IL245453B - Engineered imine reductases and methods for redox amination of ketone and amine compounds - Google Patents

Engineered imine reductases and methods for redox amination of ketone and amine compounds

Info

Publication number
IL245453B
IL245453B IL245453A IL24545316A IL245453B IL 245453 B IL245453 B IL 245453B IL 245453 A IL245453 A IL 245453A IL 24545316 A IL24545316 A IL 24545316A IL 245453 B IL245453 B IL 245453B
Authority
IL
Israel
Prior art keywords
ketone
methods
amine compounds
reductive amination
engineered imine
Prior art date
Application number
IL245453A
Other languages
English (en)
Hebrew (he)
Other versions
IL245453A0 (en
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of IL245453A0 publication Critical patent/IL245453A0/en
Publication of IL245453B publication Critical patent/IL245453B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y105/00—Oxidoreductases acting on the CH-NH group of donors (1.5)
    • C12Y105/01—Oxidoreductases acting on the CH-NH group of donors (1.5) with NAD+ or NADP+ as acceptor (1.5.1)
    • C12Y105/01028—Opine dehydrogenase (1.5.1.28)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL245453A 2013-11-13 2016-05-03 Engineered imine reductases and methods for redox amination of ketone and amine compounds IL245453B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361903772P 2013-11-13 2013-11-13
US201462022315P 2014-07-09 2014-07-09
US201462022323P 2014-07-09 2014-07-09
PCT/US2014/065259 WO2015073555A1 (en) 2013-11-13 2014-11-12 Engineered imine reductases and methods for the reductive amination of ketone and amine compounds

Publications (2)

Publication Number Publication Date
IL245453A0 IL245453A0 (en) 2016-06-30
IL245453B true IL245453B (en) 2021-04-29

Family

ID=53044107

Family Applications (1)

Application Number Title Priority Date Filing Date
IL245453A IL245453B (en) 2013-11-13 2016-05-03 Engineered imine reductases and methods for redox amination of ketone and amine compounds

Country Status (9)

Country Link
US (5) US9822346B2 (https=)
EP (1) EP3068793B1 (https=)
JP (1) JP6643987B2 (https=)
CN (1) CN106232619B (https=)
CA (1) CA2929664C (https=)
DK (1) DK3068793T3 (https=)
HU (1) HUE053379T2 (https=)
IL (1) IL245453B (https=)
WO (1) WO2015073555A1 (https=)

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Publication number Priority date Publication date Assignee Title
EP2512226B1 (en) * 2009-12-17 2019-05-01 Pioneer Hi-Bred International, Inc. Maize event dp-004114-3 and methods for detection thereof
JP6643987B2 (ja) 2013-11-13 2020-02-12 コデクシス， インコーポレイテッド ケトン化合物およびアミン化合物の還元的アミノ化のための操作されたイミンレダクターゼおよび方法
DK3224354T3 (da) * 2014-11-25 2021-03-01 Codexis Inc Manipulerede iminreductaser og fremgangsmåder til den reduktive aminering af keton- og aminforbindelser
KR101761830B1 (ko) 2015-10-21 2017-07-26 주식회사 엘지화학 리간드 화합물, 올레핀 올리고머화용 촉매계, 및 이를 이용한 올레핀 올리고머화 방법
WO2018038906A1 (en) 2016-08-26 2018-03-01 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CN107384885B (zh) * 2017-09-05 2019-12-24 武汉大学 亚胺还原酶及其突变体在合成(s)-1-芳基-1，2，3，4-四氢异喹啉中的应用
CN108504701B (zh) * 2018-04-26 2021-05-14 中南林业科技大学 一种异丙甲草胺中间体的合成方法
PL3653617T3 (pl) 2018-11-16 2021-04-06 Zanoprima Lifesciences Limited Sposób otrzymywania (s)-nikotyny z miozminy
JP7584804B2 (ja) * 2019-05-01 2024-11-18 コデクシス， インコーポレイテッド 操作されたイミンレダクターゼ、ならびにケトンおよびアミン化合物の還元的アミノ化のための方法
CN113774036B (zh) * 2021-10-18 2022-10-11 迪嘉药业集团有限公司 一种亚胺还原酶突变体及其应用
CN114717211B (zh) * 2022-03-23 2023-06-02 江苏集萃分子工程研究院有限公司 亚胺还原酶突变体m5及其在合成氮杂环手性胺中的应用
CN116814569B (zh) * 2023-05-30 2025-07-25 华东理工大学 一种催化活性提高的醇脱氢酶突变体、基因工程菌及其应用
CN119931979A (zh) * 2024-11-27 2025-05-06 南京药石科技股份有限公司 一种亚胺还原酶突变体及其应用

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Also Published As

Publication number Publication date
JP6643987B2 (ja) 2020-02-12
DK3068793T3 (da) 2021-03-22
CN106232619B (zh) 2022-09-09
JP2016536990A (ja) 2016-12-01
EP3068793A4 (en) 2017-09-20
US9822346B2 (en) 2017-11-21
US20210301266A1 (en) 2021-09-30
US12312609B2 (en) 2025-05-27
CN106232619A (zh) 2016-12-14
US11060072B2 (en) 2021-07-13
US20150132807A1 (en) 2015-05-14
WO2015073555A1 (en) 2015-05-21
HUE053379T2 (hu) 2021-06-28
IL245453A0 (en) 2016-06-30
US10407668B2 (en) 2019-09-10
US20250304924A1 (en) 2025-10-02
EP3068793A1 (en) 2016-09-21
CA2929664C (en) 2023-01-24
CA2929664A1 (en) 2015-05-21
US20190345458A1 (en) 2019-11-14
US20180030419A1 (en) 2018-02-01
EP3068793B1 (en) 2021-02-17

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