US5746720A (en) 1995-10-18 1998-05-05 Stouder, Jr.; Albert E. Method and apparatus for insertion of a cannula and trocar
US5742050A (en) * 1996-09-30 1998-04-21 Aviv Amirav Method and apparatus for sample introduction into a mass spectrometer for improving a sample analysis
US6297499B1 (en) 1997-07-17 2001-10-02 John B Fenn Method and apparatus for electrospray ionization
WO2001033605A2 (en) 1999-10-29 2001-05-10 Rijksuniversiteit Groningen Atmospheric pressure photoionization (appi): a new ionization method for liquid chromatography-mass spectrometry
US6786884B1 (en) 1999-10-29 2004-09-07 Bard Access Systems, Inc. Bolus tip design for a multi-lumen catheter
AU2002245043B2 (en) 2000-11-16 2006-10-26 Bio-Rad Laboratories, Inc. Method for analyzing mass spectra
US6784439B2 (en) 2001-07-19 2004-08-31 Ut Battelle, Llc Thin-channel electrospray emitter
US6756586B2 (en) * 2001-10-15 2004-06-29 Vanderbilt University Methods and apparatus for analyzing biological samples by mass spectrometry
US20040014227A1 (en) 2002-01-04 2004-01-22 Frederick Erik D. Apparatus, method and computer program product for automated high-throughput sampling and data acquisition
US6803566B2 (en) * 2002-04-16 2004-10-12 Ut-Battelle, Llc Sampling probe for microarray read out using electrospray mass spectrometry
JP4095349B2 (ja) * 2002-06-03 2008-06-04 ペンタックス株式会社 蛍光測定装置
US6677593B1 (en) 2002-08-28 2004-01-13 Ut-Battelle, Llc Planar flow-by electrode capacitive electrospray ion source
CA2433205A1 (en) 2003-03-18 2004-09-18 James Alexander Keenan Drug delivery, bodily fluid drainage, and biopsy device with enhanced ultrasonic visibility
US7684934B2 (en) * 2003-06-06 2010-03-23 The United States Of America As Represented By The Department Of Health And Human Services Pattern recognition of whole cell mass spectra
US7335897B2 (en) 2004-03-30 2008-02-26 Purdue Research Foundation Method and system for desorption electrospray ionization
US7588890B2 (en) * 2004-04-16 2009-09-15 Wei-Sing Chu Device for extracting biological molecules from tissue specimens and methods for preparing the same
US7445603B2 (en) 2004-05-12 2008-11-04 Zkz Science Corp. Apparatus for removable distal internal cassette for in situ fixation and specimen processing with serial collection and storage of biopsy specimens
TW200626892A (en) 2004-09-14 2006-08-01 Metara Inc In-process mass spectrometry with sample multiplexing
US20090286305A1 (en) * 2005-04-15 2009-11-19 Wei-Sing Chu Method for non-destructive macromolecule extraction from biological samples on slide
US7295026B2 (en) 2005-06-03 2007-11-13 Ut-Battelle, Llc Automated position control of a surface array relative to a liquid microjunction surface sampler
CA2611591A1 (en) 2005-06-08 2006-12-14 Vanderbilt University Analysis of tissue samples surrounding malignancies
DE102005044307B4 (de) * 2005-09-16 2008-04-17 Bruker Daltonik Gmbh Ionisierung desorbierter Moleküle
US7714276B2 (en) * 2005-09-30 2010-05-11 New York University Methods for direct biomolecule identification by matrix-assisted laser desorption ionization (MALDI) mass spectrometry
CA2867838C (en) 2005-12-14 2016-08-02 Stryker Corporation Medical surgical waste collection and disposal system including a rover and a docker, the docker having features facilitating the alignment of the docker with the rover
US7544933B2 (en) 2006-01-17 2009-06-09 Purdue Research Foundation Method and system for desorption atmospheric pressure chemical ionization
EP2035122A4 (en) 2006-05-26 2010-05-05 Ionsense Inc BENDING SAMPLING SYSTEM WITH OPEN TUBE FOR USE WITH SURFACE TREATMENT TECHNOLOGY
HU226837B1 (hu) 2006-05-31 2009-12-28 Semmelweis Egyetem Folyadéksugárral mûködõ deszorpciós ionizációs eljárás és eszköz
US7800056B2 (en) * 2006-10-26 2010-09-21 Smiths Detection Montreal Inc. Document sampler and method of sampling a document
JP2010511147A (ja) * 2006-11-23 2010-04-08 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 試料における分析物の分離及びmaldi分析のためのデバイス
US7847244B2 (en) * 2006-12-28 2010-12-07 Purdue Research Foundation Enclosed desorption electrospray ionization
WO2008097831A1 (en) * 2007-02-02 2008-08-14 Waters Investments Limited Device and method for analyzing a sample
US20080243141A1 (en) 2007-04-02 2008-10-02 Salvatore Privitera Surgical instrument with separate tool head and method of use
US8803080B2 (en) * 2007-06-02 2014-08-12 Cerno Bioscience Llc Self calibration approach for mass spectrometry
ES2407630T3 (es) 2008-01-03 2013-06-13 Board Of Regents, The University Of Texas System Detección no invasiva del cáncer de vejiga mediante hibridación fluorescente in situ de Aurora A
US20090324617A1 (en) * 2008-01-24 2009-12-31 Glykos Finland Ltd. Cancer specific glycans and use thereof
GB2469244A (en) 2008-01-28 2010-10-06 Univ Singapore Lipid tumour profile
EP2249737B1 (en) 2008-03-03 2020-07-01 Koninklijke Philips N.V. Biopsy guidance by electromagnetic tracking and photonic needle
CA2720862A1 (en) 2008-04-10 2009-10-15 The University Of British Columbia Methods of diagnosing chronic cardiac allograft rejection
US8207494B2 (en) 2008-05-01 2012-06-26 Indiana University Research And Technology Corporation Laser ablation flowing atmospheric-pressure afterglow for ambient mass spectrometry
CA2726072A1 (en) * 2008-05-29 2009-12-23 Universitaetsklinikum Muenster Ion source means for desorption / ionisation of analyte substances an d method of desorbing / ionising of analyte substances
US8084735B2 (en) 2008-09-25 2011-12-27 Ut-Battelle, Llc Pulsed voltage electrospray ion source and method for preventing analyte electrolysis
US8203117B2 (en) 2008-09-30 2012-06-19 Prosolia, Inc. Method and apparatus for embedded heater for desorption and ionization of analytes
EP2380023A2 (en) 2008-12-19 2011-10-26 Medirista Biotechnologies AB Oxidized cardiolipin as a novel pro-inflammatory factor
US20100224013A1 (en) 2009-03-05 2010-09-09 Van Berkel Gary J Method and system for formation and withdrawal of a sample from a surface to be analyzed
WO2010114976A1 (en) 2009-04-01 2010-10-07 Prosolia, Inc. Method and system for surface sampling
US9500572B2 (en) 2009-04-30 2016-11-22 Purdue Research Foundation Sample dispenser including an internal standard and methods of use thereof
US8704167B2 (en) 2009-04-30 2014-04-22 Purdue Research Foundation Mass spectrometry analysis of microorganisms in samples
US8859956B2 (en) 2009-04-30 2014-10-14 Purdue Research Foundation Ion generation using wetted porous material
CA2763145C (en) 2009-05-27 2021-05-25 Medimass Kft System and method for identification of biological tissues
CA2760027A1 (en) 2009-06-03 2010-12-09 Wayne State University Mass spectrometry using laserspray ionization
WO2011022364A1 (en) 2009-08-17 2011-02-24 Temple University Of The Commonwealth System Of Higher Education Vaporization device and method for imaging mass spectrometry
US8546752B2 (en) 2009-12-07 2013-10-01 Advion Inc. Solid-phase extraction (SPE) tips and methods of use
CN102753974A (zh) 2010-02-11 2012-10-24 勒芬天主教大学 磷脂轮廓分析和癌症
US8604423B2 (en) 2010-04-05 2013-12-10 Indiana University Research And Technology Corporation Method for enhancement of mass resolution over a limited mass range for time-of-flight spectrometry
JP5596402B2 (ja) * 2010-04-19 2014-09-24 株式会社日立ハイテクノロジーズ 分析装置、イオン化装置及び分析方法
WO2011140492A2 (en) * 2010-05-07 2011-11-10 Ut-Battelle, Llc System and method for extracting a sample from a surface
CN201811941U (zh) * 2010-05-26 2011-04-27 中国石油化工股份有限公司 液体样品解析电喷雾质谱desi-ms电离装置
EP3955004B1 (en) 2010-06-23 2024-05-29 University of Louisville Research Foundation, Inc. Use of fatty acids in methods for detecting cancer
CA2805249A1 (en) 2010-07-14 2012-01-19 The Regents Of The University Of Colorado, A Body Corporate Methods and systems for in vivo clinical data measurement of analytes
US9153425B2 (en) * 2010-09-01 2015-10-06 Ut-Battelle, Llc Device for high spatial resolution chemical analysis of a sample and method of high spatial resolution chemical analysis
WO2012031082A2 (en) 2010-09-02 2012-03-08 University Of The Sciences In Philadelphia System and method for ionization of molecules for mass spectrometry and ion mobility spectrometry
US8486703B2 (en) * 2010-09-30 2013-07-16 Ut-Battelle, Llc Surface sampling concentration and reaction probe
CN103370627B (zh) * 2010-10-29 2016-05-11 恩姆菲舍尔科技公司 用于样品制备和分析的自动化系统的系统布局
CN103201627B (zh) * 2010-11-08 2016-10-12 丹麦达科有限公司 组织学样品中单个靶标分子的定量
CN102115741B (zh) * 2010-12-10 2013-07-17 许汉鹏 一种原位分类提取生物大分子的方法及其系统
CN102221614B (zh) * 2011-03-28 2013-07-17 山东大学 一种利用金纳米探针来鉴别小分子化合物作用靶点的分析方法
US9157921B2 (en) 2011-05-18 2015-10-13 Purdue Research Foundation Method for diagnosing abnormality in tissue samples by combination of mass spectral and optical imaging
US9546979B2 (en) 2011-05-18 2017-01-17 Purdue Research Foundation Analyzing a metabolite level in a tissue sample using DESI
US9024254B2 (en) 2011-06-03 2015-05-05 Purdue Research Foundation Enclosed desorption electrospray ionization probes and method of use thereof
JP6346567B2 (ja) 2011-12-28 2018-06-20 マイクロマス・ユーケー・リミテッド 液相試料の急速蒸発イオン化を行うためのシステムおよび方法
US20150008314A1 (en) 2012-01-26 2015-01-08 The Cleveland Clinic Foundation Diagnostic and prognostic biomarkers for cancer
WO2013112680A1 (en) 2012-01-26 2013-08-01 University Of The Sciences In Philadelphia Ionization at intermediate pressure for atmospheric pressure ionization mass spectrometers
JP5955032B2 (ja) * 2012-03-01 2016-07-20 キヤノン株式会社 イオン化方法、質量分析方法、抽出方法及び精製方法
US9105458B2 (en) 2012-05-21 2015-08-11 Sarah Trimpin System and methods for ionizing compounds using matrix-assistance for mass spectrometry and ion mobility spectrometry
JP2015522260A (ja) 2012-06-15 2015-08-06 ハリー スティリ, 疾患または状態を検出する方法
WO2014045087A1 (en) 2012-09-20 2014-03-27 Oslo Universitetssykehus Hf Prostate cancer markers and uses thereof
CN104937111B (zh) 2012-11-27 2018-05-11 智利天主教教皇大学 用于诊断甲状腺肿瘤的组合物和方法
EP2939021A4 (en) 2012-12-30 2016-09-07 Brigham & Womens Hospital SYSTEM AND METHOD FOR ANALYZING BIOMETABOLITES FOR USE IN IMAGED SURGERY
US10983126B2 (en) 2013-05-31 2021-04-20 The Brigham And Women's Hospital System and method for analyzing tissue for the presence of cancer using bio-marker profiles
CA2916977A1 (en) 2013-06-26 2014-12-31 Stealth Biotherapeutics Corp Methods and compositions for detecting and diagnosing diseases and conditions
FR3007634B1 (fr) 2013-06-28 2016-09-02 Commissariat Energie Atomique Dispositif de prelevement in vivo d'especes biologiques et procede automatise d'analyse d'especes biologiques capturees au moyen d'un tel dispositif
RU2769119C2 (ru) 2013-07-19 2022-03-28 Смитс Детекшен Инк. Способ переноса ионов, интерфейс, выполненный с возможностью переноса ионов, и система, содержащая источник газообразных ионов
WO2015019159A1 (en) 2013-08-07 2015-02-12 Dh Technologies Development Pte. Ltd. Bubble removal from liquid flow into a mass spectrometer source
US9245722B2 (en) * 2013-09-16 2016-01-26 Georgia Tech Research Corporation SMS probe and SEM imaging system and methods of use
US20160341712A1 (en) 2013-10-23 2016-11-24 Brigham And Women's Hospital, Inc. System and method for analyzing tissue intra-operatively using mass spectrometry
CN106102873B (zh) * 2013-12-30 2019-09-24 普度研究基金会 用于电离样品的质谱分析探针和系统
US20150202005A1 (en) 2014-01-20 2015-07-23 Omniguide, Inc. System and Method To Control Surgical Energy Devices
JP2015171467A (ja) 2014-03-12 2015-10-01 セイコーエプソン株式会社 液体噴射装置および手術機器
US9297828B2 (en) 2014-03-27 2016-03-29 Ut-Battelle, Llc High heating rate thermal desorption for molecular surface sampling
US9595428B2 (en) 2014-06-17 2017-03-14 The Board Of Regents Of The University Oklahoma Cellular probe device, system and analysis method
US10000789B2 (en) 2014-06-17 2018-06-19 The Board Of Regents Of The University Of Oklahoma Cellular probe device, system and analysis method
US20160041138A1 (en) 2014-08-11 2016-02-11 Arizona Board Of Regents On Behalf Of Arizona State University Methods for Monitoring Airborne Contaminants and Agents using Atmospheric Condensate
JP6800875B2 (ja) 2015-03-06 2020-12-16 マイクロマス ユーケー リミテッド 急速蒸発イオン化質量分析(「reims」)装置に連結されたイオンアナライザのための流入器具
GB2551294B (en) * 2015-03-06 2021-03-17 Micromass Ltd Liquid trap or separator for electrosurgical applications
CA2977900A1 (en) * 2015-03-06 2016-09-15 Micromass Uk Limited Collision surface for improved ionisation
WO2016142691A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Rapid evaporative ionisation mass spectrometry ("reims") and desorption electrospray ionisation mass spectrometry ("desi-ms") analysis of swabs and biopsy samples
GB2556436B (en) * 2015-03-06 2022-01-26 Micromass Ltd Cell population analysis
EP3265822B1 (en) 2015-03-06 2021-04-28 Micromass UK Limited Tissue analysis by mass spectrometry or ion mobility spectrometry
US9632066B2 (en) 2015-04-09 2017-04-25 Ut-Battelle, Llc Open port sampling interface
US10060838B2 (en) 2015-04-09 2018-08-28 Ut-Battelle, Llc Capture probe
WO2016196312A1 (en) 2015-05-29 2016-12-08 Purdue Research Foundation Methods for analyzing a tissue sample
GB201509402D0 (en) 2015-06-01 2015-07-15 Micromass Ltd Lock mass library for internal correction
WO2017049403A1 (en) 2015-09-22 2017-03-30 University Health Network System and method for optimized mass spectrometry analysis
US20170097355A1 (en) 2015-10-06 2017-04-06 University Of Washington Biomarkers and methods to distinguish ovarian cancer from benign tumors
GB2548596A (en) 2016-03-22 2017-09-27 Micromass Ltd An interface probe
US20180067097A1 (en) 2016-07-13 2018-03-08 Board Of Regents, The University Of Texas System Molecular markers and methods for sample analysis via mass spectrometry
WO2018045208A1 (en) 2016-09-02 2018-03-08 Board Of Regents, The University Of Texas System Collection probe and methods for the use thereof
US10643832B2 (en) 2016-09-02 2020-05-05 Board Of Regents, The University Of Texas System Collection probe and methods for the use thereof
US10492801B2 (en) 2016-09-20 2019-12-03 Osteomed Llc Power driven surgical tool
MX2020005448A (es) 2017-11-27 2020-08-27 Univ Texas Sonda de recoleccion minimamente invasiva y metodos para el uso de esta.
WO2019165351A1 (en) 2018-02-23 2019-08-29 Board Of Regents, The University Of Texas System Tissue analysis by mass spectrometry

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