GB2569056B - Methods for development and use of minimally polarized functional units in tissue applications using LGR4, LGR5 and LGR6 expressing epithelial stem cells - Google Patents

Methods for development and use of minimally polarized functional units in tissue applications using LGR4, LGR5 and LGR6 expressing epithelial stem cells Download PDF

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Publication number
GB2569056B
GB2569056B GB201902819A GB201902819A GB2569056B GB 2569056 B GB2569056 B GB 2569056B GB 201902819 A GB201902819 A GB 201902819A GB 201902819 A GB201902819 A GB 201902819A GB 2569056 B GB2569056 B GB 2569056B
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lgr4
lgr5
development
methods
stem cells
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GB201902819D0 (en
GB2569056A (en
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M Lough Denver
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RegenETP Inc
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PolarityTE Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/362—Skin, e.g. dermal papillae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GB201902819A 2014-12-02 2015-12-01 Methods for development and use of minimally polarized functional units in tissue applications using LGR4, LGR5 and LGR6 expressing epithelial stem cells Active GB2569056B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462086526P 2014-12-02 2014-12-02
US14/954,335 US10926001B2 (en) 2014-12-02 2015-11-30 Methods related to minimally polarized functional units
GB1710646.9A GB2549872A (en) 2014-12-02 2015-12-01 Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using LGR4, LGR5 and LGR6

Publications (3)

Publication Number Publication Date
GB201902819D0 GB201902819D0 (en) 2019-04-17
GB2569056A GB2569056A (en) 2019-06-05
GB2569056B true GB2569056B (en) 2020-01-01

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ID=56078499

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Application Number Title Priority Date Filing Date
GB201902819A Active GB2569056B (en) 2014-12-02 2015-12-01 Methods for development and use of minimally polarized functional units in tissue applications using LGR4, LGR5 and LGR6 expressing epithelial stem cells
GB1710646.9A Withdrawn GB2549872A (en) 2014-12-02 2015-12-01 Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using LGR4, LGR5 and LGR6

Family Applications After (1)

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GB1710646.9A Withdrawn GB2549872A (en) 2014-12-02 2015-12-01 Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using LGR4, LGR5 and LGR6

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US (7) US10926001B2 (cg-RX-API-DMAC10.html)
EP (2) EP3227431B1 (cg-RX-API-DMAC10.html)
JP (3) JP6791854B2 (cg-RX-API-DMAC10.html)
KR (5) KR20210043024A (cg-RX-API-DMAC10.html)
CN (1) CN107250348B (cg-RX-API-DMAC10.html)
AU (3) AU2015355187C1 (cg-RX-API-DMAC10.html)
BR (1) BR112017011808A2 (cg-RX-API-DMAC10.html)
CA (1) CA2969707C (cg-RX-API-DMAC10.html)
CO (1) CO2017006640A2 (cg-RX-API-DMAC10.html)
CR (1) CR20170296A (cg-RX-API-DMAC10.html)
EA (1) EA201791125A1 (cg-RX-API-DMAC10.html)
GB (2) GB2569056B (cg-RX-API-DMAC10.html)
HK (1) HK1250515A1 (cg-RX-API-DMAC10.html)
IL (2) IL252613B (cg-RX-API-DMAC10.html)
MX (2) MX2017007243A (cg-RX-API-DMAC10.html)
MY (1) MY184931A (cg-RX-API-DMAC10.html)
NZ (2) NZ733433A (cg-RX-API-DMAC10.html)
PH (1) PH12017501009B1 (cg-RX-API-DMAC10.html)
SG (2) SG10201914058QA (cg-RX-API-DMAC10.html)
WO (1) WO2016089825A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201703907B (cg-RX-API-DMAC10.html)

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CN110913690A (zh) * 2017-03-14 2020-03-24 朱诺治疗学股份有限公司 用于低温储存的方法
CA3088129A1 (en) * 2018-01-26 2019-08-01 Polarityte, Inc. Composite-interfacing biomaterial accelerant substrate
WO2019148143A1 (en) * 2018-01-26 2019-08-01 Polarityte, Inc. Complex living interface-coordinated self-assembling materials (clicsam)
FR3082123B1 (fr) 2018-06-07 2020-10-16 Urgo Rech Innovation Et Developpement Pansement cellularise et son procede de fabrication
JP2024006681A (ja) * 2022-07-04 2024-01-17 学校法人近畿大学 生体材料
WO2025166131A1 (en) * 2024-02-01 2025-08-07 Board Of Regents, The University Of Texas System Compositions and methods for treating bone and muscle injuries

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CR20170296A (es) 2018-01-25
EP3227431B1 (en) 2025-01-29
US11266765B2 (en) 2022-03-08
WO2016089825A1 (en) 2016-06-09
EP3227431A4 (en) 2019-01-02
AU2019240603B2 (en) 2023-02-09
GB201902819D0 (en) 2019-04-17
GB2549872A (en) 2017-11-01
GB201710646D0 (en) 2017-08-16
US20160151540A1 (en) 2016-06-02
PH12017501009A1 (en) 2017-12-11
US20190046691A1 (en) 2019-02-14
US20220241464A1 (en) 2022-08-04
AU2023202857A1 (en) 2023-05-25
BR112017011808A2 (en) 2018-02-27
KR20190111167A (ko) 2019-10-01
US11338060B2 (en) 2022-05-24
US20180154044A1 (en) 2018-06-07
NZ755260A (en) 2021-12-24
IL287488B2 (en) 2023-06-01
AU2015355187B2 (en) 2019-10-03
EP3227431A1 (en) 2017-10-11
CA2969707A1 (en) 2016-06-09
AU2015355187C1 (en) 2020-02-20
EP4438128A2 (en) 2024-10-02
US12465669B2 (en) 2025-11-11
EP4438128A3 (en) 2024-11-13
CN107250348A (zh) 2017-10-13
JP2020182880A (ja) 2020-11-12
AU2015355187A1 (en) 2017-06-29
HK1245327A1 (zh) 2018-08-24
SG10201914058QA (en) 2020-03-30
US10926001B2 (en) 2021-02-23
AU2019240603A1 (en) 2019-10-17
MX2017007243A (es) 2018-01-25
MY184931A (en) 2021-04-30
MX2023001655A (es) 2023-04-24
JP2017538411A (ja) 2017-12-28
HK1250515A1 (zh) 2018-12-21
GB2569056A (en) 2019-06-05
US11000629B2 (en) 2021-05-11
US20230181797A1 (en) 2023-06-15
CA2969707C (en) 2019-08-20
EP3227431C0 (en) 2025-01-29
CO2017006640A2 (es) 2017-11-21
EA201791125A1 (ru) 2018-06-29
US20210322643A1 (en) 2021-10-21
CN107250348B (zh) 2021-09-03
KR20210043024A (ko) 2021-04-20
US20180154043A1 (en) 2018-06-07
JP6791854B2 (ja) 2020-11-25
ZA201703907B (en) 2023-03-29
IL287488A (en) 2021-12-01
NZ733433A (en) 2019-08-30
JP2019088299A (ja) 2019-06-13
US11596714B2 (en) 2023-03-07
PH12017501009B1 (en) 2022-01-21
KR20180136587A (ko) 2018-12-24
IL252613B (en) 2021-12-01
KR20170098844A (ko) 2017-08-30
SG11201704502RA (en) 2017-06-29
KR20180136588A (ko) 2018-12-24
IL252613A0 (en) 2017-07-31

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