DK3068793T3 - Manipulerede iminreductaser og fremgangsmåder til den reduktive aminering af keton- og aminforbindelser - Google Patents
Manipulerede iminreductaser og fremgangsmåder til den reduktive aminering af keton- og aminforbindelser Download PDFInfo
- Publication number
- DK3068793T3 DK3068793T3 DK14862555.1T DK14862555T DK3068793T3 DK 3068793 T3 DK3068793 T3 DK 3068793T3 DK 14862555 T DK14862555 T DK 14862555T DK 3068793 T3 DK3068793 T3 DK 3068793T3
- Authority
- DK
- Denmark
- Prior art keywords
- iminreductases
- manipulated
- ketone
- procedures
- reductive amination
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
- C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y105/00—Oxidoreductases acting on the CH-NH group of donors (1.5)
- C12Y105/01—Oxidoreductases acting on the CH-NH group of donors (1.5) with NAD+ or NADP+ as acceptor (1.5.1)
- C12Y105/01028—Opine dehydrogenase (1.5.1.28)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361903772P | 2013-11-13 | 2013-11-13 | |
| US201462022323P | 2014-07-09 | 2014-07-09 | |
| US201462022315P | 2014-07-09 | 2014-07-09 | |
| PCT/US2014/065259 WO2015073555A1 (en) | 2013-11-13 | 2014-11-12 | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3068793T3 true DK3068793T3 (da) | 2021-03-22 |
Family
ID=53044107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14862555.1T DK3068793T3 (da) | 2013-11-13 | 2014-11-12 | Manipulerede iminreductaser og fremgangsmåder til den reduktive aminering af keton- og aminforbindelser |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US9822346B2 (da) |
| EP (1) | EP3068793B1 (da) |
| JP (1) | JP6643987B2 (da) |
| CN (1) | CN106232619B (da) |
| CA (1) | CA2929664C (da) |
| DK (1) | DK3068793T3 (da) |
| HU (1) | HUE053379T2 (da) |
| IL (1) | IL245453B (da) |
| WO (1) | WO2015073555A1 (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2512226T3 (pl) * | 2009-12-17 | 2019-10-31 | Pioneer Hi Bred Int | Modyfikacja DP-004114-3 kukurydzy i sposoby jej wykrywania |
| JP6643987B2 (ja) | 2013-11-13 | 2020-02-12 | コデクシス， インコーポレイテッド | ケトン化合物およびアミン化合物の還元的アミノ化のための操作されたイミンレダクターゼおよび方法 |
| CN107002050A (zh) * | 2014-11-25 | 2017-08-01 | 科德克希思公司 | 工程化亚胺还原酶和用于酮和胺化合物的还原胺化的方法 |
| KR101761830B1 (ko) | 2015-10-21 | 2017-07-26 | 주식회사 엘지화학 | 리간드 화합물, 올레핀 올리고머화용 촉매계, 및 이를 이용한 올레핀 올리고머화 방법 |
| JP7316662B2 (ja) * | 2016-08-26 | 2023-07-28 | コデクシス， インコーポレイテッド | 操作されたイミンレダクターゼ、ならびにケトン化合物およびアミン化合物の還元的アミノ化のための方法 |
| CN107384885B (zh) * | 2017-09-05 | 2019-12-24 | 武汉大学 | 亚胺还原酶及其突变体在合成(s)-1-芳基-1，2，3，4-四氢异喹啉中的应用 |
| CN108504701B (zh) * | 2018-04-26 | 2021-05-14 | 中南林业科技大学 | 一种异丙甲草胺中间体的合成方法 |
| PT3653617T (pt) | 2018-11-16 | 2020-12-11 | Zanoprima Lifesciences Ltd | Processo de preparação de (s)-nicotina a partir de miosmina |
| SG11202110852RA (en) * | 2019-05-01 | 2021-10-28 | Codexis Inc | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
| CN114717211B (zh) * | 2022-03-23 | 2023-06-02 | 江苏集萃分子工程研究院有限公司 | 亚胺还原酶突变体m5及其在合成氮杂环手性胺中的应用 |
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| JP6643987B2 (ja) | 2013-11-13 | 2020-02-12 | コデクシス， インコーポレイテッド | ケトン化合物およびアミン化合物の還元的アミノ化のための操作されたイミンレダクターゼおよび方法 |
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2014
- 2014-11-12 JP JP2016529958A patent/JP6643987B2/ja active Active
- 2014-11-12 US US14/539,690 patent/US9822346B2/en active Active
- 2014-11-12 DK DK14862555.1T patent/DK3068793T3/da active
- 2014-11-12 CN CN201480073005.5A patent/CN106232619B/zh active Active
- 2014-11-12 WO PCT/US2014/065259 patent/WO2015073555A1/en active Application Filing
- 2014-11-12 CA CA2929664A patent/CA2929664C/en active Active
- 2014-11-12 HU HUE14862555A patent/HUE053379T2/hu unknown
- 2014-11-12 EP EP14862555.1A patent/EP3068793B1/en active Active
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2016
- 2016-05-03 IL IL245453A patent/IL245453B/en active IP Right Grant
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2017
- 2017-10-13 US US15/783,657 patent/US10407668B2/en active Active
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2019
- 2019-07-30 US US16/525,834 patent/US11060072B2/en active Active
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2021
- 2021-06-09 US US17/343,058 patent/US20210301266A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20210301266A1 (en) | 2021-09-30 |
| JP6643987B2 (ja) | 2020-02-12 |
| US11060072B2 (en) | 2021-07-13 |
| CA2929664C (en) | 2023-01-24 |
| HUE053379T2 (hu) | 2021-06-28 |
| CN106232619A (zh) | 2016-12-14 |
| WO2015073555A1 (en) | 2015-05-21 |
| US20190345458A1 (en) | 2019-11-14 |
| CN106232619B (zh) | 2022-09-09 |
| EP3068793A4 (en) | 2017-09-20 |
| US9822346B2 (en) | 2017-11-21 |
| US20150132807A1 (en) | 2015-05-14 |
| IL245453B (en) | 2021-04-29 |
| JP2016536990A (ja) | 2016-12-01 |
| US20180030419A1 (en) | 2018-02-01 |
| US10407668B2 (en) | 2019-09-10 |
| EP3068793B1 (en) | 2021-02-17 |
| CA2929664A1 (en) | 2015-05-21 |
| IL245453A0 (en) | 2016-06-30 |
| EP3068793A1 (en) | 2016-09-21 |
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