IL252613B - Methods for the development and use of minimally polarized microaggregate cell units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells - Google Patents
Methods for the development and use of minimally polarized microaggregate cell units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cellsInfo
- Publication number
- IL252613B IL252613B IL252613A IL25261317A IL252613B IL 252613 B IL252613 B IL 252613B IL 252613 A IL252613 A IL 252613A IL 25261317 A IL25261317 A IL 25261317A IL 252613 B IL252613 B IL 252613B
- Authority
- IL
- Israel
- Prior art keywords
- lgr4
- lgr5
- development
- methods
- stem cells
- Prior art date
Links
- 101150081517 LGR4 gene Proteins 0.000 title 1
- 210000004027 cell Anatomy 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/362—Skin, e.g. dermal papillae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Dermatology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Botany (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462086526P | 2014-12-02 | 2014-12-02 | |
| US14/954,335 US10926001B2 (en) | 2014-12-02 | 2015-11-30 | Methods related to minimally polarized functional units |
| PCT/US2015/063114 WO2016089825A1 (en) | 2014-12-02 | 2015-12-01 | Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL252613A0 IL252613A0 (en) | 2017-07-31 |
| IL252613B true IL252613B (en) | 2021-12-01 |
Family
ID=56078499
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL252613A IL252613B (en) | 2014-12-02 | 2017-06-01 | Methods for the development and use of minimally polarized microaggregate cell units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells |
| IL287488A IL287488B2 (en) | 2014-12-02 | 2021-10-21 | Methods for the development and use of minimally polarized microaggregate cell units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL287488A IL287488B2 (en) | 2014-12-02 | 2021-10-21 | Methods for the development and use of minimally polarized microaggregate cell units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells |
Country Status (21)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110913690A (zh) * | 2017-03-14 | 2020-03-24 | 朱诺治疗学股份有限公司 | 用于低温储存的方法 |
| CA3088129A1 (en) * | 2018-01-26 | 2019-08-01 | Polarityte, Inc. | Composite-interfacing biomaterial accelerant substrate |
| WO2019148143A1 (en) * | 2018-01-26 | 2019-08-01 | Polarityte, Inc. | Complex living interface-coordinated self-assembling materials (clicsam) |
| FR3082123B1 (fr) | 2018-06-07 | 2020-10-16 | Urgo Rech Innovation Et Developpement | Pansement cellularise et son procede de fabrication |
| JP2024006681A (ja) * | 2022-07-04 | 2024-01-17 | 学校法人近畿大学 | 生体材料 |
| WO2025166131A1 (en) * | 2024-02-01 | 2025-08-07 | Board Of Regents, The University Of Texas System | Compositions and methods for treating bone and muscle injuries |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010112678A1 (en) * | 2009-04-01 | 2010-10-07 | Helsingin Yliopisto | Regenerative matrix comprising cells activated by nemosis and/or factors released from such cells |
| EP2412800A1 (en) * | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| US20120196312A1 (en) * | 2009-02-03 | 2012-08-02 | Toshiro Sato | Culture medium for epithelial stem cells and organoids comprising the stem cells |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040126881A1 (en) * | 2002-09-06 | 2004-07-01 | Vincent Ronfard | Fibrin cell supports and methods of use thereof |
| WO2006008009A2 (en) | 2004-07-23 | 2006-01-26 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with leucine-rich repeat-containing gpcr 6 (lgr6) |
| US20060154365A1 (en) | 2004-08-30 | 2006-07-13 | Anthony Ratcliffe | Cultured three dimensional tissues and uses thereof |
| US8053559B2 (en) | 2005-10-27 | 2011-11-08 | Coloplast A/S | Biodegradable scaffold with ECM material |
| US20100328320A1 (en) | 2006-07-13 | 2010-12-30 | Kerstna Juergen | Medical information management in a patient information hub system |
| US8366723B2 (en) | 2006-08-03 | 2013-02-05 | Rassman Licensing, Llc | Hair harvesting device and method with localized subsurface dermal fluid insertion |
| WO2008031767A1 (en) | 2006-09-12 | 2008-03-20 | Dkfz Deutsches Krebsforschungszentrum, Stiftung Des Öffentlichen Rechts | Cell culture of keratinocytes under non-differentiating conditions |
| GB201111244D0 (en) | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
| JP2012531185A (ja) | 2009-06-25 | 2012-12-10 | 株式会社 資生堂 | Ａｆｆ‐４を指標とした抗白髪剤のスクリーニング方法 |
| US20110130711A1 (en) | 2009-11-19 | 2011-06-02 | Follica, Inc. | Hair growth treatment |
| US20130101564A1 (en) | 2010-06-30 | 2013-04-25 | Jinxi Chen | Method for preparing dermis tissue cells aggregation and uses thereof |
| GB201106395D0 (en) | 2011-04-14 | 2011-06-01 | Hubrecht Inst | Compounds |
| JP6215216B2 (ja) | 2011-10-27 | 2017-10-18 | ウニヴェルジテート ライプチッヒ | 毛包外毛根鞘からメラノサイトを誘導する方法および移植のための調製 |
| JP6186997B2 (ja) | 2012-08-07 | 2017-08-30 | 日油株式会社 | 塗布型帯電防止剤 |
| US9655930B2 (en) | 2012-10-01 | 2017-05-23 | Aderans Research Institute, Inc. | Compositions and methods for producing reconstituted skin |
| US20140106447A1 (en) | 2012-10-12 | 2014-04-17 | Mimedx Group, Inc. | Compositions and methods for recruiting stem cells |
| BR112015023261A2 (pt) | 2013-03-14 | 2017-07-18 | Massachusetts Inst Technology | composições e métodos para expansão e cultura de células-tronco epiteliais |
| US9592257B2 (en) | 2013-10-11 | 2017-03-14 | MWV Cell, LLC | Complete human skin organ generated from culture-expanded cells |
| CN103550828B (zh) * | 2013-10-17 | 2016-01-27 | 中国科学院动物研究所 | 一种基于毛囊干细胞和硅凝胶敷料的皮肤重建方法 |
| TWI548413B (zh) | 2014-11-07 | 2016-09-11 | 國立臺灣大學 | 誘導毛囊新生的皮膚萃取物、組合物及其用途 |
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2015
- 2015-11-30 US US14/954,335 patent/US10926001B2/en active Active
- 2015-12-01 NZ NZ733433A patent/NZ733433A/en unknown
- 2015-12-01 HK HK18104680.7A patent/HK1250515A1/zh unknown
- 2015-12-01 CN CN201580075326.3A patent/CN107250348B/zh active Active
- 2015-12-01 KR KR1020217010934A patent/KR20210043024A/ko not_active Ceased
- 2015-12-01 SG SG10201914058QA patent/SG10201914058QA/en unknown
- 2015-12-01 BR BR112017011808-4A patent/BR112017011808A2/en not_active Application Discontinuation
- 2015-12-01 WO PCT/US2015/063114 patent/WO2016089825A1/en not_active Ceased
- 2015-12-01 NZ NZ755260A patent/NZ755260A/en unknown
- 2015-12-01 EA EA201791125A patent/EA201791125A1/ru unknown
- 2015-12-01 KR KR1020187036619A patent/KR20180136588A/ko not_active Ceased
- 2015-12-01 KR KR1020187036618A patent/KR20180136587A/ko not_active Ceased
- 2015-12-01 KR KR1020177017887A patent/KR20170098844A/ko not_active Ceased
- 2015-12-01 SG SG11201704502RA patent/SG11201704502RA/en unknown
- 2015-12-01 MX MX2017007243A patent/MX2017007243A/es unknown
- 2015-12-01 EP EP15865131.5A patent/EP3227431B1/en active Active
- 2015-12-01 JP JP2017530217A patent/JP6791854B2/ja active Active
- 2015-12-01 CA CA2969707A patent/CA2969707C/en active Active
- 2015-12-01 KR KR1020197028100A patent/KR20190111167A/ko not_active Ceased
- 2015-12-01 MY MYPI2017701990A patent/MY184931A/en unknown
- 2015-12-01 CR CR20170296A patent/CR20170296A/es unknown
- 2015-12-01 EP EP24181160.3A patent/EP4438128A3/en active Pending
- 2015-12-01 AU AU2015355187A patent/AU2015355187C1/en active Active
- 2015-12-01 GB GB201902819A patent/GB2569056B/en active Active
- 2015-12-01 GB GB1710646.9A patent/GB2549872A/en not_active Withdrawn
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2017
- 2017-05-31 PH PH12017501009A patent/PH12017501009B1/en unknown
- 2017-06-01 IL IL252613A patent/IL252613B/en unknown
- 2017-06-05 MX MX2023001655A patent/MX2023001655A/es unknown
- 2017-06-07 ZA ZA2017/03907A patent/ZA201703907B/en unknown
- 2017-06-30 CO CONC2017/0006640A patent/CO2017006640A2/es unknown
- 2017-07-14 US US15/650,659 patent/US11266765B2/en active Active
- 2017-07-14 US US15/650,656 patent/US20180154043A1/en not_active Abandoned
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2018
- 2018-10-19 US US16/165,169 patent/US11000629B2/en active Active
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2019
- 2019-01-16 JP JP2019004921A patent/JP2019088299A/ja active Pending
- 2019-10-02 AU AU2019240603A patent/AU2019240603B2/en active Active
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2020
- 2020-07-30 JP JP2020129610A patent/JP2020182880A/ja active Pending
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2021
- 2021-05-21 US US17/326,734 patent/US11338060B2/en active Active
- 2021-10-21 IL IL287488A patent/IL287488B2/en unknown
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2022
- 2022-04-19 US US17/723,748 patent/US11596714B2/en active Active
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2023
- 2023-02-03 US US18/164,308 patent/US12465669B2/en active Active
- 2023-05-08 AU AU2023202857A patent/AU2023202857A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120196312A1 (en) * | 2009-02-03 | 2012-08-02 | Toshiro Sato | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| WO2010112678A1 (en) * | 2009-04-01 | 2010-10-07 | Helsingin Yliopisto | Regenerative matrix comprising cells activated by nemosis and/or factors released from such cells |
| EP2412800A1 (en) * | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
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