IL247035B2 - Crystalline solid forms of n-{4-[(7,6-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, processes for preparation and methods of use - Google Patents

Crystalline solid forms of n-{4-[(7,6-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, processes for preparation and methods of use

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Publication number
IL247035B2
IL247035B2 IL247035A IL24703516A IL247035B2 IL 247035 B2 IL247035 B2 IL 247035B2 IL 247035 A IL247035 A IL 247035A IL 24703516 A IL24703516 A IL 24703516A IL 247035 B2 IL247035 B2 IL 247035B2
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IL
Israel
Prior art keywords
compound
cancer
xxviii
iii
crystalline solid
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IL247035A
Other languages
English (en)
Hebrew (he)
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IL247035B (en
IL247035A0 (en
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Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Exelixis Inc filed Critical Exelixis Inc
Publication of IL247035A0 publication Critical patent/IL247035A0/en
Publication of IL247035B publication Critical patent/IL247035B/en
Publication of IL247035B2 publication Critical patent/IL247035B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
IL247035A 2014-02-14 2015-02-16 Crystalline solid forms of n-{4-[(7,6-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, processes for preparation and methods of use IL247035B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461939985P 2014-02-14 2014-02-14
PCT/US2015/016052 WO2015123639A1 (en) 2014-02-14 2015-02-16 Crystalline solid forms of n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl) cyclopropane-1, 1-dicarboxamide, processes for making, and methods of use

Publications (3)

Publication Number Publication Date
IL247035A0 IL247035A0 (en) 2016-09-29
IL247035B IL247035B (en) 2022-11-01
IL247035B2 true IL247035B2 (en) 2023-03-01

Family

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IL247035A IL247035B2 (en) 2014-02-14 2015-02-16 Crystalline solid forms of n-{4-[(7,6-dimethoxyquinolin-4-yl)oxy]phenyl}-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, processes for preparation and methods of use

Country Status (14)

Country Link
US (5) US10501418B2 (enExample)
EP (2) EP3105204A1 (enExample)
JP (2) JP6756617B2 (enExample)
KR (1) KR102354963B1 (enExample)
CN (1) CN106068255A (enExample)
AU (3) AU2015218236B2 (enExample)
BR (1) BR112016018450A2 (enExample)
CA (2) CA3181899A1 (enExample)
EA (1) EA032757B1 (enExample)
IL (1) IL247035B2 (enExample)
MX (2) MX384828B (enExample)
UA (1) UA123534C2 (enExample)
WO (1) WO2015123639A1 (enExample)
ZA (1) ZA201605424B (enExample)

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CA2939546C (en) 2023-01-17
JP2019163337A (ja) 2019-09-26
CN106068255A (zh) 2016-11-02
MX2021001583A (es) 2023-02-08
AU2019226302B2 (en) 2021-04-01
US11760726B2 (en) 2023-09-19
JP2017505796A (ja) 2017-02-23
AU2021204278B2 (en) 2023-10-26
MX384828B (es) 2025-03-14
AU2021204278A1 (en) 2021-07-22
US11724986B2 (en) 2023-08-15
KR20160121544A (ko) 2016-10-19
NZ723714A (en) 2021-03-26
EA032757B1 (ru) 2019-07-31
US20200190033A1 (en) 2020-06-18
AU2015218236A1 (en) 2016-09-15
JP6756617B2 (ja) 2020-09-16
CA2939546A1 (en) 2015-08-20
US20230382867A1 (en) 2023-11-30
EP3105204A1 (en) 2016-12-21
ZA201605424B (en) 2022-12-21
US20210206722A1 (en) 2021-07-08
US12486233B2 (en) 2025-12-02
IL247035B (en) 2022-11-01
US20210198205A1 (en) 2021-07-01
MX2016010266A (es) 2017-02-08
CA3181899A1 (en) 2015-08-20
EA201691629A1 (ru) 2016-11-30
IL247035A0 (en) 2016-09-29
US10501418B2 (en) 2019-12-10
AU2019226302A1 (en) 2019-09-26
UA123534C2 (uk) 2021-04-21
EP3738952A1 (en) 2020-11-18
KR102354963B1 (ko) 2022-01-21
AU2015218236B2 (en) 2019-06-13
US20170044106A1 (en) 2017-02-16
US10851061B2 (en) 2020-12-01
WO2015123639A1 (en) 2015-08-20
BR112016018450A2 (pt) 2018-09-18

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