IL225731B - Biomarkers for brain injury - Google Patents
Biomarkers for brain injuryInfo
- Publication number
- IL225731B IL225731B IL225731A IL22573113A IL225731B IL 225731 B IL225731 B IL 225731B IL 225731 A IL225731 A IL 225731A IL 22573113 A IL22573113 A IL 22573113A IL 225731 B IL225731 B IL 225731B
- Authority
- IL
- Israel
- Prior art keywords
- biomarkers
- brain injury
- brain
- injury
- Prior art date
Links
- 239000000090 biomarker Substances 0.000 title 1
- 208000029028 brain injury Diseases 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2871—Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39300910P | 2010-10-14 | 2010-10-14 | |
| US201161436956P | 2011-01-27 | 2011-01-27 | |
| US201161436955P | 2011-01-27 | 2011-01-27 | |
| PCT/US2011/056338 WO2012051519A2 (en) | 2010-10-14 | 2011-10-14 | Biomarkers of brain injury |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL225731A0 IL225731A0 (en) | 2013-06-27 |
| IL225731B true IL225731B (en) | 2018-01-31 |
Family
ID=45938999
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL225731A IL225731B (en) | 2010-10-14 | 2013-04-11 | Biomarkers for brain injury |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9746481B2 (enExample) |
| EP (1) | EP2628013B1 (enExample) |
| JP (1) | JP6071886B2 (enExample) |
| IL (1) | IL225731B (enExample) |
| WO (1) | WO2012051519A2 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010019553A2 (en) | 2008-08-11 | 2010-02-18 | Banyan Biomarkers, Inc. | Biomarker detection process and assay of neurological condition |
| US9709573B2 (en) | 2012-03-13 | 2017-07-18 | The Johns Hopkins University | Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration |
| US9378551B2 (en) * | 2013-01-03 | 2016-06-28 | Siemens Aktiengesellschaft | Method and system for lesion candidate detection |
| EP3022322A4 (en) * | 2013-07-17 | 2017-05-17 | The Johns Hopkins University | A multi-protein biomarker assay for brain injury detection and outcome |
| JP6312302B2 (ja) * | 2014-01-06 | 2018-04-18 | 公益財団法人ヒューマンサイエンス振興財団 | 脳梗塞の診断マーカー |
| EP2896702A1 (en) * | 2014-01-16 | 2015-07-22 | University College Cork, National University Of Irland Cork | A method of identifying a neonate at risk of having or developing hypoxic-ischaemic encephalopathy (HIE) |
| US10238664B2 (en) * | 2014-07-09 | 2019-03-26 | Duke University | Compositions and methods for the repair of myelin |
| US20180238907A1 (en) * | 2014-10-06 | 2018-08-23 | Université de Genéve | Markers and their use in brain injury |
| US12422442B2 (en) | 2014-10-06 | 2025-09-23 | Universite De Geneve | Markers and their use in brain injury |
| EP3254106A4 (en) | 2015-02-05 | 2018-10-03 | Immunarray USA, Inc. | Methods and compositions for diagnosing brain injury or neurodegeneration |
| EP3292414B1 (en) | 2015-05-05 | 2021-04-07 | The Regents of the University of California | Astrocyte traumatome and neurotrauma biomarkers |
| US20180106818A1 (en) * | 2016-10-03 | 2018-04-19 | Abbott Laboratories | Methods of assessing gfap status in patient samples |
| US11078298B2 (en) | 2016-10-28 | 2021-08-03 | Banyan Biomarkers, Inc. | Antibodies to ubiquitin C-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) and related methods |
| US20200191801A1 (en) * | 2016-12-23 | 2020-06-18 | Susanne PANGRATZ-FÜHRER | Alpha-b crystallin in the diagnosis of neonatal brain damage |
| CN106645755B (zh) * | 2016-12-30 | 2018-09-25 | 深圳大学 | 一种ad生物标记物及其检测方法 |
| CA3050001A1 (en) | 2017-01-13 | 2018-07-19 | Duke University | Compositions and methods for the treatment of myelin related and inflammation related diseases or disorders |
| WO2018175942A1 (en) | 2017-03-23 | 2018-09-27 | Abbott Laboratories | Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase l1 |
| EP3610268B1 (en) | 2017-04-15 | 2025-09-24 | Abbott Laboratories | Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury in a human subject using early biomarkers |
| BR112019022476A2 (pt) | 2017-04-28 | 2020-05-12 | Abbott Laboratories | Métodos para o auxílio no diagnóstico e determinação hiperagudos de lesão cerebral traumática usando biomarcadores iniciais em pelo menos duas amostras a partir do mesmo ser humano |
| US11709168B2 (en) | 2017-05-23 | 2023-07-25 | Brainbox Solutions, Inc. | Biomarker levels and neuroimaging for detecting, monitoring and treating brain injury or trauma |
| WO2018218169A1 (en) | 2017-05-25 | 2018-11-29 | Abbott Laboratories | Methods for aiding in the determination of whether to perform imaging on a human subject who has sustained or may have sustained an injury to the head using early biomarkers |
| CA3059607A1 (en) | 2017-05-30 | 2018-12-06 | Abbott Laboratories | Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin i |
| JP7454945B2 (ja) | 2017-07-03 | 2024-03-25 | アボット・ラボラトリーズ | 血液中のユビキチンカルボキシ末端ヒドロラーゼl1レベルを測定するための、改善された方法 |
| WO2019112863A1 (en) * | 2017-12-06 | 2019-06-13 | FloTBI Inc. | Assay and point of care device utilizing saliva for diagnosis and treatment of neurological conditions affected brain health |
| BR112019028254A2 (pt) | 2017-12-09 | 2020-07-14 | Abbott Laboratories | métodos para ajudar no diagnóstico e avaliação de um paciente que sofreu uma lesão ortopédica e que sofreu ou pode ter sofrido uma lesão na cabeça, tal como uma lesão cerebral traumática (lct) leve, usando a proteína ácida fibrilar glial (gfap) e/ou a hidrolase carbóxi-terminal da ubiquitina l1 (uch-l1) |
| CA3067055A1 (en) | 2017-12-09 | 2019-06-13 | Abbott Laboratories | Methods for aiding in diagnosing and evaluating a traumatic brain injury in a human subject using a combination of gfap and uch-l1 |
| EP3732489B1 (en) | 2017-12-29 | 2025-10-22 | Abbott Laboratories | Novel biomarkers and methods for diagnosing and evaluating traumatic brain injury |
| CN108872589B (zh) * | 2018-01-03 | 2021-09-03 | 深圳市人民医院 | 脑梗死外周血标志物及其应用 |
| WO2019189725A1 (ja) * | 2018-03-30 | 2019-10-03 | 国立研究開発法人国立精神・神経医療研究センター | 新生児低酸素性虚血性脳症の重症度判定方法と予後予測方法 |
| BR112021009203A2 (pt) * | 2018-11-14 | 2021-08-03 | Mark Evans | método e aparelho para reduzir o risco de lesão neurológica a uma criança humana no período neonatal |
| US20220016221A1 (en) * | 2018-12-05 | 2022-01-20 | Ipsen Biopharm Limited | Treatment of symptoms of traumatic brain injury |
| CN110261617B (zh) * | 2019-05-14 | 2022-07-01 | 深圳市人民医院 | 脑出血外周血标志物及其应用 |
| CN110907422B (zh) * | 2019-12-16 | 2021-07-06 | 吉林大学 | 基于Ti3C2的凝血酶适体传感器及其制备方法 |
| US20230088509A1 (en) * | 2020-05-20 | 2023-03-23 | St. Jude Children's Research Hospital | Detection of alzheimer's disease using specific biomarkers |
| EP3982123A1 (en) * | 2020-10-08 | 2022-04-13 | Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca | Markers and their use in brain injury |
| WO2022165431A1 (en) * | 2021-02-01 | 2022-08-04 | The University Of Chicago | Systems and methods for identifying progression of hypoxic-ischemic brain injury |
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-
2011
- 2011-10-14 WO PCT/US2011/056338 patent/WO2012051519A2/en not_active Ceased
- 2011-10-14 EP EP11833480.4A patent/EP2628013B1/en active Active
- 2011-10-14 JP JP2013534031A patent/JP6071886B2/ja active Active
- 2011-10-14 US US13/879,470 patent/US9746481B2/en active Active
-
2013
- 2013-04-11 IL IL225731A patent/IL225731B/en active IP Right Grant
-
2014
- 2014-10-27 US US14/524,217 patent/US20150051115A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20150051115A1 (en) | 2015-02-19 |
| US9746481B2 (en) | 2017-08-29 |
| IL225731A0 (en) | 2013-06-27 |
| WO2012051519A3 (en) | 2012-09-20 |
| US20140045713A1 (en) | 2014-02-13 |
| EP2628013A2 (en) | 2013-08-21 |
| EP2628013B1 (en) | 2019-06-12 |
| WO2012051519A2 (en) | 2012-04-19 |
| JP6071886B2 (ja) | 2017-02-01 |
| EP2628013A4 (en) | 2014-03-12 |
| JP2013545087A (ja) | 2013-12-19 |
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Legal Events
| Date | Code | Title | Description |
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| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |