IL235549B - Bleeding powders of regenerated oxidized cellulose and methods of preparation - Google Patents
Bleeding powders of regenerated oxidized cellulose and methods of preparationInfo
- Publication number
- IL235549B IL235549B IL235549A IL23554914A IL235549B IL 235549 B IL235549 B IL 235549B IL 235549 A IL235549 A IL 235549A IL 23554914 A IL23554914 A IL 23554914A IL 235549 B IL235549 B IL 235549B
- Authority
- IL
- Israel
- Prior art keywords
- making
- methods
- regenerated cellulose
- oxidized regenerated
- hemostatic powders
- Prior art date
Links
- 230000002439 hemostatic effect Effects 0.000 title 1
- 239000000843 powder Substances 0.000 title 1
- 239000004627 regenerated cellulose Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/717—Celluloses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/02—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of powders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/009—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
- C08L1/02—Cellulose; Modified cellulose
- C08L1/04—Oxycellulose; Hydrocellulose, e.g. microcrystalline cellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Polymers & Plastics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/480,842 US8815832B2 (en) | 2012-05-25 | 2012-05-25 | Oxidized regenerated cellulose hemostatic powders and methods of making |
| PCT/US2013/042149 WO2013177242A1 (en) | 2012-05-25 | 2013-05-22 | Oxidized regenerated cellulose hemostatic powders and methods of making |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL235549A0 IL235549A0 (en) | 2015-01-29 |
| IL235549B true IL235549B (en) | 2020-03-31 |
Family
ID=48537032
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL235549A IL235549B (en) | 2012-05-25 | 2014-11-06 | Bleeding powders of regenerated oxidized cellulose and methods of preparation |
| IL261869A IL261869B (en) | 2012-05-25 | 2018-09-20 | Bleeding powders of regenerated oxidized cellulose and methods of preparation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL261869A IL261869B (en) | 2012-05-25 | 2018-09-20 | Bleeding powders of regenerated oxidized cellulose and methods of preparation |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US8815832B2 (enExample) |
| EP (3) | EP4043042A1 (enExample) |
| JP (1) | JP6165849B2 (enExample) |
| KR (2) | KR102131601B1 (enExample) |
| CN (1) | CN104321085B (enExample) |
| AU (1) | AU2013266416B2 (enExample) |
| BR (2) | BR112014029206B1 (enExample) |
| CA (2) | CA3094664C (enExample) |
| DK (1) | DK3466455T3 (enExample) |
| ES (2) | ES2906971T3 (enExample) |
| IL (2) | IL235549B (enExample) |
| IN (1) | IN2014DN09514A (enExample) |
| MX (2) | MX354596B (enExample) |
| RU (2) | RU2629199C2 (enExample) |
| WO (1) | WO2013177242A1 (enExample) |
| ZA (1) | ZA201409429B (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2504039A4 (en) | 2009-11-25 | 2014-07-02 | Univ Loma Linda Med | HEMOSTATIC TEXTILE BASED ON CHITOSAN |
| US9259357B2 (en) | 2014-04-16 | 2016-02-16 | Loma Linda University | Composition, preparation, and use of chitosan shards for biomedical applications |
| ES2817935T3 (es) * | 2014-07-18 | 2021-04-08 | Ethicon Inc | Material celulósico combinado y método para producirlo y usarlo |
| US10183132B2 (en) | 2014-09-11 | 2019-01-22 | Ethicon Llc | Methods and devices for co-delivery of liquid and powdered hemostats and sealants |
| MX384582B (es) * | 2015-11-06 | 2025-03-14 | Ethicon Inc | Agregados celulósicos hemostáticos compactados. |
| RU2731371C2 (ru) * | 2015-11-08 | 2020-09-02 | Омрикс Биофармасьютикалс Лтд. | Гемостатическая смесь коротких и длинных волокон на основе целлюлозы |
| KR102665892B1 (ko) | 2015-11-08 | 2024-05-16 | 옴릭스 바이오파머슈티컬스 리미티드 | 셀룰로오스-기반의 짧은 섬유 및 긴 섬유의 지혈 혼합물 |
| CN107754005B (zh) | 2016-08-15 | 2021-06-15 | 广州倍绣生物技术有限公司 | 止血组合物及其制造方法 |
| US20220111020A1 (en) * | 2016-08-15 | 2022-04-14 | Guangzhou Bioseal Biotech Co. Ltd. | Hemostatic compositions and methods of making thereof |
| US11413335B2 (en) | 2018-02-13 | 2022-08-16 | Guangzhou Bioseal Biotech Co. Ltd | Hemostatic compositions and methods of making thereof |
| KR102656226B1 (ko) * | 2016-12-09 | 2024-04-09 | 한국생산기술연구원 | 칼슘 카르복시메틸 셀룰로오스 파우더 및 수용성 키토산 화합물 파우더를 포함하는 지혈 소재 및 그의 제조 방법 |
| RU2660582C1 (ru) * | 2017-07-12 | 2018-07-06 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр гематологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ гематологии" Минздрава России) | Гемостатическое покрытие в форме порошка |
| US11679177B2 (en) | 2017-08-08 | 2023-06-20 | Baxter International Inc. | Polymeric compositions, delivery devices, and methods |
| US11007299B2 (en) | 2017-11-08 | 2021-05-18 | Ethicon, Inc. | Hemostatic paste having surface enriched with hemostasis-promoting agents and devices for delivery |
| KR20210008479A (ko) | 2018-05-09 | 2021-01-22 | 훼로산 메디칼 디바이스 에이/에스 | 지혈 조성물을 제조하는 방법 |
| IL262716A (en) * | 2018-11-01 | 2018-11-29 | Omrix Biopharmaceuticals Ltd | Oxidized cellulose preparations |
| US11241386B2 (en) * | 2019-02-13 | 2022-02-08 | Biolife, L.L.C. | Wound sealing powder |
| AU2020308865A1 (en) * | 2019-06-26 | 2022-02-17 | Davol Inc. | Reactive dry powdered hemostatic materials comprising a nucleophile and a multifunctional modified polyethylene glycol based crosslinking agent |
| WO2021009016A1 (en) | 2019-07-12 | 2021-01-21 | Gatt Technologies B.V. | Method for preparing a tissue-adhesive sheet |
| BR112022000511A2 (pt) | 2019-07-12 | 2022-03-03 | Gatt Tech B V | Folha hemostática flexível biocompatível, embalagem vedada e método de preparação de folhas homeostáticas |
| ES2961107T3 (es) | 2019-07-12 | 2024-03-08 | Cilag Gmbh Int | Polvo hemostático |
| WO2021014357A1 (en) * | 2019-07-23 | 2021-01-28 | Kci Licensing, Inc. | Collagen-based biomaterials for wound management |
| IL268572A (en) | 2019-08-07 | 2019-09-26 | Omrix Biopharmaceuticals Ltd | An expandable hemostatic composed of oxidized cellulose |
| US20210106717A1 (en) * | 2019-10-10 | 2021-04-15 | Cook Medical Technologies Llc | Bonded powders for the treatment of bodily lesions |
| KR102886728B1 (ko) * | 2019-10-31 | 2025-11-14 | 주식회사 삼양홀딩스 | 분말형 지혈제 조성물 및 이의 제조 방법 |
| CN113117131B (zh) * | 2019-12-31 | 2023-01-03 | 广州迈普再生医学科技股份有限公司 | 一种纳米纤维微球材料及其制备方法和应用 |
| CN113117132B (zh) * | 2019-12-31 | 2022-11-22 | 广州迈普再生医学科技股份有限公司 | 一种可吸收膨胀式纳米短纤维粉状材料及其制备方法和应用 |
| CN113117133B (zh) * | 2019-12-31 | 2023-03-14 | 广州迈普再生医学科技股份有限公司 | 一种纤维聚集体及其制备方法和应用 |
| KR20230007378A (ko) * | 2020-04-17 | 2023-01-12 | 보스톤 싸이엔티픽 싸이메드 인코포레이티드 | 지혈 조성물 및 관련 방법 |
| RU2756316C1 (ru) * | 2020-06-15 | 2021-09-29 | Федеральное государственное бюджетное учреждение науки Байкальский институт природопользования Сибирского отделения Российской академии наук (БИП СО РАН) | Местное гемостатическое антибактериальное средство, способ его получения и медицинское изделие на его основе |
| US12285540B2 (en) * | 2020-07-21 | 2025-04-29 | Ethicon, Inc. | Hemostatic composite aggregate materials having surface enriched with hemostatis-promoting agents |
| CN114681660B (zh) * | 2020-12-31 | 2023-04-18 | 广州迈普再生医学科技股份有限公司 | 可吸收止血粉及其制备方法和应用 |
| JP2024502848A (ja) | 2021-01-08 | 2024-01-23 | シラグ・ゲーエムベーハー・インターナショナル | 生体吸収性封止粉末 |
| US20240148933A1 (en) | 2022-11-08 | 2024-05-09 | Ethicon, Inc. | Expandable hemostatic tablets comprising oxidized regenerated cellulose |
| GB2636872A (en) * | 2023-12-29 | 2025-07-02 | Futamura Chemical Uk Ltd | Composition |
| US20250262343A1 (en) * | 2024-02-21 | 2025-08-21 | Solomon Rosenblatt | Polymeric iodophor compositions and methods of use |
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| WO2005072700A2 (en) | 2004-01-30 | 2005-08-11 | Ferrosan A/S | Haemostatic sprays and compositions |
| US20070141156A1 (en) | 2005-12-21 | 2007-06-21 | Uri Herzberg | Compositions and methods for preventing or reducing postoperative ileus and gastric stasis |
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| JP5031054B2 (ja) * | 2010-03-18 | 2012-09-19 | 信越化学工業株式会社 | 低置換度ヒドロキシプロピルセルロース及びこれを含む固形製剤 |
| US10022410B2 (en) | 2010-12-22 | 2018-07-17 | Ethicon, Inc. | Hemostatic preparation containing an extract of golden moss |
| JP5259028B1 (ja) | 2011-09-12 | 2013-08-07 | グンゼ株式会社 | 親水性化セルロース繊維の製造方法 |
| US9028851B2 (en) | 2011-12-21 | 2015-05-12 | Ethicon, Inc. | Hemostatic materials and devices with galvanic particulates |
| ES2817935T3 (es) | 2014-07-18 | 2021-04-08 | Ethicon Inc | Material celulósico combinado y método para producirlo y usarlo |
| MX384582B (es) | 2015-11-06 | 2025-03-14 | Ethicon Inc | Agregados celulósicos hemostáticos compactados. |
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