IL261530B - בדיקה של רנ" א לאבחנת סוג אינפקציה - Google Patents

בדיקה של רנ" א לאבחנת סוג אינפקציה

Info

Publication number
IL261530B
IL261530B IL261530A IL26153018A IL261530B IL 261530 B IL261530 B IL 261530B IL 261530 A IL261530 A IL 261530A IL 26153018 A IL26153018 A IL 26153018A IL 261530 B IL261530 B IL 261530B
Authority
IL
Israel
Prior art keywords
infection type
diagnosing infection
analyzing rna
rna
analyzing
Prior art date
Application number
IL261530A
Other languages
English (en)
Other versions
IL261530A (he
Inventor
Oved Kfir
Eden Eran
NAVON Roy
Cohen-Dotan Assaf
BOICO Olga
Kronenfeld Gali
SIMON Einav
Original Assignee
Memed Diagnostics Ltd
Oved Kfir
Eden Eran
NAVON Roy
Assaf Cohen Dotan
BOICO Olga
Kronenfeld Gali
SIMON Einav
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59742613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL261530(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Memed Diagnostics Ltd, Oved Kfir, Eden Eran, NAVON Roy, Assaf Cohen Dotan, BOICO Olga, Kronenfeld Gali, SIMON Einav filed Critical Memed Diagnostics Ltd
Publication of IL261530A publication Critical patent/IL261530A/he
Publication of IL261530B publication Critical patent/IL261530B/he

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
IL261530A 2016-03-03 2018-09-02 בדיקה של רנ" א לאבחנת סוג אינפקציה IL261530B (he)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662302994P 2016-03-03 2016-03-03
PCT/IL2017/050270 WO2017149547A1 (en) 2016-03-03 2017-03-02 Analyzing rna for diagnosing infection type

Publications (2)

Publication Number Publication Date
IL261530A IL261530A (he) 2018-10-31
IL261530B true IL261530B (he) 2021-12-01

Family

ID=59742613

Family Applications (3)

Application Number Title Priority Date Filing Date
IL294121A IL294121B2 (he) 2016-03-03 2017-03-02 בדיקה של רנ" א לאבחנת סוג אינפקציה
IL287757A IL287757B (he) 2016-03-03 2017-03-02 בדיקה של רנ" א לאבחנת סוג אינפקציה
IL261530A IL261530B (he) 2016-03-03 2018-09-02 בדיקה של רנ" א לאבחנת סוג אינפקציה

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IL294121A IL294121B2 (he) 2016-03-03 2017-03-02 בדיקה של רנ" א לאבחנת סוג אינפקציה
IL287757A IL287757B (he) 2016-03-03 2017-03-02 בדיקה של רנ" א לאבחנת סוג אינפקציה

Country Status (6)

Country Link
US (2) US12338497B2 (he)
EP (2) EP3423589B1 (he)
CN (2) CN114959084A (he)
CA (1) CA3015043A1 (he)
IL (3) IL294121B2 (he)
WO (1) WO2017149547A1 (he)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3367099B1 (en) 2012-02-09 2021-05-26 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
EP3699930B1 (en) 2014-08-14 2024-02-07 MeMed Diagnostics Ltd. Computational analysis of biological data using manifold and a hyperplane
WO2016059636A1 (en) 2014-10-14 2016-04-21 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof
EP3230740B1 (en) 2014-12-11 2025-05-21 Memed Diagnostics Ltd. Marker combinations for diagnosing infections and methods of use thereof
WO2017149548A1 (en) 2016-03-03 2017-09-08 Memed Diagnostics Ltd. Rna determinants for distinguishing between bacterial and viral infections
IL294121B2 (he) 2016-03-03 2023-09-01 Memed Diagnostics Ltd בדיקה של רנ" א לאבחנת סוג אינפקציה
US11340223B2 (en) 2016-07-10 2022-05-24 Memed Diagnostics Ltd. Early diagnosis of infections
WO2018011795A1 (en) 2016-07-10 2018-01-18 Memed Diagnostics Ltd. Protein signatures for distinguishing between bacterial and viral infections
WO2018060998A1 (en) 2016-09-29 2018-04-05 Memed Diagnostics Ltd. Methods of prognosis and treatment
US11353456B2 (en) 2016-09-29 2022-06-07 Memed Diagnostics Ltd. Methods of risk assessment and disease classification for appendicitis
US10209260B2 (en) 2017-07-05 2019-02-19 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
US12110564B2 (en) 2018-05-07 2024-10-08 Yale University Test to distinguish viral-only from bacterial infection or viral/bacterial coinfection using a respiratory swab
EP3978628A1 (en) * 2020-10-01 2022-04-06 Koninklijke Philips N.V. Prognostic pathways for viral infections
EP4136261B1 (en) * 2020-04-16 2025-04-02 InnoSIGN B.V. Prognostic pathways for viral infections
WO2022051416A1 (en) * 2020-09-01 2022-03-10 Washington University Compositions and methods for detection of pharyngitis
EP4308729B1 (en) * 2021-03-16 2025-10-29 Cepheid Methods for discriminating bacterial and viral infections in a human subject
WO2024092169A2 (en) * 2022-10-27 2024-05-02 Cz Biohub Sf, Llc Lower respiratory tract infections
WO2024119057A2 (en) * 2022-12-02 2024-06-06 Cornell University Plasma cell-free rna signatures of tuberculosis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110183856A1 (en) * 2004-11-05 2011-07-28 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Diagnosis and Prognosis of Infectious Disease Clinical Phenotypes and other Physiologic States Using Host Gene Expression Biomarkers In Blood
WO2013117746A1 (en) * 2012-02-09 2013-08-15 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof

Family Cites Families (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4458066A (en) 1980-02-29 1984-07-03 University Patents, Inc. Process for preparing polynucleotides
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5322770A (en) 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US5018067A (en) 1987-01-12 1991-05-21 Iameter Incorporated Apparatus and method for improved estimation of health resource consumption through use of diagnostic and/or procedure grouping and severity of illness indicators
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
KR100236506B1 (ko) 1990-11-29 2000-01-15 퍼킨-엘머시터스인스트루먼츠 폴리머라제 연쇄 반응 수행 장치
CA2218875C (en) 1991-07-23 2000-11-07 The Research Foundation Of State University Of New York Improvements in the in situ pcr
DE4322330A1 (de) 1992-08-31 1994-03-03 Behringwerke Ag Verwendung des IL-4-Rezeptors zur Therapie, Prophylaxe und Diagnose von allergischen, viralen, parasitären und bakteriellen Erkrankungen sowie von Pilzinfektionen
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
DE4227454C1 (de) 1992-08-19 1994-02-03 Henning Berlin Gmbh Verfahren zur Früherkennung, zur Erkennung des Schweregrads sowie zur therapiebegleitenden Verlaufsbeurteilung einer Sepsis sowie Mittel zur Durchführung des Verfahrens
SE9401351D0 (sv) 1994-04-21 1994-04-21 Venge A method for diagnosis
US5910421A (en) 1995-12-21 1999-06-08 University Of Florida Rapid diagnostic method for distinguishing allergies and infections
US5612473A (en) 1996-01-16 1997-03-18 Gull Laboratories Methods, kits and solutions for preparing sample material for nucleic acid amplification
US6077665A (en) 1996-05-07 2000-06-20 The Board Of Trustees Of The Leland Stanford Junior University Rapid assay for infection in neonates
EP1042459A4 (en) 1997-12-24 2003-07-23 Diatech Pty Ltd BIFUNCTIONAL MOLECULES
CA2329868A1 (en) * 1998-05-18 1999-11-25 Apoptosis Technology, Inc. Compounds, screening methods, and uses involving anti-apoptotic genes and gene products
DE19847690A1 (de) 1998-10-15 2000-04-20 Brahms Diagnostica Gmbh Verfahren und Substanzen für die Diagnose und Therapie von Sepsis und sepsisähnlichen systemischen Infektionen
US6709855B1 (en) 1998-12-18 2004-03-23 Scios, Inc. Methods for detection and use of differentially expressed genes in disease states
EP1013775A1 (en) * 1998-12-21 2000-06-28 LUTZ, Hans Quantitative polymerase chain reaction using a fluorogenic real-time detection system
CA2702148C (en) 1999-01-06 2014-03-04 Genenews Inc. Method of profiling gene expression in a human subject having an infectious disease
JP4642301B2 (ja) * 1999-08-24 2011-03-02 グリコツイム エイピーエス UDP−N−アセチルグルコサミン:ガラクトース−β1,3−N−アセチル−ガラクトサミン−α−R/(GlcNAc:GalNAc)β1,6−N−アセチルグルコサミニルトランスフェラーゼ,C2GnT3
IL132687A0 (en) 1999-11-01 2001-03-19 Keren Mechkarim Ichilov Pnimit System and method for evaluating body fluid samples
US20020038227A1 (en) 2000-02-25 2002-03-28 Fey Christopher T. Method for centralized health data management
WO2001068895A1 (en) 2000-03-15 2001-09-20 Invitrogen Corporation High fidelity reverse transcriptases and uses thereof
US7668661B2 (en) 2000-04-28 2010-02-23 Siemens Healthcare Diagnostics Inc. Liver disease-related methods and systems
US20020059030A1 (en) 2000-07-17 2002-05-16 Otworth Michael J. Method and apparatus for the processing of remotely collected electronic information characterizing properties of biological entities
US20020055176A1 (en) 2000-11-08 2002-05-09 Ray Robert A. Diagnostic assay system
US20040043379A1 (en) 2001-03-27 2004-03-04 Koji Hashimoto Method of detectingnucleic acid relating to disease
US7713705B2 (en) 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
DE10119804A1 (de) 2001-04-23 2002-10-24 Brahms Ag Entzündungsspezifische Peptide und deren Verwendungen
US7115717B2 (en) 2001-05-18 2006-10-03 Kirin Beer Kabushiki Kaisha Anti-TRAIL-R antibodies
FI115165B (fi) 2001-06-04 2005-03-15 Aboatech Ab Oy Menetelmä infektion laadun määrittämiseksi
DE10130985B4 (de) 2001-06-27 2004-03-18 B.R.A.H.M.S Ag Verfahren zur Diagnose von Sepsis und schweren Infektionen unter Bestimmung löslicher Cytokeratin-1-Fragmente
US20040209307A1 (en) 2001-08-20 2004-10-21 Biosite Incorporated Diagnostic markers of stroke and cerebral injury and methods of use thereof
EP1318407B1 (de) 2001-12-07 2004-09-29 B.R.A.H.M.S Aktiengesellschaft Verwendungen der Aldose-1-Epimerase (Mutarotase) für die Diagnose von Entzündungserkrankungen und Sepsis
EP1317902B1 (en) 2001-12-10 2005-11-09 Kabushiki Gaisha K-and-S Biological data observation apparatus
US20040038201A1 (en) 2002-01-22 2004-02-26 Whitehead Institute For Biomedical Research Diagnostic and therapeutic applications for biomarkers of infection
US7468032B2 (en) 2002-12-18 2008-12-23 Cardiac Pacemakers, Inc. Advanced patient management for identifying, displaying and assisting with correlating health-related data
US20040122296A1 (en) 2002-12-18 2004-06-24 John Hatlestad Advanced patient management for triaging health-related data
CN1656378A (zh) 2002-03-22 2005-08-17 协和美帝克斯股份有限公司 诊断病毒感染的方法
US7485298B2 (en) 2002-05-23 2009-02-03 Michael Powell Diagnosis and treatment of human dormancy-related sequellae
WO2003104496A1 (en) 2002-06-11 2003-12-18 Idaho Research Foundation Type i interferon-inducible proteins to detect viral infection
AU2003296921A1 (en) 2002-10-31 2004-05-25 Health Research, Inc. Diagnostic test for west nile virus
US8563476B2 (en) 2002-11-15 2013-10-22 Morehouse School Of Medicine Anti-CXCL9, anti-CXCL10, anti-CXCL11, anti-CXCL13, anti-CXCR3 and anti-CXCR5 agents for inflammatory disorders
CA2528162A1 (en) 2003-06-04 2004-12-16 The Government Of The United States As Represented By The Secretary Of T He Department Of Health And Human Services, Centers For Disease Control Pni microarray and uses
US20050164238A1 (en) 2003-09-29 2005-07-28 Biosite, Inc. Methods and compositions for the diagnosis of sepsis
JP2005106694A (ja) 2003-09-30 2005-04-21 Mochida Pharmaceut Co Ltd 敗血症早期検出及び重篤度評価
GB0401730D0 (en) 2004-01-27 2004-03-03 Bioxell Spa Diagnosis method
US8906630B2 (en) 2004-02-27 2014-12-09 The Trustees Of The University Of Pennsylvania Assays for detecting pathogenic respiratory bacteria
US7892539B2 (en) 2004-03-24 2011-02-22 The Regents Of The University Of California Modulation of an innate immune response by altering TRIAL-R signaling
US8155993B2 (en) 2004-06-15 2012-04-10 Janssen Pharmaceutica, N.V. Apparatus and methods for assessing a pharmaceutical product
WO2006085984A2 (en) 2004-07-09 2006-08-17 Amaox, Inc. Immune cell biosensors and methods of using same
US7598080B2 (en) 2004-08-20 2009-10-06 Carl Deirmengian Diagnostic assay for source of inflammation
WO2006036182A2 (en) 2004-09-28 2006-04-06 Singulex, Inc. System and method for spectroscopic analysis of single particles
US7572640B2 (en) 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
WO2007018574A2 (en) 2004-11-10 2007-02-15 The United States Of America As Represented By The Secretary Of The Navy Diagnostic assay for rickettsia prowazekii disease by detection of responsive gene expression
CA2605143A1 (en) 2005-04-15 2006-10-26 Becton, Dickinson And Company Diagnosis of sepsis
CN101208602A (zh) 2005-04-15 2008-06-25 贝克顿迪金森公司 脓毒症的诊断
US20070015172A1 (en) 2005-06-01 2007-01-18 Z-Biomed, Inc. Expression profiles for microbial infection
DE102005050933A1 (de) * 2005-10-21 2007-04-26 Justus-Liebig-Universität Giessen Erfindung betreffend Expressionsprofile zur Vorhersage von septischen Zuständen
US20070231816A1 (en) 2005-12-09 2007-10-04 Baylor Research Institute Module-Level Analysis of Peripheral Blood Leukocyte Transcriptional Profiles
GB0601959D0 (en) 2006-01-31 2006-03-15 King S College London Sepsis test
US20070184460A1 (en) 2006-02-09 2007-08-09 Wei-Mei Ching Diagnostic assay for Orientia tsutsugamushi by detection of responsive gene expression
WO2007127801A2 (en) 2006-04-26 2007-11-08 Vertex Pharmaceuticals Incorporated Hepatitis c virus infection biomarkers
AU2007286915B2 (en) 2006-08-11 2014-05-15 Baylor Research Institute Gene expression signatures in blood leukocytes permit differential diagnosis of acute infections
AU2012244350B2 (en) 2006-09-05 2013-08-15 Statens Serum Institut Ip-10 based immunological monitoring
EP2059816A2 (en) 2006-09-05 2009-05-20 Hvidovre Hospital Ip-i0 based immunological monitoring
JP2010506166A (ja) 2006-10-05 2010-02-25 エージェンシー フォー サイエンス,テクノロジー アンド リサーチ デング熱の診断及び治療
CA2670594A1 (en) 2006-12-06 2008-06-12 Medimmune, Llc Interferon alpha-induced pharmacodynamic markers
DE102006060112A1 (de) 2006-12-20 2008-06-26 Brahms Aktiengesellschaft Diagnose und Risikostratifizierung mittels dem neuen Marker CT-proADM
CN101617056A (zh) 2006-12-21 2009-12-30 伊诺基因卡尔生物技术私人有限公司 Eb病毒相关癌症的早期诊断方法及各自的试剂和试剂盒
US20100221700A1 (en) 2007-01-11 2010-09-02 Haynes Barton F Method of monitoring hiv infection
US8293489B2 (en) 2007-01-31 2012-10-23 Henkin Robert I Methods for detection of biological substances
MX2009009146A (es) 2007-02-28 2009-09-03 Procter & Gamble Metodos y objetivos para identificar compuestos para regular la infeccion por rinovirus.
DE102007009751A1 (de) 2007-02-28 2008-09-04 B.R.A.H.M.S Aktiengesellschaft Verfahren zur selektiven Bestimmung von Procalcitonin 1-116 für diagnostische Zwecke sowie Antikörper und Kits zur Durchführung eines solchen Verfahrens
CA2689306C (en) 2007-06-01 2019-01-15 Council Of Scientific & Industrial Research A novel method for simultaneous detection and discrimination of bacterial, fungal, parasitic and viral infections of eye and central nervous system
IL184478A (he) 2007-07-08 2017-07-31 Hadasit Medical Res Services & Development Ltd תכשירים, שיטות וערכות לזיהוי נשאים של מוטציות בגנים 1brca ו–2 brca ולזיהוי מוקדם של מחלות סרטניות הקשורות במוטציות בגנים אלה
DE102007035640A1 (de) 2007-07-27 2009-01-29 Lkh-Kunststoffwerk Gmbh & Co. Kg Tauchkolben
US20110136161A1 (en) 2007-08-03 2011-06-09 Joachim Struck Use of procalcitonin (pct) in risk stratification and prognosis of patients with a primary, non-infectious disease
TW200920358A (en) 2007-08-13 2009-05-16 Lundbeck & Co As H Method of treating stress-mediated depression
WO2009025743A2 (en) 2007-08-17 2009-02-26 University Of Massachusetts Medical School Use of trail compositions as antiviral agents
EP2071334A1 (en) 2007-12-14 2009-06-17 Transmedi SA Compositions and methods of detecting TIABS
WO2009100907A1 (en) 2008-02-14 2009-08-20 Dianeering Diagnostics Engineering And Research Gmbh Means and methods for assessing the risk of patients presenting to emergency departments based on very low concentrations of troponin i or t or using a combination of markers
US8293880B2 (en) 2008-03-25 2012-10-23 University Of Southern California Prognostic panel for urinary bladder cancer
CA2719078A1 (en) 2008-04-21 2009-10-29 Witold Filipowicz Antiviral therapy
US9910036B2 (en) 2008-05-20 2018-03-06 Rapid Pathogen Screening, Inc. Method and device for combined detection of viral and bacterial infections
ES2506116T3 (es) 2008-05-23 2014-10-13 Biocartis Nv Nuevo biomarcador para diagnóstico, predicción y/o pronóstico de septicemia y usos del mismo
EA201170088A1 (ru) 2008-06-25 2011-10-31 Бейлор Рисёч Инститьют Транскрипционная сигнатура крови инфекции mycobacterium tuberculosis
US20160041153A1 (en) 2008-11-12 2016-02-11 Kirk Brown Biomarker compositions and markers
TW201021778A (en) 2008-11-12 2010-06-16 Alcon Res Ltd Intraocular lens delivery device with a multi-part plunger tip
CN107254538A (zh) 2008-11-12 2017-10-17 卡里斯生命科学瑞士控股有限责任公司 使用外来体来确定表现型的方法和系统
WO2011008349A2 (en) 2009-05-26 2011-01-20 Duke University Methods of identifying infectious disease and assays for identifying infectious disease
WO2010139475A1 (en) 2009-06-05 2010-12-09 B.R.A.H.M.S Gmbh Detection of bacterial infections in subjects suffering from dyspnea
US20110065599A1 (en) 2009-08-07 2011-03-17 Rules-Based Medicine, Inc. Methods and Devices for Detecting Kidney Damage
JP5667353B2 (ja) 2009-09-25 2015-02-12 シスメックス株式会社 血球計数装置、診断支援装置、診断支援方法及びコンピュータプログラム
JP2013513387A (ja) 2009-12-09 2013-04-22 アヴィール インコーポレイテッド 循環器疾患の診断と分類のためのバイオマーカーアッセイ
US20110312534A1 (en) 2010-03-05 2011-12-22 Erasmus University Medical Center Rotterdam Method for prediction of human iris color
EP2365456B1 (en) 2010-03-11 2016-07-20 CompuGroup Medical SE Data structure, method and system for predicting medical conditions
EP2561363B1 (en) 2010-04-21 2021-07-14 Memed Diagnostics, Ltd. Signatures and determinants for distinguishing between a bacterial and viral infection and methods of use thereof
GB2482187A (en) 2010-07-23 2012-01-25 Univ Exeter Predicting response to surgery
US8877212B2 (en) * 2011-02-07 2014-11-04 Trudeau Institute Use of an IL12 receptor-beta 1 splice variant to diagnose active tuberculosis
AU2012274461A1 (en) 2011-06-20 2014-01-16 Kyowa Hakko Kirin Co., Ltd. Anti-erbB3 antibody
EP2756103A4 (en) 2011-09-12 2015-06-03 Univ Vanderbilt CHARACTERIZATION OF MULTIPLE SCLEROSIS
JP5842107B2 (ja) 2011-10-19 2016-01-13 パナソニックIpマネジメント株式会社 循環動態測定装置
WO2013119632A1 (en) 2012-02-07 2013-08-15 Ingber Michael Apparatus and methods for analyzing a medical condition
KR102057132B1 (ko) 2012-03-08 2019-12-18 토멘 메디칼 아게 염증성 조직을 진단하기 위한 치과적 용도의 츄잉검
EP2831264B1 (en) 2012-03-30 2019-07-10 VisEn Medical, Inc. Bacterial imaging agents and methods of using same
GB201211982D0 (en) 2012-07-05 2012-08-22 Isis Innovation Biomarker
EP2872891B1 (en) 2012-07-10 2019-03-13 Nepean Blue Mountains Local Health District Risk stratification in influenza
FR2996003B1 (fr) 2012-09-25 2014-10-17 Commissariat Energie Atomique Methode pour detecter specifiquement dans un echantillon une metalloprotease matricielle (mmp) d'interet uniquement dans sa forme active
US20140127827A1 (en) 2012-11-05 2014-05-08 Gwangju Institute Of Science And Technology Method for detection of antigen using fluorescence resonance energy transfer immunoassay
CN105102629B (zh) 2013-01-22 2019-10-18 艾米克罗齐公司 用于检测病原体的快速方法
KR20150113113A (ko) 2013-01-29 2015-10-07 몰레큘러 헬스 게엠베하 임상적 판단 지원을 위한 시스템 및 방법
US10689701B2 (en) 2013-03-15 2020-06-23 Duke University Biomarkers for the molecular classification of bacterial infection
US9474903B2 (en) 2013-03-15 2016-10-25 Boston Scientific Neuromodulation Corporation Clinical response data mapping
EP3693738A1 (en) 2013-09-20 2020-08-12 Astute Medical, Inc. Methods and compositions for diagnosis and prognosis of appendicitis and differentiation of causes of abdominal pain
WO2015048098A1 (en) 2013-09-24 2015-04-02 Washington University Diagnostic methods for infectious disease using endogenous gene expression
EP3699930B1 (en) 2014-08-14 2024-02-07 MeMed Diagnostics Ltd. Computational analysis of biological data using manifold and a hyperplane
WO2016059636A1 (en) 2014-10-14 2016-04-21 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections in non-human subjects and methods of use thereof
CN107001455B (zh) 2014-11-19 2022-03-01 皇家飞利浦有限公司 利用hnl的诊断方法
EP3230740B1 (en) 2014-12-11 2025-05-21 Memed Diagnostics Ltd. Marker combinations for diagnosing infections and methods of use thereof
KR20160072626A (ko) 2014-12-15 2016-06-23 전북대학교산학협력단 패혈증 인자 il-6 간이 진단 키트
US20180310854A1 (en) 2015-11-01 2018-11-01 Elminda Ltd. Method and system for estimating potential distribution on cortical surface
WO2017149548A1 (en) 2016-03-03 2017-09-08 Memed Diagnostics Ltd. Rna determinants for distinguishing between bacterial and viral infections
IL294121B2 (he) 2016-03-03 2023-09-01 Memed Diagnostics Ltd בדיקה של רנ" א לאבחנת סוג אינפקציה
US20200124593A1 (en) 2016-06-23 2020-04-23 Memed Diagnostics Ltd. Measuring trail by lateral flow immunoassay
US11340223B2 (en) 2016-07-10 2022-05-24 Memed Diagnostics Ltd. Early diagnosis of infections
WO2018011795A1 (en) 2016-07-10 2018-01-18 Memed Diagnostics Ltd. Protein signatures for distinguishing between bacterial and viral infections
EP3514518A4 (en) 2016-09-16 2020-09-02 On-chip Biotechnologies Co., Ltd. FINE PARTICLE DISTRIBUTION DEVICE, FINE PARTICLE ANALYSIS DEVICE, REACTION DETECTION DEVICE AND PROCESS USING SAID DEVICES
US11353456B2 (en) 2016-09-29 2022-06-07 Memed Diagnostics Ltd. Methods of risk assessment and disease classification for appendicitis
WO2018060998A1 (en) 2016-09-29 2018-04-05 Memed Diagnostics Ltd. Methods of prognosis and treatment
US10209260B2 (en) 2017-07-05 2019-02-19 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof
US12348304B2 (en) 2021-04-08 2025-07-01 Infinidome Ltd. Adjustable null steering in a stationary network

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110183856A1 (en) * 2004-11-05 2011-07-28 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Diagnosis and Prognosis of Infectious Disease Clinical Phenotypes and other Physiologic States Using Host Gene Expression Biomarkers In Blood
WO2013117746A1 (en) * 2012-02-09 2013-08-15 Memed Diagnostics Ltd. Signatures and determinants for diagnosing infections and methods of use thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ARIANNA CONSIGLIO ET AL,, BEAT: BIOINFORMATICS EXON ARRAY TOOL TO STORE, ANALYZE AND VISUALIZE AFFYMETRIX GENECHIP HUMAN EXON ARRAY DATA FROM DISEASE EXPERIMENTS, 31 December 2012 (2012-12-31) *
NN NN,, UCSC GENOME BROWSER ON HUMAN FEB. 2009 (GRCH37/HG19) SHOWING LOCATION OF PROBES ON THE AFFYMETRIX EXONCHIP BINDING TO EXONS OF AIM2, 31 December 2019 (2019-12-31) *
NN NN,, UCSC GENOME BROWSER ON HUMAN FEB. 2009 (GRCH37/HG19) SHOWING LOCATION OF PROBES ON THE AFFYMETRIX EXONCHIP BINDING TO EXONS OF ANKRD22, 31 December 2019 (2019-12-31) *

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