IL229713A - Humanized antibodies against cd52 - Google Patents
Humanized antibodies against cd52Info
- Publication number
- IL229713A IL229713A IL229713A IL22971313A IL229713A IL 229713 A IL229713 A IL 229713A IL 229713 A IL229713 A IL 229713A IL 22971313 A IL22971313 A IL 22971313A IL 229713 A IL229713 A IL 229713A
- Authority
- IL
- Israel
- Prior art keywords
- antibody
- seq
- human
- cells
- humanised
- Prior art date
Links
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
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- A—HUMAN NECESSITIES
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- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Mycology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161492005P | 2011-06-01 | 2011-06-01 | |
| GBGB1109238.4A GB201109238D0 (en) | 2011-06-01 | 2011-06-01 | Antibodies |
| PCT/EP2012/060345 WO2012164063A1 (en) | 2011-06-01 | 2012-06-01 | Humanised anti-cd52 antibodies |
Publications (2)
| Publication Number | Publication Date |
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| IL229713A0 IL229713A0 (en) | 2014-01-30 |
| IL229713A true IL229713A (en) | 2017-03-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL229713A IL229713A (en) | 2011-06-01 | 2013-11-28 | Humanized antibodies against cd52 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9321841B2 (enExample) |
| EP (1) | EP2714739A1 (enExample) |
| JP (1) | JP6254522B2 (enExample) |
| KR (1) | KR20140036274A (enExample) |
| CN (1) | CN103649122B (enExample) |
| AU (1) | AU2012264643B2 (enExample) |
| BR (1) | BR112013030875A2 (enExample) |
| CA (1) | CA2837965A1 (enExample) |
| GB (1) | GB201109238D0 (enExample) |
| IL (1) | IL229713A (enExample) |
| MX (1) | MX342676B (enExample) |
| MY (1) | MY163257A (enExample) |
| RU (1) | RU2605307C2 (enExample) |
| SG (1) | SG195042A1 (enExample) |
| WO (1) | WO2012164063A1 (enExample) |
| ZA (1) | ZA201308900B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
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| NZ621170A (en) | 2009-05-13 | 2015-08-28 | Genzyme Corp | Anti-human cd52 immunoglobulins |
| CA2902026C (en) | 2013-03-13 | 2023-08-29 | Prothena Biosciences Limited | Tau immunotherapy |
| EP3452508A1 (en) | 2016-05-02 | 2019-03-13 | Prothena Biosciences Limited | Antibodies recognizing tau |
| US10752679B2 (en) | 2016-05-02 | 2020-08-25 | Prothena Biosciences Limited | Tau immunotherapy |
| PE20190208A1 (es) | 2016-05-02 | 2019-02-07 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau |
| CN106018814B (zh) * | 2016-08-07 | 2017-11-14 | 深圳市南海生物科技有限公司 | 一种用于白血病和自身免疫病检测用试剂盒 |
| JP7219721B2 (ja) * | 2017-04-21 | 2023-02-08 | ジェンザイム・コーポレーション | 抗ｃｄ５２抗体を用いて多発性硬化症を処置するための経路およびスケジュール |
| MX2019013045A (es) | 2017-05-02 | 2020-02-12 | Prothena Biosciences Ltd | Anticuerpos que reconocen tau. |
| BR112020022179A2 (pt) | 2018-05-03 | 2021-02-02 | Genmab B.V. | primeiro anticorpo, anticorpo, composição, métodos para tratar um indivíduo tendo uma doença, para esgotar uma população de célula e para induzir a proliferação em uma população de célula, e, kit. |
| AU2020231366A1 (en) * | 2019-03-03 | 2021-08-12 | Prothena Biosciences Limited | Antibodies recognizing tau |
| CN117534750B (zh) * | 2023-10-16 | 2024-06-11 | 遵义医科大学珠海校区 | 一种抗新型冠状病毒核衣壳蛋白的抗体或其抗原结合片段及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| DE68909441T2 (de) * | 1988-02-12 | 1994-02-10 | British Tech Group | Modifizierte Antikörper. |
| GB9022547D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Purified immunoglobulin |
| GB9603507D0 (en) * | 1996-02-20 | 1996-04-17 | Isis Innovation | Antibody variants |
| GB9712892D0 (en) | 1997-06-20 | 1997-08-20 | Eclagen Ltd | Identification of mhc binding peptides |
| JP4334866B2 (ja) * | 2000-10-09 | 2009-09-30 | アイシス イノヴェイション リミテッド | 治療用抗体 |
| EP2298805A3 (en) * | 2002-09-27 | 2011-04-13 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
| CN1225480C (zh) * | 2002-12-18 | 2005-11-02 | 马菁 | 抗cd52单克隆抗体、其编码序列及应用 |
| CN1898267B (zh) | 2003-11-01 | 2012-05-23 | 默克专利股份有限公司 | 修饰的抗cd52抗体 |
| US20070286857A1 (en) * | 2003-12-22 | 2007-12-13 | Genzyme Corporation | Anti-Cd52 Antibody Treatment for Diabetes |
| AU2006210724A1 (en) | 2005-02-03 | 2006-08-10 | Antitope Limited | Human antibodies and proteins |
| KR20080039843A (ko) * | 2005-05-24 | 2008-05-07 | 아베스타 겐그레인 테크놀로지스 피브이티 리미티드 | 만성 림프구성 백혈병의 치료를 위한 ｃｄ52 에 대한모노클로날 항체의 제조를 위한 재조합 방법 |
| NZ621170A (en) | 2009-05-13 | 2015-08-28 | Genzyme Corp | Anti-human cd52 immunoglobulins |
| CN102079787A (zh) * | 2010-12-09 | 2011-06-01 | 协和干细胞基因工程有限公司 | 抗人cd52的工程抗体、载体、试剂盒及其用途 |
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- 2012-06-01 WO PCT/EP2012/060345 patent/WO2012164063A1/en not_active Ceased
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- 2012-06-01 CA CA2837965A patent/CA2837965A1/en not_active Abandoned
- 2012-06-01 RU RU2013158454/10A patent/RU2605307C2/ru active
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2014518630A (ja) | 2014-08-07 |
| BR112013030875A2 (pt) | 2016-11-29 |
| JP6254522B2 (ja) | 2017-12-27 |
| IL229713A0 (en) | 2014-01-30 |
| CA2837965A1 (en) | 2012-12-06 |
| SG195042A1 (en) | 2013-12-30 |
| RU2605307C2 (ru) | 2016-12-20 |
| CN103649122B (zh) | 2017-09-05 |
| AU2012264643B2 (en) | 2016-09-29 |
| KR20140036274A (ko) | 2014-03-25 |
| US20140127236A1 (en) | 2014-05-08 |
| US9321841B2 (en) | 2016-04-26 |
| MX342676B (es) | 2016-10-07 |
| AU2012264643A1 (en) | 2013-12-19 |
| RU2013158454A (ru) | 2015-07-20 |
| MX2013014083A (es) | 2014-09-16 |
| CN103649122A (zh) | 2014-03-19 |
| GB201109238D0 (en) | 2011-07-13 |
| MY163257A (en) | 2017-08-30 |
| ZA201308900B (en) | 2015-02-25 |
| EP2714739A1 (en) | 2014-04-09 |
| WO2012164063A1 (en) | 2012-12-06 |
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