IL25939A - Nicotinic acid esters and method for producing same - Google Patents
Nicotinic acid esters and method for producing sameInfo
- Publication number
- IL25939A IL25939A IL6625939A IL2593966A IL25939A IL 25939 A IL25939 A IL 25939A IL 6625939 A IL6625939 A IL 6625939A IL 2593966 A IL2593966 A IL 2593966A IL 25939 A IL25939 A IL 25939A
- Authority
- IL
- Israel
- Prior art keywords
- nicotinic acid
- esters
- trinicotinate
- formula
- polyvalent
- Prior art date
Links
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical class OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 title claims description 22
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- 150000002148 esters Chemical class 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 235000001968 nicotinic acid Nutrition 0.000 claims description 9
- 239000011664 nicotinic acid Substances 0.000 claims description 9
- 229960003512 nicotinic acid Drugs 0.000 claims description 9
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 claims description 6
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- QXJQHYBHAIHNGG-UHFFFAOYSA-N trimethylolethane Chemical compound OCC(C)(CO)CO QXJQHYBHAIHNGG-UHFFFAOYSA-N 0.000 claims description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 229940120503 dihydroxyacetone Drugs 0.000 claims description 3
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 3
- PAXWDGYETCPYAO-UHFFFAOYSA-N 1,1-dihydroxypropan-2-one pyridine-3-carboxylic acid Chemical compound C(C1=CN=CC=C1)(=O)O.C(C1=CN=CC=C1)(=O)O.OC(C(C)=O)O PAXWDGYETCPYAO-UHFFFAOYSA-N 0.000 claims description 2
- 239000002250 absorbent Substances 0.000 claims description 2
- 230000002745 absorbent Effects 0.000 claims description 2
- -1 ethane trinicotinate Chemical compound 0.000 claims description 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 150000003512 tertiary amines Chemical class 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 description 8
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- 238000002844 melting Methods 0.000 description 5
- 230000008018 melting Effects 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 239000013078 crystal Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- KFLRWGSAMLBHBV-UHFFFAOYSA-M sodium;pyridine-3-carboxylate Chemical compound [Na+].[O-]C(=O)C1=CC=CN=C1 KFLRWGSAMLBHBV-UHFFFAOYSA-M 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- SUNMBRGCANLOEG-UHFFFAOYSA-N 1,3-dichloroacetone Chemical compound ClCC(=O)CCl SUNMBRGCANLOEG-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- ATBIAJXSKNPHEI-UHFFFAOYSA-N pyridine-3-carbonyl chloride Chemical compound ClC(=O)C1=CC=CN=C1 ATBIAJXSKNPHEI-UHFFFAOYSA-N 0.000 description 2
- 241000700199 Cavia porcellus Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000021588 free fatty acids Nutrition 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000000622 irritating effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 150000004072 triols Chemical class 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Processing Of Meat And Fish (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8215/65*A SE323679B (en:Method) | 1965-04-22 | 1965-04-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL25939A true IL25939A (en) | 1970-06-17 |
Family
ID=20273451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL6625939A IL25939A (en) | 1965-04-22 | 1966-06-09 | Nicotinic acid esters and method for producing same |
Country Status (13)
| Country | Link |
|---|---|
| AT (1) | AT263010B (en:Method) |
| BE (1) | BE682920A (en:Method) |
| BR (1) | BR6680462D0 (en:Method) |
| CH (1) | CH468383A (en:Method) |
| DE (1) | DE1645915A1 (en:Method) |
| DK (1) | DK112237B (en:Method) |
| ES (1) | ES328732A1 (en:Method) |
| FI (1) | FI47187C (en:Method) |
| FR (1) | FR5624M (en:Method) |
| GB (1) | GB1080128A (en:Method) |
| IL (1) | IL25939A (en:Method) |
| NO (1) | NO121496B (en:Method) |
| SE (1) | SE323679B (en:Method) |
-
1965
- 1965-04-22 SE SE8215/65*A patent/SE323679B/xx unknown
-
1966
- 1966-06-09 IL IL6625939A patent/IL25939A/en unknown
- 1966-06-15 DE DE19661645915 patent/DE1645915A1/de active Pending
- 1966-06-16 FI FI661592A patent/FI47187C/fi active
- 1966-06-16 AT AT574266A patent/AT263010B/de active
- 1966-06-16 BR BR180462/66A patent/BR6680462D0/pt unknown
- 1966-06-17 GB GB27265/66A patent/GB1080128A/en not_active Expired
- 1966-06-20 CH CH891266A patent/CH468383A/de unknown
- 1966-06-21 NO NO66163571A patent/NO121496B/no unknown
- 1966-06-21 FR FR66315A patent/FR5624M/fr not_active Expired
- 1966-06-21 ES ES0328732A patent/ES328732A1/es not_active Expired
- 1966-06-22 DK DK322766AA patent/DK112237B/da unknown
- 1966-06-22 BE BE682920D patent/BE682920A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR6680462D0 (pt) | 1973-06-28 |
| NO121496B (en:Method) | 1971-03-08 |
| AT263010B (de) | 1968-07-10 |
| FR5624M (en:Method) | 1967-12-18 |
| ES328732A1 (es) | 1967-04-01 |
| DK112237B (da) | 1968-11-25 |
| FI47187C (fi) | 1973-10-10 |
| FI47187B (en:Method) | 1973-07-02 |
| SE323679B (en:Method) | 1970-05-11 |
| GB1080128A (en) | 1967-08-23 |
| DE1645915A1 (de) | 1970-09-24 |
| BE682920A (en:Method) | 1966-12-01 |
| CH468383A (de) | 1969-02-15 |
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